Research Interests:

1. Human carcinogenesis.

2. Molecular epidemiology of cancer.

Academic Appointments:

Clinical Professor of Medicine (Hematology-Oncology), Department of Medicine, Georgetown University School of Medicine, Washington, DC, 1989 - 1999, 2007

Editor-in-Chief:

Carcinogenesis, 1984 -

Associate Editor:

Cancer Research, 1981 - 2007

Experimental Pathology, 1982 - 1991

Cell Biology and Toxicology, 1983 - 1992

Cancer Epidemiology, Prevention and Biomarkers, 1991 - 2001

American Journal of Respiratory Cell and Molecular Biology, 1992 - 1998, 2000-2003

Clinical Cancer Research, 1996 - 2004

Cancer Science, 2004-2009

Cancer Prevention Research, 2008-

Editorial Boards:

Carcinogenesis, 1979 - 1984

ILSI Monographs on Pathology of Laboratory Animals, 1981 - 1991

Japanese Journal of Clinical Oncology, 1992 -

Journal of Cellular Biochemistry, 1982 -

Journal of Cell Biochemistry and Function, 1982 - 1991

Chemico-Biological Interactions, 1983 - 1992

Lung Cancer, 1985 - 1995

Cancer Science (Japanese Journal for Cancer), 1986 - 2008

Molecular and Cellular Probes, 1986 - 1991

Toxicologic Pathology, 1988 - 1996

International Journal of Cancer 1991 - 2004

International Journal of Oncology 1992 - 2001

Tumori, 1992 - 2004

Predictive Oncology, 1995 - 2001

Environmental Health Perspectives, 1997 - 2004

Journal of the National Cancer Institute, 1998 - 2007

Women and Cancer, 1998 -

Gene Expression, 2000 - 2006

Hepatology, 2001 - 2004

Journal of the Nippon Medical School, 2002 -

Journal of Molecular Medicine, 2004 -

Scientific and Organizational Responsibilities:

Advisory Activities

Member, Ad Hoc Scientific Advisory Group on In Vitro Carcinogenesis, DCCP, NCI, 1974-1975

Member, Clinical Advisory Group to Viral Oncology, DCE, NCI, 1976-1977

Reviewer and Advisor, Thesis Advisory Committee, Department of Pathology, University of Maryland School of Medicine, 1977-1999

Expert Witness, Hearings concerning OSHA Regulations entitled "Identification, Classification and Regulation of Toxic Substances Posing a Potential Occupational Carcinogenic Risk", June 1978

Reviewer, Biomedical Division, Lawrence Livermore Laboratory, University of California, 1980

Consultant, Committee on Human Risk Assessment, Office of the Commissioner, Food and Drug Administration, 1980

Member, International Advisory Committee for the Danish Cancer Society, 1984-1990

Member, Research Committee, Health Effects Institute, 1984-1991

Member, External Advisory Committee, Institute of Environmental Medicine, New York University, 1985-1992

Member, Technical Review Committee, USPHS Surgeon General Report on Harmful Effects of Smokeless Tobacco, 1985-86

Founder and Member, Board of Directors, Aspen Cancer Conference (not for profit), 1985

Member, External Advisory Committee, School of Public Health, Johns Hopkins University, 1986-1990

Member, External Advisory Committee, Institute of Environmental Health, Oregon State University, 1986-1988

Member, Scientific Advisory Board, American Health Foundation, 1986-1998

Member, General Motors Mott Award Selection Committee, 1986

Overseer, Colby College, Waterville, Maine, 1988-1995

Member, Scientific Advisory Panel, Chemical Industry Institute of Technology, 1988

Member, Whitaker College Visiting Committee, M.I.T., 1988-1994

Chairman, Scientific Advisory Panel, Chemical Industry Institute of Technology, 1989-1994

Member, Scientific Council of the Radiation Effects Research Foundation, N.A.S. 1989-1997

Member, Scientific Advisory Council, International Agency for Research on Cancer, W.H.O., Lyon, 1989-1994

Chairman, Scientific Advisory Board, Dana Institute, American Health Foundation, 1989-1998

Chairman, Scientific Advisory Board and Secretary, Keystone Executive Committee, Keystone Symposia on Molecular and Cellular Biology (not for profit), 1990-2006

Member, Visiting Committee for the Brookhaven National Laboratory, N.A.S., Biology Department, 1990-1994

Member, Board of Directors, Intl. Society of Differentiation, 1990-1996

Chairman, Program Committee, AACR Annual Meeting, 1991

Committee Member, Risk Assessment of Hazardous Air Pollutants, National Research Council, Washington, DC, 1991-1993

Member, Advisory Committee for the Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, 1995-1997

Member, Board of Directors, American Association of Cancer Research, 1992-1995

Advisor, Howard Hughes Medical Institute Scholars Program, NIH, 1993-1995

Member, NIH Fogarty Scholars-in-Residence Advisory Panel, 1994-1996

Member, Division of Cancer Epidemiology and Genetics Promotions and Tenure Panel, 1995-1999

Member, Board of Directors, International Society of Gastroenterological Carcinogenesis, 1996-

Member, AACR Special Conference Committee, 1996-1999

Member, U.S.-Japan Promotion of Research Progress, NCI Steering Committee, 1997-1999

Member, AACR Public Relations Committee, 1997-2000

Member, AACR G. B. Elion Cancer Research Award Committee, 2000-2001

Member, AACR Education Committee, 2000-2002

Member, Tenure-Track Review Panel, Cancer Prevention Studies Branch, NCI, 2001

Co-Chair, Biology, Lung Cancer, NCI Program Review Group, 2001

Member, Tenure-Track Review Panel, Biostatistics Branch, NCI, 2001

Member, AACR Special Conference Committee, 2001-2006

Member, NCI Core Genotyping Oversight Committee, 2001-

Chair and Member, AACR Nomination Committee, 2003-2005

Consultant (nonpaid), Radiation Effects Research Foundation, Hiroshima, Japan 2004-

Member, AACR Grants Committee, 2004-2005

Member, AACR Program Committee, Annual Meeting, 2005 and 2007

Contributing Author, The Health Consequences of Smoking: A Report of the Surgeon General, 2004

Member, Advisory Board, Center for Cancer Research, NCI, 2005-2007

Member, NCI 2015 Strategy Development Team, 2005

Member, AACR, Centennial Committee, 2006-

Member, Nominating Committee, AACR-Princess Takamatsu Lectureship, 2007

President, Aspen Cancer Conference (not for profit), 2007-

Chairman, Board of Directors, Keystone Symposia on Molecular and Cellular Biology (not for profit), 2007-2010

Committees and Conferences

Member, Lung Cancer Segment, DCCP, NCI, 1972-1974

Member, Working Party for Therapy of Lung Cancer, DCT, NCI, 1973-1975

Member, Organizing Committee, International Conference on Late Effects of Cancer Therapy, sponsored by Cancer Clinical Investigations Review Committee, NCI, January 1975

Chairman, Human Studies Collaborative Group, NCI, 1975-1985

Chairman, Organizing Committee, International Conference on Methods to Culture Human Cells and Tissues, sponsored by NHLBI and NCI, 1979

Member, Pathology Study Section B, Ad Hoc Committee on Chemical Pathology, National Cancer Institute, 1978-1979

Member, Carcinogenesis Committee, NCI Occupational Cancer Task Force, 1978

Member, Environmental Pathology Registry Advisory Committee, International Academy of Pathology, 1979-1984

Member, Scientific Program Committee, Second World Conference on Lung Cancer, Copenhagen, sponsored by the International Association for the Study of Lung Cancer, 1980

Co-organizer, Interspecies Correlations in Chemical Carcinogenesis, U.S.-Japan Cooperative Cancer Research Program Conference, Tokyo, Japan, 1981

Co-organizer, Mechanisms of Chemical Carcinogenesis, ICN-UCLA Symposia on Molecular and Cellular Biology, Keystone, 1981

Co-organizer, Cancer and Aging, Given Institute of Pathobiology, Aspen, 1981

Member, Program Committee, III World Congress on Lung Cancer, Tokyo, 1982

Program Chairman, Carcinogenesis Studies Using Cultured Human Tissues and Cells, sponsored by National Cancer Institute, Aspen, 1982

Co-organizer, Multiple Primary Cancers, U.S.-Japan Cooperative Cancer Research Program Conference, Tokyo, Japan, 1983

Member, Program Committee, International Conf. on Cell Biochemistry and Function, Guilford, 1983

Member, Program Committee, Chemical and Radiation Carcinogenesis Conference, Bethesda, MD 1983

Organizer, Tumor Promotion in Human Cancer, NIH Combined Clinical Staff Conference, Bethesda, MD 1983

Member, Promotion Review Committee, Division of Cancer Etiology, NCI, 1983-1986

Member, Program Committee, Conference on “Interspecies Correlations in Carcinogenesis,” Aspen, 1985

Member, Program Committee, IV World Congress on Lung Cancer, Toronto, August 1985

Co-organizer, Mechanisms of Tobacco Carcinogenesis, Banbury Conference, Cold Spring Harbor, NY, 1985

Organizer, Biochemical and Molecular Epidemiology of Cancer, UCLA Symposium on Cellular and Molecular Biology, Steamboat Spr., April, 1985

Chairman, Carcinogenesis Section, AACR Program Committee, 1986

Member, Program Committee, Biochemical and Cellular Indices of Human Toxicity in Occupational Medicine, Milan, 1986

Chairman, Program Committee, III International Workshop on Carcinogenesis Studies Using Human Tissues and Cells, Copenhagen, 1987

Co-chairman, Board of Directors, Aspen Cancer Conference, 1988 -

Co-organizer, Genetic Mechanisms of Carcinogenesis and Tumor Progression, UCLA Symposium on Cellular and Molecular Biology, Keystone, 1989

Co-chairman, Fundamental and Clinic Research on Liver Cancer, Japanese Promotion for Cancer Research, Tokyo, 1989

Chairman, Program Committee, International Workshop on Prevention of Liver Cancer, Hawaii, 1989

Co-chairman, U.S.-Japan Cooperative Cancer Program Workshop on Multiple Primary Cancer, Hawaii, 1989

Chairman, Program Committee, International Symposium on N-Nitroso Compounds, Mycotoxins and Tobacco Smoke, Lyon, 1989

Co-organizer, Molecular Mechanisms of Fiber Toxicity and Carcinogenesis, Banbury Conference, 1990

Co-organizer, U.S.-Japan Cancer Cooperative Workshop, Osaka, Japan, 1990

Co-organizer, International Conference on Multiple Primary Tumors, Tokyo, Japan, 1990

Co-organizer, Genetic Instability and Cancer, Keystone Symposia on Cellular and Molecular Biology, Tamarron, 1991

Chairman, Program Committee, AACR Annual Meeting, Houston, Texas, 1991

Co-organizer, Princess Takamatsu Symposium, Tokyo, 1991

Co-organizer, Genetic Instability in Carcinogenesis and Tumor Progression, U.S.-Japan, Cooperative Cancer Research Program, Hawaii, 1992

Co-organizer, 6th International Symposium on Fundamental & Clinical Research in Esophageal Cancer, Tokyo, 1993

Co-organizer, AACR-IARC Conference, Lyon, 1992

Co-organizer, p53 in Growth Control and Neoplasia, Brupbacher Foundation, Zurich, 1993

Co-organizer, Tumor Suppressor Genes, Keystone Symposium, Taos, NM, 1994

Co-organizer, Apoptosis, UICC Workshop, Woodshole, 1994

Co-organizer, Cancer Susceptibility and Molecular Carcinogenesis, AACR Special Conference, Keystone, CO, 1996

Co-organizer, Creating a Strategy for Science-Based National Policy. Addressing Conflicting Scientific Views on the Health Risks of Low- Level Ionizing Radiation, Wingspread, 1997

Co-organizer, Molecular Epidemiology of Lung Cancer: Clinical Implications, Oslo, 1998

Co-organizer, p53 Workshop, Crete, 1998

Co-organizer, Molecular Epidemiology of Cancer, Keystone Cellular and Molecular Biology Symposium, Taos, NM, 2000

Member, Organizing Committee, p53 Workshop, Monterey, CA, 2000

Co-chair, Biology, Lung Cancer, NCI Program Review Group, Bethesda, MD, 2001

Co-chair, Impact of the Environment on Colon Cancer, Miami, FL, 2003

Co-chair, 13th International Symposium of the Hiroshima Cancer Center, Hiroshima, 2003

Co-organizer, Lung Cancer Workshop, NCI, Bethesda, MD, 2003

Member, Organizing Committee, p53 Workshop, Dunedin, New Zealand, 2004

Chair, Organizing Committee, Bloom Syndrome: Molecular Basis of Genomic Instability, NIH, Bethesda, MD, 2005

Member, Organizing Committee, Keystone Sym., Stem Cells, Senescence and Cancer, Singapore, 2005

Co-organizer, Inflammation and Colon Cancer, NCI, Bethesda, MD 2006

Co-organizer, International Symposium on Human Carcinogenesis, NCI, Bethesda, MD 2006

Member, Organizing Committee, p53 Workshop, New York, 2006

Member, Organizing Committee, p53 Workshop, Shanghai, China, 2008

Member, Organizing Committee, Inflammation and Cancer, NCI, Bethesda, MD 2007

Member, Steering Committee, Center of Excellence in Cancer Biology and Human Genomics, NCI, 2007

Inventions and Patents Assigned to U.S. Government:

1. Ultrasensitive enzymatic radioimmunoassay method (USERIA), U.S. patent

4,289,748.

2. Protoplast Fusion Method for High Frequency DNA Transfection in Human Cells; U.S. patent 4,608,339.

3. Cascade Amplification Enzyme Immunoassay, U.S. patent 4,463,090.

4. A Method and Kit for Detecting Human Exposure to Genotoxic Agents; U.S. patent 4,794,074.

5. Immortalized Human Bronchial and Mesothelial Epithelial Cell Lines; U.S. patent 4,885,238.

6. Cell Culture Medium for Human Liver Epithelial Cell Line; U.S. patent 5,342,777.

7. Immortalized Human Cell Lines Containing Exogenous Cytochrome P450; U.S. patent 5,356,806.

8. An Immortalized Human Bronchial Epithelial Cell Line; U.S. patent 5,432,060.

9. Immortalized Nontumorigenic Human Bronchial Epithelial Cell Lines; U.S. patent 5,443,954.

10. Immortalized Human Cell Lines containing Exogenous Cytochrome p450 Genes; U.S. patent 5,660,986.

11. Eukaryotic Expression Vector System; U.S. patent 5,604,118.

12. Human Liver Epithelial Cell Line and Culture Media Therefore; U.S. patent 5,529,920.

13. Human Liver Epithelial Cell Lines; U.S. patent 5,759,765.

14. Screening Assays for Compounds that cause Apoptosis; U.S. patent 6,602,979.

15. Methods for Identifying Inhibitors of GADD45 Peptide Activity and Inhibitors of Such Activity; U.S. patent 60,126,069; 7,125,850.

16. Telomerase-Immortalized Human Cell Lines; U.S. patent 60,255,722.

17. Immortalization of Human Epithelial Cells; U.S. patent 60,260,625.

18. Anticancer, Apoptosis-Inducing Compounds; application pending.

19. Methods for Assaying for Modulations of GADD45 Activity; U.S. patent 7,005,419.

20. New Tumor Suppressor Gene p33 ING2; U.S. patent 6,790,948.

21. New Tumor Suppressor Gene p47ING3; application pending.

22. p53 and VEGF Regulate Tumor Growth of NOS2 Expressing Cancer Cells; application pending.

23. New Tumor Suppressor Gene p28ING5; U.S. patent 60,351,504.

24. Telomerase Immortalized Human Cell Lines; application pending.

25. Methods and Compositions for the Diagnosis of Neuroendocrine Lung Cancer; application pending.

26. POT1 alternative splicing variants; application pending.

27. MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Lung Cancer, 2006, application pending.

28. MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Colon Cancer, 2006, application pending.

29. Methods of Determining the Prognosis of an Adenocarcinoma, 2006, application pending.

Laboratory Address: Laboratory of Human Carcinogenesis

NIH, NCI, CCR

Building 37, Room 3068

Bethesda, MD 20892

Tel: (301) 496-2048

Fax: (301) 496-0497

E-mail: Curtis_Harris@nih.gov

Homepage: http://www.nci.nih.gov/intra/lhc/lhcpage.htm

Home Address: P.O. Box 77

Garrett Park, MD 20896-0077

BIBLIOGRAPHY

CURTIS C. HARRIS, M.D.

Articles in Journals

1. Harris, C. and Leone, C. A.: Some effects of EDTA and tetraphenylboron on the ultrastructure of mitochondria in mouse liver cells. J. Cell Biology 28: 405-408, 1966.

2. Harris, C., Grady, H. and Svoboda, D.: Segregation of the nucleolus produced by Anthramycin. Cancer Res. 28: 81-90, 1968.

3. Reddy, J., Harris, C. and Svoboda, D.: Inhibition by lasiocarpine of RNA synthesis, RNA polymerase and induction of tryptophan pyrrolase activity. Nature 217: 659-661, 1968.

4. Harris, C., Grady, H. and Svoboda, D.: Alterations in pancreatic and hepatic ultrastructure following acute cycloheximide intoxication. J.Ultrastructure Res. 22: 240-251, 1968.

5. Harris, C., Reddy, J., Svoboda, D.: Isolation and ultrastructure of nucleoli altered in vivo. Exp. Cell Res. 51: 268-274, 1968.

6. Harris, C., Reddy, J. and Svoboda, D.: The effect of cycloheximide on ribonucleic acid and protein synthesis in rat liver. Biochem. Pharmacol. 18: 951-954, 1969.

7. Harris, C., Reddy, J., Chiga, M. and Svoboda, D.: Polyribosome disaggregation in rat liver by lasiocarpine. Biochem. Biophys. Acta 182: 587-589, 1969.

8. Reddy, J., Chiga, M., Harris, C. and Svoboda, D.: Polyribosome disaggregation in rat liver following administration of tannic acid. Cancer Res. 30: 58-65, 1970.

9. Svoboda, D., Reddy, J. and Harris, C.: Invasive tumors induced in rats with Actinomycin D. Cancer Res. 30: 2271-2279, 1970.

10. Harris, C.: Malignancy during methotrexate and steroid therapy for psoriasis. Arch. Derm. 103: 501-504, 1971.

11. Harris, C., Sporn, M., Kaufman, D., Smith, J., Baker, M. and Saffiotti, U.: Acute ultrastructural effects of benzo(a)pyrene and ferric oxide on the hamster tracheobronchial epithelium. Cancer Res. 31: 1977-1989, 1971.

12. Harris, C., Sporn, M., Kaufman, D., Smith, J., Jackson, F. and Saffiotti, U.: Histogenesis of squamous metaplasia in the hamster tracheal epithelium caused by vitamin A deficiency or by benzo-(a)pyrene-ferric oxide. J. Natl. Cancer Inst. 48: 743-761, 1972.

13. Kaufman, D., Baker, M., Harris, C., Smith, J., Boren, H., Sporn, M. and Saffiotti, U.: Coordinated biochemical and morphologic examination of hamster tracheal epithelium. J. Natl. Cancer Inst. 49: 783-792, 1972.

14. Kaufman, D., Baker, M., Smith, J., Henderson, W., Harris, C., Sporn, M. and Saffiotti, U.: RNA metabolism in tracheal epithelium: Alteration in hamsters deficient in vitamin A. Science 177: 1105-1108, 1972.

15. Harris, C., Kaufman, D., Sporn, M., Boren, H., Jackson, F., Smith, J., Pauley, J., Dedick, P. and Saffiotti, U.: Localization of benzo(a)- pyrene-3H and alterations in nuclear chromatin caused by benzo(a)pyrene-ferric oxide in the hamster respiratory epithelium. Cancer Res. 33: 2842-2848, 1973.

16. Harris, C., Kaufman, D., Sporn, M. and Saffiotti, U.: Histogenesis of squamous metaplasia and squamous cell carcinoma of the respiratory epithelium in an animal model. Cancer Chemotherapy Rep. 4: 43-54, 1973.

17. Harris, C.: The epidemiology of different histologic types of bronchogenic carcinoma. Cancer Chemotherapy Rep. 4: 59-61, 1973.

18. Port, C., Henry, M., Kaufman, D., Harris, C. and Ketels, K.: Acute changes in the surface morphology of hamster tracheobronchial epithelium following benzo(a)pyrene and ferric oxide administration. Cancer Res. 33: 2498-2506, 1973.

19. Harris, C., Kaufman, D., Sporn, M., Smith, J., Jackson, F. and Saffiotti, U.: Ultrastructural effects of N-methyl-N-nitrosourea on the tracheobronchial epithelium of the Syrian golden hamster. Int. J. Cancer 12: 259-269, 1973.

20. Kaufman, D., Genta, V., Harris, C., Smith, J., Sporn, M. and Saffiotti, U.: Binding of 3H-labeled benzo[a]pyrene to DNA in hamster tracheal epithelial cells. Cancer Res. 33: 2837-2841, 1973.

21. Harris, C., Silverman, T., Jackson, F., Smith, J. and Boren, H.: Proliferation of tracheal epithelial cells in normal and vitamin A deficient Syrian golden hamsters. J. Natl. Cancer Inst. 51: 1059-1064, 1973.

22. Kripke, M., Steinmuller, D., Harris, C., Lofgreen, P. and Eichwald, E.: Effects of chronic cyclophosphamide and methotrexate treatment on skin allograft survival in mice and rats. J. Natl. Cancer Inst. 51: 1355-1358, 1973.

23. Wenk, M., Reddy, J. and Harris, C.: Pancreatic regeneration caused by ethionine in the guinea pig. J. Natl. Cancer Inst. 52: 533-538, 1974.

24. Harris, C., Primack, A. and Cohen, M.: Elevated alpha1-antitrypsin serum levels in lung cancer patients. Cancer 34: 280-281, 1974.

25. Genta, V., Kaufman, D., Harris, C., Jackson, F., Smith, J., Sporn, M. and Saffiotti, U.: Vitamin A deficiency enhances binding of benzo(a)-pyrene to tracheal epithelial DNA. Nature 247: 48-49, 1974.

26. Harris, C., Kaufman, D., Jackson, F., Smith, J., Dedick, P. and Saffiotti, U.: Atypical cilia in the tracheobronchial epithelium of the hamster during respiratory carcinogenesis. J. Path. 114: 17-19, 1974.

27. Yuspa, S. and Harris, C.: Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro. Exp. Cell Res. 86: 95-105, 1974.

28. Meadows, A., D'Angio, G., Evans, A., Harris, C., Miller, R. and Mike, V.: Oncogenesis and other late effects of cancer treatment in children. Radiol. 114: 175-181, 1975.

29. Harris, C., Connor, R., Jackson, F. and Lieberman, M.: Intranuclear distribution of DNA repair synthesis induced by chemical carcinogens or ultraviolet light in human diploid fibroblasts. Cancer Res. 34: 3461-3469, 1974.

30. Boren, H., Pauley, J., Wright, E., Kaufman, D., Smith, J. and Harris, C.: Cell populations in the hamster tracheal epithelium in relation to vitamin A status. Int. J. Vit. Res. 44: 382-390, 1974.

31. Boren, H., Wright, E. and Harris, C.: Quantitative light microscopic autoradiography - Emulsion sensitivity and latent image fading. J. Cytochem. Histochem. 23: 901-909, 1975.

32. Harris, C., Genta, V., Frank, A., Kaufman, D., Barrett, L., McDowell, E. and Trump, B.: Carcinogenic polynuclear hydrocarbons bind to macromolecules in cultured human bronchi. Nature 252: 68-69, 1974.

33. Harris, C., Cohen, M., Connor, R., Primack, A., Saccomanno, G. and Talamo, R.: Serum alpha1-antitrypsin in patients with lung cancer or abnormal sputum cytology. Cancer 38: 1655-1657, 1976.

34. Harris, C., Frank, A., van Haaften, C., Kaufman, D., Connor, R., Jackson, F., Barrett, L., McDowell, E. and Trump, B.: Binding of [3H] benzo(a)pyrene to DNA in cultured human bronchus. Cancer Res. 36: 1011-1018, 1976.

35. Barrett, L., McDowell, E., Frank, A., Harris, C. and Trump, B.: Long-term organ culture of human bronchial epithelium. Cancer Res. 36: 1003-1010, 1976.

36. D'Angio, G., Meadows, A., Mike, V., Harris, C., Evans, A., Jaffe, N., Newton, W., Schweisguth, O., Sutow, W. and Morris-Jones, P.: Decreased risk of radiation-associated second malignant neoplasms in actinomycin- D-treated patients. Cancer 37: 1177-1185, 1976.

37. McDowell, E., Barrett, L., Harris, C. and Trump, B.: Abnormal cilia in human bronchial epithelium. Arch. Pathol. 100: 429-436, 1976.

38. Harris, C., Autrup, H., Connor, R., Barrett, L., McDowell, E. and Trump, B.: Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human bronchi. Science 194: 1067-1069, 1976.

39. Weinstein, I. B., Jeffrey, A., Jennette, K., Blobstein, S., Harvey, R., Harris, C., Autrup, H., Kasai, H. and Nakanishi, K.: Benzo[a]pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo. Science 193: 592-595, 1976.

40. Trump, B., McDowell, E., Barrett, L., Jones, R., Valerio, M. and Harris, C.: Ultrastructural and cytochemical studies on the mechanism of chemical carcinogenesis in the human. Microscopical Society of Canada 3: 142-145, 1976.

41. Jones, R., Barrett, L., van Haaften, C., Harris, C. and Trump, B.: Carcinogenesis in the pancreas. I. Long-term explant culture of human and bovine pancreatic ducts. J. Natl. Cancer Inst. 58: 557-565, 1977.

42. Yang, S. F., Gelboin, H. V., Trump, B. F., Autrup, H. N. and Harris, C.: Metabolic activation of benzo[a]pyrene and DNA binding in cultured human bronchus. Cancer Res. 37: 1210-1215, 1977.

43. Autrup, H. N., Harris, C. C., Stoner, G. D., Jesudason, M. L. and Trump, B. F.: Binding of chemical carcinogens to macromolecules in cultured human colon. J. Natl. Cancer Inst. 59: 351-355, 1977.

44. Harris, C. C., Autrup, H. N., Stoner, G. D., McDowell, E. M., Trump, B. F. and Schafer, P.: Metabolism of dimethylnitrosamine and l,2-dimethyl- hydrazine in cultured human bronchi. Cancer Res. 37: 2309-2311, 1977.

45. Levitt, M., Harris, C., Squire, R., Wenk, M., Mollelo, C., Thomas, D., Kingsbury, E. and Newkirk, C.: Experimental pancreatic carcinogenesis. I. Morphogenesis of pancreatic adenocarcinoma in the Syrian golden hamster induced by N-nitroso-bis(2-hydroxypropyl)amine. Amer. J. Path. 88: 5-28, 1977.

46. Harris, C., Autrup, H., Stoner, G., Yang, S., Leutz, J., Gelboin, H., Selkirk, J., Connor, R., Barrett, L., Jones, R., McDowell, E. and Trump, B.: Metabolism of benzo[a]pyrene and 7,l2-dimethylbenz[a]-anthracene in cultured human bronchus and pancreatic duct. Cancer Res. 37: 3349-3355, 1977.

47. Barrett, L., McDowell, E., Harris, C. and Trump, B.: Studies on the pathogenesis of Ischemic cell injury. XV. Reversal of Ischemic cell injury in hamster trachea and human bronchus by explant culture. Beitrage zur Pathologie 161: 109-122, 1977.

48. Meadows, A. T., D'Angio, G. J. Mike, V., Banfi, A., Harris, C., Jenkin, R. D. T. and Schwartz, A.: Patterns of second malignant neoplasms in children. Cancer 40: 1903-1912, 1977.

49. Harris, C., Autrup, H., Stoner, G., McDowell, E., Trump, B. and Schafer, P.: Metabolism of acyclic and cyclic N-nitrosamines in cultured human bronchi. J. Natl. Cancer Inst. 59: 1401-1406, 1977.

50. Autrup, H., Harris, C. C., Fugaro, S. and Selkirk, J.: Effect of various chemicals on the metabolism of benzo(a)pyrene by cultured rat colon. Chem. Biol. Interact. 18: 337-347, 1977.

51. Jeffrey, A. M., Weinstein, I. B., Jennette, K. W., Grzeskowiak, K., Nakanishi, K., Harvey, R. G., Autrup, H. and Harris, C.: Structures of benzo[a]pyrene-nucleic acid adducts formed in human and bovine bronchial explants. Nature 269: 348-350, 1977.

52. Autrup, H., Harris, C., Stoner, G., Selkirk, J., Schafer, P. and Trump, B.: Metabolism of [3H]benzo[a]pyrene by cultured human bronchus and cultured human pulmonary alveolar macrophages. Lab. Invest. 38: 217-223, 1978.

53. Autrup, H., Barrett, L. A., Jackson, F. E., Jesudason, M. L., Stoner, G., Phelps, P., Trump, B. F. and Harris, C. C.: Explant culture of human colon. Gastroenterology 74: 1248-1257, 1978.

54. Levitt, M., Harris, C., Squire, R., Wenk, M., Mollelo, C. and Springer, S.: Experimental pancreatic carcinogenesis. II. Lifetime carcinogenesis studies in the outbred Syrian golden hamster with N-nitroso-bis(2-hydroxypropyl)amine. J. Natl. Cancer Inst. 60: 701-706, 1978.

55. Stoner, G. D., Harris, C. C., Bostwick, D. G., Jones, R. T., Trump, B. F., Kingsbury, E. W., Fineman, E. and Newkirk, C.: Isolation and characterization of epithelial cells from bovine pancreatic duct. In Vitro 14: 581-590, 1978.

56. Stoner, G. D., Harris, C. C., Autrup, H., Trump, B. F., Kingsbury, E. W. and Myers, G. A.: Explant culture of human peripheral lung. I. Metabolism of benzo[a]pyrene. Lab. Invest. 38: 685-692, 1978.

57. Harris, C. C., Hsu, I. C., Stoner, G. D., Trump, B. F. and Selkirk, J. K.: Human pulmonary alveolar macrophages metabolize benzo[a]pyrene to proximate and ultimate mutagens. Nature 272: 633-634, 1978.

58. Hsu, I. C., Autrup, H., Stoner, G. D., Trump, B. F., Selkirk, J. K. and Harris, C. C.: Human bronchus-mediated mutagenesis of mammalian cells by carcinogenic polynuclear aromatic hydrocarbons. Proc. Natl. Acad. Sci. 75: 2003-2007, 1978.

59. McDowell, E. M., Barrett, L. A., Glavin, F., Harris, C. C. and Trump, B. F.: The respiratory epithelium. I. Human bronchus. J. Natl. Cancer Inst. 61: 539-550, 1978.

60. Trump, B. F., McDowell, E. M., Becci, P. J., Barrett, L. A., Glavin, F., Kaiser, H. and Harris, C. C.: The respiratory epithelium. III. Histogenesis of epidermoid metaplasia and carcinoma in situ. J. Natl. Cancer Inst. 61: 563-576, 1978.

61. McDowell, E. M., McLaughlin, J. S., Merenyl, D. K., Kieffer, R. F., Harris, C. C. and Trump, B. F.: The respiratory epithelium. V. Histogenesis of lung carcinomas in the human. J. Natl. Cancer Inst. 61: 587-606, 1978.

62. Autrup, H., Stoner, G., Jackson, F., Harris, C. C., Shamsuddin, T., Trump, B. F. and Barrett, L. A.: Explant culture of rat colon: A model system for studying metabolism of chemical carcinogens. In Vitro 14: 868-877, 1978.

63. Autrup, H., Harris, C. C., Trump, B. F. and Jeffrey, A. M.: Metabolism of benzo[a]pyrene and identification of the major benzo[a]pyrene-DNA adducts in cultured human colon. Cancer Res. 38: 3689-3697, 1978.

64. Autrup, H., Harris, C. C. and Trump, B. F.: Metabolism of acyclic and cyclic N-nitrosamines by cultured human colon. Proc. Soc. Exp. Biol. Med. 159: 111-115, 1978.

65. Autrup, H., Essigman, J. M., Croy, R., Trump, B. F., Wogan, G. N. and Harris, C. C.: Metabolism of aflatoxin B1 and identification of the major aflatoxin B1-DNA adducts formed in cultured human bronchus and colon. Cancer Res. 39: 694-698, 1979

66. Katoh, Y., Stoner, G. D., McIntire, K. R., Hill, T., Anthony, R., McDowell, E. M., Trump, B. F. and Harris, C. C.: Immunologic markers of human bronchial epithelial cells in tissue sections and in culture. J. Natl. Cancer Inst. 62: 1177-1186, 1979.

67. Daynes, R. A., Harris, C.C., Connor, R. J. and Eichwald, E. J.: Skin cancer development in mice exposed chronically to immunosuppressive agents. J. Natl. Cancer Inst. 62: 1075-1082, 1979.

68. Shamsuddin, A. K. M., Barrett, L. A., Autrup, H., Harris, C. C. and Trump, B. F.: Long term organ culture of adult rat colon. Path. Res.Pract. 163: 362-372, 1978.

69. Autrup, H., Harris, C. C., Trump, B. F., Stoner, G. D. and Hsu, I. C.: Uptake of benzo[a]pyrene-ferric oxide particulates by human pulmonary macrophages and release of benzo[a]pyrene and its metabolites. Proc.Soc. Exp. Biol. Med. 161: 280-284, 1979.

70. Hsu, I. C., Harris, C. C., Trump, B. F., Schafer, P. W. and Yamaguchi, M.: Induction of ouabain-resistant mutation and sister chromatid exchanges in Chinese hamster cells with chemical carcinogens mediated by human pulmonary macrophages. J. Clin. Invest. 64: 1245-1252, 1979.

71. Bradley, M. O., Hsu, I. C. and Harris, C. C.: Relationships between sister chromatid exchange and mutagenicity, toxicity and DNA damage. Nature 282: 318-319, 1979.

72. Harris, C. C., Autrup, H., Stoner, G. D., Trump, B. F., Hillman, E., Schafer, P. and Jeffrey, A.: Metabolism of benzo[a]pyrene, N-nitrosodi-methylamine and N-nitrosopyrrolidine and identification of the major carcinogen-DNA adducts formed in cultured human esophagus. Cancer Res. 39: 4401-4407, 1979.

73. Hsu, I. C., Bowden, G. T. and Harris, C. C.: A comparison of cytotoxicity, ouabain-resistant mutation, sister-chromatid exchanges and nascent DNA synthesis in Chinese hamster cells treated with dihydrodiol epoxide derivatives of benzo[a]pyrene. Mutat. Res. 63: 351-359, 1979.

74. Bowden, G. T., Hsu, I. C. and Harris, C. C.: The effect of caffeine on cytotoxicity, mutagenesis and sister-chromatid exchanges in Chinese hamster cells treated with dihydrodiol epoxide derivatives of benzo[a]pyrene. Mutat. Res. 63: 361-370, 1979.

75. Harris, C. C., Yolken R., Krokan, H. and Hsu, I. C.: Ultrasensitive enzymatic radioimmunoassay: Application to detection of cholera toxin and rotavirus. Proc. Natl. Acad. Sci. 76: 5336-5339, 1979.

76. Stoner, G. D., Harris, C. C., Myers, G. A., Trump, B. F. and Connor, R. D.: Putrescine stimulates growth of human bronchial epithelial cells in primary culture. In Vitro 16: 399-406, 1980.

77. Autrup, H., Wefald, F., Jeffrey, A., Tate, H., Schwartz, R. D., Trump, B. F. and Harris, C. C.: Metabolism of benzo[a]pyrene by cultured tracheobronchial tissues from mice, rats, hamsters, bovines and humans. Int. J. Cancer 25: 293-300, 1980.

78. Autrup, H., Schwartz, R. D., Essigmann, J. M., Smith, L., Trump, B. F. and Harris, C. C.: Metabolism of aflatoxin B1, benzo[a]pyrene and 1,2- dimethylhydrazine by cultured rat and human colon. Teratogenesis, Mutagenesis and Carcinogenesis 1: 3-13, 1980.

79. Autrup, H., Harris, C. C., Schwartz, R. D., Trump, B. F. and Smith, L.: Metabolism of l,2-dimethylhydrazine by cultured human colon. Carcinogenesis 1: 375-380, 1980.

80. Barrett, L. A., McDowell, E. M., Hill, T. A., Pyeatte, J. C., Harris, C. C. and Trump, B. F.: Induction of atypical squamous metaplasia with benzo[a]pyrene in cultured hamster tracheas. Pathol. Res. Pract. 168: 134-145, 1980.

81. Hsu, I. C., Poirier, M., Yuspa, S., Yolken, R. and Harris, C. C.: Ultra-sensitive enzymatic radioimmunoassay (USERIA) detects femtomoles of acetylaminofluorene-DNA adducts. Carcinogenesis 1: 455-458, 1980.

82. Hsu, I. C., Poirier, M. C., Yuspa, S. H., Grunberger, D., Weinstein, I. B., Yolken, R. H. and Harris, C.: Measurement of benzo(a)pyrene-DNA adducts by enzyme immunoassays and radioimmunoassay. Cancer Res. 41: 1091-1096, 1981.

83. Stoner, G. D., Katoh, Y., Foidart, J-M., Trump, B. F., Steinert, P. M. and Harris, C. C.: Cultured human bronchial epithelial cells: Blood group antigens, keratin, collagens and fibronectin. In Vitro 17: 577-587, 1981.

84. Valerio, M. G., Fineman, E. L., Bowman, R. L., Harris, C. C., Stoner, G. D., Autrup, H., Trump, B. F., McDowell, E. M. and Jones, R.: Long-term survival of normal adult human tissues as xenografts in congenitally athymic nude mice. J. Natl. Cancer Inst. 66: 849-859, 1981.

85. Haugen, A., Groopman, J., Hsu, I. C., Goodrich, G., Wogan, G. and Harris, C. C.: Monoclonal antibody to aflatoxin B1-modified DNA detected by enzyme immunoassay. Proc. Natl. Acad. Sci. 78: 4124-4127, 1981.

86. Lechner, J. F., Haugen, A., Autrup, H., McClendon, I., Trump, B. F. and Harris, C. C.: Clonal growth of epithelial cells from normal adult human bronchus. Cancer Res. 41: 2294-2304, 1981.

87. Fornace, A. J. Jr., Seres, D. S., Lechner, J. F. and Harris, C. C.: DNA- protein crosslinking by chromium salts. Chem.-Biol. Interactions 36: 345-354, 1981.

88. Stoner, G. D., Pettis, W., Haugen, A., Jackson, F. and Harris, C. C.: Explant culture of rat esophagus in a chemically defined medium. In Vitro 17: 681-688, 1981.

89. Autrup, H., Grafstrom, R. C., Brugh, M., Lechner, J. F., Haugen, A., Trump, B. F. and Harris, C. C.: Comparison of benzo[a]pyrene metabolism in bronchus, esophagus, colon and duodenum from the same individual. Cancer Res. 42: 934-938, 1982.

90. Groopman, J. D., Haugen, A., Goodrich, G. R., Wogan, G. N. and Harris, C. C.: Quantitation of aflatoxin B1-modified DNA using monoclonal antibodies. Cancer Res. 42: 3120-3124, 1982.

91. Haugen, A., Schafer, P., Lechner, J. F., Stoner, G. D., Trump, B. F. and Harris, C. C.: Cellular ingestion, toxic effects and lesions observed in human bronchial epithelial tissue and cells cultured with asbestos and glass fibers. Int. J. Cancer 30: 265-272, 1982.

92. Fornace, A. J., Lechner, J. F., Grafstrom, R. C. and Harris, C. C.: DNA repair in human bronchial epithelial cells. Carcinogenesis 3: 1373-1378, 1982.

93. Cohen, G. M., Grafstrom, R., Gibby, E. M., Smith, L., Autrup, H. and Harris, C. C.: Metabolism of benzo[a]pyrene and 1-naphthol in cultured human tumorous and non-tumorous colon. Cancer Res. 43:1312-1315, 1983.

94. Grafstrom, R. C., Fornace Jr., A. J., Autrup, H., Lechner, J. L. and Harris, C. C.: Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells. Science 220: 216-218, 1983.

95. Hsia, C. C., Tzian, B. L. and Harris, C. C.: Proliferative and cytotoxic effects of fusarium T2 toxin on cultured human fetal esophagus. Carcinogenesis 4: 1101-1107, 1983.

96. Shamsuddin, A. K. M. and Harris, C. C.: Improved enzyme immunoassays using biotin-avidin-enzyme complex. Arch. Path. Lab. Med. 107: 514-517, 1983.

97. Banks-Schlegel, S. P. and Harris, C. C.: Tissue-specific expression of keratin proteins in human esophageal and epidermal epithelium and their cultured keratinocytes. Exp. Cell Res. 146: 271-280, 1983.

98. Yoakum, G. H., Korba, B. E., Lechner, J. F., Tokiwa, T., Gazdar, A. F., Seeley, T., Siegel, M., Leeman, L., Autrup, H. and Harris, C. C.: High frequency transfection and cytopathology of the hepatitis B virus core antigen gene in human cells. Science 222: 385-389, 1983.

99. Lechner, J. F., McClendon, I. A., LaVeck, M. A., Shamsuddin, A. K. M. and Harris, C. C.: Differential control by platelet factors of squamous differentiation in normal and malignant human bronchial cells. Cancer Res. 43: 5915-5921, 1983.

100. Banks-Schlegel, S. P., McDowell, E. M., Wilson, T.S., Trump, B.F. and Harris, C. C.: Keratin proteins in human lung carcinomas: Combined use of morphology, keratin immunocytochemistry and keratin immuno-precipitation. Am. J.Pathol. 114: 273-286, 1984.

101. Willey, J. C., Saladino, A. J., Lechner, J. F. and Harris, C. C.: Acute effects of 12-0-tetradecanoylphorbol-13-acetate, teleocidin B, or 2,3,7,8-tetrachlorodibenzo-p-dioxin in cultured normal human bronchial epithelial cells. Carcinogenesis 5: 209-215, 1984.

102. Willey, J. C., Lechner, J. F. and Harris, C. C.: Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells. Exp. Cell Res. 153: 245-248, 1984.

103. Grafstrom, R. C., Pegg, A. E., Trump, B. F. and Harris, C. C.: O6-Alkyl-guanine-DNA alkyltransferase activity in normal human tissues and cells. Cancer Res. 44: 2855-2857, 1984.

104. Banks-Schlegel, S. P. and Harris, C. C.: Aberrant expression of keratin proteins and cross-linked envelopes in human esophageal carcinoma. Cancer Res. 44: 1153-1157, 1984.

105. Autrup, H., Harris, C. C., Wu, S. M., Bao, L. Y., Pei, H. T., Lu, S., Sun, T. T. and Hsia, C. C.: Activation of chemical carcinogens by cultured human fetal liver, esophagus and stomach. Chem.-Biol. Inter. 50: 15-25, 1984.

106. Trump, B. F., McDowell, E. M. and Harris, C. C.: Chemical carcinogenesis in the tracheobronchial epithelium. Environ. Health Perspec. 55: 77-84, 1984.

107. Grafstrom, R. C., Fornace, Jr., A. J. and Harris, C. C.: Repair of DNA damage caused by formaldehyde in human cells. Cancer Res. 44: 4323-4327, 1984.

108. Willey, J. C., Moser, C. E., Lechner, J. F. and Harris, C. C.: Differential effects of 12-0-tetradecanoylphorbol-13-acetate on cultured normal and neoplastic bronchial epithelial cells. Cancer Res. 44: 5124-5126, 1984.

109. Willey, J. C., Moser, C. E. and Harris, C. C.: Effects of aplysiatoxin and debromoaplysiatoxin on growth and differentiation of normal human bronchial epithelial cells. Cell Biol. Toxicol. 1: 145-154, 1984.

110. Shamsuddin, A. K. M., Sinopoli, N. T., Hemminki, K., Boesch, R. R. and Harris, C. C.: Detection of benzo(a)pyrene-DNA adducts in human white blood cells. Cancer Res. 45: 66-68, 1985.

111. Banks-Schlegel, S. P., Gazdar, A. F. and Harris, C. C.: Intermediate filament and cross-linked envelope expression in human lung tumor cell lines. Cancer Res. 45: 1187-1197, 1985.

112. Yoakum, G. H., Lechner, J. F., Gabrielson, E., Korba, B. E., Malan-Shibley, L., Willey, J. C., Valerio, M. G., Shamsuddin, A. K. M., Trump, B. F. and Harris, C. C.: Transformation of human bronchial epithelial cells transfected by Harvey ras oncogene. Science 227: 1174-1179, 1985. Note: We have discovered that the TBE-1 cells are infected with the SV-40 virus (McMenamin, M G. and Harris, C.C., 1999, unpublished results).

113. Grafstrom, R. C., Curren, R. D., Yang, L. L. and Harris, C. C.: Genotoxicity of formaldehyde in cultured human bronchial cells. Science 228: 89-91, 1985.

114. Saladino, A. J., Willey, J. C., Lechner, J. F., Grafstrom, R. C., LaVeck, M. and Harris, C. C.: Effects of formaldehyde, acetaldehyde, benzoyl peroxide and hydrogen peroxide on cultured human bronchial epithelial cells in vitro. Cancer Res. 45: 2522-2526, 1985.

115. Lechner, J. F., Tokiwa, T., Benedict, W. F., Banks-Schlegel, S., Yeager, Jr., H., Banerjee, A. and Harris, C. C.: Asbestos-associated chromosomal changes in human mesothelial cells. Proc. Natl. Acad. Sci. USA 82: 3884-3888, 1985.

116. Vahakangas, K., Haugen, A. and Harris, C. C.: An applied synchronous fluorescence spectrophotometric assay to study benzo(a)pyrene-diol epoxide-DNA adducts. Carcinogenesis 6: 1109-1116, 1985.

117. Harris, C. C., Vahakangas, K., Newman, M., Trivers, G. E., Mann, D. L. and Wright, W.: Detection of benzo(a)pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in sera from coke oven workers. Proc. Natl. Acad. Sci. USA 82: 6672-6676, 1985.

118. Krokan, H., Lechner, J., Krokan, R. H. and Harris, C. C.: Normal human bronchial epithelial cells do not show an adaptive response after treatment with N-methyl-N'-nitrosoguanidine. Mutat. Res. 146: 205-209, 1985.

119. Garner, R. C., Stanton, C. A., Martin, C. N., Harris, C. C. and Grafstrom, R. C.: Rat and human explant metabolism binding studies and DNA adduct analysis on benzo(a)pyrene and its 6-nitro-derivative. Cancer Res. 45: 6225-6232, 1985.

120. Krokan, H., Grafstrom, R. C., Sundqvist, K., Esterbauer, H. and Harris, C. C.: Cytotoxicity, thiol depletion and inhibition of O6-methyl-guanine-DNA methyltransferase by various aldehydes in cultured human bronchial fibroblasts. Carcinogenesis 6: 1755-1759, 1985.

121. Wilson, V., Smith, R., Autrup, H., Krokan, H., Musci, D.E., Le, N.-N.-T., Longoria, J., Ziska, D. and Harris, C. C.: Genomic 5-methylcytosine determination by 32P-ostlabeling analysis. Anal. Biochem. 152: 275-284, 1986.

122. Burg-Kurland, C. L., Purnell, D. M., Combs, J. W., Hillman, E. A., Harris, C. C. and Trump, B. F.: Immunocytochemical evaluation of primary human esophageal neoplasms and preneoplastic lesions for beta-chorionic gonadotropin, human placental lactogen, α-fetoprotein, carcino-embryonic antigen and nonspecific cross-reacting antigen. Cancer Res. 46: 5730-5737, 1986.

123. Masui, T., Wakefield, L. M., Lechner, J. F., LaVeck, M. A., Sporn, M. B. and Harris, C. C.: Type β transforming growth factor: A differentiation-inducing serum factor for normal human bronchial epithelial cells. Proc. Natl. Acad. Sci. USA 83: 2438-2442, 1986.

124. Harris, C. C., LaVeck, G., Groopman, J. Wilson, V. and Mann, D. L.: Measurement of aflatoxin B1, its metabolites and DNA adducts by synchronous fluorescence spectrophotometry. Cancer Res. 46: 3249-3253, 1986.

125. Boumpas, D. T., Tsokos, G. C., Mann, D. L., Eleftheriades, E. G., Harris, C. C. and Mark, G. E.: Increased proto-oncogene expression in peripheral blood lymphocytes of patients with sytemic lupus erythematosus. Arth. Rheum. 29: 755-760, 1986.

126. Haugen, A., Bechner, G., Benestad, C., Vahakangas, K., Trivers, G. E., Newman, M. J. and Harris, C. C.: Determination of polycyclic aromatic hydrocarbons (PAH) in the urine, benzo(a)pyrene diol epoxide-DNA adducts in lymphocyte DNA and antibodies to the adducts in sera from coke oven workers exposed to measured amounts of PAH in the work atmosphere. Cancer Res. 46: 4178-4183, 1986.

127. Gabrielson, E. W., Rosen, G. M., Grafstrom, R. C., Strauss, K. E. and Harris, C. C.: Studies on the role of oxygen radicals in asbestos-induced cytopathology of cultured human mesothelial cells. Carcinogenesis 7: 1161-1164, 1986.

128. Plummer, S. M., Grafstrom, R. C., Yang, L. L., Curren, R. D., Linnainmaa, K. and Harris, C. C.: Fecapentaene-12 causes DNA damage and mutations in human cells. Carcinogenesis 7: 1607-1610, 1986.

129. Masui, T., Lechner, J. F., Yoakum, G. H., Willey, J. C. and Harris, C. C.: Growth and differentiation of normal and transformed human bronchial epithelial cells. J. Cell. Physiol. Suppl. 4: 73-81, 1986.

130. Burg-Kurland, C. L., Purnell, D. M., Combs, J. W., Valerio, M. G., Harris, C. C. and Trump, B. F.: Immunocytochemical evaluation of human esophageal neoplasms for β-chorionic gonadotropin, placental lactogen, α-feto-protein, carcinoembryonic antigen and nonspecific cross-reacting antigen. Cancer Res. 46: 2936-2943, 1986.

131. Weston, A., Plummer, S. M., Grafstrom, R. C., Trump, B. F. and Harris, C. C.: Genotoxicity of chemical and physical agents in cultured human tissues and cells in vitro. Food Chem. Toxicol. 24: 675-679, 1986.

132. Mitchell, S. C., Waring, R. H., Wilson, V. L., Idle, J. R., Autrup, H., Harris, C. C., Ritchie, J. C., Crothers, M. J. and Sieber, S. M.: Sulphoxidation of S-carboxymethyl-L-cysteine in rhesus monkey (Macaca mulatta), cynomologus monkey (Macaca fascicularis), African green monkey (Cercopithecus aethiops) and the marmoset (Callithrix jacchus). Comp. Biochem. Physiol. 84B: 143-144, 1986.

133. Wakefield, L. M., Robert, A. B., Assoian, R. K., Fanger, B. O., Masui, T., Lechner, J. F., Harris, C. C. and Sporn, M. B.: Structure and function of transforming growth factor beta. Proc. Western Pharmacol. Soc. 29: 475-477, 1986.

134. Burg-Kurland, C. L., Purnell, D. M., Combs, J. W., Harris, C. C. and Trump, B. F.: Monolayer culture of normal human esophageal epithelial cells. J. Tissue Cult. Meth. 10: 227-232, 1986.

135. Baba, M., Klein-Szanto, A. J. P., Trono, D., Obara, T., Yoakum, G. H. and Harris, C. C.: Preneoplastic and neoplastic growth of xenotransplanted lung-derived human cell lines using de-epithelialized rat tracheas. Cancer Res. 47: 573-578, 1987.

136. Shamsuddin, A. K. M., Harris, C. C. and Hinzman, M. J.: Localization of aflatoxin B₁ - nucleic acid adducts in mitochondria and nuclei. Carcinogenesis 8: 109-114, 1987.

137. Curren, R. D., Putman, D. L., Yang, L. L., Haworth, S. R., Lawlor, T. E., Plummer, S. M. and Harris, C. C.: Genotoxicity of Fecapentaene-12 in bacterial and mammalian cell assay systems. Carcinogenesis 8: 349-352, 1987.

138. Sasajima, K., Willey, J. C., Banks-Schlegel, S. P. and Harris, C. C.: Effects of tumor promoters and cocarcinogens on growth and differentiation of cultured human esophageal epithelial cells. J. Natl. Cancer Inst. 78: 419-423, 1987.

139. Willey, J. C., Grafstrom, R. C., Moser, Jr., C. E., Ozanne, C. Sundqvist, K. and Harris, C. C.: Biochemical and morphological effects of cigarette smoke condensate and its fractions on normal human bronchial epithelial cells in vitro. Cancer Res. 47: 2045-2049, 1987.

140. Brash, D. E., Reddel, R. R., Quanrud, M., Farrell, M. and Harris, C. C.: Strontium phosphate transfection of human cells in primary culture. Cell Mol. Biol. 7: 2031-2034, 1987.

141. Gabrielson, E. W., Lechner, J. F., Gerwin, B. I., LaVeck, M. A. and Harris, C. C.: Growth factors for mesothelial and mesothelioma cells. Chest Suppl. 91: 17-18, 1987.

142. Wilson, V. L., Smith, R. A., Longoria, J., Liotta, M. A., Harper, C. M. and Harris C. C.: Chemical carcinogen-induced decreases in genomic 5-methyl-deoxycytidine content of normal human bronchial epithelial cells. Proc. Natl. Acad. Sci USA 84: 3298-3301, 1987.

143. Wakefield, L. M., Smith, D. M., Masui, T., Harris, C. C. and Sporn, M. B.: Distribution and modulation of the cellular receptor for transforming growth factor-beta. J. Cell Biol. 105: 965-975, 1987.

144. Gerwin, B. I., Lechner, J. F., Reddel, R. R., Roberts, A. B., Robbins, K. C., Gabrielson, E. W. and Harris, C. C.: Comparison of production of transforming growth factor-β and platelet-derived growth factor by normal human mesothelial cells and mesothelioma cell lines. Cancer Res. 47: 6180-6184, 1987.

145. Gabrielson, E. W., Rosen, G. M., Grafstrom, R. C., Strauss, K. E., Miyashita, M. and Harris, C. C.: Role of oxygen radicals in 12-0-tetradecanoyl-phorhol-13-acetate-induced squamous differentiation of cultured normal human bronchial epithelial cells. Cancer Res. 48: 822-825, 1988.

146. Hsu, I. C., Harris, C. C., Lipsky, M. M., Snyder, S. and Trump, B. F.: Cell and species differences in metabolic activation of chemical carcinogens. Mutat. Res. 177: 1-7, 1987.

147. Reddel, R. R., Ke, Y., Gerwin, B. I., McMenamin, M. G., Lechner, J. F., Su, R. T., Brash, D. E., Park, J-B., Rhim, J. S. and Harris, C. C.: Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. Cancer Res. 48: 1904-1909, 1988.

148. Grafstrom, R. C., Dypbukt, J. M., Willey, J. C., Sundqvist, K., Edman, C., Atzori, L. and Harris, C. C.: Pathobiological effects of acrolein in cultured human bronchial epithelial cells. Cancer Res. 48: 1717-1721, 1988.

149. Wilson, V. L., Basu, A. K., Essigmann, J. M., Smith, R. A. and Harris, C. C.: O6 Alkyldeoxyguanosine detection by 32P postlabeling and nucleotide chromatographic analysis. Cancer Res. 48: 2156-2161, 1988.

150. Weston, A., Rowe, M., Poirier, M., Trivers, G., Vahakangas, K., Newman, M., Haugen, A., Manchester, D., Mann, D. and Harris, C.: The application of immunoassays and fluorometry to the detection of polycyclic hydrocarbon-macromolecular adducts and anti-adduct antibodies in humans. Int. Arch. Occup. Environ. Health 60: 157-162, 1988.

151. Gabrielson, E. W., Gerwin, B. I., Harris, C. C., Roberts, A. B., Sporn, M. B. and Lechner, J. L.: Stimulation of DNA synthesis in cultured primary human mesothelial cells by specific growth factors. FASEB J. 2: 2717-2722, 1988.

152. Newman, M. J., Light, B. A., Weston, A., Tollerude, D., Clark, J., Mann, D. L. and Harris, C. C.: Detection and characterization of human serum antibodies to polycyclic aromatic hydrocarbon diol-epoxide DNA adducts. J. Clin. Invest. 82: 145-153, 1988.

153. Santella, R. M., Weston, A., Perera, F. P., Trivers, G. T., Harris, C. C., Young, T. L., Nguyen, D., Lee, B. M. and Poirier, M. C.: Interlaboratory comparison of antisera and immunoassays for benzo[a]pyrene-diol-epoxide-I-modified DNA. Carcinogenesis 9: 1265-1269, 1988.

154. Ke, Y., Reddel, R. R., Gerwin, B. I., Miyashita, M., McMenamin, M., Lechner, J. F. and Harris, C. C.: Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation. Differentiation 38: 60-66, 1988.

155. Curren, R. D., Yang, L. L., Conklin, P. M., Grafstrom, R. C. and Harris, C. C.: Mutagenesis of xeroderma pigmentosum fs ibroblastby acrolein. Mutat. Res. Lett. 209: 17-22, 1988.

156. Reddel, R. R., Ke, Y., Kaighn, M. E., Malan-Shibley, L., Lechner, J. F., Rhim, J. S. and Harris, C.C.: Human bronchial epithelial cells neoplastically transformed by v-Ki-ras: Altered response to inducers of terminal squamous differentiation. Oncogene Res. 3: 401-408, 1988.

157. Bonnard, C., Lechner, J. F., Gerwin, B. I., Fujiki, H. and Harris, C. C.: Effects of palytoxin or ouabain on growth and squamous differentiation of human bronchial epithelial cells in vitro. Carcinogenesis 9: 2245-2249, 1988.

158. Wilson, V. L., Masui, T., Smith, R. A. and Harris, C. C.: Genomic 5-methyldeoxycytidine decreases associated with the induction of squamous differentiation in cultured normal human bronchial epithelial cells. Carcinogenesis 9: 2155-2160, 1988.

159. Manchester, D. K., Weston, A., Choi, J. S., Trivers, G. E., Fennessey, P. V., Quintana, E., Farmer, P. B., Mann, D. L. and Harris, C. C.: Detection of benzo[a]pyrene diol-epoxide-DNA adducts in human placenta. Proc. Natl. Acad. Sci. USA 85: 9243-9247, 1988.

160. Miyashita, M., Smith, M. W., Willey, J. C., Lechner, J. F., Trump, B. F. and Harris, C. C.: Effects of serum, transforming growth factor type beta or 12-0-tetradecanoylphorbol-13-acetate on ionized cytosolic calcium concentration in normal and transformed human bronchial epithelial cells. Cancer Res. 49: 63-67, 1989.

161. Amstad, P., Reddel, R. R., Pfeifer, A., Malan-Shibley, L., Mark, G. E. and Harris, C. C.: Neoplastic transformation of a human bronchial epithelial cell line by a recombinant retrovirus encoding viral Harvey ras. Mol. Carcinogenesis 1: 151-160, 1988.

162. Weston, A., Rowe, M. L., Manchester, D. K., Farmer, P. B., Mann, D. L. and Harris, C. C.: Fluorescence and mass spectral evidence for the formation of benzo[a]pyrene anti-diol-epoxide-DNA and -hemoglobin adducts in humans. Carcinogenesis 10: 251-257, 1989.

163. Bonfil, R. D., Reddel, R. R., Ura, H., Reich, R., Fridman, R., Harris, C. C. and Klein-Szanto, A. J. P.: Invasive and metastatic potential of a Ha-ras transformed human bronchial epithelial cell line. J. Natl. Cancer Inst. 81: 587-594, 1989.

164. Weston, A., Manchester, D. K., Poirier, M. C., Choi, J. S., Trivers, G. E., Mann, D. L. and Harris, C. C.: Derivative fluorescence spectral analysis of polycyclic aromatic hydrocarbon-DNA adducts in human placenta. Chem. Res. Toxicol. 2: 104-108, 1989.

165. Ke, Y., Reddel, R. R., Gerwin, B. I., Reddel, H. K., Somers, A. N. A., McMenamin, M., LaVeck, M. A., Stahel, R. A., Lechner, J. F. and Harris, C. C.: Establishment of a human in vitro mesothelial cell model system for investigating mechanisms of asbestos-induced mesothelioma. Am. J. Pathol. 134: 979-991, 1989.

166. Kaighn, M. E., Reddel, R. R., Lechner, J. F., Peehl, D. M., Camalier, R. F., Brash, D. E., Saffiotti, U. and Harris, C. C.: Transformation of human neonatal prostate epithelial cells by strontium phosphate transfection with a plasmid containing SV40 early region genes. Cancer Res. 49: 3050-3056, 1989.

167. Weston, A., Willey, J. C., Modali, R., Sugimura, H., McDowell, E., Resau, J., Light, B., Haugen, A., Mann, D. L., Trump, B. F. and Harris, C. C.: Differential DNA sequence deletions from chromosomes 3, 11, 13 and 17 in squamous cell carcinoma, large cell carcinoma and adenocarcinoma of the human lung. Proc. Natl. Acad. Sci. USA 86: 5099-5103, 1989.

168. Reddel, R. R., Malan-Shibley, L., Gerwin, B. I., Metcalf, R. A. and Harris, C. C.: Tumorigenicity of a human mesothelial cell line transfected with the EJ-ras oncogene. J. Natl. Cancer Inst. 81: 945-948, 1989.

169. Ura, H., Bonfil, R. D., Reich, R., Reddel, R., Pfeifer, A. M., Harris, C. C. and Klein-Szanto, A. J. P.: Expression of type IV collagenase and pro-collagen genes in oncogene transformed human bronchial epithelial cells: Correlation with tumorigenic, invasive and metastatic abilities. Cancer Res. 49: 4615-4621, 1989.

170. Dypbukt, J. M., Edman, C. C., Sundqvist, K., Kakefuda, T., Plummer, S. M., Harris, C. C. and Grafstrom, R. C.: Reactivity of fecapentaene-12 towards thiols, DNA and these constituents in human fibroblasts. Cancer Res. 49: 6058-6063, 1989.

171. Bonfil, R. D., Momiki, S., Fridman, R., Reich, R., Reddel, R., Harris, C. C. and Klein-Szanto, A.: Enhancement of the invasive ability of a transformed human bronchial epithelial cell line by TPA and diacylglycerol. Carcinogenesis 10: 2335-2338, 1989.

172. Wilson, V. L., Weston, A., Manchester, D. K., Trivers, G. E., Roberts, D. W., Kadlubar, F. F., Wild, C. P., Montesano, R., Willey, J. C., Mann, D. L. and Harris, C. C.: Alkyl and aryl carcinogen adducts detected in human peripheral lung. Carcinogenesis 11: 2149-2153, 1989.

173. Nigro, J. M., Baker, S. J., Preisinger, A. C., Jessup, J. M., Hostetter, R., Cleary, K., Bigner, S. H., Davidson, N., Baylin, S., Devilee, P., Glover, T., Weston, A., Modali, R., Harris, C. C. and Vogelstein, B.: Mutations in the p53 gene occur in diverse human tumor types. Nature 342: 705-708, 1989.

174. Lechner, J. F., Cole, K. H., Reddel, R. R., Anderson, L. and Harris, C. C.: Replicative cultures of adult human and rhesus monkey liver epithelial cells. Cancer Detect. Prevent. 14: 239-244, 1989.

175. Pfeifer, A. M. A., Mark, G. E., Malan-Shibley, L., Graziano, S., Amstad, P. and Harris, C. C.: Cooperation of c-raf-1 and c-myc protooncogenes in the neoplastic transformation of SV-40 T antigen immortalized human bronchial epithelial cells. Proc. Natl. Acad. Sci. USA 86: 10075-10079, 1989.

176. Miyashita, M., Willey, J. C., Sasajima, K., Lechner, J. F., LaVoie, L. J., Hoffmann, D., Smith, M., Trump, B. F. and Harris, C. C.: Differential effects of cigarette smoke condensate and its fractions on cultured normal and malignant human bronchial epithelial cells. Exp. Pathol. 38: 19-29, 1990.

177. Sugimura, H., Caporaso, N. E., Hoover, R. N., Modali, R., Resau, J., Trump, B. F., Lonergan, J. A., Krontiris, T. G., Mann, D. L., Weston, A. and Harris, C. C.: Association of rare alleles of the Ha-ras-1 locus with lung cancer. Cancer Res. 50: 1857-1862, 1990.

178. Kaighn, M. E., Gabrielson, E. W., Iman, D. S., Pauls, E. A. and Harris, C. C.: Suppression of tumorigenicity of a human lung carcinoma line by nontumorigenic bronchial epithelial cells in somatic cell hybrids. Cancer Res. 50: 1890-1896, 1990.

179. Manchester, D. K., Wilson, V. L., Hsu, I. C., Choi, J. S., Parker, N. B., Mann, D. L., Weston, A. and Harris, C. C.: Synchronous fluorescence spectroscopic, immunoaffinity chromatographic and ³²P-postlabeling analyses of human placental DNA known to contain benzo(a)pyrene diol epoxide adducts. Carcinogenesis 11: 553-559, 1990.

180. Pelin-Enlund, K., Husgafvel-Pursiainen, K., Tammilehto, L., Klockars, M., Jantunen, K., Gerwin, B. I., Harris, C. C., Tuomi, T., Vanhala, E., Mattson, K. and Linnainmaa, K.: Asbestos-related malignant mesothelioma: growth, cytology, tumourigenicity and consistent chromosome findings in cell lines from five patients. Carcinogenesis 11: 673-681, 1990.

181. Caporaso, N. E., Tucker, M. A., Hoover, R., Hayes, R. B., Pickle, L. W., Issaq, H., Muschik, G., Green-Gallo, L., Buivys, D., Aisner, S., Resau, J., Trump, B., Tollerud, D., Weston, A. and Harris, C. C.: Lung cancer and the debrisoquine metabolic phenotype. J. Natl. Cancer Inst. 85: 1264-1272, 1990.

182. McDonald, J. W., Brash, D. E., Oseroff, A. R. and Harris, C. C.: Photosensitizing dyes for the selection of nontumorigenic revertants from human lung cancer cell lines. Cancer Res. 50: 5369-5373, 1990.

183. Shields, P. G., Povey, A. C., Wilson, V. W., Weston, A. and Harris, C. C.: Combined high performance liquid chromatography/³²P-postlabeling assay of N⁷methyldeoxyguanosine. Cancer Res. 50: 6580-6584, 1990.

184. Sugimura, H., Caporaso, N. E., Shaw, G. L., Modali, R. V., Gonzalez, F. J., Hoover, R. N., Resau, J. H., Trump, B. F., Weston, A. and Harris, C. C.: Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls. Carcinogenesis 11: 1527-1530, 1990.

185. Tamai, S., Sugimura, H., Caporaso, N. E., Resau, J. H., Trump, B. F., Weston, A. and Harris, C. C.: Restriction fragment length polymorphism analysis of the L-myc gene locus in a case-control study of lung cancer. Int. J. Cancer 46: 411-415, 1990.

186. Gerwin, B. I., Keski-Oja, J., Seddon, M., Lechner, J. F. and Harris, C. C.: TGF-β₁ modulation of urokinase and PAI-1 expression in human bronchial epithelial cells. Am. J. Physiol. 259 (Lung Cell. Mol. Physiol. 3): L262-L269, 1990.

187. Ke, Y., Gerwin, B. I., Ruskie, S. E., Pfeifer, A. M. A., Harris, C. C. and Lechner, J. F.: Cell density governs the ability of human bronchial epithelial cells to recognize serum and transforming growth factor β-1 as squamous differentiation inducing agents. Am. J. Pathol. 137: 833-843, 1990.

188. Newman, M. J., Weston, A., Carver, D. C., Mann, D. L. and Harris, C. C.: Serological characterization of polycyclic aromatic hydrocarbon diol epoxide-DNA adducts using monoclonal antibodies. Carcinogenesis 11: 1903-1907, 1990.

189. Trump, B. F., Berezesky, I. K., Smith, M. W., Jones, R. T., Phelps, P. C., Miyashita, M. and Harris, C. C.: Studies of human bronchial epithelium in vitro: changes of [Ca²⁺]_i in relation to injury, growth and differentiation. Toxicol. In Vitro 4: 646-653, 1990.

190. Hollstein, M., Metcalf, R. A., Welsh, J., Montesano, R. and Harris, C. C.: Frequent mutation of the p53 gene in human esophageal cancer. Proc. Natl. Acad. Sci. USA 87: 9958-9961, 1990.

191. Stoner, G. D., Kaighn, M. E., Reddel, R. R., Resau, J. H., Bowman, D., Naito, Z., Matsukura, N., You, M., Galati, A. J. and Harris, C. C.: Establishment and characterization of SV40 T-antigen immortalized human esophageal epithelial cells. Cancer Res. 51: 365-371, 1991.

192. Hsu, I. C., Metcalf, R. A, Welsh, J., Sun, T., Wang, N. J. and Harris, C. C.: p53 gene mutational hotspot in human hepatocellular carcinomas from Qidong, China. Nature 350: 427-428, 1991.

193. Matsukura, N., Willey, J., Miyashita, M., Taffe, B., Waldren, C., Puck, T. T. and Harris, C. C.: Detection of direct mutagenicity of cigarette smoke condensate in mammalian cells. Carcinogenesis 12: 685-689, 1991.

194. Povey, A. C., Schiffman, M., Taffe, B. G. and Harris, C. C.: Laboratory and epidemiologic studies of fecapentaenes. Mutat. Res. 259: 387-397, 1991.

195. Pfeifer, A. M. A., Jones, R. T., Bowden, P. E., Mann, D., Klein-Szanto, A. J. P., Trump, B. F. and Harris, C. C.: Human bronchial epithelial cells transformed by the c-raf-1 and c-myc protooncogenes induce multidifferentiated carcinomas in nude mice: A model for lung carcinogenesis. Cancer Res. 51: 3793-3801, 1991.

196. Lehman, T. A., Bennett, W. P., Metcalf, R. A., Reddel, R., Welsh, J. A., Ecker, J., Modali, R. V., Ullrich, S., Romano, J. W., Appella, E., Testa, J. R., Gerwin, B. I., Harris, C. C.: p53 mutations, ras mutations and p53-heat shock 70 protein complexes in human lung cell lines. Cancer Res. 51: 4090-4096, 1991.

197. Leone, A., McBride, O. W., Weston, A., Wang, M., Anglard, P., Cropp, C. S., Gorpel, J., Lidereau, R., Callahan, R., Linehan, W. M., Rees, R. C., Harris, C. C., Liotta, L. A. and Steeg, P. S.: Somatic allelic deletion of nm23 in human cancer. Cancer Res. 51: 2490-2493, 1991.

198. Vahakangas, K., Trivers, G. E., Plummer, S., Krokan, H., Rowe, M., Yeager, H., Swartz, R. P. and Harris, C. C.: O⁶-Methylguanine DNA methyltransferase and uracil DNA glycosylase in human broncho-alveolar lavage cells and peripheral blood mononuclear cells from tobacco smokers and non-smokers. Carcinogenesis 12: 1389-1394, 1991.

199. Reddel, R. R., Hsu, I. C., Mass, M. J., Hukku, B., Gerwin, B. I., Salghetti, S. E., Somers, A. N. A., Galati, A. J., Gunning, III, W. T., Harris, C. C. and Stoner, G. D.: A human bronchial epithelial cell strain with unusual in vitro growth potential which undergoes neoplastic transformation after SV40 T antigen gene transfection. Int. J. Cancer 48: 764-773, 1991.

200. Hollstein, M., Sidransky, D., Vogelstein, B. and Harris, C. C.: p53 mutations in human cancers. Science 253: 49-53, 1991.

201. Hollstein, M. C., Peri, R., Mandard, A., Welsh, J., Montesano, R., Metcalf, R., Bak, M. and Harris, C. C.: Genetic analysis of human esophageal tumors from two high incidence areas: frequent p53 base substitutions and absence of ras mutations. Cancer Res. 51: 4102-4106, 1991.

202. Wilson, V. L., Foiles, P. G., Chung, F. L., Povey, A. C., Frank, A. A. and Harris, C. C.: Detection of acrolein and crotonaldehyde DNA adducts in cultured human cells and canine peripheral blood lymphocytes by ³²P postlabeling and nucleotide chromatography. Carcinogenesis 12: 1483-1490, 1991.

203. LaForgia, S., Morse, B., Levy, J., Barnea, G., Cannizzaro, L. A., Li, F., Nowell, P. C., Boghosian-Sell, L., Glick, J., Weston, A., Harris, C. C., Drabkin, H., Patterson, D., Croce, C. M., Schlessinger, J. and Huebner, K.: Receptor protein-tyrosine-phosphatase, PTPγ, is a candidate tumor suppressor gene at human chromosome region 3p21. Proc. Natl. Acad. Sci. USA 88: 5036-5040, 1991.

204. Weston, A., Caporaso, N. E., Taghizadeh, K., Hoover, R. N., Tannenbaum, S. R., Skipper, P. L., Resau, J. H., Trump, B. F. and Harris, C. C.: Measurement of 4-aminobiphenyl-hemoglobin adducts in lung cancer cases and controls. Cancer Res. 51: 5219-23, 1991.

205. Willey, J. C., Broussoud, A., Sleemi, A., Bennett, W. P., Cerutti, P. and Harris, C. C.: Immortalization of normal human bronchial epithelial cells by human papillomaviruses 16 or 18. Cancer Res. 51: 5370-77, 1991.

206. Bennett, W. P., Hollstein, M. C., He, A., Zhu, S. M., Resau, J., Trump, B. F., Metcalf, R. A., Welsh, J. A., Gannon, J. V., Lane, D. P. and Harris, C. C.: Archival analysis of p53 genetic and protein alterations in Chinese esophageal cancer. Oncogene 6: 1779-84, 1991.

207. Maehle, L., Metcalf, R. A., Ryberg, D., Bennett, W. P., Harris, C. C. and Haugen, A.: Altered p53 gene structure and expression in human epithelial cells after exposure to nickel. Cancer Res. 52: 218-221, 1992.

208. Vahakangas, K. H., Samet, J. M., Metcalf, R. A., Welsh, J. A., Bennett, W. P., Lane, D. P. and Harris, C. C.: p53 and ras mutations in radon-associated lung cancer from uranium miners. Lancet 339: 576-580, 1992.

209. Povey, A. C., Wilson, V. L., Zweier, J. L., Kuppusamy, P., O'Neill, I. K. and Harris, C. C.: Detection by ³²P-postlabeling of DNA adducts induced by free radical and unsaturated aldehydes formed during the aerobic decomposition of fecapentaene-12. Carcinogenesis 13: 395-401, 1992.

210. Gerwin, B. I., Spillare, E., Lehman, T. A., Forrester, K., Kispert, J., Pfeifer, A. M. A., Baker, S. J., Vogelstein, B. and Harris, C. C.: Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor β₁. Proc. Natl. Acad. Sci. USA 89: 2759-2763, 1992.

211. Metcalf, R. A., Welsh, J. A., Bennett, W. P., Seddon, M. B., Lehman, T. A., Pelin, K., Linnainmaa, K., Tammilehto, L., Mattson, K., Gerwin, B. I. and Harris, C. C.: p53 and Kirsten-ras mutations in human mesothelioma cell lines. Cancer Res. 52: 2610-2615, 1992.

212. Gabrielson, E. W., Van der Meeren, A., Reddel, R. R., Reddel, H., Gerwin, B. I. and Harris, C. C.: Human mesothelioma cells and asbestos-exposed mesothelial cells are selectively resistant to amosite toxicity: a possible mechanism for tumor promotion by asbestos. Carcinogenesis 13: 1359-1363, 1992.

213. Klein-Szanto, A. J. P., Iizasa T., Momiki, S., Garcia-Palazzo, I., Caamano, J., Metcalf, R., Welsh, J. and Harris, C. C.: A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells. Proc. Natl. Acad. Sci. USA 89: 6693-6697, 1992.

214. Bennett, W. P., Hollstein, M. C., Metcalf, R. A., Welsh, J. A., He, A., Zhu, S., Kusters, I., Resau, J. H., Trump, B. F., Lane, D. P. and Harris, C. C.: p53 mutation and protein accumulation during multistage human esophageal carcinogenesis. Cancer Res. 52: 6092-6097, 1992.

215. Kato, S., Shields, P. G., Caporaso, N. E., Hoover, R. N., Trump, B. F., Sugimura, H., Weston, A. and Harris, C. C.: Cytochrome P450IIE1 (CYP2E1) genetic polymorphisms, racial variation and lung cancer risk. Cancer Res. 52: 6712-6715, 1992.

216. Caporaso, N. E., Shields, P. G., Landi, M. T., Shaw, G. L., Tucker, M. A., Hoover, R., Sugimura, H., Weston, A. and Harris, C. C.: The epidemiologic and laboratory implications of non-correspondence between the debrisoquine metabolic phenotype and DNA-based assays: implications of misclassification for the association of lung cancer and the debrisoquine metabolic phenotype. Environ. Health Perspect. 98: 101-105, 1992.

217. Weston, A., Perrin, L. S., Forrester, K., Hoover, R. N., Trump, B. F., Harris, C. C. and Caporaso, N. E.: Allelic frequency of a p53 polymorphism in human lung cancer. Cancer Epidemiology, Biomarkers & Prevention 1: 481-483, 1992.

218. Gabrielson, E. W., Kuppusamy, P., Povey, A. C., Zweier, J. L. and Harris, C. C.: Measurement of neutrophil activation and epidermal cell toxicity by palytoxin and 12-0-tetracanoylphorbol-13-acetate/ Carcinogenesis 13: 1671-1674, 1992.

219. Hollstein, M. C., Wild, C. P., Bleicher, F., Chutimataewin, S., Harris, C. C., Srivatanakul, P. and Montesano, R.: p53 mutations and aflatoxin B₁ exposure in hepatocellular carcinoma patients from Thailand. Int. J. Cancer 53: 51-55, 1993.

220. Reddel, R. R., Salghetti, S. E., Willey, J. C., Ohnuki, Y., Ke, Y., Gerwin, B. I., Lechner, J. F. and Harris, C. C.: Development of tumorigenicity in Simian virus 40-immortalized human bronchial epithelial cell lines. Cancer Res. 53: 985-991, 1993.

221. Grafstrom, R. C., Hsu, I. C. and Harris, C. C.: Mutagenicity of formaldehyde in Chinese hamster lung fibroblasts: synergy with ionizing radiation and N-Nitroso-N-Methylurea. Chem. Biol. Interactions 86: 41-49, 1993.

222. Lehman, T. A., Modali, R., Boukamp, P., Stanek, J., Bennett, W. P., Welsh, J. A., Metcalf, R. A., Stampfer, M. R., Fusenig, N., Rogan, E. M., Reddel, R. and Harris C. C.: p53 mutations in human immortalized epithelial cell lines. Carcinogenesis 14: 833-839, 1993.

223. Hsu, I. C., Tokiwa, T., Bennett, W., Metcalf, R. A., Welsh, J. A., Sun, T. and Harris, C. C.: p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines. Carcinogenesis 14: 987-992, 1993.

224. Vertino, P. M., Spillare, E., Harris, C. C. and Baylin, S. B.: Altered chromosomal methylation patterns accomplany oncogene-induced transformation of human bronchial epithelial cells. Cancer Res. 53: 1684-1689, 1993.

225. Noguchi, M., Murakami, M., Bennett, W., Lupu, R., Hui Jr., Harris, C. C. and Gerwin, B.I.: Biological consequences of overexpression of a transfected c-erbB-2 gene in "immortalized" human bronchial epithelial cells. Cancer Res. 53: 2035-2043, 1993.

226. Pfeifer, A. M. A., Cole, K. E., Smoot, D.T., Weston, A., Groopman, J. D., Shields, P. G., Vignaud, J.-M., Juillerat, M., Lipsky, M. M., Trump, B. F., Lechner, J. F. and Harris, C. C.: SV40 T-antigen immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens. Proc. Natl. Acad. Sci. USA 90: 5123-5127, 1993.

227. Wilson, V. L., Taffe, B. G., Shields, P. G., Povey, A. C. and Harris, C. C.: Detection and quantitation of 8-hydroxyguanosine adducts in peripheral blood of people exposed to ionizing radiation. Environ. Health Prospectives 99: 261-263, 1993.

228. Evans, M. K., Taffe, B. G., Harris, C. C. and Bohr, V. A.: DNA strand bias in the repair of the p53 gene in normal human and Xeroderma Pigmentosum Group C fibroblasts. Cancer Res. 53: 5377-5381, 1993.

229. Esteve, A., Lehman, T. A., Jiang, W., Weinstein, I. B., Harris, C. C., Ruol, A., Peracchia, A., Montesano, R. and Hollstein, M.: Correlation of p53 mutations with epidermal growth factor receptor overexpression and absence of mdm2 amplification in human esophageal carcinomas. Mol. Carcinogenesis 8: 306-311, 1993.

230. Shields, P. G., Harris, C. C., Petruzzelli, S., Bowman, E. D. and Weston, A.: Standardization of the 32P-postlabeling assay for polycyclic aromatic hydrocarbon-DNA adducts. Mutagenesis 8: 121-126, 1993.

231. Felley-Bosco, E. Weston, A., Cawley, H. M., Bennett, W. P. and Harris, C. C.: Functional studies of a germline polymorphism at codon 47 within the p53 gene. Am. J. Human Genetics 53: 752-759, 1993.

232. Bennett, W. P., Colby, T. V., Vahakangas, K. H., Soini, Y., Takeshima, Y., Metcalf, R. A., Welsh, J. A., Borkowski, A., Jones, R. T., Trump, B. F., Lane, D. P., Travis, W. D., Samet, J. M. and Harris, C. C.: p53 protein accumulates frequently in early bronchial neoplasia. Cancer Res. 53: 4817-4822, 1993.

233. Jiang, W., Zhang, Y. J., Kahn, S. M., Hollstein, M. C., Santella, R. M., Lu, S. H., Harris, C. C., Montesano, R. and Weinstein, I. B.: Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc. Natl. Acad. Sci. USA 90: 9026-9030, 1993.

234. Iizasa, T., Momiki, S., Bauer, B., Caamano, J., Metcalf, R., Harris, C. C. and Klein-Szanto, A. J. P.: Invasive tumors derived from xenotransplanted, immortilized human cells after in vivo exposure to chemical carcinogens. Carcinogenesis 14: 1789-1794, 1993.

235. Van der Meeren, A., Seddon, M. B., Kispert, J., Harris, C. C. and Gerwin, B. I.: Lack of expression of the retinoblastoma gene is not frequently involved in the genesis of human mesothelioma. Eur. Respir. Rev. 3: 177-179, 1993.

236. Shields, P. G., Caporaso, N. E., Falk, R. T., Sugimura, H., Trivers, G. E., Trump, B. F., Hoover, R. N., Weston, A. and Harris, C. C.: Lung cancer, race and a CYP1A1 genetic polymorphism. Cancer Epidemiol. Biomarkers Prev. 2: 481-485, 1993.

237. Harris, C. C.: p53: At the crossroads of molecular carcinogenesis and risk assessment. Science 262: 1980-1981, 1993.

238. Harris, C. C. and Hollstein, M. C.: Clinical implications of the p53 tumor suppressor gene. New Engl. J. Med. 329: 1318-1327, 1993.

239. Takeshima, Y., Seyama, T., Bennett, W. P., Akiyama, M., Tokuoka, S., Inai, K., Mabuchi, K., Land, C. E. and Harris, C. C.: p53 mutations in lung cancers from non-smoking atomic bomb survivors. Lancet 342: 1520-1521, 1993.

240. Mace, K., Gonzales, F., McConnell, I. R., Garner, R. C., Aventi, O., Harris, C. C. and Pfeifer, A. M. A.: Activation of promutagens in a human bronchial epithelial cell line stably expressing the human CYP1A2. Mol. Carcinogenesis 11: 65-73, 1994.

241. Hollstein, M. C., Marion, M. J., Lehman, T., Welsh, J., Harris, C. C., Martel-Planche, G., Kusters, I. and Montesano, R.: p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers. Carcinogenesis 15: 1-3, 1994.

242. Wang, X. W., Forrester, K., Yeh, H., Feitelson, M. A., Gu, J. and Harris, C. C.: Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity and association with transcription factor ERCC3. Proc. Natl. Acad. Sci. USA 91: 2230-2234, 1994.

243. Weston, A., Ling-Cawley, H. M., Caporaso, N. E., Bowman, E. D., Hoover, R. N., Trump, B. F. and Harris, C. C.: Determination of the allelic frequencies of an L-myc and a p53 polymorphism in human lung cancer. Carcinogenesis 15: 583-589, 1994.

244. Aguilar, F., Harris, C. C., Sun, T., Hollstein, M. and Cerutti, P.: Geographic variation of p53 mutational profile in nonmalignant human liver. Science 264: 1317-1319, 1994.

245. Grafstrom, R. C., Dypbukt, J. M., Sundqvist, K., Atzori, L., Nielsen, I., Curren, R. D. and Harris, C. C.: Pathobiological effects of acetaldehyde in cultured human epithelial cells and fibroblasts. Carcinogenesis 15: 985-990, 1994.

246. Kato, S., Shields, P. G., Caporaso, N. E., Sugimura, H., Trivers, G. E., Tucker, M. A., Trump, B. F., Weston, A. and Harris, C. C.: Analysis of cytochrome P450 2E1 genetic polymorphisms in relation to human lung cancer. Cancer Epidemiol. Biomarkers and Prev. 3: 515-518, 1994.

247. Forrester, K., Kispert, J., Sanchez, J. H., Gerwin, B. I., Tlsty, T. D. and Harris, C. C.: Clonal variation of tumorigenic potential in v-Ha-ras oncogene expression and CAD gene amplification. Molecular Carcinogenesis 11: 34-41, 1994.

248. Felley-Bosco, E., Ambs, S., Lowenstein, C. J., Keefer, L. K. and Harris, C. C.: Constitutive expression of inducible nitric oxide synthase in human bronchial epithelial cells induces c-fos and stimulates the cGMP pathway. Am. J. Respir. Cell Mol. Biol. 11: 159-164, 1994.

249. Hollstein, M., Rice, K., Greenblatt, M. S., Soussi, T., Fuchs, R., Sorlie, T., Hovig, E., Smith-Sorensen, B., Montesano, R. and Harris, C. C.: Database of p53 gene somatic mutations in human tumors and cell lines. Nucl. Acids Res. 22: 3551-3555, 1994.

250. Zabrenetzky, V., Harris, C. C., Steeg, P. S. and Roberts, D. D.: Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines. Internatl. J. Cancer 58: 191-195, 1994.

251. Takeshima, Y., Inai, K., Bennett, W. P., Metcalf, R. A., Welsh, J. A., Yonehara, S., Hayashi, Y., Fujihara, M., Yamakido, M., Akiyama, M., Tokuoka, S., Land, C. E. and Harris, C. C.: p53 mutations in lung cancers from Japanese mustard gas workers. Carcinogenesis 15: 2075-2079, 1994.

252. Okamoto, A., Demetrick, D. J., Spillare, E. A., Hagiwara, K., Hussain, S. P., Bennett, W. P., Forrester, K., Gerwin, B. I., Serrano, M., Beach, D. H. and Harris, C. C.: Mutations and altered expression of p16^INK4 in human cancer. Proc. Natl. Acad. Sci. USA 91: 11045-11049, 1994.

253. Okamoto, A., Jiang, W., Kim, S. J., Spillare, E. A., Stoner G. D., Weinstein, I. B. and Harris, C. C.: Overexpression of human cyclin D1 reduces the TGF-β type II receptor and growth inhibition of TGF-β1 in an immortalized human esophageal epithelial cell line. Proc. Natl. Acad. Sci. USA 91: 11576-11580, 1994.

254. De Silva, R., Englezou, A., Schevzov, G., Gerwin, B. I., Harris, C. C., Gunning, P. and Reddel, R. R.: Induction of anchorage independent growth and serum resistance in immortalized human bronchial epithelial cells by alteration of the cytoskeleton. Cellul. and Molec. Biol. Res. 40: 323-335, 1994.

255. Greenblatt, M. S., Bennett, W. P., Hollstein, M. and Harris, C. C.: Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54: 4855-4878, 1994.

256. Okamoto, A., Hussain, S. P., Hagiwara, K., Spillare, E. A., Rusin, M. R., Demetrick, D. J., Serrano, M., Hannon, G. J., Shiseki, M., Zariwala, M., Xiong, Y., Beach, D. H., Yokota, J. and Harris, C. C.: Mutations in the p16^INK4/MTS1/CDKN2, p15^INK4B/MTS2 and p18 genes in primary and metastatic lung cancer. Cancer Res. 55: 1448-1451, 1995.

257. Reddel, R. R., De Silva, R., Duncan, E. L., Rogan, E. M., Whitaker, N. J., Zahra, D. G., Ke, Y., McMenamin, M. G., Gerwin, B. I. and Harris, C. C.: SV-40-induced immortalization and ras-transformation of human bronchial epithelial cells. Int. J. Cancer 61: 199-205, 1995.

258. Guinee, Jr., D. G., Travis, W. D., Trivers, G. E., De Benedetti, V. M. G., Cawley, H., Welsh, J. A., Bennett, W. P., Jett, J., Colby, T. V., Tazelaar, H., Abbondanzo, S. L., Pairolero, P., Trastek, V., Caporaso, N. E., Liotta, L. A. and Harris, C. C.: Gender comparisons in human lung cancer: analysis of p53 mutations, anti-p53 serum antibodies and c-erbB-2 expression. Carcinogenesis 16: 993-1002, 1995.

259. Shields, P. G., Xu, G. X., Blot, J., Fraumeni, Jr., J. F., Trivers, G. E., Pellizzari, E. D., Qu, Y. H., Gao, Y. T. and Harris, C. C.: Mutagens and from heated Chinese and U. S. cooking oils. J. Natl. Cancer Inst. 87: 836-841, 1995.

260. Pellizzari, E. D., Michael, L. C., Thomas, K. W., Shields, P. G. and Harris, C.: Identification of 1,3-butadiene, benzene and other volatile organics from wok oil emissions. J. Expos. Anal. Environ. Epidemiol. 5: 77-87, 1995.

261. Borkowski, A., Bennett, W. P., Jones, R. T., Borkowski, P., Harris, C. C., Ferreira, L. R., Kao, G. and Trump, B. F.: Quantitative image analysis of p53 protein accumulation in keratoacanthomas. Am. J. Dermatol. Path. 17: 335-338, 1995.

262. Forrester, K., Lupold, S. E., Ott, V. L., Chay, C. H., Band, V., Wang, X. W. and Harris, C. C.: Effects of p53 mutants on wild-type p53 mediated transactivation are cell type dependent. Oncogene 10: 2103-2111, 1995.

263. Trivers, G. E., Cawley, H. L., De Benedetti, V. M. G., Hollstein, M., Marion, M. J., Bennett, W. P., Hoover, M. L., Prives, C., Tamburro, C. and Harris, C. C.: Anti-p53 antibodies in the serum of workers occupationally exposed to vinyl chloride. J. Natl. Cancer Inst. 87: 1400-1407, 1995.

264. Wang, X. W., Yeh, H., Schaeffer, L., Roy, R., Moncollin, V., Egly, J. M., Wang, Z., Friedberg, E. C., Evans, M. K., Taffe, B. G., Bohr, V. A., Weeda, G., Hoeijmakers, J. H. J., Forrester, K. and Harris, C. C.: p53 Modulation of TFIIH-associated nucleotide excision repair activity. Nature Genet. 10: 188-195, 1995.

265. Felley-Bosco, E., Mirkovitch, J., Ambs, S., Mace, K., Pfeifer, A., Keefer, L. K. and Harris, C. C.: Nitric oxide and ethylnitrosurea: relative mutagenicity in the p53 tumor suppressor and hypoxanathine-phosphoribosyltransferase genes. Carcinogenesis 16: 2069-2074, 1995.

266. Ueda, H., Ohkoshi, S., Harris, C. C. and Jay, G.: Synergism between the HBx gene and aflatoxin B₁ in the development of murine liver cancer. Int. J. Oncol. 7: 735-740, 1995.

267. Wang, X. W., Gibson, M. K., Vermeulen, W., Yeh, H., Forrester, K., Sturzbacher, H. W., Hoeijmakers, J. H. J. and Harris, C. C.: Abrogation of p53-induced apoptosis by the hepatitis B virus X gene. Cancer Res. 55: 6012-6016, 1995.

268. Greenblatt, M. S. and Harris, C. C.: Molecular genetics of lung cancer. Cancer Surveys 25: 293-313, 1995.

269. Hollstein, M., Shomer, B., Greenblatt, M., Soussi, T., Hovig, E., Montesano, R. and Harris, C. C.: Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation. Nucl. Acids Res. 24: 141-146, 1996.

270. Forrester, K., Ambs, S., Lupold, S. E., Kapust, R. B., Weinberg, W. C., Felley-Bosco, E., Wang, X. W., Geller, D. A., Billiar, T. R. and Harris, C. C.: Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase (NOS2) expression by wild-type p53. Proc. Natl. Acad. Sci. USA 93: 2442-2447, 1996.

271. Rusin, M. R., Okamoto, A., Chorazy, M., Czyzewski, K., Harasim, J., Spillare, E., Hagiwara, K., Hussain, S. P., Xiong, Y., Demetrick, D. J. and Harris, C. C.: Intragenic mutations of the p16^INK4, p15^INK4B and the p18 genes in primary non-small-cell lung cancers. Int. J. Cancer 65: 734-739, 1996.

272. Greenblatt, M. S., Grollman, A. P. and Harris, C. C.: Deletions and insertions in the p53 tumor suppressor gene in human cancers: confirmation of the DNA polymerase slippage/misalignment model. Cancer Res. 56: 2130-2136, 1996.

273. Spillare, E. A., Okamoto, A., Hagiwara, K., Demetrick, D. J., Serrano, M., Beach, D. and Harris, C. C.: Suppression of growth in vitro and tumorigenicity in vivo of human carcinoma cell lines by transfected p16^INK4. Mol. Carcinogen. 16: 53-60, 1996.

274. Wang, X. W., Vermeulen, W., Coursen, J. D., Gibson, M., Lupold, S. E., Forrester, K., K., Xu, G., Elmore, L., Yeh, H., Hoeijmakers, J. H. J. and Harris, C. C.: The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. Genes and Development 10: 1219-1232, 1996.

275. Soini, Y., Chia, S. C., Bennett, W. P., Groopman, J. D., Wang, J. S., DeBenedetti, V. M. G., Cawley, H., Welsh, J. A., Hansen, C., Bergasa, N. V., Jones, E. A., DiBisceglie, A. M., Trivers, G. E., Sandoval, C. A., Calderon, I. E., Munoz Espinosa, L. E. and Harris, C. C.: An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico. Carcinogenesis 17: 1007-1012, 1996.

276. Hagiwara, K. and Harris, C. C.: 'Long distance sequencer' method; a novel strategy for large DNA sequencing projects. Nucl. Acids Res. 24: 2460-2461, 1996.

277. Takenoshita, S., Hagiwara, K., Nagashima, M., Gemma, A., Bennett, W. P., Harris, C. C.: The genomic structure of the gene encoding the human transforming growth factor β type II receptor (TGF-β RII). Genomics 36: 341-344, 1996.

278. Trivers, G. E., De Benedetti, V. G. M., Cawley, H. L., Caron, G., Harrington, A. M., Bennett, W. P., Jett, J. R., Colby, T. V., Tazalaar, H., Pairolero, P., Miller, R. D. and Harris, C. C.: Anti-p53 in sera from patients with chronic obstructive pulmonary disease can predate a diagnosis of cancer. Clin. Cancer Res. 2: 1767-1775, 1996.

279. Xu, G. W., Sun, Z. T., Forrester, K., Wang, X. W., Coursen, J. and Harris, C. C.: Tissue-specific growth suppression and chemosensitivity promotion in human hepatocellular carcinoma cells by retroviral-mediated transfer of the wild-type p53 gene. Hepatology 24: 1264-1268, 1996.

280. Ohnuki, Y., Reddel, R. R., Bates, S. E., Lechner, J. F. and Harris, C. C.: Chromosomal changes and progressive tumorigenesis of human bronchial epithelial cell lines. Cancer Genetics and Cytogenetics 92: 99-110, 1996.

281. Gemma, A., Takenoshita, S., Hagiwara, K., Okamoto, A., Spillare, E. A., McMenamin, M. G., Hussain, S. P., Forrester, K., Zariwala, M., Xiong, Y. and Harris, C. C.: Molecular analysis of the cyclin dependent kinase inhibitor genes p15INK4b/MTS2, p16INK4/MTS1, p18 and p19 in human cancer cell lines. Int. J. Cancer 68: 605-611, 1996.

282. Wang, X. W. and Harris, C. C.: TP53 tumor suppressor gene: clues to molecular carcinogenesis and cancer therapy. Genetic Instability of Cancer. Cancer Surveys 28: 169-196, 1996.

283. Harty, L. C., Guinee, D. G., Travis, W. D., Bennett, W. P., Jett, J., Colby, T. V., Tazelaar, H., Trastek, V., Pairolero, P., Liotta, L. A., Harris, C. C. and Caporaso, N. E.: p53 mutations and occupational exposures in a surgical series of lung cancers." Cancer Epidemiology, Biomarkers and Prev. 5: 997-1003, 1996.

284. Hussain, S. P., Kennedy, C. H., Amstad, P., Lui, H., Lechner, J. F. and Harris, C. C.: Radon and lung carcinogenesis: mutability of p53 codons 249 and 250 to ²³⁸Pu α-particles in human bronchial epithelial cells. Carcinogenesis 18: 121-125, 1997.

285. Bowman, E. D., Shields, P. G., Caporaso, N. E., Tucker, M. A., Hoover, R. N., Trump, B. F. and Harris, C. C.: Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk. Oncology Reports 4: 269-272, 1997.

286. Hainaut, P., Soussi, T., Shomer, B., Hollstein, M., Greenblatt, M., Hovig, E., Harris, C. C. and Montesano, R.: Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects. Nucl. Acids Res. 25: 151-157, 1997.

287. Greenblatt, M. S., Feitelson, M. A., Zhu, M., Bennett, W. P., Welsh, J. A., Jones, R., Borkowski, A. and Harris, C. C.: Integrity of p53 in hepatitis B x antigen-positive and -negative hepatocellular carcinomas. Cancer Res. 57: 426-432, 1997.

288. Adler, V., Pincus, M. R., Minamoto, T., Fuchs, S. Y., Bluth, M. J., Brandt-Rauf, P. W., Friedman, F., Robinson, R. C., Chen, J. M., Wang, X. W., Harris, C. C. and Ronai, Z.: Conformation-dependent phosphorylation of p53. Proc. Natl. Acad. Sci. USA 94: 1686-1691, 1997.

289. Gemma, A., Hagiwara, K., Ke, Y., Burke, L. M., Khan, M. A., Nagashima, M., Bennett, W. P. and Harris, C. C.: FHIT mutations in human primary gastric cancer. Cancer Res. 57: 1435-1437, 1997.

290. Takenoshita, S., Tani, M., Nagashima, M., Hagiwara, K., Bennett, W. P., Yokota, J. and Harris, C. C.: Mutation analysis of coding sequences region of the transforming growth factor beta type II receptor gene in sporadic human colon cancer using genomic DNA and intron primers. Oncogene 14: 1255-1258, 1997.

291. Mace, K., Vautravers, P., Granato, D., Gonzalez, F. J., Harris, C. C. and Pfeifer, A. M. A.: Development of CYP450-expressing human bronchial epithelial cell lines for in vitro pharmatoxicologic applications. In Vitro Toxicol. 10: 85-92, 1997.

292. Tani, M., Takenoshita, S., Kohno, T., Hagiwara, K., Nagamachi, Y., Harris, C. C. and Yokota, J.: Infrequent mutations of the transforming growth factor beta type II receptor gene at chromosome 3p22 in human lung cancers with chromosome 3p deletions. Carcinogenesis 18: 1119-1121, 1997.

293. Ambs, S., Hussain, S. P. and Harris, C. C.: Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression. FASEB J. 11: 443-448, 1997.

294. Mace, K., Aguilar, F., Wang, J. S., Vautravers, P., Gomez-Lechon, M., Gonzalez, F. J., Groopman, J., Harris, C. C. and Pfeifer, A. M. A.: Aflatoxin B₁ induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines. Carcinogenesis 18: 1291-1297, 1997.

295. Takenoshita, S., Hagiwara, K., Gemma, A., Nagashima, M., Ryberg, D., Lindstedt, B. A., Bennett, W. P., Haugen, A. and Harris, C. C.: Absense of mutations in the transforming growth factor-β type II receptor in sporadic lung cancers with microsatellite instability and rare H-ras alleles. Carcinogenesis 18: 1427-1429, 1997.

296. Coursen, J. D., Bennett, W. P., Khan, M. A., Forrester, K., Pietenpol, J. A. and Harris, C. C.: Differential effects of p53 mutants on the growth of human bronchial epithelial cells. Mol. Carcinogenesis 19: 191-203, 1997.

297. Blomeke, B., Bennett, W. P., Harris, C. C. and Shields, P. G.: Serum, plasma and paraffin-embedded tissues as sources of DNA for studying cancer susceptibility genes. Carcinogenesis 18: 1271-1275, 1997.

298. Buchhop, S., Gibson, M. K., Wang, X. W., Wagner, P., Sturzbecher, H. W. and Harris, C. C.: Interaction of p53 with the human RAD51 protein. Nucl. Acids Res. 25: 3868-3874, 1997.

299. Coursen, J. D., Bennett, W. P., Gollahon, L., Shay, J. W. and Harris, C. C.: Genomic instability and telomerase activity in human bronchial epithelial cells during immortalization by human Papillomavirus-16 E6 and E7 genes. Exptl. Cell Res. 235: 245-253, 1997.

300. Elmore, L. W., Hancock, A. R., Chang, S. F., Wang, X. W., Chang, S., Callahan, C. P., Geller, D. A., Will, H. and Harris, C. C.: Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc. Natl. Acad. Sci.USA 94: 14707-14712, 1997.

301. Ambs, S., Merriam, W. G., Bennett, W. P., Felley-Bosco, E., Ogunfusika, M. O., Oser, S. M., Klein, S., Shields, P. G., Billiar, T. R. and Harris, C. C.: Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. Cancer Res. 58: 334-341, 1998.

302. Fleming, M. V., Guinee, Jr., D. G., Chu, W. S., Freedman, A. N., Caporaso, N. E., Bennett, W. P., Colby, T. V., Tazelaar, H., Abbondanzo, S. L., Jett, J., Pairolero, P., Trastek, V., Liotta, L. A., Harris, C. C. and Travis, W. D.: Bcl-2 immunohistochemistry in a surgical series of non-small cell lung cancer patients. Human Pathol. 29: 60-64, 1998.

303. Mace, K., Offord, E. A., Harris, C. C. and Pfeifer, A. M.: Development of in vitro models for cellular and molecular studies. Arch. Toxicol. Suppl. 20: 227-236, 1998.

304. Gemma, A., Hagiwara, K., Vincent, F., Ke Y., Hancock, A. R., Nagashima, M., Bennett, W. P. and Harris, C. C.: hSmad5, a human Smad family member: Its full length cDNA, genomic structure, promoter region and mutation analysis in human tumors. Oncogene 16: 951-956, 1998.

305. Ambs, S., Bennett, W. P., Merriam, W. G., Ogunfusika, M. O., Oser, S. M., Khan, M. A., Jones, R. T. and Harris, C. C.: Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53. Brit. J. Cancer 78: 233-239, 1998.

306. Burke, L., Khan, M. A., Freedman, A. N., Gemma, A., Rusin, M., Guinee, D. G., Bennett, W. P., Caporaso, N. E., Fleming, M. V., Travis, W. D., Colby, T. V., Trastek, V., Pairolero, P. C., Tazelaar, H. F., Midthun, D., Liotta, L. A. and Harris, C. C.: Allelic deletion analysis of the fragile histidine triad (FHIT) gene predicts poor survival in non-small cell lung cancer. Cancer Res. 58: 2533-2536, 1998.

307. Bennett, W. P., El-Diery, W. S., Rush, W. L., Guinee, D. G., Freedman, A. N., Caporaso, N. E., Welsh, J. A., Jones, R. T., Borkowski, A., Travis, W. D., Fleming, M. V., Trastek, V., Pairolero, P. C., Tazelaar, H. D., Midthun, D., Jett, J. R., Liotta, L. A., Harris, C. C.: p21waf1/cip1 and transforming growth factor-b1 protein expression correlate with survival in non-small cell lung cancer. Clin. Cancer Res. 4: 1499-1506, 1998.

308. Ambs, S. Ogunfusika, M. O., Merriam, W. G., Bennett, W. P., Billiar, T. R. and Harris, C. C.: Upregulation of NOS2 expression in cancer-prone p53 knockout mice. Proc. Natl. Acad. Sci.USA 95: 8823-8828, 1998.

309. Takenoshita, S., Tani, M., Mogi, A., Nagashima, M., Nagmachi, Y., Hagiwara, K., Harris, C. C. and Yokota, J.: Mutation analysis of the Smad2 gene in human colon cancers using genomic DNA and intron primers. Carcinogenesis 19: 803-807, 1998.

310. Guo, R. J., Wang, Y., Kaneko, E., Wang, D. Y., Arai, H., Hanai, H., Takenoshita, S., Hagiwara, K., Harris, C. C. and Sugimura, H.: Analyses of mutation and loss of heterozygosity of coding sequences of the entire transforming growth factor beta type II receptor gene in sporadic human gastric cancer. Carcinogenesis 19: 1539-1544, 1998.

311. Hussain, S. P. and Harris, C. C.: Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes. Cancer Res. 58: 4023-4037, 1998.

312. Mace, K., Bowman, E. D., Vautravers, P., Shields, P. G., Harris, C. C. and Pfeifer, A. M. A.: Characterization of xenobiotic-metabolizing enzyme expression in human bronchial mucosa and peripheral lung tissues. Eur. J. Cancer 34: 914-920, 1998.

313. Hagiwara, K., Freeman, A. H., McMenamin, M. G. and Harris, C. C.: Screening cloned PCR fragments by restriction endonuclease fingerprinting (REF) to obtain wild-type sequences. Biotechniques 25: 554-555, 1998.

314. Ambs, S., Merriam, W. G., Ogunfusika, M. O., Bennett, W. P., Ishibe, N., Hussain, P. S., Tzeng, E. E., Geller, D. A., Billiar, T. R. and Harris, C. C.: p53 and vascular endothelial growth factor regulate tumor growth of NOS2-Expressing human carcinoma cells. Nature Med. 4: 1371-1376, 1998.

315. Von Brevern, M., Hollstein, M., Risk, J. M., Garde, J., Bennett, W. P., Harris, C. C., Muehlbauer, K. R. and Field, J. K.: Loss of heterozygosity in sporadic oesophageal tumours at the tylosis oesophageal cancer (TOC) gene locus of chromosome 17q. Oncogene 17: 2101-2105, 1998.

316. Przygodzki, R. M., Bennett, W. P., Guinee, Jr., D. G., Khan, M. A., Friedman, A., Shields, P. G., Travis, W. D., Jett, J. R., Tazelaar, H., Pairolero, P., Trastek, V., Liotta, L. A., Harris, C. C. and Caporaso, N. E.: p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated patients with non-small cell lung cancer. Pharmacogenetics 8: 503-511, 1998.

317. Ambs, S., Bennett, W. P., Merriam, W. G., Ogunfusika, M. O., Oser, S. M., Harrington, A. M., Shields, P. G., Felley-Bosco, E., Hussain, S. P. and Harris, C. C.: Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer. J. Natl. Cancer Inst. 91: 86-88, 1999.

318. Jia, L., Wang, X. W. and Harris, C. C.: Hepatitis B virus X protein inhibits nucleotide excision repair. Int. J. Cancer 80: 875-879, 1999.

319. Zhou, X., Wang, X. W., Xu, L., Hagiwara, K., Nagashima, M., Wolkowicz, R., Zurer, I., Rotter, V. and Harris, C. C.: COOH-Terminal domain of p53 modulates p53-mediated transcriptional transactivation, cell growth and apoptosis. Cancer Res. 59: 843-848, 1999.

320. Walker, D. R., Bond, J. P., Tarone, R. E., Harris, C. C., Makalowski, W., Boguski, M. S. and Greenblatt, M. S.: Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features. Oncogene 18: 211-218, 1999.

321. Wang, X. W., Zhan, Q., Coursen, J. D., Khan, M. A., Kontny, H. U., Yu, L., Hollander, M. C., O’Connor, P. M., Fornace, Jr., A. J. and Harris, C. C.: GADD45 induction of a G2-M cell cycle checkpoint. Proc. Natl. Acad. Sci.USA 96: 3706-3711, 1999.

322. Xu, X., Weaver, Z., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T. and Deng, C. X.: Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Molecular Cell 3: 389-395, 1999.

323. Zhan, Q., Antinore, M. J., Wang, X. W., Carrier, F., Smith, M. L., Harris, C. C. and Fornace, Jr., A. J.: Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene 18: 2892-2900, 1999.

324. Yoshikawa, H., Nagashima, M., Khan, M. A., McMenamin, M. G., Hagiwara, K. and Harris, C. C.: Mutational analysis of p73 and p53 in human cancer cell lines. Oncogene 18: 3415-3421, 1999.

325. Rusin, M., Butkiewicz, D., Malusecka, E., Zborek, A., Harasim, J., Czyzewski, K., Bennett, W. P., Shields, P. G., Weston, A., Welsh, J. A., Krzyzowska-Gruca, S., Chorazy, M. and Harris, C. C.: Molecular epidemiological study of non-small-cell lung cancer from an environmentally polluted region of Poland. Brit. J. Cancer 80: 1445-1452, 1999.

326. Spillare, E. A., Robles, A. I., Wang, X. W., Shen, J. C., Yu, C. E., Schellenberg, G. D. and Harris, C. C.: p53-mediated apoptosis is attenuated in Werner syndrome cells. Genes and Development 13: 1355-1360, 1999.

327. Robles, A. I., Wang, X. W. and Harris, C. C.: Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death. Oncogene 18: 4681-4688, 1999.

328. Rusin, M., Samogedny, A., Harris, C. C. and Chorazy, M.: Novel genetic polymorphisms in DNA repair genes: O(6)-methylguanine-DNA methyltransferease (MGMT) and N-methylpurine-DNA glycosylase (MPG) in lung cancer patients from Poland. Human Mut. 14: 269-270, 1999.

329. Butkiewicz, D., Cole, K. J., Phillips, D. H., Harris, C. C. and Chorazy, M.: GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms in lung cancer patients from an environmentally polluted region of Poland: correlation with lung DNA adduct levels. Eur. J. Cancer Prev. 8: 315-323, 1999.

330. Hagiwara, K., McMenamin, M. G., Miura, K. and Harris, C. C.: Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in the human cancer cell lines using intronic primers. Cancer Res. 59: 4165-4169, 1999.

331. Mazur, S. J., Sakaguchi, K., Appella, E., Wang, X. W., Harris, C. C. and Bohr, V. A.: Preferencial binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain. J. Mol. Biol. 292: 241-249, 1999.

332. Bennett, W. P., Alavanja, M. C., (co-first authors), Blomeke, B., Vahakangas, K. H., Castren, K., Welsh, J. A., Bowman, E. D., Khan, M. A., Flieder, D. B. and Harris, C. C.: Environmental tobacco smoke and genetic susceptibility as lung cancer risk factors in never-smoking women. J. Natl. Cancer Inst. 91: 2009-2014, 1999.

333. Lebel, M., Spillare, E. A., Harris, C. C. and Leder, P. The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I. J. Biol. Chem. 274: 37795-37799, 1999.

334. Ambs, S. and Harris, C. C.: Response: Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer. J. Natl. Cancer Inst. 91: 1510-1511, 1999.

335. Hsia, C. C., Nakashima, Y., Thorgeirsson, S. S., Harris, C. C., Minemura, M., Momosaki, S., Wang, N. J. and Tabor, E.: Correlation of immunohistochemical staining and mutations of p53 in human hepatocellular carcinoma. Oncol. Rep. 7: 353-356, 2000.

336. Zhou, X., Espey, M. G., Chen, J. X., Hofseth, L.J., Miranda, K. M., Hussain, S. P., Wink, D. and Harris, C. C.: Inhibitory effects of nitric oxide and nitrosative stress on dopamine-β-hydroxylase. J. Biol. Chem. Vol. 275: 21241-21246, 2000.

337. Hussain, S. P., Amstad, P., Raja, K., Ambs, S., Nagashima, M., Bennett, W. P., Shields, P. G., Ham, A J., Swenberg, J. A., Marrogi, A. J. and Harris, C. C.: Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease. Cancer Res. 60: 3333-3337, 2000.

338. Marrogi, A. J., Pass, H. I., Khan, M., Metheny-Barlow, L. J., Harris, C. C., Gerwin, B. I.: Human mesothelioma samples overexpressed both COX2 and NOS2: In Vitro anti-proliferative effects of a COX-2 inhibitor. Cancer Res. 60: 3696-3700, 2000.

339. Galateau-Salle, F. B., Luna, R. E., Horiba, K., Sheppard, M. N., Hayashi, T., Fleming, M. V., Colby, T. V., Bennett, W., Harris, C. C., Stetler-Stevenson, W. G., Liotta, L., Ferrans, V. J. and Travis, W. D.: Matrix metalloproteinases and tissue inhibitors of metalloproteinases in bronchial squamous preinvasive lesions. Hum. Pathol. 31: 296-305, 2000.

340. Butkiewicz, D., Rusin, M., Harris, C. C. and Chorazy, M.: Identification of four single nucleotide polymorphisms in DNA repair genes: XPA and XPB (ERCC3) in Polish population. Human Mutat. 15: 577-578, 2000.

341. Bennett, W. P., Alavanja, M. C. and Harris, C. C.: Response: re: environmental tobacco smoke, genetic susceptibility and risk of lung cancer in never-smoking women. J. Natl. Cancer Inst. 92: 760-761, 2000.

342. Gemma, A., Seike, M., Seike, Y., Uematsu, K., Hibino, S., Kurimoto, F., Yoshimura, A., Shibya, M., Harris, C. C. and Kudoh, S.: Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer. Genes, Chromosome and Cancer 29: 213-218, 2000.

343. Hussain, S. P., Raja, K., Amstad, P. A., Sawyer, M., Trudel, L. J., Wogan, G. N., Hofseth, L. J., Shields, P. G., Billiar, T. R., Trautwein, C., Hohler, T., Galle, P. R., Phillips, D. H., Markin, R., Marrogi, A. J. and Harris, C. C.: Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: oxyradical overload diseases. Proc. Natl. Acad. Sci.USA 97: 12770-12775, 2000.

344. Marrogi, A. J., Travis, W. D., Welsh, J. A., Khan, M. A., Rahim, H., Tazelaar, H., Pairolero, P., Trastek, V., Jett, J., Caporaso, N. E., Liotta, L. A. and Harris, C. C.: NOS2, COX2 and VEGF in the angiogenesis of non-small cell lung carcinoma. Clin. Cancer Res. 6: 4739-4744, 2000.

345. Liu, J., Akoulitchev, S., Weber, A., Ge, H., Chuikov, S., Libutti, D., Wang, X. W., Conaway, J. W., Harris, C. C., Conaway, R. C., Reinberg, D. and Levens, D.: Defective interplay of activators and repressors with TFIIH in Xeroderma Pigmentosum. Cell 104: 353-363, 2001.

346. Butkiewicz, D., Rusin, M., Enewold, L., Shields, P. G., Chorazy, M. and Harris, C. C.: Genetic polymorphisms in DNA repair genes and risk of lung cancer. Carcinogeneis 22: 593-597, 2001.

347. Offer, H., Milyavsky, M., Erez, N., Matas, D., Zurer, I., Harris, C. C. and Rotter, V.: Structural and functional involvement of p53 in BER in vitro and in vivo. Oncogene 20: 581-589, 2001.

348. Yoshikawa, H., Matsubara, K., Qian, G. S., Jackson, P., Groopman, J. D., Manning, J. E., Harris, C. C. and Herman, J. G.: SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nature Genetics 28: 29-35, 2001.

349. Vahakangas, K. H., Bennett, W. P., (co-first authors), Castren, K., Welsh, J. A., Khan, M. A., Blomeke, B., Alavanja, M. and Harris, C. C.: TP53 and K-ras mutations in a lung cancer cohort of non-smoking women. Cancer Res. 61: 4350-4356, 2001.

350. Minamoto, T., Buschmann, T., Habelhah, H., Mutusevich, E., Tahara, H., Boerresen-Dale, A. L., Harris, C. C., Sidransky, D. and Ronai, Z.: Distinct pattern of p53 phosphorylation in human tumors. Oncogene 20: 3341-3347, 2001.

351. Huo, T. I., Wang, X. W., Forgues, M., Wu, C. G., Spillare, E. A., Giannini, C., Brechot, C. and Harris, C. C.: Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis. Oncogene 20: 3620-3628, 2001.

352. Nicholson, S. A., Okby, N. T., Khan, M. A., Welsh, J. A., McMenamin, M. G., Travis, W. D., Jett, J. R., Tazelaar, H. D., Trastek, V., Pairolero, P. C., Corn, P. G., Herman, J. G., Liotta, L. A., Caporaso, N. E. and Harris, C. C.: Alterations of p14ARF, p53 and p73 genes involved in the E2F-1-mediated apoptotic pathways in non-small cell lung carcinoma. Cancer Res. 61: 5636-5643, 2001.

353. Xu, X., Qiao, W., Linke, S. P., Li, W. M., Harris, C. C. and Deng, C. X.: Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle, genomic stability and tumorigenesis. Nature Genetics 28: 266-271, 2001.

354. Wang, X. W., Tseng, A., Ellis, N. A., Spillare, E. A., Linke, S. P., Robles, A. I., Seker, H., Yang, Q., Hu, P., Beresten, S., Bemmels, N. A., Garfield, S. and Harris, C. C.: Functional interaction of p53 and BLM DNA helicase in apoptosis. J. Biol. Chem. 276: 32948-32955, 2001.

355. Nagashima, M., Shiseki, M., Miura, K., Hagiwara, K., Linke, S. P., Peduex, R., Wang, X. W., Yokota, J., Riabowol, K. and Harris, C. C.: DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Proc. Natl. Acad. Sci. USA 98: 9671-9676, 2001.

356. Hussain, S. P., Amsted, P., Raja, K., Sawyer, M., Hofseth, L., Shields, P. G., Hewer, A., Phillips, D. H., Ryberg, D., Haugen, A. and Harris, C. C.: Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung. Cancer Res. 61: 6350-6355, 2001.

357. Robles, A. I., Bemmels, N. A., Foraker, A. B. and Harris, C. C.: APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis. Cancer Res. 61: 6660-6664, 2001.

358. Brosh, Jr., R. M., Karmakar, P., Sommers, J. A., Yang Q., Wang, X. W., Spillare, E. A., Harris, C. C. and Bohr, V. A.: p53 modulates the exonuclease activity of Werner syndrome. J. Biol. Chem. 276: 35093-35102, 2001.

359. Seker, H., Butkiewicz, D., Bowman, E. D., Rusin, M., Hedayati, M., Grossman, L. and Harris, C. C.: Functional significance of XPD polymorphic varients: Attenuated apoptosis in human lymphoblastoid cells with the XPD 312 Asp/Asp genotype. Cancer Res. 61: 7430-7434, 2001.

360. Marrogi, A. J., Khan, M. A. (first co-authors), van Gijssel, H. E., Welsh, J. A., Rahim, H., Demetris, A. J., Kowdley, K. V., Hussain, S. P., Nair, J., Bartsch, H., Okby, N., Poirier, M. C., Ishak, K. G. and Harris, C. C.: Oxidative stress and p53 mutations in the carcinogenesis of iron overload-associated hepatocellular carcinoma. J. Natl. Cancer Inst. 93: 1652-1655, 2001.

361. Miura, K., Bowman, E.D., Simon, R., Peng, A.C., Robles, A.I., Jones, R.T., Katagiri, T., He, P., Mizukami, H., Charboneau, L., Kikuchi, T., Liotta, L.A., Nakamura, Y.