Cellular and Molecular Immunology Section

Laboratory of Experimental Immunology, National Cancer Institute, National Institutes of Health.

Recent Publications

Cippitelli, M., Sica, A., Viggiano, V., Ye, J., Ghosh, P., Birrer, M.J., and Young, H.A.: Negative transcriptional regulation of the interferon- gamma promoter by glucocorticoids and dominant negative mutants of c-Jun. . J. Biol. Chem. 270:12548-12556, 1995.

Ye, J., Ortaldo, J.R., Conlon, K., Winkler-Pickett, R., and Young, H.A.: Cellular and molecular mechanisms of IFN-gamma production induced by IL-2 and IL-12 in a human NK cell line. . J. Leukoc. Biol. 58:225-233, 1995.

Young, H.A. and Hardy, K.J.: Role of interferon-gamma in immune cell regulation. . J. Leukoc. Biol., 58: 373-381, 1995

Ghosh, P., Komschlies, K.L., Cippitelli, M., Longo, D.L., Subleski, J., Ye, J., Sica, A., Young, H.A., Wiltrout, R.H., and Ochoa, A.C.: Gradual loss of T-helper 1 (Th1) populations in the spleen of mice during progressive tumor growth. . JNCI, 87: 1478-1483, 1995

Ye, J., Cippitelli, M., Dorman, L., Ortaldo, J.R., and Young H.A.: The nuclear factor YY1 suppresses th human gamma interferon promoter through two mechanisms: Inhibition of AP1 binding and activation of a silencer element. Mol. Cell. Biol. 16: 4744-4753, 1996

Ghosh, P., Sica, A., Cippitelli, M., Subleski, J., Lahesmaa, R., Young, H.A., and Rice, N.R.: Activation of nuclear factor of activated T cells in a cyclosporin A resistant pathway. J. Biol. Chem 271: 7700-7704, 1996.

Cippitelli, M., Ye, J., Viggiano, V., Sica, A., Ghosh, P., Gulino, A., Santoni, A., and H.A. Young: Retinoic acid-induced transcriptional modulation of the human interferon- promoter. J. Biol.Chem. 271:26783-26793, 1996.

Young, H.A.: Regulation of interferon-g gene expression. J. Interferon & Cytokine Res. 16:563-568, 1996.

Kwak, L.W., Young, H.A., Pennington, R.W., and Weeks, S.D.: Vaccination with syngeneic, lymphoma-derived Ig idiotype combined with GM-CSF primes mice for a protective T-cell response. Proc. Natl. Acad. Sci. USA, 93: 10972-77, 1996.

Young, H.A., Klinman, D.M., Reynolds, D.A., Grzegorzewski, K.J., Nii, A., Ward, J.M., Winkler-Pickett, R.T., Ortaldo, J.R., Kenny, J.J., and Komschlies, K.L.: Bone marrow and thymus expression of interferon- results in severe B-cell lineage reduction, T-cell lineage alterations and hematopoietic progenitor deficiencies. Blood, in press.

Last Updated January 1997

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