CPCB
Mission Statement
The
Staff and Program Areas
Program
Components
Requests
for Applications (RFAs) and Program Announcements (PAs)
Chemical
Carcinogen Reference Standards Repository
CPCB
Address
Table of Contents:
CPCB
Mission Statement
The
Staff and Program Areas
Program
Components
Requests
for Applications (RFAs) and Program Announcements (PAs)
Chemical
Carcinogen Reference Standards Repository
CPCB
Address
Chemical and Physical Carcinogenesis Staff:
-Dr.
David G. Longfellow, Chief
-Dr.
Yung-Pin Liu, Program Director for Carcinogenesis Mechanisms
-Dr.
Paul Okano, Program Director for Molecular Carcinogenesis
-Dr.
Harold E. Seifried, Program Director for Research Resources
-Ms.
Karen R. Grotzinger, Program Administrator
-Mr.
William C. Miller III, Program Administrator
-Ms.
Ellen L. Zaika, Program Analyst
-Mr.
Cleveland Cooper III, Grants Technical Assistant
-Ms.
Andrea Tomonaga, SecretaryThe Carcinogenesis Mechanisms component, headed by Dr. Yung-Pin Liu, is concerned with the metabolism, toxicity, physiological disposition, and mechanisms of action of carcinogens and their metabolites; syntheses of both known and suspect carcinogens or the development of derivatives for molecular structure-activity relationships; development of carcinogenicity/mutagenicity testing procedures; development of organ and cell culture systems and whole animal biological models for use in carcinogenesis studies; development of procedures for the qualitative and quantitative analysis of body fluids and tissues and environmental specimens for the presence of chemical carcinogens and associated substances; genetics and regulation of enzymes characteristically associated with carcinogenesis; identification of biochemical and molecular markers and properties of cells transformed by carcinogens; hormone-related biochemistry of cancer and cancerous hosts; and etiology of neoplasia in poikilothermic, aquatic animals.
The Molecular Carcinogenesis component, headed by Dr. Paul Okano, focuses on the genetics and mechanisms of cell transformation; the role of oxygen radicals in the carcinogenesis process; and identification and properties of tumor promoters and mechanisms of tumor promotion.
The Experimental Tobacco Carcinogenesis component, headed by Dr. David Longfellow, supports studies on the toxicology and pharmacology of smoking and tobacco-related exposures. A number of epidemiological studies have demonstrated a causative association between cigarette smoking and cancer of the lung, upper digestive tract, pancreas, renal pelvis and bladder. Smoking has also been associated with cancer of the liver and cervix, and with leukemia. Available epidemiological reports on the adverse health effects from the use of smokeless tobacco are less numerous but nevertheless quite convincing. Lastly, the synergistic effect of alcohol and tobacco-derived carcinogens is also of concern. The research in this category is directed toward understanding the nature of the chemicals involved, and the reaction mechanisms behind, the deleterious effects of tobacco smoke and smokeless tobacco products. To date, nearly 50 carcinogens have been identified in tobacco smoke, including myriad polynuclear aromatic hydrocarbons (PAHs); tobacco-specific N-nitrosamines (TSNAs); aromatic amines such as 2-toluidine, 2-naphthylamine and 4-aminobiphenyl; some volatile aldehydes such as acrolein, formaldehyde and acetaldehyde; benzene; vinyl chloride; butadiene; and acrylonitrile.
The Nutritional Carcinogenesis component, headed by Dr. David Longfellow, supports basic studies on the etiologic effects of dietary macronutrients such as fat, vitamins and proteins; food mutagens and carcinogens formed during cooking; carcinogenic compounds and other substances closely associated with food preparation such as free radicals, fibers, and pyrolysis products; and digestive tract mutagens which form as a result of compound biodegradation, biotransformation, etc. The etiology of cancer resulting from deficiencies in the availability of various micronutrients, vitamins, metals, etc., is also of interest. Research studies currently supported focus on the role of food mutagens and/or carcinogens in human cancer causation; influence of fat source and degree of fat saturation on tumor induction; role of nutrients and micronutrients in carcinogenesis; effects on cancer of increasing or decreasing dietary constituents such as fats, protein and orotate; and effects of calorie consumption and energy expenditure on cancer causation and prevention.
The Research Resources component, headed by Dr. Harold E. Seifried, focuses on providing contract support to synthesize and make available to the research community laboratory quantities of chemical carcinogens and mutagens, their metabolites and adducts, as well as experimental tumor inhibitors. These compounds are used primarily as authentic reference standards for chemical carcinogenesis and mutagenesis studies, e.g., research on metabolic activation pathways and molecular mechanism(s) of action of carcinogens and mutagens.
Requests
for Applications (RFAs) and Program Announcements (PAs)
Chemical
Carcinogen Reference Standards Repository
The CPCB supports a chemical carcinogen reference standards repository for the benefit of the research community. Reference quantities of over 750 compounds are available. The newest additions are dilute aqueous standards of polynuclear aromatic hydrocarbon (PAH) deoxyguanosine 3'-monophosphates for Randerath 32P postlabeling assays. Other classes of available compounds are: food mutagens, PAHs, PAH metabolites, nitrogen heterocycles, nitrosomines/nitrosamides, aromatic amines, aromatic amine metabolites, azo/azoxy aromatics, inorganics, nitroaromatics, pesticides, pharmaceuticals, natural products, dyes, dioxins, and chlorinated aliphatics. A number of radiolabeled PAH adducts, metabolites and nitrosamines are also available.
Data Sheets provided with the compounds include chemical and physical properties, analytical data, hazards, storage, and handling information.
The cost of the compounds is determined by the chemical class code and the quantity requested. Handling and shipping charges are included.
Rhododendron 'Ben Morrison', an evergreen azalea. Azaleas contain flavanols (e.g., Quercetin) which are a class of naturally occurring chemicals that are being evaluated for their chemopreventive qualities. If you need high purity and well characterized research chemicals such as Quercetin for your research, consider the Chemical Carcinogen Reference Standards Repository as your quality source. Let the Repository know of your hard to find carcinogen and chemopreventive chemical needs.
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