CURRICULUM VITAE

Name: Curtis C. Harris, M.D.

Place of Birth: Anthony, Kansas

Citizenship: United States of America

Education:

1965 B.A., University of Kansas

1969 M.D., University of Kansas School of Medicine

1970 Intern Certificate, Internal Medicine, U.C.L.A. Hospital, Los Angeles, CA

1976 Resident Certificate, Internal Medicine, V. A. Hospital, Washington, DC

Brief Chronology of Employment and Training:

1964 - 1965 Undergraduate Teaching and Research Assistant, Department of Zoology, University of Kansas

1969 - 1970 Intern, Department of Medicine, U.C.L.A. Hospital, Los Angeles, CA

1970 - 1972 Research Associate, Lung Cancer Unit, OASDC, DCCP, NCI, NIH, Bethesda, MD

1972 - 1975 Head, Ultrastructure Unit, Pathogenesis Section, Lung Cancer Branch, DCCP, NCI, NIH, Bethesda, MD

1973 - 1976 Resident and Trainee in Clinical Oncology, NCI-VA Oncology Branch, Department of Medicine, VA Hospital, Washington, DC (4 months/year)

1975 - 1981 Head, Human Tissue Studies Section, Laboratory of Experimental Pathology, DCCP, NCI, NIH, Bethesda, MD

1979 - 1981 Associate Chief, Laboratory of Experimental Pathology, NCI, NIH, Bethesda, MD

1981 - Pres. Chief, Laboratory of Human Carcinogenesis, CCR, NCI, NIH and Head, Molecular Genetics and Carcinogenesis Section, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD

Honorary Degrees:

Ph.D., Nippon Medical School, Tokyo, Japan - February 28, 2011

Military Service: USPHS: July 1970-2000

Rank: Medical Director (Captain), 0-6

Medical Certification and License:

1970 Diplomate, National Board of Medical Examiners

1971 Medical License, District of Columbia

1975 Medical License, California

1976 Diplomate, American Board of Internal Medicine

Societies:

American Association for Cancer Research

American Association for the Advancement of Science

American Society for Clinical Investigation

International Society for Gastroenterological Carcinogenesis

International Association for the Study of Lung Cancer

International Liver Cancer Association

Editor-in-Chief:

Carcinogenesis, 1984 -

Associate Editor:

Cancer Research, 1981 - 2007

Experimental Pathology, 1982 - 1991

Cell Biology and Toxicology, 1983 - 1992

Cancer Epidemiology, Prevention and Biomarkers, 1991 - 2001

American Journal of Respiratory Cell and Molecular Biology, 1992 - 1998, 2000-2003

Clinical Cancer Research, 1996 - 2004

Cancer Science, 2004-

Cancer Prevention Research, 2008-

Editorial Boards:

Carcinogenesis, 1979 - 1984

ILSI Monographs on Pathology of Laboratory Animals, 1981 - 1991

Japanese Journal of Clinical Oncology, 1992 -

Journal of Cellular Biochemistry, 1982 -

Journal of Cell Biochemistry and Function, 1982 - 1991

Chemico-Biological Interactions, 1983 - 1992

Lung Cancer, 1985 - 1995

Cancer Science (Japanese Journal for Cancer), 1986 -

Molecular and Cellular Probes, 1986 - 1991

Toxicologic Pathology, 1988 - 1996

International Journal of Cancer 1991 - 2004

International Journal of Oncology 1992 - 2001

Tumori, 1992 - 2004

Predictive Oncology, 1995 - 2001

Environmental Health Perspectives, 1997 - 2004

Journal of the National Cancer Institute, 1998 - 2007

Gene Expression, 2000 - 2006

Hepatology, 2001 - 2004

Journal of the Nippon Medical School, 2002 -

Journal of Molecular Medicine, 2004 -

Cancer Prevention Research, 2008 -

Scientific and Organizational Responsibilities:

Advisory Activities

Member, Ad Hoc Scientific Advisory Group on In Vitro Carcinogenesis, DCCP, NCI, 1974-1975

Member, Clinical Advisory Group to Viral Oncology, DCE, NCI, 1976-1977

Reviewer and Advisor, Thesis Advisory Committee, Department of Pathology, University of Maryland School of Medicine, 1977-1999

Expert Witness, Hearings concerning OSHA Regulations entitled "Identification, Classification and Regulation of Toxic Substances Posing a Potential Occupational Carcinogenic Risk", June 1978

Reviewer, Biomedical Division, Lawrence Livermore Laboratory, University of California, 1980

Consultant, Committee on Human Risk Assessment, Office of the Commissioner, Food and Drug Administration, 1980

Member, International Advisory Committee for the Danish Cancer Society, 1984-1990

Member, Research Committee, Health Effects Institute, 1984-1991

Member, External Advisory Committee, Institute of Environmental Medicine, New York University, 1985-1992

Member, Technical Review Committee, USPHS Surgeon General Report on Harmful Effects of Smokeless Tobacco, 1985-86

Founder and Member, Board of Directors, Aspen Cancer Conference (not for profit), 1985-

Member, External Advisory Committee, School of Public Health, Johns Hopkins University, 1986-1990

Member, External Advisory Committee, Institute of Environmental Health, Oregon State University, 1986-1988

Member, Scientific Advisory Board, American Health Foundation, 1986-1998

Member, General Motors Mott Award Selection Committee, 1986

Overseer, Colby College, Waterville, Maine, 1988-1995

Member, Scientific Advisory Panel, Chemical Industry Institute of Technology, 1988

Member, Whitaker College Visiting Committee, M.I.T., 1988-1994

Chairman, Scientific Advisory Panel, Chemical Industry Institute of Technology, 1989-1994

Member, Scientific Council of the Radiation Effects Research Foundation, N.A.S. 1989-1997

Member, Scientific Advisory Council, International Agency for Research on Cancer, W.H.O., Lyon, 1989-1994

Chairman, Scientific Advisory Board, Dana Institute, American Health Foundation, 1989-1998

Chairman, Scientific Advisory Board and Secretary, Keystone Executive Committee, Keystone Symposia on Molecular and Cellular Biology (not for profit), 1990-2006

Member, Visiting Committee for the Brookhaven National Laboratory, N.A.S., Biology Department, 1990-1994

Member, Board of Directors, Intl. Society of Differentiation, 1990-1996

Chairman, Program Committee, AACR Annual Meeting, 1991

Committee Member, Risk Assessment of Hazardous Air Pollutants, National Research Council, Washington, DC, 1991-1993

Member, Advisory Committee for the Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, 1995-1997

Member, Board of Directors, American Association of Cancer Research, 1992-1995

Advisor, Howard Hughes Medical Institute Scholars Program, NIH, 1993-1995

Member, NIH Fogarty Scholars-in-Residence Advisory Panel, 1994-1996

Member, Division of Cancer Epidemiology and Genetics Promotions and Tenure Panel, 1995-1999

Member, Board of Directors, International Society of Gastroenterological Carcinogenesis, 1996-

Member, AACR Special Conference Committee, 1996-1999

Consultant, Radiation Effects Research Foundation, Hiroshima, Japan, 1996-2014

Member, U.S.-Japan Promotion of Research Progress, NCI Steering Committee, 1997-1999

Member, AACR Public Relations Committee, 1997-2000

Member, AACR G. B. Elion Cancer Research Award Committee, 2000-2001

Member, AACR Education Committee, 2000-2002

Member, Tenure-Track Review Panel, Cancer Prevention Studies Branch, NCI, 2001

Co-Chair, Biology, Lung Cancer, NCI Program Review Group, 2001

Member, Tenure-Track Review Panel, Biostatistics Branch, NCI, 2001

Member, AACR Special Conference Committee, 2001-2006

Member, NCI Core Genotyping Oversight Committee, 2001-2010

International Advisory Committee, Princess Chulabhorn Research Institute and Hospital, Bangkok, Thailand, 2002

Chair and Member, AACR Nomination Committee, 2003-2005

Consultant (non-paid), Radiation Effects Research Foundation, Hiroshima, Japan 2004-

Member, AACR Grants Committee, 2004-2005

Member, AACR Program Committee, Annual Meeting, 2005 and 2007

Contributing Author, The Health Consequences of Smoking: A Report of the Surgeon General, 2004

Member, Advisory Board, Center for Cancer Research, NCI, 2005-2007

Member, NCI 2015 Strategy Development Team, 2005

Member, Advisory Board, FAMRI Center of Excellence in Israel, 2005-

Member, AACR, Centennial Committee, 2006-2008

Member, Nominating Committee, AACR-Princess Takamatsu Lectureship, 2007

Chairman, Board of Directors, Aspen Cancer Conference (not for profit), 2007-

Chairman, Board of Directors, Keystone Symposia on Molecular and Cellular Biology (not for profit), 2007-2010

Member, Steering Committee, Center of Excellence in Integrative Cancer Biology and Genomics, 2008-

Member, Governing Board, International Liver Cancer Association, 2009-2013

Member, INFLA-CARE Scientific Advisory Board, 2009-2012

Chair, Selection Committee, AACR Princess Takamutsu Award Lecture, 2010

Member, Selection Committee, Landon-Foundation-AACR INNOVATOR Award for Cancer Prevention Research, 2011

External Advisory Committee, National Cancer Center Research Institute, Tokyo, Japan, 2012-

Honors and Other Special Scientific Recognition:

NSF Research Participation Awardee and Gifted Student Program, University of Kansas, 1963-1965

George Bailey Award, University of Kansas, School of Medicine, 1967

Commendation Medal, USPHS Honor Award, 1979

Medical Alumni Scholar and Lecturer, first to be awarded, University of Kansas School of Medicine, 1982

NCI Equal Employment Opportunity Special Recognition Award, 1983

Fellow, American Society of Clinical Investigation, 1984

Meritorious Service Award, USPHS, 1986

G. Scott Award, Toxicology Forum, 1991

Keynote Address, Princess Takamatsu Symposium, 1991

George Peabody Award, Southwestern University School of Medicine, 1993

Alton Ochsner Award Relating Smoking and Health, Alton Ochsner Medical Foundation and American College of Chest Physicians, 1993

Keynote Address, Beatson International Cancer Conference, 1993

Keynote Address, Japanese Research Society for Gastrointestinal Cancers, 1993

William A. Gardner Award and Lecturer, Yale University, 1994

Keynote Address, Barton Creek Cancer Conference, University of Texas, 1994

Keynote Address, Annual Meeting, Chinese Oncology Society, 1994

Maud L. Menten Award and Lecturer, University of Pittsburg School of Medicine, 1995

Walter Hubert Award and Lecturer, British Association for Cancer Research, Nottingham, 1995

Don Coffey Award and Lecturer, Society for Basic Urological Research, Las Vegas, 1995

CIIT Founders Award, Durham, 1995

Deichmann Award and Keynote Lecture: VII International Congress of Toxicology, Seattle, 1995

Keynote Address, 5th International Inhalation Symposium, Hannover, 1995

Keynote Address, Japanese Lung Cancer Society, 1995

International Keynote Lecturer, Japanese Surgical Society Annual Meeting, Chiba, 1996

Lewis M. Schiffer Memorial Award and Lecturer, Cell Proliferation Society, Toledo, 1996

Bob Champion Award and Lecturer, British Oncological Association, 1996

Keynote Address, AACR-IARC Conference, Molecular Epidemiology, Budapest, 1996

William Stenberg Memorial Lecture, Tulane, 1997

Elizabeth and James Miller Distinguished Lecturer, Rutgers University, New Jersey, 1997

Keynote Address, Genes and Environment in Cancer, Dr. Mildred Stiftung FDN, Bonn, 1997

Robert Greenfield Memorial Lecturer, University of Nebraska, 1998

Federal Technology Transfer Award, 1998-2006

Distinguished Lectureship, Japanese Foundation for Cancer Research, Tokyo, 1998

Identified as one of the 50 most cited scientists in biomedical research in the 1990s (ISI Science Watch, March, 1998)

Keynote Address, Latin-American Meeting, Environmental Mutagenesis, Carcinogenesis and Teratogenesis, Curitiba, 1998

Distinguished Lecturer, Cancer Institute of New Jersey, Rutgers University, 1999

Robert F. E. Stier Memorial Lecturer, Washington State University, 1999

Keynote Address, 2nd International Congress on Gastroenterological Carcinogenesis, Ulm, 1999

Charles Heidelberger Award, International Society on Gastroenterological Carcinogenesis, Ulm, 1999

Distinguished Service Medal, highest award of the U.S.Public Health Service, 1999

Gerald N. Wogan Lecturer, Massachusettes Institute of Technology, 2000

Keynote Address, Molecular Epidemiology of Human Cancer Conference, International Agency for Research on Cancer, Lyon, 2000

Distinguished Alumni Lecturer, University of Kansas, Lawrence, 2001

Honorary Member, Japanese Cancer Association, Tokyo, 2001

Special Lecturer, Japanese Cancer Association, Annual Meeting, Tokyo, 2002

Award of Merit, Princess Takamatsu Cancer Research Fund, Japan, 2002

Keynote Address, Lovelace Symposium, Santa Fe, 2002

Fellow, AAAS, 2003

Senior Fellow and Lecturer, Japanese Cancer Research Foundation, 2003

Keynote Address, Environmental Health Conference, Lancaster, 2003

Keynote Address, p53 Satellite Meeting, Tenth International Toxicology Congress, Finland, 2004

Keynote Address, Tenth International Toxicology Congress, Finland, 2004

Undergraduate Scholarship Program Recognition Award, National Institutes of Health, Bethesda, MD, 2005

Keynote Address, Environmental Mutagen Society United Kingdom, Bradford, 2005

Keynote Address, International Symposium, Chronic Oxidative Stress and Cancer: Mechanisms, Biomarkers and Prevention, German Cancer Research Center, Heidelberg, 2005

Keynote Address and Visiting Professor: Frontiers in Biomedical Research, Hong Kong School of Medicine, Hong Kong, 2005

Presidential Lecture, International Liver Congress, Shanghai, 2006

Keynote Address, Microenvironment and Cancer Symposium, Japanese Foundation Cancer Research, Tokyo, 2006

State of the Art Address, International Liver Cancer Association, Barcelona, 2007

NCI Outstanding Mentor Award, 2007

Keynote Address, Nitric Oxide Gordon Conference Research Conference, Barga, Italy, 2009

AACR-Princess Takamatsu Award, AACR Annual Meeting, Denver, CO, 2009

Keynote Address: Inflammation and Cancer: microRNA and p53 isoforms in cancer diagnosis, prognosis, and therapeutic therapy, 1st International Meeting on Molecular Based Treatment of GI-Cancer, Göttengen, Germany, 2009

Keynote Address, Hiroshima Cancer Symposium, Hiroshima, Japan, 2009

NCI Merit Award, 2009

Distinguished Professor Lecture, Johns Hopkins University, School of Medicine, Baltimore, MD, 2010

Provost Distinguished Lecture, (Inaugural lecture), M.D. Anderson Cancer Center, Houston, TX, 2010

Ben Trump Memorial Lecture, Aspen Cancer Conference, Aspen, CO, 2010

Distinguished Lecture, Frontiers of Cancer Prevention, AACR Conference, Philadelphia, PA, 2010

Keynote Address, Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer, AACR Conference, San Diego, CA 2011

Invited Talks (2005-present):

1. “Radical causes of human cancer”. Keystone Symposia, Breckenridge, CO, March 2005

2. “p53: At the Crossroads of DNA Repair, DNA Recombination and Carcinogenesis”. Keystone Symposia, Taos, New Mexico, March 2005

3. “p53: At the Crossroads of Inflammation, Aging and Cancer”. FAMRI Advisory Board Mtg/Weizman Institute, Rehovot, Israel, March 2005

4. “Chronic Inflammation and Cancer”. Oregon State University, Portland OR, April 2005;

5. “p53 Tumor Suppressor: At the Crossroads of Molecular, Pathogenesis, Therapy and Epidemiology of Hepatocellular Carcinoma”. Barcelona, Spain, June 2005

6. “p53 tumor suppressor and genomic instability diseases”. University of Oxford, London, England, June 2005

7. “p53 at the Crossroads of DNA repair and DNA Recombination”. 28^th Annual Conference of the UK Environmental Mutagenesis Society, Bradford, United Kingdom, August 2005

8. “Inflammation and Cancer”. Mechanisms, Biomarkers and Prevention Symposium, Heidelberg, Germany, October 2005

9. “p53 Senescence and Cancer”. Keystone Symposium, Singapore, October 2005

10. “Chronic Inflammation and Cancer: Radical Causes of Cancer”. Boston University, Boston, MA, October 2005

11. “Chronic Inflammation and Cancer”. China, Beijing, November 2005

12. “p53 Tumor Suppressor Colon: At the Crossroads of Inflammatory Stress and Cancer”. Second International Workshop, Ein Gedi, Israel, November 2005

13. “p53 Biological Network: Chronic inflammation and Cancer”. University of Hong/Frontiers in Biomedical Research Symposium, Hong Kong, December 2005

14. “p53 Biological network: Inflammation and cancer”. 11^th International Charles Heidelberger Symposium on Cancer Research, Naresuan University Hospital, Phitsanulok, Thialand, January 2006

15. “p53 Tumor Suppressor network: At the crossroads of the molecular carcinogenesis and molecular epidemiology of liver cancer”. Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, March 2006

16. “Cause and Prevention of Colon Cancer”. University of South Carolina, National Colorectal Awareness, Columbia, SC, March 2006

17. “p53 Biological network: chronic inflammation and cancer”. International Symposium on Carcinogenesis and Tissue Environment, Tokyo, Japan, April 2006

18. “p53 mediated senescence”. International p53 workshop, Columbia University, New York, NY, May 2006

19. “p53 biological network: chronic inflammation and cancer”. CNIO Cancer Conference on Inflammation and Cancer, Madrid, Spain, May 2006

20. “Chronic Inflammation and Cancer: Radical Causes of Human Cancer”. 4^th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide, Monterey, CA, June 2006

21. “Microenvironment and Cancer: Inflammation microRNA profiles and p53 Network”. Kansas University Cancer Center Symposium, Kansas City, KS, June 2006

22. “Inflammation and Cancer”. 46^th annual meeting of Japanese Respiratory Society, Japan, Tokyo, June 2006

23. “Molecular and Profiling of Lung Cancer”. National Cancer Center Research Institute, Tokyo, Japan, June 2006

24. “Unique microRNAs predict lung cancer diagnosis and prognosis”. Aspen Cancer Conference, Aspen, CO, July 2006

25. “Microenvironment and p53 Biological Network”. European Environmental Mutagen Society Meeting, Prague, Czech Republic, July 2006

26. “Chronic Inflammation and Cancer: Radical causes of cancer”. 4^th International Gastroenterological Carcinogenesis Conference 2006, Honolulu, HI, August 2006

27. “Microenvironment and Cancer: Inflammation, microRNA and cytokine profiles, and p53 network”. University of California, San Francisco, CA, August 2006

28. “Microenvironment and Cancer: Inflammation, microRNA and cytokine profiles, and p53 network”. University of Calgary, Alberta, Canada, August 2006

29. “p53 Biological Network”. Eurotox 2006 meeting, Cavtat/Dubrovnik, Croatia, September 2006

30. “Microenvironment and Cancer: inflammation, microRNA and cytokines”. Northwestern University School of Medicine Pathology Department, Chicago, IL, September 2006

31. “Microenvironment and Cancer: Inflammation, microRNAs and Cytokines”. 5^th Cytokines and Inflammation Conference, Breckenridge, CO, January 2007

32. “Inflammation and Cancer”. Keystone Symposium on Genome Instability & Repair, Breckenridge, CO, January 2007

33. “Microenvironment and Cancer: Inflammation, microRNA and p53”. Weizmann Institute of Science, Rehovot, Israel, February 2007

34. “Microenvironment and Cancer: Inflammation, microRNA and p53”. Mainz University, Mainz, Germany, February 2007

35. “microRNAs and Cytokines modulate lung cancer progression and prognosis: Mechanistic insights and clinical potential”. AEK Congress of the Experimental Branch of the German Cancer Society, Frankfurt, Germany, March 2007

36. “microRNAs predict cancer diagnosis and prognosis”. AACR annual meeting, Los Angeles, CA, April 2007

37. “microRNA and cytokine profiling predict cancer diagnosis and prognosis”. 12^th International Heidelberger Symposium on Cancer Research, Jerusalem, Israel, May 2007

38. “Microenvironment and Cancer: inflammation and microRNA”. San Antonio Cancer Institute, San Antonio, TX, May 2007

39. “Microenvironment and Cancer”. IN University, Center for Environmental Health, Indianapolis, IN, May 2007

40. “Microenvironment and Cancer: Inflammation, microRNA and p53”. The Falk Symposium, Portoroz, Slovenia, June 2007

41. “microRNAs in cancer diagnosis and prognosis”. Gordon Research Conference on Molecular Therapeutics of Cancer, New London, NH, July 2007

42. “Inflammation and Cancer: Interactions of microRNA cytokine and p53 pathways”. XIII Charles Heidelberger International Symposium, New York, NY, September 2007

43. “Chronic Inflammation and Cancer: Interaction of free radical, microRNA cytokine pathways”. University of Geneva Department of Molecular Biology, Geneva, Switzerland, October 2007

44. “Inflammation and Cancer: Interactions of microRNA cytokine and p53 pathways”. International Liver Cancer Association Meeting, Barcelona, Spain, October 2007

45. “Inflammation and Cancer”. 4^th Nestle International Nutrition Symposium, Lausanne, Switzerland, October 2007

46. “Inflammation and Cancer: Interactions of microRNA cytokine and p53 pathways”. Keystone Symposium on Frontiers in Gastrointestinal Cancer, Beijing, China, October 2007

47. “Inflammation and Cancer: Interactive MicroRNA, Cytokine and free radicals pathways”. Sixth Princess Chulabhorn International Science Congress, Bangkok, Thialand, November 2007

48. “MicroRNAs as biomarkers of colon cancer and prognosis”. AACR Special Conference on Advances in Colon Cancer Research, Cambridge, MA, November 2007

49. “Inflammation and Cancer: Interaction of the p53, microRNA and cytokine pathways”. 3^rd International Workshop on Mutant p53, Lyon, France, November 2007

50. “Inflammation and Cancer: Interactions of microRNA, cytokine and p53 pathways”. National Cancer Center Research Institute, Tokyo, Japan; December 2007

51. “Chronic Inflammation and Cancer: Interaction of microRNA, free radical and cytokine and p53 pathway”. Ludwig Institute for Cancer Research/University of Oxford Branch, Headington, Oxford, UK, April 2008

52. “Inflammation and cancer: Interpretation of microRNA, free radical cytokine and p53 pathway”. UCLA Schools of Medicine and Public Health, Los Angeles, CA, April 2008

53. “Chronic inflammation and cancer”. Offices of Life Sciences, National University of Singapore, Singapore, May 2008

54. “Chronic Inflammation: and Cancer: Interweaving microRNA, cytokine, free radical and p53 pathways”. Nippon Medical School, Tokyo, Japan, May 2008

55. “Inflammation and Cancer: Interaction of microRNA, free radical and cytokine and p53 pathway”. University of Dundee, Biomedical Research Centre Ninewells Hospital & Medical School, Dundee, Scotland, May 2008

56. “Inflammation and liver cancer: interweaving hepatitis virus, microRNA, aflatoxin B1 and p53 pathways”. Hong Kong-Shanghai International Liver Conference, Hong Kong, China, June 2008

57. “Inflammation at the intersect of chemical microbial carcinogenesis”. University of Vienna, Vienna Switzerland, September 2008

58. “p53 independent cellular senescence”. p53 Workshop, Shanghai, China, October 2008

59. “MicroRNAs and inflammatory cytokines as clinical biomarkers of cancer diagnosis, prognosis and therapeutic outcome”. Dublin Cancer Conference, Dublin, Ireland, December 2008

60. “Inflammation and cancer”. Brupbacker Symposium, Zurich, Germany, February 2009

61. “Inflammation and cancer: Interweaving microRNA, p53 and cytokine pathways”. Japan Foundation of Cancer Research, February 2009

62. “MicroRNAs in cellular senescence and carcinogenesis”. National Cancer Research Institute, February 2009

63. “MicroRNA and p53 pathways in cellular senescence and cancer”. p53 Workshop, Acore, Israel, March 2009

64. “MicroRNAs as cancer biomarkers”. AACR Symposium, AACR, Denver, CO, April 2009

65. “MicroRNA and inflammatory cytokines as cancer biomarkers”. MicroRNA and Cancer, Keystone Symposium, Keystone, CO, June 2009

66. “Inflammation and cancer”, National Cancer Research Institute, Tokyo, Japan, December 2009

67. “p53, thirty years and counting”, National Cancer Research Institute, Tokyo, Japan, December 2009

68. “p53 and liver cancer”, 30^th Anniversary of Chinese and US Coorperation Conference, Beijing, China, December 2009

69. “Inflammation and cancer”, Susan Cooper Jones Memorial Lecture, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, February 2010

70. “Inflammation and cancer”, Grand Rounds, Johns Hopkins University, School of Medicine, Baltimore, MD, March 2010

71. “Interweaving MicroRNA, Inflammatory Cytokines and p53 pathways in human cancer”, The Weizmann Institute, Rehovot, Israel, March 2010

72. “MicroRNA, p53 and innate immunity pathways in human cancer”, M.D. Anderson Cancer Center, Houston, TX, March 2010

73. “Inflammation and Cancer”, Grand Rounds, Mayo Clinic, Rochester, MN, April 2010

74. “Inflammation and Cancer”, Johns Hopkins University Medical School, Baltimore, MD, May 2010

75. “Colon Cancer: microRNA and inflammatory cytokine”, Mildred Scheel Cancer Conference, Bonn, Germany, May 2010

76. “Inflammation and Cancer”, Symposium “New Advances in Colocteral Cancer Research”, Madrid, Spain, May 2010

77. “microRNA and Cancer”, Genomic Instability Conference, University of Calgary, Calgary, Canada, June 2010

78. “Inflammation and Cancer: microRNA and p53 pathways”, Ben Trump Memorial Lecture, Aspen Cancer Conference, Aspen, CO, July 2010

79. “Inflammation and Cancer”, AACR workshop for Young Oncologists, Aspen, CO, July 2010

80. “Interweaving p53, Innate Immune and microRNA networks in human carcinogenesis and molecular epidemiology”, 16^th International Charles Heidelberger Symposium on Cancer Research being held in Coimbra, Portugal, September 2010

81. “Interweaving microRNA, innate immunity and p53 networks in human cancer”, INFLA-CARE related summer school, Heraklion (Crete), Greece, September 2010

82. “Inflammation and cancer: Interweaving microRNA, innate immune, and p53 pathways”, 9^th Annual AACR Conference on Frontiers in Cancer Prevention Research, Philadelphia, PA, November 2010

83. "Senescence as a tumor suppressor: Interaction of the p53 and microRNA networks", National Cancer Center Research Institute, Tokyo, Japan, November 2010

84. “Inflammation and Cancer: Interweaving microRNA, p53 and Innate immune mediators networks”, p53 Laboratory, Singapore, November 2010

85. “p53 isoforms as endogenous regulators of replicative senescence”, 1^st International p53 Isoforms meeting in Lyon, France, September 2010

86. “p53 and cellular senescence”, 15^th International p53 workshop, Philadelphia, PA, October 2010

87. “Inflammation and Colon Cancer: Interweaving microRNA and p53 Pathways”, 6^th International Society of Gastroenterological Carcinogenesis (ISGC) Conference in Houston, TX, January 2011

88. “microRNAs and Colon Cancer”, 2011 ASCO: GI Cancers Symposium, San Francisco, CA, January 2011

89. “Inflammation and cancer: Interweaving microRNA, free radicals, inflammatory cytokines, and p53 networks” Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer, AACR Conference, San Diego, CA, January 2011

90. “MicroRNAs and Inflammatory Cytokines as Biomarkers and Diagnosis, Prognosis and Therapeutic Outcomes” 2011 Keystone Symposium on microRNA and non-coding RNA and Cancer, Banff, Canada, February 2011

91. “p53, microRNAs and senescence in human carcinogenesis”, 3^rd JCA-AACR Special Joint Conference in Tokyo, Japan, March 2011

92. “Chemical Carcinogenesis”, Society of Toxicology 50^th Anniversary Meeting, Washington, DC, March 2011

93. “Microenvironment modulation of asymmetric cell division” AACR 102^nd Annual Meeting, Innovation and Collaboration: The path to Progress, Orlando, FL, April 2011

94. “Inflammation and p53” VCU Massey Cancer Center, Richmond, VA, May 2011

95. “Interweaving microRNAs, Inflammation and p53 networks in Human Cancer” Cancer Institute of New Jersey at the Robert Wood Johnson Medical School, New Brunswick, NJ, May 2011

96. “p53 tumor suppressor in cancer, aging and inflammation” University of Kansas, Kansas City, KS, May 2011

97. “p53, microRNAs and Senescence in Human Carcinogenesis, 5^th Mutant p53 workshop, Ariccia, Italy, May 2011“Inflammation, Senescence and Tumour Suppression: Interweaving microRNA, Free Radicals and p53 networks” International Liver Cancer Association 5th Annual Conference, Hong Kong, Sept. 2011

98. “Interweaving microRNA, p53 and Inflammation Networks in Human Cancer” 4th AACR Conference: The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, Washington, DC, Sept. 2011

99. “Role of cellular senescence and asymmetric cell division in human cancer” Fourth International Symposium on Translational Cancer Research Cancer Prevention, Udaipur, India, Dec. 2011

100. “MicroRNAs and inflammatory cytokines predict diagnosis, prognosis, and therapeutic outcome of colon cancer” Falk Symposium, Munich, Germany, Feb. 2012

101. “Inflammation, non-coding RNAs and Cancer” at the National Cancer Center Research Institute, Tokyo, Japan, March 2012

102. “Inflammation, non-coding RNAs and cancer” Scientific meeting at Hiroshima University in conjunction with Hiroshima Cancer Seminar (HCS), March 2012

103. Keynote Lecture, 18th International Charles Heidelberger Symposium: Translational cancer research: From bench to bedside, Ulm, Germany, June 2012

104. “Interweaving pathways of microRNA and immune regulatory molecules in inflammation and cancer” Workshop: “Small RNA in Cancer, Inflammation, and Aging”, Copenhagen, Denmark from Sept. 2012

105. “Inflammation and Cancer”, AACR Health Disparity Conference, San Diego, CA, Oct. 2012

106. Plenary Lecture, Interweaving the threads of microRNA and inflammation networks into the tapestry of cancer”, 19^th Princess Chulabhorn Congress, Bangkok, Thailand, Nov. 2012

Committees and Conferences:

Member, Lung Cancer Segment, DCCP, NCI, 1972-1974

Member, Working Party for Therapy of Lung Cancer, DCT, NCI, 1973-1975

Member, Organizing Committee, International Conference on Late Effects of Cancer Therapy, sponsored by Cancer Clinical Investigations Review Committee, NCI, January 1975

Chairman, Human Studies Collaborative Group, NCI, 1975-1985

Chairman, Organizing Committee, International Conference on Methods to Culture Human Cells and Tissues, sponsored by NHLBI and NCI, 1979

Member, Pathology Study Section B, Ad Hoc Committee on Chemical Pathology, National Cancer Institute, 1978-1979

Member, Carcinogenesis Committee, NCI Occupational Cancer Task Force, 1978

Member, Environmental Pathology Registry Advisory Committee, International Academy of Pathology, 1979-1984

Member, Scientific Program Committee, Second World Conference on Lung Cancer, Copenhagen, sponsored by the International Association for the Study of Lung Cancer, 1980

Co-organizer, Interspecies Correlations in Chemical Carcinogenesis, U.S.-Japan Cooperative Cancer Research Program Conference, Tokyo, Japan, 1981

Co-organizer, Mechanisms of Chemical Carcinogenesis, ICN-UCLA Symposia on Molecular and Cellular Biology, Keystone, 1981

Co-organizer, Cancer and Aging, Given Institute of Pathobiology, Aspen, 1981

Member, Program Committee, III World Congress on Lung Cancer, Tokyo, 1982

Program Chairman, Carcinogenesis Studies Using Cultured Human Tissues and Cells, sponsored by National Cancer Institute, Aspen, 1982

Co-organizer, Multiple Primary Cancers, U.S.-Japan Cooperative Cancer Research Program Conference, Tokyo, Japan, 1983

Member, Program Committee, International Conf. on Cell Biochemistry and Function, Guilford, 1983

Member, Program Committee, Chemical and Radiation Carcinogenesis Conference, Bethesda, MD 1983

Organizer, Tumor Promotion in Human Cancer, NIH Combined Clinical Staff Conference, Bethesda, MD 1983

Member, Promotion Review Committee, Division of Cancer Etiology, NCI, 1983-1986

Member, Program Committee, Conference on “Interspecies Correlations in Carcinogenesis,” Aspen, 1985

Member, Program Committee, IV World Congress on Lung Cancer, Toronto, August 1985

Co-organizer, Mechanisms of Tobacco Carcinogenesis, Banbury Conference, Cold Spring Harbor, NY, 1985

Organizer, Biochemical and Molecular Epidemiology of Cancer, UCLA Symposium on Cellular and Molecular Biology, Steamboat Spr., April, 1985

Chairman, Carcinogenesis Section, AACR Program Committee, 1986

Member, Program Committee, Biochemical and Cellular Indices of Human Toxicity in Occupational Medicine, Milan, 1986

Chairman, Program Committee, III International Workshop on Carcinogenesis Studies Using Human Tissues and Cells, Copenhagen, 1987

Co-chairman, Board of Directors, Aspen Cancer Conference, 1988 -

Co-organizer, Genetic Mechanisms of Carcinogenesis and Tumor Progression, UCLA Symposium on Cellular and Molecular Biology, Keystone, 1989

Co-chairman, Fundamental and Clinic Research on Liver Cancer, Japanese Promotion for Cancer Research, Tokyo, 1989

Chairman, Program Committee, International Workshop on Prevention of Liver Cancer, Hawaii, 1989

Co-chairman, U.S.-Japan Cooperative Cancer Program Workshop on Multiple Primary Cancer, Hawaii, 1989

Chairman, Program Committee, International Symposium on N-Nitroso Compounds, Mycotoxins and Tobacco Smoke, Lyon, 1989

Co-organizer, Molecular Mechanisms of Fiber Toxicity and Carcinogenesis, Banbury Conference, 1990

Co-organizer, U.S.-Japan Cancer Cooperative Workshop, Osaka, Japan, 1990

Co-organizer, International Conference on Multiple Primary Tumors, Tokyo, Japan, 1990

Co-organizer, Genetic Instability and Cancer, Keystone Symposia on Cellular and Molecular Biology, Tamarron, 1991

Chairman, Program Committee, AACR Annual Meeting, Houston, Texas, 1991

Co-organizer, Princess Takamatsu Symposium, Tokyo, 1991

Co-organizer, Genetic Instability in Carcinogenesis and Tumor Progression, U.S.-Japan, Cooperative Cancer Research Program, Hawaii, 1992

Co-organizer, AACR-IARC Conference, Lyon, 1992

Co-organizer, 6th International Symposium on Fundamental & Clinical Research in Esophageal Cancer, Tokyo, 1993

Co-organizer, p53 in Growth Control and Neoplasia, Brupbacher Foundation, Zurich, 1993

Co-organizer, Tumor Suppressor Genes, Keystone Symposium, Taos, NM, 1994

Co-organizer, Apoptosis, UICC Workshop, Woodshole, 1994

Co-organizer, Cancer Susceptibility and Molecular Carcinogenesis, AACR Special Conference, Keystone, CO, 1996

Co-organizer, Creating a Strategy for Science-Based National Policy, Addressing Conflicting Scientific Views on the Health Risks of Low- Level Ionizing Radiation, Wingspread, 1997

Co-organizer, Molecular Epidemiology of Lung Cancer: Clinical Implications, Oslo, 1998

Co-organizer, p53 Workshop, Crete, 1998

Co-organizer, Molecular Epidemiology of Cancer, Keystone Cellular and Molecular Biology Symposium, Taos, NM, 2000

Member, Organizing Committee, p53 Workshop, Monterey, CA, 2000

Co-chair, Biology, Lung Cancer, NCI Program Review Group, Bethesda, MD, 2001

Co-chair, Impact of the Environment on Colon Cancer, Miami, FL, 2003

Co-chair, 13th International Symposium of the Hiroshima Cancer Center, Hiroshima, 2003

Co-organizer, Lung Cancer Workshop, NCI, Bethesda, MD, 2003

Member, Organizing Committee, p53 Workshop, Dunedin, New Zealand, 2004

Chair, Organizing Committee, Bloom Syndrome: Molecular Basis of Genomic Instability, NIH, Bethesda, MD, 2005

Member, Organizing Committee, Keystone Sym., Stem Cells, Senescence and Cancer, Singapore, 2005

Co-organizer, Inflammation and Colon Cancer, NCI, Bethesda, MD 2006

Co-organizer, International Symposium on Human Carcinogenesis, NCI, Bethesda, MD, 2006

Member, Organizing Committee, p53 Workshop, New York, 2006

Co-organizer, Japan-US Cooperative Cancer Research Seminar on Molecular Epidemiological Characteristics of Lung and Colon Cancer Development Among Atomic-Bomb Survivors, Bethesda, MD, 2006

Member, Organizing Committee, Inflammation and Cancer, NCI, Bethesda, MD, 2007

Member, Steering Committee, Center of Excellence in Cancer Biology and Human Genomics, NCI, 2007

Member, Organizing Committee, p53 Workshop, Shanghai, China, 2008

Co-organizer, Bloom Syndrome Conference, Chicago, IL, 2008

Member, Governing Board, International Liver Cancer Association, 2009-1013

Member, Organizing Committee, p53 Workshop, Philadelphia, PA, 2010

Co-organizer, MicroRNA and Non-coding RNAs in Cancer, Keystone Symposium, 2011

Co-organizer, Liver Cancer AACR-JCA Joint Conference, 2011

Member, Organizing Committee, p53 Workshop, 2014

Research Interests:

1. Human carcinogenesis.

2. Molecular epidemiology of cancer.

Inventions and Patents Assigned to U.S. Government:

1. Ultrasensitive enzymatic radioimmunoassay method (USERIA), U.S. patent 4,289,748

2. Protoplast Fusion Method for High Frequency DNA Transfection in Human Cells; U.S. patent 4,608,339

3. Cascade Amplification Enzyme Immunoassay, U.S. patent 4,463,090

4. A Method and Kit for Detecting Human Exposure to Genotoxic Agents; U.S. patent 4,794,074

5. Immortalized Human Bronchial and Mesothelial Epithelial Cell Lines; U.S. patent 4,885,238

6. Cell Culture Medium for Human Liver Epithelial Cell Line; U.S. patent 5,342,777

7. Immortalized Human Cell Lines Containing Exogenous Cytochrome P450; U.S. patent 5,356,806

8. An Immortalized Human Bronchial Epithelial Cell Line; U.S. patent 5,432,060

9. Immortalized Nontumorigenic Human Bronchial Epithelial Cell Lines; U.S. patent 5,443,954

10. Immortalized Human Cell Lines containing Exogenous Cytochrome p450 Genes; U.S. patent 5,660,986

11. Eukaryotic Expression Vector System; U.S. patent 5,604,118

12. Human Liver Epithelial Cell Line and Culture Media Therefore; U.S. patent 5,529,920

13. Human Liver Epithelial Cell Lines; U.S. patent 5,759,765

14. Screening Assays for Compounds that cause Apoptosis; U.S. patent 6,602,979

15. Methods for Identifying Inhibitors of GADD45 Peptide Activity and Inhibitors of Such Activity; U.S. patent 60,126,069; 7,125,850

16. Telomerase-Immortalized Human Cell Lines; U.S. patent 60,255,722

17. Immortalization of Human Epithelial Cells; U.S. patent 60,260,625

18. Anticancer, Apoptosis-Inducing Compounds; Application pending

19. Methods for Assaying for Modulations of GADD45 Activity; U.S. patent 7,005,419

20. New Tumor Suppressor Gene p33 ING2; U.S. patent 6,790,948

21. New Tumor Suppressor Gene p47ING3; U.S. patent 7,709,609

22. p53 and VEGF Regulate Tumor Growth of NOS2 Expressing Cancer Cells; Application pending

23. New Tumor Suppressor Gene p28ING5; U.S. patent 60,351,504

24. Telomerase Immortalized Human Cell Lines; Application pending

25. Methods and Compositions for the Diagnosis of Neuroendocrine Lung Cancer; Application pending

26. Pot1 alternative splicing variants, U.S. Patent number 7,892,738

27. MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Lung Cancer, U.S. Patent number 7,973,318

28. MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Colon Cancer; Application pending

29. Molecular Characteristics of non-small cell lung cancer; Application pending

30. Mirna Biomarkers predict esophageal carcinoma diagnosis and Barrett’s esophagus status; Application pending

31. Method and analysis of tissue samples for diagnosis and prognosis; Application pending

32. Unique MicroRNA molecular profiles in lung cancer diagnosis and prognosis; Application pending

33. MicroRNA profiles predict colon cancer prognosis; Application pending

34. Compositions and methods for diagnosis and treatment of tumors; Application pending

35. Inflammatory genes and MicroRNA-21 as biomarkers for colon cancer prognosis; Application pending

36. New Tumor Suppressor Gene, p28ING5, U.S. Patent number 7,432,349

37. Tumor Suppressor Gene p33ING2, U.S. Patent number 7,919,590

38. Therapeutic applications of a p53 isoform in regenerative medicine, aging and cancer; Application pending

39. Methods of determining the prognosis of an adenocarcinoma, issued European Patent number 2041313

40. MicroRNAs in never-smokers and related materials and methods; Application pending

41. SOCS-1 gene methylation in cancer, issued U.S. Patent number 7,749,709

42. Manipulation of stem cell function by p53 isoforms; Application pending

43. Inflammatory genes and microRNA-21 as biomarkers for colon cancer prognosis, Application pending, 13/121,020

44. Method of Diagnosing Poor Survival Prognosis Colon Cancer Using microRNA-21, issued U.S. Patent number 8,084,199

45. New Tumor Suppressor Gene, p28ING5, U.S. Patent Application No. 13/197,595

46. Tumor Suppressor Gene p33ING2, U.S. Patent number 8,206,937 B2

47. New Tumor Suppressor Gene, p28ING5, U.S. Patent Application No. 13/747,282

Laboratory Address: Laboratory of Human Carcinogenesis

NIH, NCI, CCR

Building 37, Room 3068A

Bethesda, MD 20892-4258

Tel: 301-496-2048

Fax: 301-496-0497

Email: curtis_harris@nih.gov

Homepage: http://www.nci.nih.gov/intra/lhc/lhcpage.htm

Home Address: P.O. Box 77

Garrett Park, MD 20896-0077

BIBLIOGRAPHY

Articles in Journals

1. Harris, C. and Leone, C. A.: Some effects of EDTA and tetraphenylboron on the ultrastructure of mitochondria in mouse liver cells. J. Cell Biology 28: 405-408, 1966.

2. Harris, C., Grady, H. and Svoboda, D.: Segregation of the nucleolus produced by Anthramycin. Cancer Res. 28: 81-90, 1968.

3. Reddy, J., Harris, C. and Svoboda, D.: Inhibition by lasiocarpine of RNA synthesis, RNA polymerase and induction of tryptophan pyrrolase activity. Nature 217: 659-661, 1968.

4. Harris, C., Grady, H. and Svoboda, D.: Alterations in pancreatic and hepatic ultrastructure following acute cycloheximide intoxication. J.Ultrastructure Res. 22: 240-251, 1968.

5. Harris, C., Reddy, J., Svoboda, D.: Isolation and ultrastructure of nucleoli altered in vivo. Exp. Cell Res. 51: 268-274, 1968.

6. Harris, C., Reddy, J. and Svoboda, D.: The effect of cycloheximide on ribonucleic acid and protein synthesis in rat liver. Biochem. Pharmacol. 18: 951-954, 1969.

7. Harris, C., Reddy, J., Chiga, M. and Svoboda, D.: Polyribosome disaggregation in rat liver by lasiocarpine. Biochem. Biophys. Acta 182: 587-589, 1969.

8. Reddy, J., Chiga, M., Harris, C. and Svoboda, D.: Polyribosome disaggregation in rat liver following administration of tannic acid. Cancer Res. 30: 58-65, 1970.

9. Svoboda, D., Reddy, J. and Harris, C.: Invasive tumors induced in rats with Actinomycin D. Cancer Res. 30: 2271-2279, 1970.

10. Harris, C.: Malignancy during methotrexate and steroid therapy for psoriasis. Arch. Derm. 103: 501-504, 1971.

11. Harris, C., Sporn, M., Kaufman, D., Smith, J., Baker, M. and Saffiotti, U.: Acute ultrastructural effects of benzo(a)pyrene and ferric oxide on the hamster tracheobronchial epithelium. Cancer Res. 31: 1977-1989, 1971.

12. Harris, C., Sporn, M., Kaufman, D., Smith, J., Jackson, F. and Saffiotti, U.: Histogenesis of squamous metaplasia in the hamster tracheal epithelium caused by vitamin A deficiency or by benzo-(a)pyrene-ferric oxide. J. Natl. Cancer Inst. 48: 743-761, 1972.

13. Kaufman, D., Baker, M., Harris, C., Smith, J., Boren, H., Sporn, M. and Saffiotti, U.: Coordinated biochemical and morphologic examination of hamster tracheal epithelium. J. Natl. Cancer Inst. 49: 783-792, 1972.

14. Kaufman, D., Baker, M., Smith, J., Henderson, W., Harris, C., Sporn, M. and Saffiotti, U.: RNA metabolism in tracheal epithelium: Alteration in hamsters deficient in vitamin A. Science 177: 1105-1108, 1972.

15. Harris, C., Kaufman, D., Sporn, M., Boren, H., Jackson, F., Smith, J., Pauley, J., Dedick, P. and Saffiotti, U.: Localization of benzo(a)- pyrene-3H and alterations in nuclear chromatin caused by benzo(a)pyrene-ferric oxide in the hamster respiratory epithelium. Cancer Res. 33: 2842-2848, 1973.

16. Harris, C., Kaufman, D., Sporn, M. and Saffiotti, U.: Histogenesis of squamous metaplasia and squamous cell carcinoma of the respiratory epithelium in an animal model. Cancer Chemotherapy Rep. 4: 43-54, 1973.

17. Harris, C.: The epidemiology of different histologic types of bronchogenic carcinoma. Cancer Chemotherapy Rep. 4: 59-61, 1973.

18. Port, C., Henry, M., Kaufman, D., Harris, C. and Ketels, K.: Acute changes in the surface morphology of hamster tracheobronchial epithelium following benzo(a)pyrene and ferric oxide administration. Cancer Res. 33: 2498-2506, 1973.

19. Harris, C., Kaufman, D., Sporn, M., Smith, J., Jackson, F. and Saffiotti, U.: Ultrastructural effects of N-methyl-N-nitrosourea on the tracheobronchial epithelium of the Syrian golden hamster. Int. J. Cancer 12: 259-269, 1973.

20. Kaufman, D., Genta, V., Harris, C., Smith, J., Sporn, M. and Saffiotti, U.: Binding of 3H-labeled benzo[a]pyrene to DNA in hamster tracheal epithelial cells. Cancer Res. 33: 2837-2841, 1973.

21. Harris, C., Silverman, T., Jackson, F., Smith, J. and Boren, H.: Proliferation of tracheal epithelial cells in normal and vitamin A deficient Syrian golden hamsters. J. Natl. Cancer Inst. 51: 1059-1064, 1973.

22. Kripke, M., Steinmuller, D., Harris, C., Lofgreen, P. and Eichwald, E.: Effects of chronic cyclophosphamide and methotrexate treatment on skin allograft survival in mice and rats. J. Natl. Cancer Inst. 51: 1355-1358, 1973.

23. Wenk, M., Reddy, J. and Harris, C.: Pancreatic regeneration caused by ethionine in the guinea pig. J. Natl. Cancer Inst. 52: 533-538, 1974.

24. Harris, C., Primack, A. and Cohen, M.: Elevated alpha1-antitrypsin serum levels in lung cancer patients. Cancer 34: 280-281, 1974.

25. Genta, V., Kaufman, D., Harris, C., Jackson, F., Smith, J., Sporn, M. and Saffiotti, U.: Vitamin A deficiency enhances binding of benzo(a)-pyrene to tracheal epithelial DNA. Nature 247: 48-49, 1974.

26. Harris, C., Kaufman, D., Jackson, F., Smith, J., Dedick, P. and Saffiotti, U.: Atypical cilia in the tracheobronchial epithelium of the hamster during respiratory carcinogenesis. J. Path. 114: 17-19, 1974.

27. Yuspa, S. and Harris, C.: Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro. Exp. Cell Res. 86: 95-105, 1974.

28. Meadows, A., D'Angio, G., Evans, A., Harris, C., Miller, R. and Mike, V.: Oncogenesis and other late effects of cancer treatment in children. Radiol. 114: 175-181, 1975.

29. Harris, C., Connor, R., Jackson, F. and Lieberman, M.: Intranuclear distribution of DNA repair synthesis induced by chemical carcinogens or ultraviolet light in human diploid fibroblasts. Cancer Res. 34: 3461-3469, 1974.

30. Boren, H., Pauley, J., Wright, E., Kaufman, D., Smith, J. and Harris, C.: Cell populations in the hamster tracheal epithelium in relation to vitamin A status. Int. J. Vit. Res. 44: 382-390, 1974.

31. Boren, H., Wright, E. and Harris, C.: Quantitative light microscopic autoradiography - Emulsion sensitivity and latent image fading. J. Cytochem. Histochem. 23: 901-909, 1975.

32. Harris, C., Genta, V., Frank, A., Kaufman, D., Barrett, L., McDowell, E. and Trump, B.: Carcinogenic polynuclear hydrocarbons bind to macromolecules in cultured human bronchi. Nature 252: 68-69, 1974.

33. Harris, C., Cohen, M., Connor, R., Primack, A., Saccomanno, G. and Talamo, R.: Serum alpha1-antitrypsin in patients with lung cancer or abnormal sputum cytology. Cancer 38: 1655-1657, 1976.

34. Harris, C., Frank, A., van Haaften, C., Kaufman, D., Connor, R., Jackson, F., Barrett, L., McDowell, E. and Trump, B.: Binding of [3H] benzo(a)pyrene to DNA in cultured human bronchus. Cancer Res. 36: 1011-1018, 1976.

35. Barrett, L., McDowell, E., Frank, A., Harris, C. and Trump, B.: Long-term organ culture of human bronchial epithelium. Cancer Res. 36: 1003-1010, 1976.

36. D'Angio, G., Meadows, A., Mike, V., Harris, C., Evans, A., Jaffe, N., Newton, W., Schweisguth, O., Sutow, W. and Morris-Jones, P.: Decreased risk of radiation-associated second malignant neoplasms in actinomycin- D-treated patients. Cancer 37: 1177-1185, 1976.

37. McDowell, E., Barrett, L., Harris, C. and Trump, B.: Abnormal cilia in human bronchial epithelium. Arch. Pathol. 100: 429-436, 1976.

38. Harris, C., Autrup, H., Connor, R., Barrett, L., McDowell, E. and Trump, B.: Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human bronchi. Science 194: 1067-1069, 1976.

39. Weinstein, I. B., Jeffrey, A., Jennette, K., Blobstein, S., Harvey, R., Harris, C., Autrup, H., Kasai, H. and Nakanishi, K.: Benzo[a]pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo. Science 193: 592-595, 1976.

40. Trump, B., McDowell, E., Barrett, L., Jones, R., Valerio, M. and Harris, C.: Ultrastructural and cytochemical studies on the mechanism of chemical carcinogenesis in the human. Microscopical Society of Canada 3: 142-145, 1976.

41. Jones, R., Barrett, L., van Haaften, C., Harris, C. and Trump, B.: Carcinogenesis in the pancreas. I. Long-term explant culture of human and bovine pancreatic ducts. J. Natl. Cancer Inst. 58: 557-565, 1977.

42. Yang, S. F., Gelboin, H. V., Trump, B. F., Autrup, H. N. and Harris, C.: Metabolic activation of benzo[a]pyrene and DNA binding in cultured human bronchus. Cancer Res. 37: 1210-1215, 1977.

43. Autrup, H. N., Harris, C. C., Stoner, G. D., Jesudason, M. L. and Trump, B. F.: Binding of chemical carcinogens to macromolecules in cultured human colon. J. Natl. Cancer Inst. 59: 351-355, 1977.

44. Harris, C. C., Autrup, H. N., Stoner, G. D., McDowell, E. M., Trump, B. F. and Schafer, P.: Metabolism of dimethylnitrosamine and l,2-dimethyl- hydrazine in cultured human bronchi. Cancer Res. 37: 2309-2311, 1977.

45. Levitt, M., Harris, C., Squire, R., Wenk, M., Mollelo, C., Thomas, D., Kingsbury, E. and Newkirk, C.: Experimental pancreatic carcinogenesis. I. Morphogenesis of pancreatic adenocarcinoma in the Syrian golden hamster induced by N-nitroso-bis(2-hydroxypropyl)amine. Amer. J. Path. 88: 5-28, 1977.

46. Harris, C., Autrup, H., Stoner, G., Yang, S., Leutz, J., Gelboin, H., Selkirk, J., Connor, R., Barrett, L., Jones, R., McDowell, E. and Trump, B.: Metabolism of benzo[a]pyrene and 7,l2-dimethylbenz[a]-anthracene in cultured human bronchus and pancreatic duct. Cancer Res. 37: 3349-3355, 1977.

47. Barrett, L., McDowell, E., Harris, C. and Trump, B.: Studies on the pathogenesis of Ischemic cell injury. XV. Reversal of Ischemic cell injury in hamster trachea and human bronchus by explant culture. Beitrage zur Pathologie 161: 109-122, 1977.

48. Meadows, A. T., D'Angio, G. J. Mike, V., Banfi, A., Harris, C., Jenkin, R. D. T. and Schwartz, A.: Patterns of second malignant neoplasms in children. Cancer 40: 1903-1912, 1977.

49. Harris, C., Autrup, H., Stoner, G., McDowell, E., Trump, B. and Schafer, P.: Metabolism of acyclic and cyclic N-nitrosamines in cultured human bronchi. J. Natl. Cancer Inst. 59: 1401-1406, 1977.

50. Autrup, H., Harris, C. C., Fugaro, S. and Selkirk, J.: Effect of various chemicals on the metabolism of benzo(a)pyrene by cultured rat colon. Chem. Biol. Interact. 18: 337-347, 1977.

51. Jeffrey, A. M., Weinstein, I. B., Jennette, K. W., Grzeskowiak, K., Nakanishi, K., Harvey, R. G., Autrup, H. and Harris, C.: Structures of benzo[a]pyrene-nucleic acid adducts formed in human and bovine bronchial explants. Nature 269: 348-350, 1977.

52. Autrup, H., Harris, C., Stoner, G., Selkirk, J., Schafer, P. and Trump, B.: Metabolism of [3H]benzo[a]pyrene by cultured human bronchus and cultured human pulmonary alveolar macrophages. Lab. Invest. 38: 217-223, 1978.

53. Autrup, H., Barrett, L. A., Jackson, F. E., Jesudason, M. L., Stoner, G., Phelps, P., Trump, B. F. and Harris, C. C.: Explant culture of human colon. Gastroenterology 74: 1248-1257, 1978.

54. Levitt, M., Harris, C., Squire, R., Wenk, M., Mollelo, C. and Springer, S.: Experimental pancreatic carcinogenesis. II. Lifetime carcinogenesis studies in the outbred Syrian golden hamster with N-nitroso-bis(2-hydroxypropyl)amine. J. Natl. Cancer Inst. 60: 701-706, 1978.

55. Stoner, G. D., Harris, C. C., Bostwick, D. G., Jones, R. T., Trump, B. F., Kingsbury, E. W., Fineman, E. and Newkirk, C.: Isolation and characterization of epithelial cells from bovine pancreatic duct. In Vitro 14: 581-590, 1978.

56. Stoner, G. D., Harris, C. C., Autrup, H., Trump, B. F., Kingsbury, E. W. and Myers, G. A.: Explant culture of human peripheral lung. I. Metabolism of benzo[a]pyrene. Lab. Invest. 38: 685-692, 1978.

57. Harris, C. C., Hsu, I. C., Stoner, G. D., Trump, B. F. and Selkirk, J. K.: Human pulmonary alveolar macrophages metabolize benzo[a]pyrene to proximate and ultimate mutagens. Nature 272: 633-634, 1978.

58. Hsu, I. C., Autrup, H., Stoner, G. D., Trump, B. F., Selkirk, J. K. and Harris, C. C.: Human bronchus-mediated mutagenesis of mammalian cells by carcinogenic polynuclear aromatic hydrocarbons. Proc. Natl. Acad. Sci. 75: 2003-2007, 1978.

59. McDowell, E. M., Barrett, L. A., Glavin, F., Harris, C. C. and Trump, B. F.: The respiratory epithelium. I. Human bronchus. J. Natl. Cancer Inst. 61: 539-550, 1978.

60. Trump, B. F., McDowell, E. M., Becci, P. J., Barrett, L. A., Glavin, F., Kaiser, H. and Harris, C. C.: The respiratory epithelium. III. Histogenesis of epidermoid metaplasia and carcinoma in situ. J. Natl. Cancer Inst. 61: 563-576, 1978.

61. McDowell, E. M., McLaughlin, J. S., Merenyl, D. K., Kieffer, R. F., Harris, C. C. and Trump, B. F.: The respiratory epithelium. V. Histogenesis of lung carcinomas in the human. J. Natl. Cancer Inst. 61: 587-606, 1978.

62. Autrup, H., Stoner, G., Jackson, F., Harris, C. C., Shamsuddin, T., Trump, B. F. and Barrett, L. A.: Explant culture of rat colon: A model system for studying metabolism of chemical carcinogens. In Vitro 14: 868-877, 1978.

63. Autrup, H., Harris, C. C., Trump, B. F. and Jeffrey, A. M.: Metabolism of benzo[a]pyrene and identification of the major benzo[a]pyrene-DNA adducts in cultured human colon. Cancer Res. 38: 3689-3697, 1978.

64. Autrup, H., Harris, C. C. and Trump, B. F.: Metabolism of acyclic and cyclic N-nitrosamines by cultured human colon. Proc. Soc. Exp. Biol. Med. 159: 111-115, 1978.

65. Autrup, H., Essigman, J. M., Croy, R., Trump, B. F., Wogan, G. N. and Harris, C. C.: Metabolism of aflatoxin B1 and identification of the major aflatoxin B1-DNA adducts formed in cultured human bronchus and colon. Cancer Res. 39: 694-698, 1979

66. Katoh, Y., Stoner, G. D., McIntire, K. R., Hill, T., Anthony, R., McDowell, E. M., Trump, B. F. and Harris, C. C.: Immunologic markers of human bronchial epithelial cells in tissue sections and in culture. J. Natl. Cancer Inst. 62: 1177-1186, 1979.

67. Daynes, R. A., Harris, C.C., Connor, R. J. and Eichwald, E. J.: Skin cancer development in mice exposed chronically to immunosuppressive agents. J. Natl. Cancer Inst. 62: 1075-1082, 1979.

68. Shamsuddin, A. K. M., Barrett, L. A., Autrup, H., Harris, C. C. and Trump, B. F.: Long term organ culture of adult rat colon. Path. Res.Pract. 163: 362-372, 1978.

69. Autrup, H., Harris, C. C., Trump, B. F., Stoner, G. D. and Hsu, I. C.: Uptake of benzo[a]pyrene-ferric oxide particulates by human pulmonary macrophages and release of benzo[a]pyrene and its metabolites. Proc.Soc. Exp. Biol. Med. 161: 280-284, 1979.

70. Hsu, I. C., Harris, C. C., Trump, B. F., Schafer, P. W. and Yamaguchi, M.: Induction of ouabain-resistant mutation and sister chromatid exchanges in Chinese hamster cells with chemical carcinogens mediated by human pulmonary macrophages. J. Clin. Invest. 64: 1245-1252, 1979.

71. Bradley, M. O., Hsu, I. C. and Harris, C. C.: Relationships between sister chromatid exchange and mutagenicity, toxicity and DNA damage. Nature 282: 318-319, 1979.

72. Harris, C. C., Autrup, H., Stoner, G. D., Trump, B. F., Hillman, E., Schafer, P. and Jeffrey, A.: Metabolism of benzo[a]pyrene, N-nitrosodi-methylamine and N-nitrosopyrrolidine and identification of the major carcinogen-DNA adducts formed in cultured human esophagus. Cancer Res. 39: 4401-4407, 1979.

73. Hsu, I. C., Bowden, G. T. and Harris, C. C.: A comparison of cytotoxicity, ouabain-resistant mutation, sister-chromatid exchanges and nascent DNA synthesis in Chinese hamster cells treated with dihydrodiol epoxide derivatives of benzo[a]pyrene. Mutat. Res. 63: 351-359, 1979.

74. Bowden, G. T., Hsu, I. C. and Harris, C. C.: The effect of caffeine on cytotoxicity, mutagenesis and sister-chromatid exchanges in Chinese hamster cells treated with dihydrodiol epoxide derivatives of benzo[a]pyrene. Mutat. Res. 63: 361-370, 1979.

75. Harris, C. C., Yolken R., Krokan, H. and Hsu, I. C.: Ultrasensitive enzymatic radioimmunoassay: Application to detection of cholera toxin and rotavirus. Proc. Natl. Acad. Sci. 76: 5336-5339, 1979.

76. Stoner, G. D., Harris, C. C., Myers, G. A., Trump, B. F. and Connor, R. D.: Putrescine stimulates growth of human bronchial epithelial cells in primary culture. In Vitro 16: 399-406, 1980.

77. Autrup, H., Wefald, F., Jeffrey, A., Tate, H., Schwartz, R. D., Trump, B. F. and Harris, C. C.: Metabolism of benzo[a]pyrene by cultured tracheobronchial tissues from mice, rats, hamsters, bovines and humans. Int. J. Cancer 25: 293-300, 1980.

78. Autrup, H., Schwartz, R. D., Essigmann, J. M., Smith, L., Trump, B. F. and Harris, C. C.: Metabolism of aflatoxin B1, benzo[a]pyrene and 1,2- dimethylhydrazine by cultured rat and human colon. Teratogenesis, Mutagenesis and Carcinogenesis 1: 3-13, 1980.

79. Autrup, H., Harris, C. C., Schwartz, R. D., Trump, B. F. and Smith, L.: Metabolism of l,2-dimethylhydrazine by cultured human colon. Carcinogenesis 1: 375-380, 1980.

80. Barrett, L. A., McDowell, E. M., Hill, T. A., Pyeatte, J. C., Harris, C. C. and Trump, B. F.: Induction of atypical squamous metaplasia with benzo[a]pyrene in cultured hamster tracheas. Pathol. Res. Pract. 168: 134-145, 1980.

81. Hsu, I. C., Poirier, M., Yuspa, S., Yolken, R. and Harris, C. C.: Ultra-sensitive enzymatic radioimmunoassay (USERIA) detects femtomoles of acetylaminofluorene-DNA adducts. Carcinogenesis 1: 455-458, 1980.

82. Hsu, I. C., Poirier, M. C., Yuspa, S. H., Grunberger, D., Weinstein, I. B., Yolken, R. H. and Harris, C.: Measurement of benzo(a)pyrene-DNA adducts by enzyme immunoassays and radioimmunoassay. Cancer Res. 41: 1091-1096, 1981.

83. Stoner, G. D., Katoh, Y., Foidart, J-M., Trump, B. F., Steinert, P. M. and Harris, C. C.: Cultured human bronchial epithelial cells: Blood group antigens, keratin, collagens and fibronectin. In Vitro 17: 577-587, 1981.

84. Valerio, M. G., Fineman, E. L., Bowman, R. L., Harris, C. C., Stoner, G. D., Autrup, H., Trump, B. F., McDowell, E. M. and Jones, R.: Long-term survival of normal adult human tissues as xenografts in congenitally athymic nude mice. J. Natl. Cancer Inst. 66: 849-859, 1981.

85. Haugen, A., Groopman, J., Hsu, I. C., Goodrich, G., Wogan, G. and Harris, C. C.: Monoclonal antibody to aflatoxin B1-modified DNA detected by enzyme immunoassay. Proc. Natl. Acad. Sci. 78: 4124-4127, 1981.

86. Lechner, J. F., Haugen, A., Autrup, H., McClendon, I., Trump, B. F. and Harris, C. C.: Clonal growth of epithelial cells from normal adult human bronchus. Cancer Res. 41: 2294-2304, 1981.

87. Fornace, A. J. Jr., Seres, D. S., Lechner, J. F. and Harris, C. C.: DNA- protein crosslinking by chromium salts. Chem.-Biol. Interactions 36: 345-354, 1981.

88. Stoner, G. D., Pettis, W., Haugen, A., Jackson, F. and Harris, C. C.: Explant culture of rat esophagus in a chemically defined medium. In Vitro 17: 681-688, 1981.

89. Autrup, H., Grafstrom, R. C., Brugh, M., Lechner, J. F., Haugen, A., Trump, B. F. and Harris, C. C.: Comparison of benzo[a]pyrene metabolism in bronchus, esophagus, colon and duodenum from the same individual. Cancer Res. 42: 934-938, 1982.

90. Groopman, J. D., Haugen, A., Goodrich, G. R., Wogan, G. N. and Harris, C. C.: Quantitation of aflatoxin B1-modified DNA using monoclonal antibodies. Cancer Res. 42: 3120-3124, 1982.

91. Haugen, A., Schafer, P., Lechner, J. F., Stoner, G. D., Trump, B. F. and Harris, C. C.: Cellular ingestion, toxic effects and lesions observed in human bronchial epithelial tissue and cells cultured with asbestos and glass fibers. Int. J. Cancer 30: 265-272, 1982.

92. Fornace, A. J., Lechner, J. F., Grafstrom, R. C. and Harris, C. C.: DNA repair in human bronchial epithelial cells. Carcinogenesis 3: 1373-1378, 1982.

93. Cohen, G. M., Grafstrom, R., Gibby, E. M., Smith, L., Autrup, H. and Harris, C. C.: Metabolism of benzo[a]pyrene and 1-naphthol in cultured human tumorous and non-tumorous colon. Cancer Res. 43:1312-1315, 1983.

94. Grafstrom, R. C., Fornace Jr., A. J., Autrup, H., Lechner, J. L. and Harris, C. C.: Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells. Science 220: 216-218, 1983.

95. Hsia, C. C., Tzian, B. L. and Harris, C. C.: Proliferative and cytotoxic effects of fusarium T2 toxin on cultured human fetal esophagus. Carcinogenesis 4: 1101-1107, 1983.

96. Shamsuddin, A. K. M. and Harris, C. C.: Improved enzyme immunoassays using biotin-avidin-enzyme complex. Arch. Path. Lab. Med. 107: 514-517, 1983.

97. Banks-Schlegel, S. P. and Harris, C. C.: Tissue-specific expression of keratin proteins in human esophageal and epidermal epithelium and their cultured keratinocytes. Exp. Cell Res. 146: 271-280, 1983.

98. Yoakum, G. H., Korba, B. E., Lechner, J. F., Tokiwa, T., Gazdar, A. F., Seeley, T., Siegel, M., Leeman, L., Autrup, H. and Harris, C. C.: High frequency transfection and cytopathology of the hepatitis B virus core antigen gene in human cells. Science 222: 385-389, 1983.

99. Lechner, J. F., McClendon, I. A., LaVeck, M. A., Shamsuddin, A. K. M. and Harris, C. C.: Differential control by platelet factors of squamous differentiation in normal and malignant human bronchial cells. Cancer Res. 43: 5915-5921, 1983.

100. Banks-Schlegel, S. P., McDowell, E. M., Wilson, T.S., Trump, B.F. and Harris, C. C.: Keratin proteins in human lung carcinomas: Combined use of morphology, keratin immunocytochemistry and keratin immuno-precipitation. Am. J.Pathol. 114: 273-286, 1984.

101. Willey, J. C., Saladino, A. J., Lechner, J. F. and Harris, C. C.: Acute effects of 12-0-tetradecanoylphorbol-13-acetate, teleocidin B, or 2,3,7,8-tetrachlorodibenzo-p-dioxin in cultured normal human bronchial epithelial cells. Carcinogenesis 5: 209-215, 1984.

102. Willey, J. C., Lechner, J. F. and Harris, C. C.: Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells. Exp. Cell Res. 153: 245-248, 1984.

103. Grafstrom, R. C., Pegg, A. E., Trump, B. F. and Harris, C. C.: O6-Alkyl-guanine-DNA alkyltransferase activity in normal human tissues and cells. Cancer Res. 44: 2855-2857, 1984.

104. Banks-Schlegel, S. P. and Harris, C. C.: Aberrant expression of keratin proteins and cross-linked envelopes in human esophageal carcinoma. Cancer Res. 44: 1153-1157, 1984.

105. Autrup, H., Harris, C. C., Wu, S. M., Bao, L. Y., Pei, H. T., Lu, S., Sun, T. T. and Hsia, C. C.: Activation of chemical carcinogens by cultured human fetal liver, esophagus and stomach. Chem.-Biol. Inter. 50: 15-25, 1984.

106. Trump, B. F., McDowell, E. M. and Harris, C. C.: Chemical carcinogenesis in the tracheobronchial epithelium. Environ. Health Perspec. 55: 77-84, 1984.

107. Grafstrom, R. C., Fornace, Jr., A. J. and Harris, C. C.: Repair of DNA damage caused by formaldehyde in human cells. Cancer Res. 44: 4323-4327, 1984.

108. Willey, J. C., Moser, C. E., Lechner, J. F. and Harris, C. C.: Differential effects of 12-0-tetradecanoylphorbol-13-acetate on cultured normal and neoplastic bronchial epithelial cells. Cancer Res. 44: 5124-5126, 1984.

109. Willey, J. C., Moser, C. E. and Harris, C. C.: Effects of aplysiatoxin and debromoaplysiatoxin on growth and differentiation of normal human bronchial epithelial cells. Cell Biol. Toxicol. 1: 145-154, 1984.

110. Shamsuddin, A. K. M., Sinopoli, N. T., Hemminki, K., Boesch, R. R. and Harris, C. C.: Detection of benzo(a)pyrene-DNA adducts in human white blood cells. Cancer Res. 45: 66-68, 1985.

111. Banks-Schlegel, S. P., Gazdar, A. F. and Harris, C. C.: Intermediate filament and cross-linked envelope expression in human lung tumor cell lines. Cancer Res. 45: 1187-1197, 1985.

112. Yoakum, G. H., Lechner, J. F., Gabrielson, E., Korba, B. E., Malan-Shibley, L., Willey, J. C., Valerio, M. G., Shamsuddin, A. K. M., Trump, B. F. and Harris, C. C.: Transformation of human bronchial epithelial cells transfected by Harvey ras oncogene. Science 227: 1174-1179, 1985. Note: We have discovered that the TBE-1 cells are infected with the SV-40 virus (McMenamin, M G. and Harris, C.C., 1999, unpublished results).

113. Grafstrom, R. C., Curren, R. D., Yang, L. L. and Harris, C. C.: Genotoxicity of formaldehyde in cultured human bronchial cells. Science 228: 89-91, 1985.

114. Saladino, A. J., Willey, J. C., Lechner, J. F., Grafstrom, R. C., LaVeck, M. and Harris, C. C.: Effects of formaldehyde, acetaldehyde, benzoyl peroxide and hydrogen peroxide on cultured human bronchial epithelial cells in vitro. Cancer Res. 45: 2522-2526, 1985.

115. Lechner, J. F., Tokiwa, T., Benedict, W. F., Banks-Schlegel, S., Yeager, Jr., H., Banerjee, A. and Harris, C. C.: Asbestos-associated chromosomal changes in human mesothelial cells. Proc. Natl. Acad. Sci. USA 82: 3884-3888, 1985.

116. Vahakangas, K., Haugen, A. and Harris, C. C.: An applied synchronous fluorescence spectrophotometric assay to study benzo(a)pyrene-diol epoxide-DNA adducts. Carcinogenesis 6: 1109-1116, 1985.

117. Harris, C. C., Vahakangas, K., Newman, M., Trivers, G. E., Mann, D. L. and Wright, W.: Detection of benzo(a)pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in sera from coke oven workers. Proc. Natl. Acad. Sci. USA 82: 6672-6676, 1985.

118. Krokan, H., Lechner, J., Krokan, R. H. and Harris, C. C.: Normal human bronchial epithelial cells do not show an adaptive response after treatment with N-methyl-N'-nitrosoguanidine. Mutat. Res. 146: 205-209, 1985.

119. Garner, R. C., Stanton, C. A., Martin, C. N., Harris, C. C. and Grafstrom, R. C.: Rat and human explant metabolism binding studies and DNA adduct analysis on benzo(a)pyrene and its 6-nitro-derivative. Cancer Res. 45: 6225-6232, 1985.

120. Krokan, H., Grafstrom, R. C., Sundqvist, K., Esterbauer, H. and Harris, C. C.: Cytotoxicity, thiol depletion and inhibition of O6-methyl-guanine-DNA methyltransferase by various aldehydes in cultured human bronchial fibroblasts. Carcinogenesis 6: 1755-1759, 1985.

121. Wilson, V., Smith, R., Autrup, H., Krokan, H., Musci, D.E., Le, N.-N.-T., Longoria, J., Ziska, D. and Harris, C. C.: Genomic 5-methylcytosine determination by 32P-ostlabeling analysis. Anal. Biochem. 152: 275-284, 1986.

122. Burg-Kurland, C. L., Purnell, D. M., Combs, J. W., Hillman, E. A., Harris, C. C. and Trump, B. F.: Immunocytochemical evaluation of primary human esophageal neoplasms and preneoplastic lesions for beta-chorionic gonadotropin, human placental lactogen, α-fetoprotein, carcino-embryonic antigen and nonspecific cross-reacting antigen. Cancer Res. 46: 5730-5737, 1986.

123. Masui, T., Wakefield, L. M., Lechner, J. F., LaVeck, M. A., Sporn, M. B. and Harris, C. C.: Type β transforming growth factor: A differentiation-inducing serum factor for normal human bronchial epithelial cells. Proc. Natl. Acad. Sci. USA 83: 2438-2442, 1986.

124. Harris, C. C., LaVeck, G., Groopman, J. Wilson, V. and Mann, D. L.: Measurement of aflatoxin B1, its metabolites and DNA adducts by synchronous fluorescence spectrophotometry. Cancer Res. 46: 3249-3253, 1986.

125. Boumpas, D. T., Tsokos, G. C., Mann, D. L., Eleftheriades, E. G., Harris, C. C. and Mark, G. E.: Increased proto-oncogene expression in peripheral blood lymphocytes of patients with sytemic lupus erythematosus. Arth. Rheum. 29: 755-760, 1986.

126. Haugen, A., Bechner, G., Benestad, C., Vahakangas, K., Trivers, G. E., Newman, M. J. and Harris, C. C.: Determination of polycyclic aromatic hydrocarbons (PAH) in the urine, benzo(a)pyrene diol epoxide-DNA adducts in lymphocyte DNA and antibodies to the adducts in sera from coke oven workers exposed to measured amounts of PAH in the work atmosphere. Cancer Res. 46: 4178-4183, 1986.

127. Gabrielson, E. W., Rosen, G. M., Grafstrom, R. C., Strauss, K. E. and Harris, C. C.: Studies on the role of oxygen radicals in asbestos-induced cytopathology of cultured human mesothelial cells. Carcinogenesis 7: 1161-1164, 1986.

128. Plummer, S. M., Grafstrom, R. C., Yang, L. L., Curren, R. D., Linnainmaa, K. and Harris, C. C.: Fecapentaene-12 causes DNA damage and mutations in human cells. Carcinogenesis 7: 1607-1610, 1986.

129. Masui, T., Lechner, J. F., Yoakum, G. H., Willey, J. C. and Harris, C. C.: Growth and differentiation of normal and transformed human bronchial epithelial cells. J. Cell. Physiol. Suppl. 4: 73-81, 1986.

130. Burg-Kurland, C. L., Purnell, D. M., Combs, J. W., Valerio, M. G., Harris, C. C. and Trump, B. F.: Immunocytochemical evaluation of human esophageal neoplasms for β-chorionic gonadotropin, placental lactogen, α-feto-protein, carcinoembryonic antigen and nonspecific cross-reacting antigen. Cancer Res. 46: 2936-2943, 1986.

131. Weston, A., Plummer, S. M., Grafstrom, R. C., Trump, B. F. and Harris, C. C.: Genotoxicity of chemical and physical agents in cultured human tissues and cells in vitro. Food Chem. Toxicol. 24: 675-679, 1986.

132. Mitchell, S. C., Waring, R. H., Wilson, V. L., Idle, J. R., Autrup, H., Harris, C. C., Ritchie, J. C., Crothers, M. J. and Sieber, S. M.: Sulphoxidation of S-carboxymethyl-L-cysteine in rhesus monkey (Macaca mulatta), cynomologus monkey (Macaca fascicularis), African green monkey (Cercopithecus aethiops) and the marmoset (Callithrix jacchus). Comp. Biochem. Physiol. 84B: 143-144, 1986.

133. Wakefield, L. M., Robert, A. B., Assoian, R. K., Fanger, B. O., Masui, T., Lechner, J. F., Harris, C. C. and Sporn, M. B.: Structure and function of transforming growth factor beta. Proc. Western Pharmacol. Soc. 29: 475-477, 1986.

134. Burg-Kurland, C. L., Purnell, D. M., Combs, J. W., Harris, C. C. and Trump, B. F.: Monolayer culture of normal human esophageal epithelial cells. J. Tissue Cult. Meth. 10: 227-232, 1986.

135. Baba, M., Klein-Szanto, A. J. P., Trono, D., Obara, T., Yoakum, G. H. and Harris, C. C.: Preneoplastic and neoplastic growth of xenotransplanted lung-derived human cell lines using de-epithelialized rat tracheas. Cancer Res. 47: 573-578, 1987.

136. Shamsuddin, A. K. M., Harris, C. C. and Hinzman, M. J.: Localization of aflatoxin B₁ - nucleic acid adducts in mitochondria and nuclei. Carcinogenesis 8: 109-114, 1987.

137. Curren, R. D., Putman, D. L., Yang, L. L., Haworth, S. R., Lawlor, T. E., Plummer, S. M. and Harris, C. C.: Genotoxicity of Fecapentaene-12 in bacterial and mammalian cell assay systems. Carcinogenesis 8: 349-352, 1987.

138. Sasajima, K., Willey, J. C., Banks-Schlegel, S. P. and Harris, C. C.: Effects of tumor promoters and cocarcinogens on growth and differentiation of cultured human esophageal epithelial cells. J. Natl. Cancer Inst. 78: 419-423, 1987.

139. Willey, J. C., Grafstrom, R. C., Moser, Jr., C. E., Ozanne, C. Sundqvist, K. and Harris, C. C.: Biochemical and morphological effects of cigarette smoke condensate and its fractions on normal human bronchial epithelial cells in vitro. Cancer Res. 47: 2045-2049, 1987.

140. Brash, D. E., Reddel, R. R., Quanrud, M., Farrell, M. and Harris, C. C.: Strontium phosphate transfection of human cells in primary culture. Cell Mol. Biol. 7: 2031-2034, 1987.

141. Gabrielson, E. W., Lechner, J. F., Gerwin, B. I., LaVeck, M. A. and Harris, C. C.: Growth factors for mesothelial and mesothelioma cells. Chest Suppl. 91: 17-18, 1987.

142. Wilson, V. L., Smith, R. A., Longoria, J., Liotta, M. A., Harper, C. M. and Harris C. C.: Chemical carcinogen-induced decreases in genomic 5-methyl-deoxycytidine content of normal human bronchial epithelial cells. Proc. Natl. Acad. Sci USA 84: 3298-3301, 1987.

143. Wakefield, L. M., Smith, D. M., Masui, T., Harris, C. C. and Sporn, M. B.: Distribution and modulation of the cellular receptor for transforming growth factor-beta. J. Cell Biol. 105: 965-975, 1987.

144. Gerwin, B. I., Lechner, J. F., Reddel, R. R., Roberts, A. B., Robbins, K. C., Gabrielson, E. W. and Harris, C. C.: Comparison of production of transforming growth factor-β and platelet-derived growth factor by normal human mesothelial cells and mesothelioma cell lines. Cancer Res. 47: 6180-6184, 1987.

145. Gabrielson, E. W., Rosen, G. M., Grafstrom, R. C., Strauss, K. E., Miyashita, M. and Harris, C. C.: Role of oxygen radicals in 12-0-tetradecanoyl-phorhol-13-acetate-induced squamous differentiation of cultured normal human bronchial epithelial cells. Cancer Res. 48: 822-825, 1988.

146. Hsu, I. C., Harris, C. C., Lipsky, M. M., Snyder, S. and Trump, B. F.: Cell and species differences in metabolic activation of chemical carcinogens. Mutat. Res. 177: 1-7, 1987.

147. Reddel, R. R., Ke, Y., Gerwin, B. I., McMenamin, M. G., Lechner, J. F., Su, R. T., Brash, D. E., Park, J-B., Rhim, J. S. and Harris, C. C.: Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. Cancer Res. 48: 1904-1909, 1988.

148. Grafstrom, R. C., Dypbukt, J. M., Willey, J. C., Sundqvist, K., Edman, C., Atzori, L. and Harris, C. C.: Pathobiological effects of acrolein in cultured human bronchial epithelial cells. Cancer Res. 48: 1717-1721, 1988.

149. Wilson, V. L., Basu, A. K., Essigmann, J. M., Smith, R. A. and Harris, C. C.: O6 Alkyldeoxyguanosine detection by 32P postlabeling and nucleotide chromatographic analysis. Cancer Res. 48: 2156-2161, 1988.

150. Weston, A., Rowe, M., Poirier, M., Trivers, G., Vahakangas, K., Newman, M., Haugen, A., Manchester, D., Mann, D. and Harris, C.: The application of immunoassays and fluorometry to the detection of polycyclic hydrocarbon-macromolecular adducts and anti-adduct antibodies in humans. Int. Arch. Occup. Environ. Health 60: 157-162, 1988.

151. Gabrielson, E. W., Gerwin, B. I., Harris, C. C., Roberts, A. B., Sporn, M. B. and Lechner, J. L.: Stimulation of DNA synthesis in cultured primary human mesothelial cells by specific growth factors. FASEB J. 2: 2717-2722, 1988.

152. Newman, M. J., Light, B. A., Weston, A., Tollerude, D., Clark, J., Mann, D. L. and Harris, C. C.: Detection and characterization of human serum antibodies to polycyclic aromatic hydrocarbon diol-epoxide DNA adducts. J. Clin. Invest. 82: 145-153, 1988.

153. Santella, R. M., Weston, A., Perera, F. P., Trivers, G. T., Harris, C. C., Young, T. L., Nguyen, D., Lee, B. M. and Poirier, M. C.: Interlaboratory comparison of antisera and immunoassays for benzo[a]pyrene-diol-epoxide-I-modified DNA. Carcinogenesis 9: 1265-1269, 1988.

154. Ke, Y., Reddel, R. R., Gerwin, B. I., Miyashita, M., McMenamin, M., Lechner, J. F. and Harris, C. C.: Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation. Differentiation 38: 60-66, 1988.

155. Curren, R. D., Yang, L. L., Conklin, P. M., Grafstrom, R. C. and Harris, C. C.: Mutagenesis of xeroderma pigmentosum fs ibroblastby acrolein. Mutat. Res. Lett. 209: 17-22, 1988.

156. Reddel, R. R., Ke, Y., Kaighn, M. E., Malan-Shibley, L., Lechner, J. F., Rhim, J. S. and Harris, C.C.: Human bronchial epithelial cells neoplastically transformed by v-Ki-ras: Altered response to inducers of terminal squamous differentiation. Oncogene Res. 3: 401-408, 1988.

157. Bonnard, C., Lechner, J. F., Gerwin, B. I., Fujiki, H. and Harris, C. C.: Effects of palytoxin or ouabain on growth and squamous differentiation of human bronchial epithelial cells in vitro. Carcinogenesis 9: 2245-2249, 1988.

158. Wilson, V. L., Masui, T., Smith, R. A. and Harris, C. C.: Genomic 5-methyldeoxycytidine decreases associated with the induction of squamous differentiation in cultured normal human bronchial epithelial cells. Carcinogenesis 9: 2155-2160, 1988.

159. Manchester, D. K., Weston, A., Choi, J. S., Trivers, G. E., Fennessey, P. V., Quintana, E., Farmer, P. B., Mann, D. L. and Harris, C. C.: Detection of benzo[a]pyrene diol-epoxide-DNA adducts in human placenta. Proc. Natl. Acad. Sci. USA 85: 9243-9247, 1988.

160. Miyashita, M., Smith, M. W., Willey, J. C., Lechner, J. F., Trump, B. F. and Harris, C. C.: Effects of serum, transforming growth factor type beta or 12-0-tetradecanoylphorbol-13-acetate on ionized cytosolic calcium concentration in normal and transformed human bronchial epithelial cells. Cancer Res. 49: 63-67, 1989.

161. Amstad, P., Reddel, R. R., Pfeifer, A., Malan-Shibley, L., Mark, G. E. and Harris, C. C.: Neoplastic transformation of a human bronchial epithelial cell line by a recombinant retrovirus encoding viral Harvey ras. Mol. Carcinogenesis 1: 151-160, 1988.

162. Weston, A., Rowe, M. L., Manchester, D. K., Farmer, P. B., Mann, D. L. and Harris, C. C.: Fluorescence and mass spectral evidence for the formation of benzo[a]pyrene anti-diol-epoxide-DNA and -hemoglobin adducts in humans. Carcinogenesis 10: 251-257, 1989.

163. Bonfil, R. D., Reddel, R. R., Ura, H., Reich, R., Fridman, R., Harris, C. C. and Klein-Szanto, A. J. P.: Invasive and metastatic potential of a Ha-ras transformed human bronchial epithelial cell line. J. Natl. Cancer Inst. 81: 587-594, 1989.

164. Weston, A., Manchester, D. K., Poirier, M. C., Choi, J. S., Trivers, G. E., Mann, D. L. and Harris, C. C.: Derivative fluorescence spectral analysis of polycyclic aromatic hydrocarbon-DNA adducts in human placenta. Chem. Res. Toxicol. 2: 104-108, 1989.

165. Ke, Y., Reddel, R. R., Gerwin, B. I., Reddel, H. K., Somers, A. N. A., McMenamin, M., LaVeck, M. A., Stahel, R. A., Lechner, J. F. and Harris, C. C.: Establishment of a human in vitro mesothelial cell model system for investigating mechanisms of asbestos-induced mesothelioma. Am. J. Pathol. 134: 979-991, 1989.

166. Kaighn, M. E., Reddel, R. R., Lechner, J. F., Peehl, D. M., Camalier, R. F., Brash, D. E., Saffiotti, U. and Harris, C. C.: Transformation of human neonatal prostate epithelial cells by strontium phosphate transfection with a plasmid containing SV40 early region genes. Cancer Res. 49: 3050-3056, 1989.

167. Weston, A., Willey, J. C., Modali, R., Sugimura, H., McDowell, E., Resau, J., Light, B., Haugen, A., Mann, D. L., Trump, B. F. and Harris, C. C.: Differential DNA sequence deletions from chromosomes 3, 11, 13 and 17 in squamous cell carcinoma, large cell carcinoma and adenocarcinoma of the human lung. Proc. Natl. Acad. Sci. USA 86: 5099-5103, 1989.

168. Reddel, R. R., Malan-Shibley, L., Gerwin, B. I., Metcalf, R. A. and Harris, C. C.: Tumorigenicity of a human mesothelial cell line transfected with the EJ-ras oncogene. J. Natl. Cancer Inst. 81: 945-948, 1989.

169. Ura, H., Bonfil, R. D., Reich, R., Reddel, R., Pfeifer, A. M., Harris, C. C. and Klein-Szanto, A. J. P.: Expression of type IV collagenase and pro-collagen genes in oncogene transformed human bronchial epithelial cells: Correlation with tumorigenic, invasive and metastatic abilities. Cancer Res. 49: 4615-4621, 1989.

170. Dypbukt, J. M., Edman, C. C., Sundqvist, K., Kakefuda, T., Plummer, S. M., Harris, C. C. and Grafstrom, R. C.: Reactivity of fecapentaene-12 towards thiols, DNA and these constituents in human fibroblasts. Cancer Res. 49: 6058-6063, 1989.

171. Bonfil, R. D., Momiki, S., Fridman, R., Reich, R., Reddel, R., Harris, C. C. and Klein-Szanto, A.: Enhancement of the invasive ability of a transformed human bronchial epithelial cell line by TPA and diacylglycerol. Carcinogenesis 10: 2335-2338, 1989.

172. Wilson, V. L., Weston, A., Manchester, D. K., Trivers, G. E., Roberts, D. W., Kadlubar, F. F., Wild, C. P., Montesano, R., Willey, J. C., Mann, D. L. and Harris, C. C.: Alkyl and aryl carcinogen adducts detected in human peripheral lung. Carcinogenesis 11: 2149-2153, 1989.

173. Nigro, J. M., Baker, S. J., Preisinger, A. C., Jessup, J. M., Hostetter, R., Cleary, K., Bigner, S. H., Davidson, N., Baylin, S., Devilee, P., Glover, T., Weston, A., Modali, R., Harris, C. C. and Vogelstein, B.: Mutations in the p53 gene occur in diverse human tumor types. Nature 342: 705-708, 1989.

174. Lechner, J. F., Cole, K. H., Reddel, R. R., Anderson, L. and Harris, C. C.: Replicative cultures of adult human and rhesus monkey liver epithelial cells. Cancer Detect. Prevent. 14: 239-244, 1989.

175. Pfeifer, A. M. A., Mark, G. E., Malan-Shibley, L., Graziano, S., Amstad, P. and Harris, C. C.: Cooperation of c-raf-1 and c-myc protooncogenes in the neoplastic transformation of SV-40 T antigen immortalized human bronchial epithelial cells. Proc. Natl. Acad. Sci. USA 86: 10075-10079, 1989.

176. Miyashita, M., Willey, J. C., Sasajima, K., Lechner, J. F., LaVoie, L. J., Hoffmann, D., Smith, M., Trump, B. F. and Harris, C. C.: Differential effects of cigarette smoke condensate and its fractions on cultured normal and malignant human bronchial epithelial cells. Exp. Pathol. 38: 19-29, 1990.

177. Sugimura, H., Caporaso, N. E., Hoover, R. N., Modali, R., Resau, J., Trump, B. F., Lonergan, J. A., Krontiris, T. G., Mann, D. L., Weston, A. and Harris, C. C.: Association of rare alleles of the Ha-ras-1 locus with lung cancer. Cancer Res. 50: 1857-1862, 1990.

178. Kaighn, M. E., Gabrielson, E. W., Iman, D. S., Pauls, E. A. and Harris, C. C.: Suppression of tumorigenicity of a human lung carcinoma line by nontumorigenic bronchial epithelial cells in somatic cell hybrids. Cancer Res. 50: 1890-1896, 1990.

179. Manchester, D. K., Wilson, V. L., Hsu, I. C., Choi, J. S., Parker, N. B., Mann, D. L., Weston, A. and Harris, C. C.: Synchronous fluorescence spectroscopic, immunoaffinity chromatographic and ³²P-postlabeling analyses of human placental DNA known to contain benzo(a)pyrene diol epoxide adducts. Carcinogenesis 11: 553-559, 1990.

180. Pelin-Enlund, K., Husgafvel-Pursiainen, K., Tammilehto, L., Klockars, M., Jantunen, K., Gerwin, B. I., Harris, C. C., Tuomi, T., Vanhala, E., Mattson, K. and Linnainmaa, K.: Asbestos-related malignant mesothelioma: growth, cytology, tumourigenicity and consistent chromosome findings in cell lines from five patients. Carcinogenesis 11: 673-681, 1990.

181. Caporaso, N. E., Tucker, M. A., Hoover, R., Hayes, R. B., Pickle, L. W., Issaq, H., Muschik, G., Green-Gallo, L., Buivys, D., Aisner, S., Resau, J., Trump, B., Tollerud, D., Weston, A. and Harris, C. C.: Lung cancer and the debrisoquine metabolic phenotype. J. Natl. Cancer Inst. 85: 1264-1272, 1990.

182. McDonald, J. W., Brash, D. E., Oseroff, A. R. and Harris, C. C.: Photosensitizing dyes for the selection of nontumorigenic revertants from human lung cancer cell lines. Cancer Res. 50: 5369-5373, 1990.

183. Shields, P. G., Povey, A. C., Wilson, V. W., Weston, A. and Harris, C. C.: Combined high performance liquid chromatography/³²P-postlabeling assay of N⁷methyldeoxyguanosine. Cancer Res. 50: 6580-6584, 1990.

184. Sugimura, H., Caporaso, N. E., Shaw, G. L., Modali, R. V., Gonzalez, F. J., Hoover, R. N., Resau, J. H., Trump, B. F., Weston, A. and Harris, C. C.: Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls. Carcinogenesis 11: 1527-1530, 1990.

185. Tamai, S., Sugimura, H., Caporaso, N. E., Resau, J. H., Trump, B. F., Weston, A. and Harris, C. C.: Restriction fragment length polymorphism analysis of the L-myc gene locus in a case-control study of lung cancer. Int. J. Cancer 46: 411-415, 1990.

186. Gerwin, B. I., Keski-Oja, J., Seddon, M., Lechner, J. F. and Harris, C. C.: TGF-β₁ modulation of urokinase and PAI-1 expression in human bronchial epithelial cells. Am. J. Physiol. 259 (Lung Cell. Mol. Physiol. 3): L262-L269, 1990.

187. Ke, Y., Gerwin, B. I., Ruskie, S. E., Pfeifer, A. M. A., Harris, C. C. and Lechner, J. F.: Cell density governs the ability of human bronchial epithelial cells to recognize serum and transforming growth factor β-1 as squamous differentiation inducing agents. Am. J. Pathol. 137: 833-843, 1990.

188. Newman, M. J., Weston, A., Carver, D. C., Mann, D. L. and Harris, C. C.: Serological characterization of polycyclic aromatic hydrocarbon diol epoxide-DNA adducts using monoclonal antibodies. Carcinogenesis 11: 1903-1907, 1990.

189. Trump, B. F., Berezesky, I. K., Smith, M. W., Jones, R. T., Phelps, P. C., Miyashita, M. and Harris, C. C.: Studies of human bronchial epithelium in vitro: changes of [Ca²⁺]_i in relation to injury, growth and differentiation. Toxicol. In Vitro 4: 646-653, 1990.

190. Hollstein, M., Metcalf, R. A., Welsh, J., Montesano, R. and Harris, C. C.: Frequent mutation of the p53 gene in human esophageal cancer. Proc. Natl. Acad. Sci. USA 87: 9958-9961, 1990.

191. Stoner, G. D., Kaighn, M. E., Reddel, R. R., Resau, J. H., Bowman, D., Naito, Z., Matsukura, N., You, M., Galati, A. J. and Harris, C. C.: Establishment and characterization of SV40 T-antigen immortalized human esophageal epithelial cells. Cancer Res. 51: 365-371, 1991.

192. Hsu, I. C., Metcalf, R. A, Welsh, J., Sun, T., Wang, N. J. and Harris, C. C.: p53 gene mutational hotspot in human hepatocellular carcinomas from Qidong, China. Nature 350: 427-428, 1991.

193. Matsukura, N., Willey, J., Miyashita, M., Taffe, B., Waldren, C., Puck, T. T. and Harris, C. C.: Detection of direct mutagenicity of cigarette smoke condensate in mammalian cells. Carcinogenesis 12: 685-689, 1991.

194. Povey, A. C., Schiffman, M., Taffe, B. G. and Harris, C. C.: Laboratory and epidemiologic studies of fecapentaenes. Mutat. Res. 259: 387-397, 1991.

195. Pfeifer, A. M. A., Jones, R. T., Bowden, P. E., Mann, D., Klein-Szanto, A. J. P., Trump, B. F. and Harris, C. C.: Human bronchial epithelial cells transformed by the c-raf-1 and c-myc protooncogenes induce multidifferentiated carcinomas in nude mice: A model for lung carcinogenesis. Cancer Res. 51: 3793-3801, 1991.

196. Lehman, T. A., Bennett, W. P., Metcalf, R. A., Reddel, R., Welsh, J. A., Ecker, J., Modali, R. V., Ullrich, S., Romano, J. W., Appella, E., Testa, J. R., Gerwin, B. I., Harris, C. C.: p53 mutations, ras mutations and p53-heat shock 70 protein complexes in human lung cell lines. Cancer Res. 51: 4090-4096, 1991.

197. Leone, A., McBride, O. W., Weston, A., Wang, M., Anglard, P., Cropp, C. S., Gorpel, J., Lidereau, R., Callahan, R., Linehan, W. M., Rees, R. C., Harris, C. C., Liotta, L. A. and Steeg, P. S.: Somatic allelic deletion of nm23 in human cancer. Cancer Res. 51: 2490-2493, 1991.

198. Vahakangas, K., Trivers, G. E., Plummer, S., Krokan, H., Rowe, M., Yeager, H., Swartz, R. P. and Harris, C. C.: O⁶-Methylguanine DNA methyltransferase and uracil DNA glycosylase in human broncho-alveolar lavage cells and peripheral blood mononuclear cells from tobacco smokers and non-smokers. Carcinogenesis 12: 1389-1394, 1991.

199. Reddel, R. R., Hsu, I. C., Mass, M. J., Hukku, B., Gerwin, B. I., Salghetti, S. E., Somers, A. N. A., Galati, A. J., Gunning, III, W. T., Harris, C. C. and Stoner, G. D.: A human bronchial epithelial cell strain with unusual in vitro growth potential which undergoes neoplastic transformation after SV40 T antigen gene transfection. Int. J. Cancer 48: 764-773, 1991.

200. Hollstein, M., Sidransky, D., Vogelstein, B. and Harris, C. C.: p53 mutations in human cancers. Science 253: 49-53, 1991.

201. Hollstein, M. C., Peri, R., Mandard, A., Welsh, J., Montesano, R., Metcalf, R., Bak, M. and Harris, C. C.: Genetic analysis of human esophageal tumors from two high incidence areas: frequent p53 base substitutions and absence of ras mutations. Cancer Res. 51: 4102-4106, 1991.

202. Wilson, V. L., Foiles, P. G., Chung, F. L., Povey, A. C., Frank, A. A. and Harris, C. C.: Detection of acrolein and crotonaldehyde DNA adducts in cultured human cells and canine peripheral blood lymphocytes by ³²P postlabeling and nucleotide chromatography. Carcinogenesis 12: 1483-1490, 1991.

203. LaForgia, S., Morse, B., Levy, J., Barnea, G., Cannizzaro, L. A., Li, F., Nowell, P. C., Boghosian-Sell, L., Glick, J., Weston, A., Harris, C. C., Drabkin, H., Patterson, D., Croce, C. M., Schlessinger, J. and Huebner, K.: Receptor protein-tyrosine-phosphatase, PTPγ, is a candidate tumor suppressor gene at human chromosome region 3p21. Proc. Natl. Acad. Sci. USA 88: 5036-5040, 1991.

204. Weston, A., Caporaso, N. E., Taghizadeh, K., Hoover, R. N., Tannenbaum, S. R., Skipper, P. L., Resau, J. H., Trump, B. F. and Harris, C. C.: Measurement of 4-aminobiphenyl-hemoglobin adducts in lung cancer cases and controls. Cancer Res. 51: 5219-23, 1991.

205. Willey, J. C., Broussoud, A., Sleemi, A., Bennett, W. P., Cerutti, P. and Harris, C. C.: Immortalization of normal human bronchial epithelial cells by human papillomaviruses 16 or 18. Cancer Res. 51: 5370-77, 1991.

206. Bennett, W. P., Hollstein, M. C., He, A., Zhu, S. M., Resau, J., Trump, B. F., Metcalf, R. A., Welsh, J. A., Gannon, J. V., Lane, D. P. and Harris, C. C.: Archival analysis of p53 genetic and protein alterations in Chinese esophageal cancer. Oncogene 6: 1779-84, 1991.

207. Maehle, L., Metcalf, R. A., Ryberg, D., Bennett, W. P., Harris, C. C. and Haugen, A.: Altered p53 gene structure and expression in human epithelial cells after exposure to nickel. Cancer Res. 52: 218-221, 1992.

208. Vahakangas, K. H., Samet, J. M., Metcalf, R. A., Welsh, J. A., Bennett, W. P., Lane, D. P. and Harris, C. C.: p53 and ras mutations in radon-associated lung cancer from uranium miners. Lancet 339: 576-580, 1992.

209. Povey, A. C., Wilson, V. L., Zweier, J. L., Kuppusamy, P., O'Neill, I. K. and Harris, C. C.: Detection by ³²P-postlabeling of DNA adducts induced by free radical and unsaturated aldehydes formed during the aerobic decomposition of fecapentaene-12. Carcinogenesis 13: 395-401, 1992.

210. Gerwin, B. I., Spillare, E., Lehman, T. A., Forrester, K., Kispert, J., Pfeifer, A. M. A., Baker, S. J., Vogelstein, B. and Harris, C. C.: Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor β₁. Proc. Natl. Acad. Sci. USA 89: 2759-2763, 1992.

211. Metcalf, R. A., Welsh, J. A., Bennett, W. P., Seddon, M. B., Lehman, T. A., Pelin, K., Linnainmaa, K., Tammilehto, L., Mattson, K., Gerwin, B. I. and Harris, C. C.: p53 and Kirsten-ras mutations in human mesothelioma cell lines. Cancer Res. 52: 2610-2615, 1992.

212. Gabrielson, E. W., Van der Meeren, A., Reddel, R. R., Reddel, H., Gerwin, B. I. and Harris, C. C.: Human mesothelioma cells and asbestos-exposed mesothelial cells are selectively resistant to amosite toxicity: a possible mechanism for tumor promotion by asbestos. Carcinogenesis 13: 1359-1363, 1992.

213. Klein-Szanto, A. J. P., Iizasa T., Momiki, S., Garcia-Palazzo, I., Caamano, J., Metcalf, R., Welsh, J. and Harris, C. C.: A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells. Proc. Natl. Acad. Sci. USA 89: 6693-6697, 1992.

214. Bennett, W. P., Hollstein, M. C., Metcalf, R. A., Welsh, J. A., He, A., Zhu, S., Kusters, I., Resau, J. H., Trump, B. F., Lane, D. P. and Harris, C. C.: p53 mutation and protein accumulation during multistage human esophageal carcinogenesis. Cancer Res. 52: 6092-6097, 1992.

215. Kato, S., Shields, P. G., Caporaso, N. E., Hoover, R. N., Trump, B. F., Sugimura, H., Weston, A. and Harris, C. C.: Cytochrome P450IIE1 (CYP2E1) genetic polymorphisms, racial variation and lung cancer risk. Cancer Res. 52: 6712-6715, 1992.

216. Caporaso, N. E., Shields, P. G., Landi, M. T., Shaw, G. L., Tucker, M. A., Hoover, R., Sugimura, H., Weston, A. and Harris, C. C.: The epidemiologic and laboratory implications of non-correspondence between the debrisoquine metabolic phenotype and DNA-based assays: implications of misclassification for the association of lung cancer and the debrisoquine metabolic phenotype. Environ. Health Perspect. 98: 101-105, 1992.

217. Weston, A., Perrin, L. S., Forrester, K., Hoover, R. N., Trump, B. F., Harris, C. C. and Caporaso, N. E.: Allelic frequency of a p53 polymorphism in human lung cancer. Cancer Epidemiology, Biomarkers & Prevention 1: 481-483, 1992.

218. Gabrielson, E. W., Kuppusamy, P., Povey, A. C., Zweier, J. L. and Harris, C. C.: Measurement of neutrophil activation and epidermal cell toxicity by palytoxin and 12-0-tetracanoylphorbol-13-acetate/ Carcinogenesis 13: 1671-1674, 1992.

219. Hollstein, M. C., Wild, C. P., Bleicher, F., Chutimataewin, S., Harris, C. C., Srivatanakul, P. and Montesano, R.: p53 mutations and aflatoxin B₁ exposure in hepatocellular carcinoma patients from Thailand. Int. J. Cancer 53: 51-55, 1993.

220. Reddel, R. R., Salghetti, S. E., Willey, J. C., Ohnuki, Y., Ke, Y., Gerwin, B. I., Lechner, J. F. and Harris, C. C.: Development of tumorigenicity in Simian virus 40-immortalized human bronchial epithelial cell lines. Cancer Res. 53: 985-991, 1993.

221. Grafstrom, R. C., Hsu, I. C. and Harris, C. C.: Mutagenicity of formaldehyde in Chinese hamster lung fibroblasts: synergy with ionizing radiation and N-Nitroso-N-Methylurea. Chem. Biol. Interactions 86: 41-49, 1993.

222. Lehman, T. A., Modali, R., Boukamp, P., Stanek, J., Bennett, W. P., Welsh, J. A., Metcalf, R. A., Stampfer, M. R., Fusenig, N., Rogan, E. M., Reddel, R. and Harris C. C.: p53 mutations in human immortalized epithelial cell lines. Carcinogenesis 14: 833-839, 1993.

223. Hsu, I. C., Tokiwa, T., Bennett, W., Metcalf, R. A., Welsh, J. A., Sun, T. and Harris, C. C.: p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines. Carcinogenesis 14: 987-992, 1993.

224. Vertino, P. M., Spillare, E., Harris, C. C. and Baylin, S. B.: Altered chromosomal methylation patterns accomplany oncogene-induced transformation of human bronchial epithelial cells. Cancer Res. 53: 1684-1689, 1993.

225. Noguchi, M., Murakami, M., Bennett, W., Lupu, R., Hui Jr., Harris, C. C. and Gerwin, B.I.: Biological consequences of overexpression of a transfected c-erbB-2 gene in "immortalized" human bronchial epithelial cells. Cancer Res. 53: 2035-2043, 1993.

226. Pfeifer, A. M. A., Cole, K. E., Smoot, D.T., Weston, A., Groopman, J. D., Shields, P. G., Vignaud, J.-M., Juillerat, M., Lipsky, M. M., Trump, B. F., Lechner, J. F. and Harris, C. C.: SV40 T-antigen immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens. Proc. Natl. Acad. Sci. USA 90: 5123-5127, 1993.

227. Wilson, V. L., Taffe, B. G., Shields, P. G., Povey, A. C. and Harris, C. C.: Detection and quantitation of 8-hydroxyguanosine adducts in peripheral blood of people exposed to ionizing radiation. Environ. Health Prospectives 99: 261-263, 1993.

228. Evans, M. K., Taffe, B. G., Harris, C. C. and Bohr, V. A.: DNA strand bias in the repair of the p53 gene in normal human and Xeroderma Pigmentosum Group C fibroblasts. Cancer Res. 53: 5377-5381, 1993.

229. Esteve, A., Lehman, T. A., Jiang, W., Weinstein, I. B., Harris, C. C., Ruol, A., Peracchia, A., Montesano, R. and Hollstein, M.: Correlation of p53 mutations with epidermal growth factor receptor overexpression and absence of mdm2 amplification in human esophageal carcinomas. Mol. Carcinogenesis 8: 306-311, 1993.

230. Shields, P. G., Harris, C. C., Petruzzelli, S., Bowman, E. D. and Weston, A.: Standardization of the 32P-postlabeling assay for polycyclic aromatic hydrocarbon-DNA adducts. Mutagenesis 8: 121-126, 1993.

231. Felley-Bosco, E. Weston, A., Cawley, H. M., Bennett, W. P. and Harris, C. C.: Functional studies of a germline polymorphism at codon 47 within the p53 gene. Am. J. Human Genetics 53: 752-759, 1993.

232. Bennett, W. P., Colby, T. V., Vahakangas, K. H., Soini, Y., Takeshima, Y., Metcalf, R. A., Welsh, J. A., Borkowski, A., Jones, R. T., Trump, B. F., Lane, D. P., Travis, W. D., Samet, J. M. and Harris, C. C.: p53 protein accumulates frequently in early bronchial neoplasia. Cancer Res. 53: 4817-4822, 1993.

233. Jiang, W., Zhang, Y. J., Kahn, S. M., Hollstein, M. C., Santella, R. M., Lu, S. H., Harris, C. C., Montesano, R. and Weinstein, I. B.: Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc. Natl. Acad. Sci. USA 90: 9026-9030, 1993.

234. Iizasa, T., Momiki, S., Bauer, B., Caamano, J., Metcalf, R., Harris, C. C. and Klein-Szanto, A. J. P.: Invasive tumors derived from xenotransplanted, immortilized human cells after in vivo exposure to chemical carcinogens. Carcinogenesis 14: 1789-1794, 1993.

235. Van der Meeren, A., Seddon, M. B., Kispert, J., Harris, C. C. and Gerwin, B. I.: Lack of expression of the retinoblastoma gene is not frequently involved in the genesis of human mesothelioma. Eur. Respir. Rev. 3: 177-179, 1993.

236. Shields, P. G., Caporaso, N. E., Falk, R. T., Sugimura, H., Trivers, G. E., Trump, B. F., Hoover, R. N., Weston, A. and Harris, C. C.: Lung cancer, race and a CYP1A1 genetic polymorphism. Cancer Epidemiol. Biomarkers Prev. 2: 481-485, 1993.

237. Harris, C. C.: p53: At the crossroads of molecular carcinogenesis and risk assessment. Science 262: 1980-1981, 1993.

238. Harris, C. C. and Hollstein, M. C.: Clinical implications of the p53 tumor suppressor gene. New Engl. J. Med. 329: 1318-1327, 1993.

239. Takeshima, Y., Seyama, T., Bennett, W. P., Akiyama, M., Tokuoka, S., Inai, K., Mabuchi, K., Land, C. E. and Harris, C. C.: p53 mutations in lung cancers from non-smoking atomic bomb survivors. Lancet 342: 1520-1521, 1993.

240. Mace, K., Gonzales, F., McConnell, I. R., Garner, R. C., Aventi, O., Harris, C. C. and Pfeifer, A. M. A.: Activation of promutagens in a human bronchial epithelial cell line stably expressing the human CYP1A2. Mol. Carcinogenesis 11: 65-73, 1994.

241. Hollstein, M. C., Marion, M. J., Lehman, T., Welsh, J., Harris, C. C., Martel-Planche, G., Kusters, I. and Montesano, R.: p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers. Carcinogenesis 15: 1-3, 1994.

242. Wang, X. W., Forrester, K., Yeh, H., Feitelson, M. A., Gu, J. and Harris, C. C.: Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity and association with transcription factor ERCC3. Proc. Natl. Acad. Sci. USA 91: 2230-2234, 1994.

243. Weston, A., Ling-Cawley, H. M., Caporaso, N. E., Bowman, E. D., Hoover, R. N., Trump, B. F. and Harris, C. C.: Determination of the allelic frequencies of an L-myc and a p53 polymorphism in human lung cancer. Carcinogenesis 15: 583-589, 1994.

244. Aguilar, F., Harris, C. C., Sun, T., Hollstein, M. and Cerutti, P.: Geographic variation of p53 mutational profile in nonmalignant human liver. Science 264: 1317-1319, 1994.

245. Grafstrom, R. C., Dypbukt, J. M., Sundqvist, K., Atzori, L., Nielsen, I., Curren, R. D. and Harris, C. C.: Pathobiological effects of acetaldehyde in cultured human epithelial cells and fibroblasts. Carcinogenesis 15: 985-990, 1994.

246. Kato, S., Shields, P. G., Caporaso, N. E., Sugimura, H., Trivers, G. E., Tucker, M. A., Trump, B. F., Weston, A. and Harris, C. C.: Analysis of cytochrome P450 2E1 genetic polymorphisms in relation to human lung cancer. Cancer Epidemiol. Biomarkers and Prev. 3: 515-518, 1994.

247. Forrester, K., Kispert, J., Sanchez, J. H., Gerwin, B. I., Tlsty, T. D. and Harris, C. C.: Clonal variation of tumorigenic potential in v-Ha-ras oncogene expression and CAD gene amplification. Molecular Carcinogenesis 11: 34-41, 1994.

248. Felley-Bosco, E., Ambs, S., Lowenstein, C. J., Keefer, L. K. and Harris, C. C.: Constitutive expression of inducible nitric oxide synthase in human bronchial epithelial cells induces c-fos and stimulates the cGMP pathway. Am. J. Respir. Cell Mol. Biol. 11: 159-164, 1994.

249. Hollstein, M., Rice, K., Greenblatt, M. S., Soussi, T., Fuchs, R., Sorlie, T., Hovig, E., Smith-Sorensen, B., Montesano, R. and Harris, C. C.: Database of p53 gene somatic mutations in human tumors and cell lines. Nucl. Acids Res. 22: 3551-3555, 1994.

250. Zabrenetzky, V., Harris, C. C., Steeg, P. S. and Roberts, D. D.: Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines. Internatl. J. Cancer 58: 191-195, 1994.

251. Takeshima, Y., Inai, K., Bennett, W. P., Metcalf, R. A., Welsh, J. A., Yonehara, S., Hayashi, Y., Fujihara, M., Yamakido, M., Akiyama, M., Tokuoka, S., Land, C. E. and Harris, C. C.: p53 mutations in lung cancers from Japanese mustard gas workers. Carcinogenesis 15: 2075-2079, 1994.

252. Okamoto, A., Demetrick, D. J., Spillare, E. A., Hagiwara, K., Hussain, S. P., Bennett, W. P., Forrester, K., Gerwin, B. I., Serrano, M., Beach, D. H. and Harris, C. C.: Mutations and altered expression of p16^INK4 in human cancer. Proc. Natl. Acad. Sci. USA 91: 11045-11049, 1994.

253. Okamoto, A., Jiang, W., Kim, S. J., Spillare, E. A., Stoner G. D., Weinstein, I. B. and Harris, C. C.: Overexpression of human cyclin D1 reduces the TGF-β type II receptor and growth inhibition of TGF-β1 in an immortalized human esophageal epithelial cell line. Proc. Natl. Acad. Sci. USA 91: 11576-11580, 1994.

254. De Silva, R., Englezou, A., Schevzov, G., Gerwin, B. I., Harris, C. C., Gunning, P. and Reddel, R. R.: Induction of anchorage independent growth and serum resistance in immortalized human bronchial epithelial cells by alteration of the cytoskeleton. Cellul. and Molec. Biol. Res. 40: 323-335, 1994.

255. Greenblatt, M. S., Bennett, W. P., Hollstein, M. and Harris, C. C.: Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54: 4855-4878, 1994.

256. Okamoto, A., Hussain, S. P., Hagiwara, K., Spillare, E. A., Rusin, M. R., Demetrick, D. J., Serrano, M., Hannon, G. J., Shiseki, M., Zariwala, M., Xiong, Y., Beach, D. H., Yokota, J. and Harris, C. C.: Mutations in the p16^INK4/MTS1/CDKN2, p15^INK4B/MTS2 and p18 genes in primary and metastatic lung cancer. Cancer Res. 55: 1448-1451, 1995.

257. Reddel, R. R., De Silva, R., Duncan, E. L., Rogan, E. M., Whitaker, N. J., Zahra, D. G., Ke, Y., McMenamin, M. G., Gerwin, B. I. and Harris, C. C.: SV-40-induced immortalization and ras-transformation of human bronchial epithelial cells. Int. J. Cancer 61: 199-205, 1995.

258. Guinee, Jr., D. G., Travis, W. D., Trivers, G. E., De Benedetti, V. M. G., Cawley, H., Welsh, J. A., Bennett, W. P., Jett, J., Colby, T. V., Tazelaar, H., Abbondanzo, S. L., Pairolero, P., Trastek, V., Caporaso, N. E., Liotta, L. A. and Harris, C. C.: Gender comparisons in human lung cancer: analysis of p53 mutations, anti-p53 serum antibodies and c-erbB-2 expression. Carcinogenesis 16: 993-1002, 1995.

259. Shields, P. G., Xu, G. X., Blot, J., Fraumeni, Jr., J. F., Trivers, G. E., Pellizzari, E. D., Qu, Y. H., Gao, Y. T. and Harris, C. C.: Mutagens and from heated Chinese and U. S. cooking oils. J. Natl. Cancer Inst. 87: 836-841, 1995.

260. Pellizzari, E. D., Michael, L. C., Thomas, K. W., Shields, P. G. and Harris, C.: Identification of 1,3-butadiene, benzene and other volatile organics from wok oil emissions. J. Expos. Anal. Environ. Epidemiol. 5: 77-87, 1995.

261. Borkowski, A., Bennett, W. P., Jones, R. T., Borkowski, P., Harris, C. C., Ferreira, L. R., Kao, G. and Trump, B. F.: Quantitative image analysis of p53 protein accumulation in keratoacanthomas. Am. J. Dermatol. Path. 17: 335-338, 1995.

262. Forrester, K., Lupold, S. E., Ott, V. L., Chay, C. H., Band, V., Wang, X. W. and Harris, C. C.: Effects of p53 mutants on wild-type p53 mediated transactivation are cell type dependent. Oncogene 10: 2103-2111, 1995.

263. Trivers, G. E., Cawley, H. L., De Benedetti, V. M. G., Hollstein, M., Marion, M. J., Bennett, W. P., Hoover, M. L., Prives, C., Tamburro, C. and Harris, C. C.: Anti-p53 antibodies in the serum of workers occupationally exposed to vinyl chloride. J. Natl. Cancer Inst. 87: 1400-1407, 1995.

264. Wang, X. W., Yeh, H., Schaeffer, L., Roy, R., Moncollin, V., Egly, J. M., Wang, Z., Friedberg, E. C., Evans, M. K., Taffe, B. G., Bohr, V. A., Weeda, G., Hoeijmakers, J. H. J., Forrester, K. and Harris, C. C.: p53 Modulation of TFIIH-associated nucleotide excision repair activity. Nature Genet. 10: 188-195, 1995.

265. Felley-Bosco, E., Mirkovitch, J., Ambs, S., Mace, K., Pfeifer, A., Keefer, L. K. and Harris, C. C.: Nitric oxide and ethylnitrosurea: relative mutagenicity in the p53 tumor suppressor and hypoxanathine-phosphoribosyltransferase genes. Carcinogenesis 16: 2069-2074, 1995.

266. Ueda, H., Ohkoshi, S., Harris, C. C. and Jay, G.: Synergism between the HBx gene and aflatoxin B₁ in the development of murine liver cancer. Int. J. Oncol. 7: 735-740, 1995.

267. Wang, X. W., Gibson, M. K., Vermeulen, W., Yeh, H., Forrester, K., Sturzbacher, H. W., Hoeijmakers, J. H. J. and Harris, C. C.: Abrogation of p53-induced apoptosis by the hepatitis B virus X gene. Cancer Res. 55: 6012-6016, 1995.

268. Greenblatt, M. S. and Harris, C. C.: Molecular genetics of lung cancer. Cancer Surveys 25: 293-313, 1995.

269. Hollstein, M., Shomer, B., Greenblatt, M., Soussi, T., Hovig, E., Montesano, R. and Harris, C. C.: Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation. Nucl. Acids Res. 24: 141-146, 1996.

270. Forrester, K., Ambs, S., Lupold, S. E., Kapust, R. B., Weinberg, W. C., Felley-Bosco, E., Wang, X. W., Geller, D. A., Billiar, T. R. and Harris, C. C.: Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase (NOS2) expression by wild-type p53. Proc. Natl. Acad. Sci. USA 93: 2442-2447, 1996.

271. Rusin, M. R., Okamoto, A., Chorazy, M., Czyzewski, K., Harasim, J., Spillare, E., Hagiwara, K., Hussain, S. P., Xiong, Y., Demetrick, D. J. and Harris, C. C.: Intragenic mutations of the p16^INK4, p15^INK4B and the p18 genes in primary non-small-cell lung cancers. Int. J. Cancer 65: 734-739, 1996.

272. Greenblatt, M. S., Grollman, A. P. and Harris, C. C.: Deletions and insertions in the p53 tumor suppressor gene in human cancers: confirmation of the DNA polymerase slippage/misalignment model. Cancer Res. 56: 2130-2136, 1996.

273. Spillare, E. A., Okamoto, A., Hagiwara, K., Demetrick, D. J., Serrano, M., Beach, D. and Harris, C. C.: Suppression of growth in vitro and tumorigenicity in vivo of human carcinoma cell lines by transfected p16^INK4. Mol. Carcinogen. 16: 53-60, 1996.

274. Wang, X. W., Vermeulen, W., Coursen, J. D., Gibson, M., Lupold, S. E., Forrester, K., K., Xu, G., Elmore, L., Yeh, H., Hoeijmakers, J. H. J. and Harris, C. C.: The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. Genes and Development 10: 1219-1232, 1996.

275. Soini, Y., Chia, S. C., Bennett, W. P., Groopman, J. D., Wang, J. S., DeBenedetti, V. M. G., Cawley, H., Welsh, J. A., Hansen, C., Bergasa, N. V., Jones, E. A., DiBisceglie, A. M., Trivers, G. E., Sandoval, C. A., Calderon, I. E., Munoz Espinosa, L. E. and Harris, C. C.: An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico. Carcinogenesis 17: 1007-1012, 1996.

276. Hagiwara, K. and Harris, C. C.: 'Long distance sequencer' method; a novel strategy for large DNA sequencing projects. Nucl. Acids Res. 24: 2460-2461, 1996.

277. Takenoshita, S., Hagiwara, K., Nagashima, M., Gemma, A., Bennett, W. P., Harris, C. C.: The genomic structure of the gene encoding the human transforming growth factor β type II receptor (TGF-β RII). Genomics 36: 341-344, 1996.

278. Trivers, G. E., De Benedetti, V. G. M., Cawley, H. L., Caron, G., Harrington, A. M., Bennett, W. P., Jett, J. R., Colby, T. V., Tazalaar, H., Pairolero, P., Miller, R. D. and Harris, C. C.: Anti-p53 in sera from patients with chronic obstructive pulmonary disease can predate a diagnosis of cancer. Clin. Cancer Res. 2: 1767-1775, 1996.

279. Xu, G. W., Sun, Z. T., Forrester, K., Wang, X. W., Coursen, J. and Harris, C. C.: Tissue-specific growth suppression and chemosensitivity promotion in human hepatocellular carcinoma cells by retroviral-mediated transfer of the wild-type p53 gene. Hepatology 24: 1264-1268, 1996.

280. Ohnuki, Y., Reddel, R. R., Bates, S. E., Lechner, J. F. and Harris, C. C.: Chromosomal changes and progressive tumorigenesis of human bronchial epithelial cell lines. Cancer Genetics and Cytogenetics 92: 99-110, 1996.

281. Gemma, A., Takenoshita, S., Hagiwara, K., Okamoto, A., Spillare, E. A., McMenamin, M. G., Hussain, S. P., Forrester, K., Zariwala, M., Xiong, Y. and Harris, C. C.: Molecular analysis of the cyclin dependent kinase inhibitor genes p15INK4b/MTS2, p16INK4/MTS1, p18 and p19 in human cancer cell lines. Int. J. Cancer 68: 605-611, 1996.

282. Wang, X. W. and Harris, C. C.: TP53 tumor suppressor gene: clues to molecular carcinogenesis and cancer therapy. Genetic Instability of Cancer. Cancer Surveys 28: 169-196, 1996.

283. Harty, L. C., Guinee, D. G., Travis, W. D., Bennett, W. P., Jett, J., Colby, T. V., Tazelaar, H., Trastek, V., Pairolero, P., Liotta, L. A., Harris, C. C. and Caporaso, N. E.: p53 mutations and occupational exposures in a surgical series of lung cancers." Cancer Epidemiology, Biomarkers and Prev. 5: 997-1003, 1996.

284. Hussain, S. P., Kennedy, C. H., Amstad, P., Lui, H., Lechner, J. F. and Harris, C. C.: Radon and lung carcinogenesis: mutability of p53 codons 249 and 250 to ²³⁸Pu α-particles in human bronchial epithelial cells. Carcinogenesis 18: 121-125, 1997.

285. Bowman, E. D., Shields, P. G., Caporaso, N. E., Tucker, M. A., Hoover, R. N., Trump, B. F. and Harris, C. C.: Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk. Oncology Reports 4: 269-272, 1997.

286. Hainaut, P., Soussi, T., Shomer, B., Hollstein, M., Greenblatt, M., Hovig, E., Harris, C. C. and Montesano, R.: Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects. Nucl. Acids Res. 25: 151-157, 1997.

287. Greenblatt, M. S., Feitelson, M. A., Zhu, M., Bennett, W. P., Welsh, J. A., Jones, R., Borkowski, A. and Harris, C. C.: Integrity of p53 in hepatitis B x antigen-positive and -negative hepatocellular carcinomas. Cancer Res. 57: 426-432, 1997.

288. Adler, V., Pincus, M. R., Minamoto, T., Fuchs, S. Y., Bluth, M. J., Brandt-Rauf, P. W., Friedman, F., Robinson, R. C., Chen, J. M., Wang, X. W., Harris, C. C. and Ronai, Z.: Conformation-dependent phosphorylation of p53. Proc. Natl. Acad. Sci. USA 94: 1686-1691, 1997.

289. Gemma, A., Hagiwara, K., Ke, Y., Burke, L. M., Khan, M. A., Nagashima, M., Bennett, W. P. and Harris, C. C.: FHIT mutations in human primary gastric cancer. Cancer Res. 57: 1435-1437, 1997.

290. Takenoshita, S., Tani, M., Nagashima, M., Hagiwara, K., Bennett, W. P., Yokota, J. and Harris, C. C.: Mutation analysis of coding sequences region of the transforming growth factor beta type II receptor gene in sporadic human colon cancer using genomic DNA and intron primers. Oncogene 14: 1255-1258, 1997.

291. Mace, K., Vautravers, P., Granato, D., Gonzalez, F. J., Harris, C. C. and Pfeifer, A. M. A.: Development of CYP450-expressing human bronchial epithelial cell lines for in vitro pharmatoxicologic applications. In Vitro Toxicol. 10: 85-92, 1997.

292. Tani, M., Takenoshita, S., Kohno, T., Hagiwara, K., Nagamachi, Y., Harris, C. C. and Yokota, J.: Infrequent mutations of the transforming growth factor beta type II receptor gene at chromosome 3p22 in human lung cancers with chromosome 3p deletions. Carcinogenesis 18: 1119-1121, 1997.

293. Ambs, S., Hussain, S. P. and Harris, C. C.: Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression. FASEB J. 11: 443-448, 1997.

294. Mace, K., Aguilar, F., Wang, J. S., Vautravers, P., Gomez-Lechon, M., Gonzalez, F. J., Groopman, J., Harris, C. C. and Pfeifer, A. M. A.: Aflatoxin B₁ induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines. Carcinogenesis 18: 1291-1297, 1997.

295. Takenoshita, S., Hagiwara, K., Gemma, A., Nagashima, M., Ryberg, D., Lindstedt, B. A., Bennett, W. P., Haugen, A. and Harris, C. C.: Absense of mutations in the transforming growth factor-β type II receptor in sporadic lung cancers with microsatellite instability and rare H-ras alleles. Carcinogenesis 18: 1427-1429, 1997.

296. Coursen, J. D., Bennett, W. P., Khan, M. A., Forrester, K., Pietenpol, J. A. and Harris, C. C.: Differential effects of p53 mutants on the growth of human bronchial epithelial cells. Mol. Carcinogenesis 19: 191-203, 1997.

297. Blomeke, B., Bennett, W. P., Harris, C. C. and Shields, P. G.: Serum, plasma and paraffin-embedded tissues as sources of DNA for studying cancer susceptibility genes. Carcinogenesis 18: 1271-1275, 1997.

298. Buchhop, S., Gibson, M. K., Wang, X. W., Wagner, P., Sturzbecher, H. W. and Harris, C. C.: Interaction of p53 with the human RAD51 protein. Nucl. Acids Res. 25: 3868-3874, 1997.

299. Coursen, J. D., Bennett, W. P., Gollahon, L., Shay, J. W. and Harris, C. C.: Genomic instability and telomerase activity in human bronchial epithelial cells during immortalization by human Papillomavirus-16 E6 and E7 genes. Exptl. Cell Res. 235: 245-253, 1997.

300. Elmore, L. W., Hancock, A. R., Chang, S. F., Wang, X. W., Chang, S., Callahan, C. P., Geller, D. A., Will, H. and Harris, C. C.: Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc. Natl. Acad. Sci.USA 94: 14707-14712, 1997.

301. Ambs, S., Merriam, W. G., Bennett, W. P., Felley-Bosco, E., Ogunfusika, M. O., Oser, S. M., Klein, S., Shields, P. G., Billiar, T. R. and Harris, C. C.: Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression. Cancer Res. 58: 334-341, 1998.

302. Fleming, M. V., Guinee, Jr., D. G., Chu, W. S., Freedman, A. N., Caporaso, N. E., Bennett, W. P., Colby, T. V., Tazelaar, H., Abbondanzo, S. L., Jett, J., Pairolero, P., Trastek, V., Liotta, L. A., Harris, C. C. and Travis, W. D.: Bcl-2 immunohistochemistry in a surgical series of non-small cell lung cancer patients. Human Pathol. 29: 60-64, 1998.

303. Mace, K., Offord, E. A., Harris, C. C. and Pfeifer, A. M.: Development of in vitro models for cellular and molecular studies. Arch. Toxicol. Suppl. 20: 227-236, 1998.

304. Gemma, A., Hagiwara, K., Vincent, F., Ke Y., Hancock, A. R., Nagashima, M., Bennett, W. P. and Harris, C. C.: hSmad5, a human Smad family member: Its full length cDNA, genomic structure, promoter region and mutation analysis in human tumors. Oncogene 16: 951-956, 1998.

305. Ambs, S., Bennett, W. P., Merriam, W. G., Ogunfusika, M. O., Oser, S. M., Khan, M. A., Jones, R. T. and Harris, C. C.: Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53. Brit. J. Cancer 78: 233-239, 1998.

306. Burke, L., Khan, M. A., Freedman, A. N., Gemma, A., Rusin, M., Guinee, D. G., Bennett, W. P., Caporaso, N. E., Fleming, M. V., Travis, W. D., Colby, T. V., Trastek, V., Pairolero, P. C., Tazelaar, H. F., Midthun, D., Liotta, L. A. and Harris, C. C.: Allelic deletion analysis of the fragile histidine triad (FHIT) gene predicts poor survival in non-small cell lung cancer. Cancer Res. 58: 2533-2536, 1998.

307. Bennett, W. P., El-Diery, W. S., Rush, W. L., Guinee, D. G., Freedman, A. N., Caporaso, N. E., Welsh, J. A., Jones, R. T., Borkowski, A., Travis, W. D., Fleming, M. V., Trastek, V., Pairolero, P. C., Tazelaar, H. D., Midthun, D., Jett, J. R., Liotta, L. A., Harris, C. C.: p21waf1/cip1 and transforming growth factor-b1 protein expression correlate with survival in non-small cell lung cancer. Clin. Cancer Res. 4: 1499-1506, 1998.

308. Ambs, S. Ogunfusika, M. O., Merriam, W. G., Bennett, W. P., Billiar, T. R. and Harris, C. C.: Upregulation of NOS2 expression in cancer-prone p53 knockout mice. Proc. Natl. Acad. Sci.USA 95: 8823-8828, 1998.

309. Takenoshita, S., Tani, M., Mogi, A., Nagashima, M., Nagmachi, Y., Hagiwara, K., Harris, C. C. and Yokota, J.: Mutation analysis of the Smad2 gene in human colon cancers using genomic DNA and intron primers. Carcinogenesis 19: 803-807, 1998.

310. Guo, R. J., Wang, Y., Kaneko, E., Wang, D. Y., Arai, H., Hanai, H., Takenoshita, S., Hagiwara, K., Harris, C. C. and Sugimura, H.: Analyses of mutation and loss of heterozygosity of coding sequences of the entire transforming growth factor beta type II receptor gene in sporadic human gastric cancer. Carcinogenesis 19: 1539-1544, 1998.

311. Hussain, S. P. and Harris, C. C.: Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes. Cancer Res. 58: 4023-4037, 1998.

312. Mace, K., Bowman, E. D., Vautravers, P., Shields, P. G., Harris, C. C. and Pfeifer, A. M. A.: Characterization of xenobiotic-metabolizing enzyme expression in human bronchial mucosa and peripheral lung tissues. Eur. J. Cancer 34: 914-920, 1998.

313. Hagiwara, K., Freeman, A. H., McMenamin, M. G. and Harris, C. C.: Screening cloned PCR fragments by restriction endonuclease fingerprinting (REF) to obtain wild-type sequences. Biotechniques 25: 554-555, 1998.

314. Ambs, S., Merriam, W. G., Ogunfusika, M. O., Bennett, W. P., Ishibe, N., Hussain, P. S., Tzeng, E. E., Geller, D. A., Billiar, T. R. and Harris, C. C.: p53 and vascular endothelial growth factor regulate tumor growth of NOS2-Expressing human carcinoma cells. Nature Med. 4: 1371-1376, 1998.

315. Von Brevern, M., Hollstein, M., Risk, J. M., Garde, J., Bennett, W. P., Harris, C. C., Muehlbauer, K. R. and Field, J. K.: Loss of heterozygosity in sporadic oesophageal tumours at the tylosis oesophageal cancer (TOC) gene locus of chromosome 17q. Oncogene 17: 2101-2105, 1998.

316. Przygodzki, R. M., Bennett, W. P., Guinee, Jr., D. G., Khan, M. A., Friedman, A., Shields, P. G., Travis, W. D., Jett, J. R., Tazelaar, H., Pairolero, P., Trastek, V., Liotta, L. A., Harris, C. C. and Caporaso, N. E.: p53 mutation spectrum in relation to GSTM1, CYP1A1 and CYP2E1 in surgically treated patients with non-small cell lung cancer. Pharmacogenetics 8: 503-511, 1998.

317. Ambs, S., Bennett, W. P., Merriam, W. G., Ogunfusika, M. O., Oser, S. M., Harrington, A. M., Shields, P. G., Felley-Bosco, E., Hussain, S. P. and Harris, C. C.: Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer. J. Natl. Cancer Inst. 91: 86-88, 1999.

318. Jia, L., Wang, X. W. and Harris, C. C.: Hepatitis B virus X protein inhibits nucleotide excision repair. Int. J. Cancer 80: 875-879, 1999.

319. Zhou, X., Wang, X. W., Xu, L., Hagiwara, K., Nagashima, M., Wolkowicz, R., Zurer, I., Rotter, V. and Harris, C. C.: COOH-Terminal domain of p53 modulates p53-mediated transcriptional transactivation, cell growth and apoptosis. Cancer Res. 59: 843-848, 1999.

320. Walker, D. R., Bond, J. P., Tarone, R. E., Harris, C. C., Makalowski, W., Boguski, M. S. and Greenblatt, M. S.: Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features. Oncogene 18: 211-218, 1999.

321. Wang, X. W., Zhan, Q., Coursen, J. D., Khan, M. A., Kontny, H. U., Yu, L., Hollander, M. C., O’Connor, P. M., Fornace, Jr., A. J. and Harris, C. C.: GADD45 induction of a G2-M cell cycle checkpoint. Proc. Natl. Acad. Sci.USA 96: 3706-3711, 1999.

322. Xu, X., Weaver, Z., Linke, S. P., Li, C., Gotay, J., Wang, X. W., Harris, C. C., Ried, T. and Deng, C. X.: Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Molecular Cell 3: 389-395, 1999.

323. Zhan, Q., Antinore, M. J., Wang, X. W., Carrier, F., Smith, M. L., Harris, C. C. and Fornace, Jr., A. J.: Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene 18: 2892-2900, 1999.

324. Yoshikawa, H., Nagashima, M., Khan, M. A., McMenamin, M. G., Hagiwara, K. and Harris, C. C.: Mutational analysis of p73 and p53 in human cancer cell lines. Oncogene 18: 3415-3421, 1999.

325. Rusin, M., Butkiewicz, D., Malusecka, E., Zborek, A., Harasim, J., Czyzewski, K., Bennett, W. P., Shields, P. G., Weston, A., Welsh, J. A., Krzyzowska-Gruca, S., Chorazy, M. and Harris, C. C.: Molecular epidemiological study of non-small-cell lung cancer from an environmentally polluted region of Poland. Brit. J. Cancer 80: 1445-1452, 1999.

326. Spillare, E. A., Robles, A. I., Wang, X. W., Shen, J. C., Yu, C. E., Schellenberg, G. D. and Harris, C. C.: p53-mediated apoptosis is attenuated in Werner syndrome cells. Genes and Development 13: 1355-1360, 1999.

327. Robles, A. I., Wang, X. W. and Harris, C. C.: Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death. Oncogene 18: 4681-4688, 1999.

328. Rusin, M., Samogedny, A., Harris, C. C. and Chorazy, M.: Novel genetic polymorphisms in DNA repair genes: O(6)-methylguanine-DNA methyltransferease (MGMT) and N-methylpurine-DNA glycosylase (MPG) in lung cancer patients from Poland. Human Mut. 14: 269-270, 1999.

329. Butkiewicz, D., Cole, K. J., Phillips, D. H., Harris, C. C. and Chorazy, M.: GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms in lung cancer patients from an environmentally polluted region of Poland: correlation with lung DNA adduct levels. Eur. J. Cancer Prev. 8: 315-323, 1999.

330. Hagiwara, K., McMenamin, M. G., Miura, K. and Harris, C. C.: Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in the human cancer cell lines using intronic primers. Cancer Res. 59: 4165-4169, 1999.

331. Mazur, S. J., Sakaguchi, K., Appella, E., Wang, X. W., Harris, C. C. and Bohr, V. A.: Preferencial binding of tumor suppressor p53 to positively or negatively supercoiled DNA involves the C-terminal domain. J. Mol. Biol. 292: 241-249, 1999.

332. Bennett, W. P., Alavanja, M. C., (co-first authors), Blomeke, B., Vahakangas, K. H., Castren, K., Welsh, J. A., Bowman, E. D., Khan, M. A., Flieder, D. B. and Harris, C. C.: Environmental tobacco smoke and genetic susceptibility as lung cancer risk factors in never-smoking women. J. Natl. Cancer Inst. 91: 2009-2014, 1999.

333. Lebel, M., Spillare, E. A., Harris, C. C. and Leder, P. The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I. J. Biol. Chem. 274: 37795-37799, 1999.

334. Ambs, S. and Harris, C. C.: Response: Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer. J. Natl. Cancer Inst. 91: 1510-1511, 1999.

335. Hsia, C. C., Nakashima, Y., Thorgeirsson, S. S., Harris, C. C., Minemura, M., Momosaki, S., Wang, N. J. and Tabor, E.: Correlation of immunohistochemical staining and mutations of p53 in human hepatocellular carcinoma. Oncol. Rep. 7: 353-356, 2000.

336. Zhou, X., Espey, M. G., Chen, J. X., Hofseth, L.J., Miranda, K. M., Hussain, S. P., Wink, D. and Harris, C. C.: Inhibitory effects of nitric oxide and nitrosative stress on dopamine-β-hydroxylase. J. Biol. Chem. Vol. 275: 21241-21246, 2000.

337. Hussain, S. P., Amstad, P., Raja, K., Ambs, S., Nagashima, M., Bennett, W. P., Shields, P. G., Ham, A J., Swenberg, J. A., Marrogi, A. J. and Harris, C. C.: Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease. Cancer Res. 60: 3333-3337, 2000.

338. Marrogi, A. J., Pass, H. I., Khan, M., Metheny-Barlow, L. J., Harris, C. C., Gerwin, B. I.: Human mesothelioma samples overexpressed both COX2 and NOS2: In Vitro anti-proliferative effects of a COX-2 inhibitor. Cancer Res. 60: 3696-3700, 2000.

339. Galateau-Salle, F. B., Luna, R. E., Horiba, K., Sheppard, M. N., Hayashi, T., Fleming, M. V., Colby, T. V., Bennett, W., Harris, C. C., Stetler-Stevenson, W. G., Liotta, L., Ferrans, V. J. and Travis, W. D.: Matrix metalloproteinases and tissue inhibitors of metalloproteinases in bronchial squamous preinvasive lesions. Hum. Pathol. 31: 296-305, 2000.

340. Butkiewicz, D., Rusin, M., Harris, C. C. and Chorazy, M.: Identification of four single nucleotide polymorphisms in DNA repair genes: XPA and XPB (ERCC3) in Polish population. Human Mutat. 15: 577-578, 2000.

341. Bennett, W. P., Alavanja, M. C. and Harris, C. C.: Response: re: environmental tobacco smoke, genetic susceptibility and risk of lung cancer in never-smoking women. J. Natl. Cancer Inst. 92: 760-761, 2000.

342. Gemma, A., Seike, M., Seike, Y., Uematsu, K., Hibino, S., Kurimoto, F., Yoshimura, A., Shibya, M., Harris, C. C. and Kudoh, S.: Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer. Genes, Chromosome and Cancer 29: 213-218, 2000.

343. Hussain, S. P., Raja, K., Amstad, P. A., Sawyer, M., Trudel, L. J., Wogan, G. N., Hofseth, L. J., Shields, P. G., Billiar, T. R., Trautwein, C., Hohler, T., Galle, P. R., Phillips, D. H., Markin, R., Marrogi, A. J. and Harris, C. C.: Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: oxyradical overload diseases. Proc. Natl. Acad. Sci.USA 97: 12770-12775, 2000.

344. Marrogi, A. J., Travis, W. D., Welsh, J. A., Khan, M. A., Rahim, H., Tazelaar, H., Pairolero, P., Trastek, V., Jett, J., Caporaso, N. E., Liotta, L. A. and Harris, C. C.: NOS2, COX2 and VEGF in the angiogenesis of non-small cell lung carcinoma. Clin. Cancer Res. 6: 4739-4744, 2000.

345. Liu, J., Akoulitchev, S., Weber, A., Ge, H., Chuikov, S., Libutti, D., Wang, X. W., Conaway, J. W., Harris, C. C., Conaway, R. C., Reinberg, D. and Levens, D.: Defective interplay of activators and repressors with TFIIH in Xeroderma Pigmentosum. Cell 104: 353-363, 2001.

346. Butkiewicz, D., Rusin, M., Enewold, L., Shields, P. G., Chorazy, M. and Harris, C. C.: Genetic polymorphisms in DNA repair genes and risk of lung cancer. Carcinogeneis 22: 593-597, 2001.

347. Offer, H., Milyavsky, M., Erez, N., Matas, D., Zurer, I., Harris, C. C. and Rotter, V.: Structural and functional involvement of p53 in BER in vitro and in vivo. Oncogene 20: 581-589, 2001.

348. Yoshikawa, H., Matsubara, K., Qian, G. S., Jackson, P., Groopman, J. D., Manning, J. E., Harris, C. C. and Herman, J. G.: SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. Nature Genetics 28: 29-35, 2001.

349. Vahakangas, K. H., Bennett, W. P., (co-first authors), Castren, K., Welsh, J. A., Khan, M. A., Blomeke, B., Alavanja, M. and Harris, C. C.: TP53 and K-ras mutations in a lung cancer cohort of non-smoking women. Cancer Res. 61: 4350-4356, 2001.

350. Minamoto, T., Buschmann, T., Habelhah, H., Mutusevich, E., Tahara, H., Boerresen-Dale, A. L., Harris, C. C., Sidransky, D. and Ronai, Z.: Distinct pattern of p53 phosphorylation in human tumors. Oncogene 20: 3341-3347, 2001.

351. Huo, T. I., Wang, X. W., Forgues, M., Wu, C. G., Spillare, E. A., Giannini, C., Brechot, C. and Harris, C. C.: Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis. Oncogene 20: 3620-3628, 2001.

352. Nicholson, S. A., Okby, N. T., Khan, M. A., Welsh, J. A., McMenamin, M. G., Travis, W. D., Jett, J. R., Tazelaar, H. D., Trastek, V., Pairolero, P. C., Corn, P. G., Herman, J. G., Liotta, L. A., Caporaso, N. E. and Harris, C. C.: Alterations of p14ARF, p53 and p73 genes involved in the E2F-1-mediated apoptotic pathways in non-small cell lung carcinoma. Cancer Res. 61: 5636-5643, 2001.

353. Xu, X., Qiao, W., Linke, S. P., Li, W. M., Harris, C. C. and Deng, C. X.: Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle, genomic stability and tumorigenesis. Nature Genetics 28: 266-271, 2001.

354. Wang, X. W., Tseng, A., Ellis, N. A., Spillare, E. A., Linke, S. P., Robles, A. I., Seker, H., Yang, Q., Hu, P., Beresten, S., Bemmels, N. A., Garfield, S. and Harris, C. C.: Functional interaction of p53 and BLM DNA helicase in apoptosis. J. Biol. Chem. 276: 32948-32955, 2001.

355. Nagashima, M., Shiseki, M., Miura, K., Hagiwara, K., Linke, S. P., Peduex, R., Wang, X. W., Yokota, J., Riabowol, K. and Harris, C. C.: DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53. Proc. Natl. Acad. Sci. USA 98: 9671-9676, 2001.

356. Hussain, S. P., Amsted, P., Raja, K., Sawyer, M., Hofseth, L., Shields, P. G., Hewer, A., Phillips, D. H., Ryberg, D., Haugen, A. and Harris, C. C.: Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung. Cancer Res. 61: 6350-6355, 2001.

357. Robles, A. I., Bemmels, N. A., Foraker, A. B. and Harris, C. C.: APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis. Cancer Res. 61: 6660-6664, 2001.

358. Brosh, Jr., R. M., Karmakar, P., Sommers, J. A., Yang Q., Wang, X. W., Spillare, E. A., Harris, C. C. and Bohr, V. A.: p53 modulates the exonuclease activity of Werner syndrome. J. Biol. Chem. 276: 35093-35102, 2001.

359. Seker, H., Butkiewicz, D., Bowman, E. D., Rusin, M., Hedayati, M., Grossman, L. and Harris, C. C.: Functional significance of XPD polymorphic varients: Attenuated apoptosis in human lymphoblastoid cells with the XPD 312 Asp/Asp genotype. Cancer Res. 61: 7430-7434, 2001.

360. Marrogi, A. J., Khan, M. A. (first co-authors), van Gijssel, H. E., Welsh, J. A., Rahim, H., Demetris, A. J., Kowdley, K. V., Hussain, S. P., Nair, J., Bartsch, H., Okby, N., Poirier, M. C., Ishak, K. G. and Harris, C. C.: Oxidative stress and p53 mutations in the carcinogenesis of iron overload-associated hepatocellular carcinoma. J. Natl. Cancer Inst. 93: 1652-1655, 2001.

361. Miura, K., Bowman, E.D., Simon, R., Peng, A.C., Robles, A.I., Jones, R.T., Katagiri, T., He, P., Mizukami, H., Charboneau, L., Kikuchi, T., Liotta, L.A., Nakamura, Y. and Harris, C.C.: Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles. Cancer Res., 62: 3244-50, 2002.

362. Lechner, J. F., Wang, Y., Siddiq, F., Fugaro, J. M., Wali, A., Lonardo, F., Willey, J. C., Harris, C. C. and Pass, H. I.: Human lung cancer cells and tissues partially recapitulate the homeobox gene expression profile of embryonic lung. Lung Cancer 37: 41-47, 2002.

363. Gruber, S. B., Ellis, N. A., Rennert, G., Offit, K., Scott, K. K., Almog, R., Kolachana, P., Bonner, J. D., Kirchhoff, T., Tomsho, L. P., Nafa, K., Pierce, H., Low, M., Satagopan, J., Rennart, H., Huang, H., Greenson, J. K., Groden, J., Rapaport, B., Shia, J., Johnson, S., Gregersen, P. K., Harris, C. C. and Boyd, J.: BLM heterozygosity and the risk of colorectal cancer. Science 297: 2013, 2002.

364. Yang, Q., Zhang, R., Wang, X. W., Spillare, E. A., Linke, S. P., Subramanian, D., Griffith, J.D., Li, J.-L., Hickson, I. D., Shen, J. C., Kamath-Loeb, A., Loeb, L. A., Mazur, S. J., Appella, E., Brosh, Jr., R. M., Karmakar, P., Bohr, V. A. and Harris, C. C.: The processing of Holliday junctions by BLM and WRN helicases is regulated by p53. J. Biol. Chem., 277: 31980-31987, 2002.

365. Ming, L., Thorgeirsson, S. S., Gail, M. H., Lu, P., Harris, C. C., Wang, N., Shao, Y., Wu, Z., Liu G., Wang, X. and Sun Z.: Dominant role of hepatitis B virus and co-factor role of aflatoxin in hepatocarcinogenesis in Qidong, China. Hepatology, 36: 1214-1220, 2002.

366. Nagashima, M., Shiseki, M., Pedeux, R. M., Kitahama-Shiseki, M., Miura, K., Yokota, J. and Harris, C. C.: A novel PHD-finger motif protein, p47ING3, modulates p53-mediated transcription, cell cycle control and apoptosis. Oncogene, 22: 343-350, 2003.

367. West, K. A., Brognard, J., Clark, A. S., Linnoila, I. R., Yang, X., Swain, S. M., Harris, C. C., Belinsky, S. and Dennis, P. A.: Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J. Clin. Invest., 111: 81-90, 2003.

368. Hofseth, L. J., Saito, S., Hussain, S. P., Espey, M. G., Miranda, K. M., Araki, Y., Jhappan, C., Higashimoto, Y., He, P., Linke, S. P., Quezado, M.M., Zurer, I., Rotter, V., Wink, D. A., Appella, E. and Harris, C. C.: Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc. Natl. Acad. Sci. USA, 100: 143-148, 2003.

369. Araki, Y., Okamura, S., Hussain, S. P., Nagashima, M., He, P., Shiseki, M., Miura, K. and Harris, C. C.: Regulation of cyclooxygenase-2 expression by the Wnt and Ras pathways. Cancer Res., 63: 728-734, 2003.

370. Sengupta, S., Linke, S. P., Pedeux, R., Yang, Q., Farnsworth, J., Garfield, S. H., Valerie, K., Shay, J. W., Ellis, N. A., Wasylyk, B. and Harris, C. C.: BLM helicase-dependent transport of p53 to sites of stalled DNA repliction forks modulates homologous recombination. E.M.B.O. J., 22: 1210-1222, 2003.

371. Zheng, Y. L., Loffredo, C. A., Yu, Z., Jones, R. T., Krasna, M. J., Alberg, A. J., Yung, R., Perlmutter, D., Enewold, L., Harris, C. C. and Shields, P. G.: Bleomycin-induced chromosome breaks as a risk marker for lung cancer: A case-control study with population and hospital controls. Carcinogenesis, 24: 269-274, 2003.

372. Seker, H, Rubbi, C., Linke, S. P., Bowman, E. D., Garfield, S., Hansen, L., Borden, K. L. B., Milner, J. and Harris, C. C.: UV-C-induced DNA damage leads to p53-dependent nuclear trafficking of PML. Oncogene, 22: 1620-1628, 2003.

373. Shiseki, M., Nagashima, M., Pedeux, R.M., Kitahama-Shiseki, M., Miura, K., Okamura, S., Onogi, H., Higashimoto, Y., Appella, E., Yokota, J. and Harris, C.C.: p29ING4 and p28ING5 bind to p53 and p300 and enhance p53 activity. Cancer Res., 63: 2373-2378, 2003.

374. Linke, S. P., Sengupta, S., Khabie, N., Jeffries, B. A., Buchhop, S., Miska, S., Henning, W., Pedeux, R., Wang, X. W., Hofseth, L. J., Yang, Q., Garfield, S., Sturzbecher, H. W. and Harris, C. C.: p53 interacts with hRAD51 and hRAD54 and directly modulates homologous recombination. Cancer Res., 63: 2596-2605, 2003.

375. Kataoka, H., Bonnefin, P., Vieyra, D., Feng, X., Hara, Y., Miura, Y., Joh, T., Nakabayashi, H., Vaziri, H., Harris, C. C. and Raibowol, K.: ING1 represses transcription by direct DNA binding and through effects on p53. Cancer Res., 63: 5785-5792, 2003.

376. Milyavsky, M., Shats, I., Erez, N., Tang, X., Senderovich, S., Meerson, A., Tabach, Y., Goldfinger, N., Ginsberg, D., Harris, C.C. and Rotter, V.: Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype. Cancer Res. 63: 7147-7157, 2003.

377. Hofseth, L. J., Khan, M. A., Ambrose, M., Nikolayeva, O., Xu-Welliver, M., Kartalou, M., Hussain, S. P., Roth, R. B., Zhou, X., Mechanic, L. E., Zurer, I., Rotter, V., Samson, L. D. and Harris, C. C.: The adaptive imbalance in base excision repair enzymes generates microsatellite instability in chronic inflammation. J. Clin. Invest., 112: 1887-1894, 2003.

378. Zurer, I., Hofseth, L. J., Cohen, Y., Xu-Welliver, M., Hussain, S. P., Harris, C. C. and Rotter, V.: The role of p53 in base excision repair following genotoxic stress. Carcinogenesis, 25: 11-19, 2003.

379. West, K. A., Linnoila, I. R., Belinsky, S. A., Harris, C. C. and Dennis, P. A.: Tobacco carcinogen-induced cellular transformation increases activation of the PI3K/Akt pathway in vitro and in vivo. Cancer Res. 64: 446-451, 2004.

380. Hussain, S. P., Amstad, P., He, P., Robles, A., Lupold, S., Kaneko, I., Ichimiya, M., Sengupta, S., Mechanic, L., Okamura, S., Hofseth, L. J., Moake, M., Nagashima, M., Forrester, K. S. and Harris, C. C.: p53-induced up-regulation of MnSOD and GPX but not catalase increases oxidative stress and apoptosis. Cancer Res., 64: 2350-2356, 2004.

381. Li, C. Q., Robles, A. I., Hanigan, C. L., Hofseth, L. J., Trudel, L. J., Harris, C. C. and Wogan, G. N.: Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res., 64: 3022-3029, 2004.

382. Yang, Q., Zhang, R., Wang, X. W., Linke, S. P., Sengupta, S., Hickson, I. D., Pedrazzi, G., Perrera, C., Stagljar, I., Littman, S. J., Modrich, P. and Harris, C. C.: The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase. Oncogene, 23: 3749-3756, 2004.

383. Thomas, D. D., Espey, M. G., Ridnour, L. A., Hofseth, L. J., Mancardi, D., Harris, C. C. and Wink, D. A.: Hypoxic inducible factor 1α, extracellular signal-regulated kinase and p53 are regulated by distinct threshold concentrations of nitric oxide. Proc. Natl. Acad. Sci. USA, 101: 8894-8899, 2004.

384. De Sousa-Pinto, N. C., Harris, C. C. and Bohr, V. A.: p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria. Oncogene, 23: 6559-6568, 2004.

385. Sengupta, S., Robles, A. I., Linke, S. P., Sinogeeva, N. I., Zhang, R, Pedeux, R., Ward, I. M., Celeste, A., Nussenzweig, A., Chen, J., Halazonetis, T. D. and Harris, C. C.: Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated checkpoint pathway during S-phase arrest. J. Cell Biol., 166: 801-813, 2004.

386. Hussain, S. P., Trivers, G. E., Hofseth, L. J., He, P., Shaikh, I., Mechanic, L., Doja, S., Jiang, W., Subleski, J., Shorts, L., Haines, D., Laubach, V. E., Wiltrout, R. H., Djurickovic, D. and Harris, C. C.: Nitric oxide, a mediator of inflammation, suppresses tumorigenesis. Cancer Res., 64: 6849-6853, 2004.

387. He, P., Varticovski, L., Bowman, E. D., Fukuoka, J., Welsh, J. A., Miura, K., Jen, J., Gabrielson, E., Brambilla, E., Travis, W. D. and Harris, C. C.: Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray. Human Pathol. 35: 1196-1209, 2004.

388. Goodman, J. E., Bowman, E. D., Chanock, S. J., Alberg, A. J. and Harris, C. C.: Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. Carcinogenesis, 25: 2467-2472, 2004.

389. Yang, Q., Zheng, Y. L. and Harris, C. C.: POT1 and TRF2 cooperate to maintain telomeric integrity. Mol. Cell. Biol., 25: 1070-1080, 2005.

390. Burke, L., Flieder, D. B., Guinee, D. G., Brambilla, E., Freedman, A. N., Bennett, W. P., Jones, J. T., Borkowski, A., Caporaso, N. A., Fleming, M., Trastek, V. F., Pairolero, P. C., Tazelaar, H. D., Midthun, D. E., Jett, J. R., Liotta, L. A., Travis, W. D. and Harris, C. C.: Prognostic implications of molecular and immunohistochemical profiles of the Rb and p53 cell cycle regulatory pathways in primary non-small cell lung carcinoma. Clin. Cancer Res., 11: 232-241, 2005.

391. Sommers, J. A., Karmakar, P., Yang, Q., Kenny, M. K., Harris, C. C. and Brosh, Jr., R. M.: p53 modulates WRN helicase activity by RPA-dependent and independent mechanisms. Cancer Res., 65: 1223-1233, 2005.

392. Sengupta, S., Shimamoto, A., Koshiji, M., Pedeux, R., Rusin, M., Spillare, E. A., Shen, J. C., Huang, L. E., Lindor, N. M., Furuichi, Y. and Harris, C. C.: Tumor suppressor p53 represses transcription of RECQ4 helicase. Oncogene, 24: 1738-1748, 2005.

393. Mechanic, L. E., Marrogi, A. J., Welsh, J. A., Bowman, E. D., Khan, M. A., Enewold, L., Zheng, Y. L., Chanock, S., Shields, P. G. and Harris, C. C.: Polymorphisms in XPD and TP53 and mutation in human lung cancer. Carcinogenesis, 26: 597-604, 2005.

394. Yang, S. H., Mechanic, L. E., Yang, P., Landi, M. T., Bowman, E. D., Wampfler, J., Meerzaman, D., Hong, K., Mann, F., Dracheva, T., Fukuoka, J., Travis, W., Caporaso, N. E., Harris, C. C. and Jen, J.: Mutations in the tyrosine kinase domain of the epidermal growth factor receptor in non-small cell lung cancer. Clin. Cancer Res. 11: 2106-2110, 2005.

395. Marrogi, A. J., Mechanic, L. E., Welsh, J. A., Bowman, E. D., Khan, M. A., Enewold, L., Shields, P. G. and Harris, C. C.: TP53 mutation spectrum in lung cancer are not different in women and men. Cancer Epidemiol. Biomarkers and Prev. 14: 1031-1033, 2005.

396. Zhang, R., Sengupta, S., Yang, Q., Linke, S. P., Yanaihara, N., Bradsher, J., Blais, V., McGowan, C. H. and Harris, C. C.: BLM helicase facilitates Mus81 endonuclease activity in human cells. Cancer Res., 65: 2526-2531, 2005.

397. Milyavsky, M., Tabach, Y., Shats, I., Erez, N., Cohen, Y., Tang, X., Kalis, M., Kogan, R., Buganim, Y., Goldfinger, N., Ginsburg, D., Harris, C. C., Domany, E. and Rotter, V.: Transcriptional programs following genetic alterations in p53, INK4 and H-Ras genes along defined stages of malignant transformation. Cancer Res. 65: 4530-4543, 2005.

398. Ewart-Toland, A., Dai, Q., Gao, Y. T., Nagase, H., Dunlop, M. G., Farrington, S. M., Barnetson, R. A., Anton-Culver, H., Peel, D., Ziogas, A., Lin, D., Miao, X., Sun, T., Ostrander, E. A., Stanford, J. L., Langlois, M., Chan, J. M., Yuan, J., Harris, C. C., Bowman, E. D., Clayman, G. L., Lippman, S. M., Lee, J. J., Zheng, W. and Balmain, A.: Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis, 26: 1368-1373, 2005.

399. Pedeux, R., Sengupta, S., Shen, J. C., Demidov, O. N., Saito, S., Onogi, H., Kumamoto, K., Wincovitch, S., Garfield, S. H., McMenamin, M., Nagashima, M., Grossman, S. R., Appella, E. and Harris, C. C.: ING2 regulates onset of replicative senescence by induction of p300-dependent p53 acetylation. Molec and Cellular Biol., 25: 6639-6648, 2005.

400. Ying, L., Marino, J., Hussain, S. P., Khan, M. A., You, S., Hofseth, A. B., Trivers, G. E., Dixon, D. A., Harris, C. C. and Hofseth, L. J.: Chronic inflammation promotes retinoblastoma protein hyperphosphorylation and E2F1 activation. Cancer Res. 65: 9132-9136, 2005.

401. Zheng, Y. L., Loffredo, C. A., Alberg, A. J., Yu, Z., Jones, R. T., Perlmutter, D., Enewold, L., Krasna, M. J., Yung, R., Shields, P. G. and Harris, C. C.: Less efficient G2/M checkpoint is associated with an increased risk of lung cancer in African Americans. Cancer Res., 65: 9566-9573, 2005.

402. Staib, F., Robles, A. I., Varticovski, L., Wang, X. W., Zeeberg, B. R., Sirotin, M., Zhurkin, V. B., Hofseth, L. J., Hussain, S. P., Weinstein, J. N., Galle, P. R. and Harris, C. C.: The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammation stress. Cancer Res. 65: 10255-10264, 2005.

403. Hofseth, L. J., Robles, A. I., Espey, M. G. and Harris, C. C.: Nitric oxide is a signaling molecule that regulates gene expression. Methods Enzymol. 396: 326-340, 2005.

404. Spillare, E. A., Wang, X. W., von Kobbe, C., Bohr, V. A., Hickson, I. D. and Harris, C. C.: Redundancy of DMA helicases in p53-mediated apoptosis. Oncogene. 25: 2119-2123, 2006.

405. Volinia, S., Calin, G. A., Liu, C. G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., Prueitt, R. L., Yanaihara, N., Lanza, G., Scarpa, A., Vecchione, A., Negrini, M., Harris, C. C. and Croce, C. M.: A microRNA expression signature of human solid tumors defines cancer gene targets. Proc. Natl. Acad. Sci. USA , 103: 2257-2261, 2006.

406. Goodman, J. E., Mechanic, L. E., Luke, B. T., Ambs, S., Chanock, S. and Harris, C. C.: Exploring SNP-SNP interactions and colon cancer risk using polymorphism interaction analysis. Int.J.Cancer, 118: 1790-1797, 2006.

407. Yanaihara, N., Caplen, N., Bowman, E., Kumamoto, K., Yi, M., Stephens, R. M., Okamoto, A., Yokota, J., Tanaka, T., Calin, G. A., Liu, C.-G., Croce, C. M. and Harris, C. C.: microRNA expression signature predicts lung cancer diagnosis and prognosis. Cancer Cell 9: 189-198, 2006.

408. Okano, T., Gemma, A., Hosoya, Y., Hosomi, Y., Nara, M., Kokubo, Y., Yoshimura, A., Shibuya, M., Nagashima, M., Harris, C. C. and Kudoh, S.: Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer. Oncol. Rep. 15: 545-549, 2006.

409. Bonner, M. R., Bennett, W. P., Xiong, W., Lan, Q., Brownson, R. C., Harris, C. C., Field, R. W., Lubin, J. H. and Alavanja, M. C.: Radon, secondhand smoke, glutathione-S-transferase M1 and lung cancer among women. Int. J. Cancer, 119: 1462-1467, 2006.

410. Pine, S. R., Mechanic, L. E., Bowman, E. D., Welsh, J. A., Chanock, S. C., Shields, P. G. and Harris, C. C.: MDM2 SNP309 and SNP354 are not associated with lung cancer risk. Cancer Epidemiol. Biomarkers and Prev., 15: 1559-1561, 2006.

411. Hagiwara, N., Mechanic, L. E., Trivers, G. E., Cawley, H. L., Taga, M., Bowman, E. D., Kumamoto, K., He, P., Bernard, M., Doja, S., Miyashita, M., Tajiri, T., Sasajima, K., Nomura, T., Makino, H., Takahashi, K., Hussain, S. P. and Harris, C. C.: Quantitative detection of p53 mutations in plasma DNA from tobacco smokers. Cancer Res. 66: 8309-8317, 2006.

412. Thomas, D. D., Ridnour, L. A., Espey, M. G., Donzelli, S., Ambs, S., Hussain, S. P., Harris, C. C., DeGraff, W., Roberts, D. D., Mitchell, J. B. and Wink, D. A.: Superoxide fluxes limit nitric oxide-induced signalling. J. Biol. Chem. 281: 25984-25993, 2006.

413. Unoki, M., Shen, J. C., Zheng, Z. M. and Harris, C. C.: Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility. J. Biol. Chem., 281: 34677-34686, 2006.

414. Mechanic, L. E., Bowman, E. D., Welsh, J. A., Khan, M. A., Hagiwara, N., Enewold, L., Shields, P. G., Burdette, L., Chanock, S. and Harris, C. C.: Common genetic variation in TP53 is associated with lung cancer risk and prognosis in African Americans and somatic mutations in lung tumors. Cancer Epidemiol. Biomarkers Prev. 16: 214-222, 2007.

415. Koshiji, M., Kumamoto, K., Morimura, K., Utsumi, Y., Aizawa, M., Hoshino, M., Sekikawa, K., Takenoshita, S., Costa, M., Commes, T., Piquemal, D., Harris, C. C. and Tchou-Wong, K. M.: Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity. World J Gastroenterology 13: 2803-2810, 2007.

416. Shen, J. C., Unoki, M., Ythier, D., Dupperray A., Varticovski, L., Kumamoto, K., Pedeux, R. and Harris, C. C.: Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin α1. Cancer Res., 67: 2552-2558, 2007.

417. Budhu, A., Chen, Y., Kim, J., Forgues, M., Valerie, K., Harris, C. C. and Wang, X. W.: Induction of a unique gene expression profile in primary human hepatocytes by hepatitis C virus core, NS5A proteins. Carcinogenesis, 28: 1552-1560, 2007.

418. Vaitiekunaite, R., Butkiewicz, D., Krzesniak, M., Przybylek, M., Gryc, A., Snietura, M., Benedyk, M., Harris, C. C. and Rusin, M.: Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML proteins. Mech. Ageing and Dev., 128: 650-661, 2007.

419. Seike, M., Yanaihara, N., Bowman, E. D., Zanetti, K. A., Budhu, A., Kumamoto, K., Mechanic, L. E., Matsumoto, S., Yokota, J., Shibata, T., Sugimura, H., Gemma, A., Kudoh, S., Wang, X. W. and Harris, C. C.: Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier. J. N. C. I., 99: 1257-1269, 2007.

420. Pine, S. R., Mechanic, L. E., Ambs, S., Bowman, E. D., Chanock, S. J., Loffredo, C.., Shields, P. G. and Harris, C. C.: Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene. J. N. C. I., 99: 1401-1409, 2007.

421. Yoshikawa, H., Matsubara, K., Zhou, X., Okamura, S., Kubo, T., Murase, Y., Shikauchi, Y., Esteller, M., Herman, J. G., Wang, X. W. and Harris, C. C.: WNT10B functional dualism: beta-catenin/Tcf-dependent growth promotion or independent suppression with deregulated expression in cancer. Molec. Biol. Cell, 18: 4292-4303, 2007.

422. Yang, Q., Horikawa, I., Zhang, R., Afshar, Y., Kokko, A., Laiho, P., Aaltonen, L. A. and Harris, C. C.: Functional diversity of human POT1 isoforms in telomere protection and cellular senescence. Cancer Res., 67: 11677-11686, 2007.

423. Mechanic, L. E., Luke, B. T., Goodman, J. E., Chanock, S. J. and Harris, C. C.: Polymorphism interaction analysis (PIA): a method for investigating complex gene-gene interactions. BMC Bioinformatics, 9:146, 2008.

424. Thomas, D. D., Ridnour, L. A., Isenberg, J. S., Flores-Santana, W., Switzer, C. H., Donzelli, S., Hussain, P., Vecoli, C., Paolocci, N., Ambs, S., Colton, C. A., Harris, C. C., Roberts, D. D. and Wink, D. A.: The chemical biology of nitric oxide: Implications in cellular signaling. Free Radical Biol. & Medicine, 45: 18-31, 2008.

425. Kumamoto, K., Spillare, E. A., Fujita, K., Horikawa, I., Yamashita, T., Appella, E., Nagashima, M., Takenoshita, S., Yokota, J. and Harris, C. C.: Nutlin-3a activates p53 to both down-regulate ING2 and up-regulate mir-34a, b and c expression and induces senescence. Cancer Res., 68: 3193-3203, 2008.

426. Schetter, A. J., Leung, S. Y., Sohn, J. J., Zanetti, K. A., Bowman, E. D., Yanaihara, N., Yuen, S. T., Chan, T. L., Kwong, D.L.W., Au, G. K. H., Liu, C. G., Calin, G. A., Croce, C. M. and Harris, C. C.: MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA, 299: 425-436, 2008.

427. Martin, R. C., Barker, D. F., Doll, M. A., Pine, S. R., Mechanic, L., Bowman, E. D., Harris, C. C. and Hein, D. W.: Manganese superoxide dismutase gene coding region polymorphisms lack clinical incidence in general population. DNA Cell Biol., 27: 321-323, 2008.

428. Hussain, S. P., He, P., Subleski, J., Hofseth, L. J., Trivers, G. E., Mechanic, L., Hofseth, A. B., Bernard, M., Schwank, J., Nguyen, G., Mathe, E., Djurickovic, D., Haines, D., Weiss, J., Back, T., Gruys, E., Laubach, V. E., Wiltrout, R. H. and Harris, C. C.: Nitric oxide is a key component in inflammation-accelerated tumorigenesis. Cancer Res., 68: 7130-7136, 2008.

429. Amr, S., Wolpert, B., Loffredo, C. A., Zheng, Y. L., Shields, P. G., Jones, R. and Harris, C. C.: Occupation, gender, race, and lung cancer. JOEM, 50: 1167-1175, 2008.

430. Vanmeter, A. J., Rodriguez, A. S., Bowman, E. D., Harris, C. C., Deng, J., Calvert, V. S., Silvestri, A., Fredolini, C., Chandhoke, V., Petricoin, E. F., 3rd, Liotta, L. A. and Espina, V.: LCM and protein microarray analysis of human NSCLC: Differential EGFR phosphorylation events associated with mutated EGFR compared to wild type. Mol Cell Proteomics 7: 1902-1924, 2008.

431. Brosh, R., Shalgi, R., Liran, A., Landan, G., Korotayev, K., Nguyen, G. H., Enerly, E., Johnsen, H., Buganim, Y., Solomon, H., Goldstein, I., Madar, S., Goldfinger, N., Børresen-Dale, A. L., Ginsberg, D., Harris, C. C., Pilpel, Y., Oren, M. and Rotter, V.: p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation. Mol Syst Biol. 4: 229, 2008.

432. Unoki, M., Kumamoto, K., Robles, A. I., Shen, J. C., Zheng, Z. M. and Harris, C. C.: A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis. FEBS Letter 582: 3868-3874, 2008.

433. Enewold, L., Mechanic, L. E., Bowman, E. D., Zheng, Y. L., Yu, Z., Trivers, G., Alberg, A. J. and Harris, C. C.: Serum concentrations of cytokines and lung cancer survival in African Americans and Caucasians. CEBP 18: 215-222, 2009.

434. Zeng, S., Xiang, T., Pandita, T. K., Gonzalez-Suarez, I., Gonzalo, S., Harris, C. C. and Yang Q.: Telomere recombination requires the MUS81 endonuclease. Nat Cell Biol., 11: 616-623, 2009.

435. Hung, R. J., Christiani, D. C., Risch, A., Popanda, O., Haugen, A., Zienolddiny, S., Benhamou, S., Bouchardy, C., Lan, Q., Spitz, M. R., Wichmann, H. E., LeMarchand, L., Vineis, P., Matullo, G., Kiyohara, C., Zhang, Z. F., Pezeshki, B., Harris, C., Mechanic, L., Seow, A., Ng, D. P., Szeszenia-Dabrowska, N., Zaridze, D., Lissowska, J., Rudnai, P., Fabianova, E., Mates, D., Foretova, L., Janout, V., Bencko, V., Caporaso, N., Chen, C., Duell, E. J., Goodman, G., Field, J. K., Houlston, R. S., Hong, Y. C., Landi, M. T., Lazarus, P., Muscat, J., McLaughlin, J., Schwartz, A. G., Shen, H., Stucker, I., Tajima, K., Matsuo, K., Thun, M., Yang, P., Wiencke, J., Andrew, A. S., Monnier, S., Boffetta, P. and Brennan, P.: International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways. Cancer Epidemiol Biomarkers Prev., 17: 3081-3089, 2008.

436. Kumamoto, K., Fujita, K., Kurotani, R., Saito, M., Unoki, M., Hagiwara, N., Shiga, H., Bowman, E. D., Yanaihara, N., Okamura, S., Nagashima, M., Miyamoto, K., Takenoshita, S., Yokota, J. and Harris, C. C.: ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. Int. J. Cancer, 125: 1306-1315, 2009.

437. Seike, M., Goto, A., Okano, T., Bowman, E. D., Schetter, A. J., Horikawa, I., Mathe, E. A., Jen, J., Yang, P., Sugimura, H., Gemma, A., Kudoh, S., Croce, C. M. and Harris, C. C.: MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers. Proc Natl Acad Sci USA, 106: 12085-12090, 2009.

438. Simone, N. L., Soule, B. P., Ly, D., Saleh, A. D., Savage, J. E., Degraff, W., Cook, J., Harris, C. C., Gius, D. and Mitchell, J. B.: Ionizing radiation-induced oxidative stress alters miRNA expression. PLoS One, 4: e6377, 2009.

439. Schetter, A. J., Nguyen, G. H., Bowman, E. D., Mathe, E. A., Yuen, S. T., Hawkes, J. E., Croce, C. M., Leung, S. Y. and Harris, C. C.: Association of inflammation-related and microRNA gene expression with cancer specific mortality of colon adenocarcinoma. Clin Cancer Res, 15: 5878-5887, 2009.

440. Fujita, K., Mondal, A. M., Horikawa, I., Nguyen, G. H., Kumamoto, K., Sohn, J. J., Bowman, E. D., Mathe, E. A., Schetter, A. J., Pine, S. R., Ji, H., Vojtesek, B., Bourdon, J. C., Lane, D. P. and Harris, C. C.: p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence. Nat Cell Biol. 11: 1135-1142, 2009.

441. Schetter, A. J. and Harris, C.C.: Plasma microRNAs: a potential biomarker for colorectal cancer? Gut, 58: 1318-1319, 2009.

442. Rudin, C. M., Avila-Tang, E., Harris, C. C., Herman, J. G., Hirsch, F. R., Pao, W., Schwartz, A. G., Vahakangas, K. H. and Samet, J. M.: Lung cancer in never smokers: Molecular profiles and therapeutic implications. Clin Cancer Res., 15: 5646-5661, 2009.

443. Olivo-Marston, S. E., Hursting, S. D., Lavigne, J., Perkins, S. N., Maarouf, R. S., Yakar, S. and Harris, C. C.: Genetic reduction of circulating insulin-like growth factor-1 inhibits azoxymethane-induced colon tumorigenesis in mice. Mol Carcinog., 48: 1071-1076, 2009.

444. Mathe, E. A., Nguyen, G. H., Bowman, E. D., Zhao, Y., Budhu, A., Schetter, A. J., Braun, R., Reimers, M., Kumamoto, K., Hughes, D., Altorki, N. K., Casson, A. G., Liu, C. G., Wang, X. W., Yanaihara, N., Hagiwara, N., Dannenberg, A. J., Miyashita, M., Croce, C. M. and Harris, C. C.: MiRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus and associations with survival. Clin Cancer Res, 15: 6192-6200, 2009.

445. Jones, Jr., L. E., Ying, L., Hofseth, A. B., Jelezcova, E., Sobol, R. W., Ambs, S., Harris, C. C., Espey, M. G., Hofseth, L. J. and Wyatt, M. D.: Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase. Carcinogenesis 30: 2123-2139, 2009.

446. Binet, R., Ythier, D., Robles, A. I., Collado, M., Larrieu, D., Fonti, C., Brambilla, E., Brambilla, C., Serrano, M., Harris, C. C. and Pedeux, R.: WNT16B Is a New Marker of Cellular Senescence That Regulates p53 Activity and the Phosphoinositide 3-Kinase/AKT Pathway. Cancer Res., 69: 9183-9191, 2009.

447. Olivo-Marston, S. E., Yang, P., Mechanic, L. E., Bowman, E. D., Pine, S. R., Loffredo, C. A., Alberg, A. J., Caporaso, N., Shields, P. G., Chanock, S., Wu, Y., Jiang, R., Cunningham, J., Jen, J. and Harris, C. C.: Childhood exposure to secondhand smoke and functional mannose binding lectin polymorphisms are associated with increased lung cancer risk. Cancer Epidemiol Biomarkers Prev., 18: 3375-3383, 2009.

448. Jiang, W., Wang, X. W., Unger, T., Forgues, M., Kim, J. W., Hussain, S. P., Bowman, E., Spillare, E. A., Lipsky, M. M., Meck, J. M., Cavalli, L. R., Haddad, B. R and Harris, C. C.: Cooperation of tumor-derived HBx mutants and p53-249^ser mutant in regulating cell proliferation, anchorage-independent growth and aneuploidy in a telomerase-immortalized normal human hepatocyte-derived cell line. Int. J. Cancer, 127: 1011-1020, 2010.

449. Wang, X., Tian, X., Liu, F., Zhao, Y., Sun, M., Chen, D., Lu, C., Wang, Z., Shi, X., Zhang, Q., Zhang, D., Shen, Z., Li, F., Harris, C. C., Cai, H., Ke, Y.: Detection of HPV DNA in esophageal cancer specimens from different regions and ethnic groups: a descriptive study. BMC Cancer, 10: 19, 2010.

450. Li, Y., Sheu, C. C., Ye, Y., de Andrade, M., Wang, L., Chang, S. C., Aubry, M. C., Aakre, J. A., Allen, M. S., Chen, F., Cunningham, J. M., Deschamps, C., Jiang, R., Lin, J., Marks, R. S., Pankratz, V. S., Su, L., Li, Y., Sun, Z., Tang, H., Vasmatzis, G., Harris, C. C., Spitz, M. R., Jen, J., Wang, R., Zhang, Z. F., Christiani, D. C., Wu, X. and Yang, P.: Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. Lancet Oncol., 11: 321-330, 2010.

451. Volinia, S., Galasso, M., Costinean, S., Tagliavini, L., Gamberoni, G., Drusco, A., Marchesini, J., Mascellani, N., Sana, M. E., Abu Jarour, R., Desponts, C., Teitell, M., Baffa, R., Aqeilan, R., Iorio, M. V., Taccioli, C., Garzon, R., Di Leva, G., Fabbri, M., Catozzi, M., Previati, M., Ambs, S., Palumbo, T., Garofalo, M., Veronese, A., Bottoni, A., Gasparini, P., Harris, C. C., Visone, R., Pekarsky, Y., de la Chapelle, A., Bloomston, M., Dillhoff, M., Rassenti, L. Z., Kipps, T. J., Huebner, K., Pichiorri, F., Lenze, D., Cairo, S., Buendia, M. A., Pineau, P., Dejean, A., Zanesi, N., Rossi, S., Calin, G. A., Liu, C. G., Palatini, J., Negrini, M., Vecchione, A., Rosenberg, A. and Croce, C. M.: Reprogramming of miRNA networks in cancer and leukemia. Genome Res., 20: 589-599, 2010.

452. Meinhold, C. L., Berrington de González, A., Bowman, E. D., Brenner, A. V., Jones, R. T., Lacey, Jr., J. V., Loffredo, C. A., Perlmutter, D., Schonfeld, S. J., Trivers, G. E. and Harris, C. C.: Reproductive and hormonal factors and the risk of nonsmall cell lung cancer. Int J Cancer, 128:1404-1413, 2011.

453. Schwartz, A. G., Wenzlaff, A. S., Bock, C. H., Ruterbusch, J. J., Chen, W., Cote, M. L., Artis, A. S., Van Dyke, A. L., Land, S. J., Harris, C. C., Pine, S. R., Spitz, M. R., Amos, C. I., Levin, A. M. and McKeigue, P. M.: Admixture Mapping of Lung Cancer in 1812 African-Americans. Carcinogenesis, 32: 312-317, 2011.

454. Woo, H. G., Wang, X. W., Budhu, A., Kim, Y. H., Kwon, S. M., Tang, Z. Y., Sun, Z., Harris, C. C. and Thorgeirsson, S. S.: Association of TP53 Mutations with Stem Cell-Like Gene Expression and Survival of Patients with Hepatocellular Carcinoma. Gastroenterology, 140: 1063-1070.e8, 2011.

455. Voortman, J., Goto, A., Mendiboure, J., Sohn, J. J., Schetter, A. J., Saito, M., Dunant, A., Pham, T. C., Petrini, I., Lee, A., Khan, M. A., Hainaut, P., Pignon, J. P., Brambilla, E., Popper, H. H., Filipits, M., Harris, C. C. and Giaccone, G.: MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma. Cancer Res., 70: 8288-8298, 2010.

456. Saito, M., Kumamoto, K., Robles, A. I., Horikawa, I., Furusato, B., Okamura, S., Goto, A., Yamashita, T., Nagashima, M., Lee, T. L., Baxendale, V. J., Rennert, O. M., Takenoshita, S., Yokota, J., Sesterhenn, I. A., Trivers, G. E., Hussain, S. P. and Harris, C. C.: Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. PLos One, 5: e15541, 2010.

457. Nguyen, G. H., Schetter, A. J., Chou, D. B., Bowman, E. D., Zhao, R., Hawkes, J. E., Mathé, E. A., Kumamoto, K., Zhao, Y., Budhu, A., Hagiwara, N., Wang, X. W., Miyashita, M., Casson, A. G. and Harris, C. C.: Inflammatory and microRNA gene expression as prognostic classifier of Barrett's-associated esophageal adenocarcinoma. Clin. Cancer Res., 16: 5824-5834, 2010.

458. Olivo-Marston S. E., Mechanic. L. E., Mollerup, S., Bowman, E. D., Remaley, A. T., Forman, M. R., Skaug, V., Zheng, Y. L., Haugen, A. and Harris, C. C.: Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women. Carcinogenesis, 31: 1778-1786, 2010.

459. Weiss, J. M., Ridnour, L. A., Back, T., Hussain, S. P., He, P., Maciag, A. E., Keefer, L. K., Murphy, W. J., Harris, C. C., Wink, D. A. and Wiltrout, R. H.: Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy. J Exp Med., 207:2455-2467, 2010.

460. Pine, S. R., Ryan. B. M., Varticovski, L., Robles, A. I. And Harris, C. C.: Microenvironmental modulation of asymmetric cell division in human lung cacner cells. Proc Natl Acad Sci USA, 107: 2195-200, 2010.

461. Fujita, F., Horikawa, I., Mondal, A. M., Jenkins, L.M., Appella, E., Vojtesek, B., Bourdon, J. C., Lane, D. P. and Harris, C. C.: Positive feedback between p53 and TRF2 during telomere-dameage signalling and cellular senescence. Nat Cell Biol, 12: 1205-1212, 2010.

462. Au, A. Y., Hackl, T., Yeager, T. R., Cohen, S. B., Pass, H. I., Harris, C. C. and Reddel, R. R.: Telomerase activity in pleural malignant mesotheliomas. Lung Cancer, 2011 Jan 28. [Epub ahead of print]

463. Cheng, H., Zhang, L., Cogdell, D. E., Zheng, H., Schetter, A. J., Nykter, M., Harris, C. C., Chen, K., Hamilton, S. R. and Zhang, W.: Circulating Plasma MiR-141 Is a Novel Biomarker for Metastatic Colon Cancer and Predicts Poor Prognosis. PLos One, 6: e17745, 2011.

464. Saito, M., Schetter, A. J., Mollerup, S., Kohno, T., Skaug, V., Bowman, E. D., Mathe, E., Takenoshita, S., Yokota, J., Haugen, A. and Harris, C. C.: The association of microRNA expression with prognosis and progression in early stage, non small cell lung adenocarcinoma: a retrospective analysis of three cohorts. Clin Cancer Res., 17: 1875-1882, 2011.

465. Pine, S. R., Mechanic, L. E., Enewold, L., Chaturvedi, A. K., Katki, H. A., Zheng, Y. L., Bowman, E. D., Engels, E. A., Caporaso, N. E. and Harris, C. C: Increased levels of circulating interleukin-6, interleukin-8, C-reactive protein, and risk of lung cancer. J Natl Cancer Inst., 103: 1112-1122, 2011.

466. Tsuchiya, N., Izumiya, M., Ogata-Kawata, H., Okamoto, K., Fujiwara, Y., Nakai, M., Okabe, A., Schetter, A. J., Bowman, E. D., Midorikawa, Y., Sugiyama, Y., Aburatani, H., Harris, C. C. and Nakagama, H.: Tumor-suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21. Cancer Res., 71:4628-4639, 2011.

467. Hinch, A. G., Tandon, A., Patterson, N., Song, Y., Rohland, N., Palmer, C. D., Chen, G. K., Wang, K., Buxbaum, S. G., Akylbekova, E. L., Aldrich, M. C., Ambrosone, C. B., Amos, C., Bandera, E. V., Berndt, S. I., Bernstein, L., Blot, W. J., Bock, C. H., Boerwinkle, E., Cai, Q., Caporaso, N., Casey, G., Adrienne Cupples, L., Deming, S. L., Ryan Diver, W., Divers, J., Fornage, M., Gillanders, E. M., Glessner, J., Harris, C. C., Hu, J. J., Ingles, S. A., Isaacs, W., John, E. M., Linda Kao, W. H., Keating, B., Kittles, R. A., Kolonel, L. N., Larkin, E., Le Marchand, L., McNeill, L. H., Millikan, R. C., Murphy, Musani, S., Neslund-Dudas, C., Nyante, S., Papanicolaou, G. J., Press, M. F., Psaty, B. M., Reiner, A. P., Rich, S. S., Rodriguez-Gil, J. L., Rotter, J. I, Rybicki, B. A., Schwartz, A. G., Signorello, L. B., Spitz, M., Strom, S. S., Thun, M. J., Tucker, M. A., Wang, Z., Wiencke, J. K., Witte, J. S., Wrensch, M., Wu, X., Yamamura, Y., Zanetti, K. A., Zheng, W., Ziegler, R. G., Zhu, X., Redline, S., Hirschhorn, J. N., Henderson, B. E., Taylor Jr., H. A., Price, A. L., Hakonarson, H., Chanock, S. J., Haiman, C. A., Wilson, J. G., Reich, D. and Myers, S. R.: The landscape of recombination in African Americans. Nature. 2011 Jul 20. doi: 10.1038/nature10336. [Epub ahead of print].

468. Heegaard, N. H., Schetter, A. J., Welsh, J. A., Yoneda, M., Bowman, E. D. and Harris, C. C.: Circulating micro-RNA expression profiles in early stage nonsmall cell lung cancer. Int. J. Cancer, 130: 1378-1386, 2012.

469. Kohno, T., Ichikawa, H., Totoki, Y., Yasuda, K., Hiramoto, M., Nammo, T., Sakamoto, H., Tsuta, K., Furuta, K., Shimada, Y., Iwakawa, R., Ogiwara, H., Oike, T., Enari, M., Schetter, A. J., Okayama, H., Haugen, A., Skaug, V., Chiku, S., Yamanaka, I., Arai, Y., Watanabe, S., Sekine, I., Ogawa, S., Harris, C. C., Tsuda, H., Yoshida, T., Yokota, J., and Shibata, T.: KIF5B-RET fusions in lung adenocarcinoma. Nature Medicine, 18: 375-377, 2012.

470. Zanetti, K. A., Haznadar, M., Welsh, J. A., Robles, A. I., Ryan, B. M., McClary, A. C., Bowman, E. D., Goodman, J. E., Bernig, T., Chanock, S. J. and Harris, C. C.: 3’UTR and functional secretor haplotypes in mannose-binding lectin 2 are associated with increased colon cancer risk in African-Americans. Cancer Res., 72: 1467-77, 2012.

471. Coté, M. L., Liu, M., Bonassi, S., Neri, M., Schwartz, A. G., Christiani, D. C., Spitz, M. R., Muscat, J. E., Rennert, G., Aben, K. K., Andrew, A. S., Bencko, V., Bickeböller, H., Boffetta, P., Brennan, P., Brenner, H., Duell, E. J., Fabianova, E., Field, J. K., Foretova, L., Friis, S., Harris, C. C., Holcatova, I., Hong, Y. C., Isla, D., Janout, V., Kiemeney, L. A., Kiyohara, C., Lan, Q., Lazarus, P., Lissowska, J., Le Marchand, L., Mates, D., Matsuo, K., Mayordomo, J. I., McLaughlin, J. R., Morgenstern, H., Müeller, H., Orlow, I., Park, B. J., Pinchev, M., Raji, O.Y., Rennert, H. S., Rudnai, P., Seow, A., Stucker, I., Szeszenia-Dabrowska, N., Dawn Teare, M., Tjønnelan, A., Ugolini, D., van der Heijden, H. F., Wichmann, E., Wiencke, J. K., Woll, P. J., Yang, P., Zaridze, D., Zhang, Z. F., Etzel, C. J. and Hung, R. J.: Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium. Eur J Cancer, 48: 1957-1968, 2012.

472. Taga, M., Mechanic, L. E., Hagiwara, N., Vahakangas, K. H., Bennett, W. P., Alavanja, M. C., Welsh, J. A., Khan, M. A., Lee, A., Diasio, R., Edell, E., Bungum, A., Jang, J. S., Yang, P., Jen, J. and Harris, C. C.: EGFR somatic mutations in lung tumors: radon exposure and passive smoking in former- and never-smoking U.S. women. Cancer Epidemiol. Biomarkers Prev., 21: 988-992, 2012.

473. Jacobs, K. B., Yeager, M., Zhou, W., Wacholder, S., Wang, Z., Rodriguez-Santiago, B., Hutchinson, A., Deng, X., Liu, C., Horner, M. J., Cullen, M., Epstein, C. G., Burdett, L., Dean, M. C., Chatterjee, N., Sampson, J., Chung, C. C., Kovaks, J., Gapstur, S. M., Stevens, V. L., Teras, L. T., Gaudet, M. M., Albanes, D., Weinstein, S. J., Virtamo, J., Taylor, P. R., Freedman, N. D., Abnet, C. C., Goldstein, A. M., Hu, N., Yu, K., Yuan, J. M., Liao, L., Ding, T., Qiao, Y. L., Gao, Y. T., Koh, W. P., Xiang, Y. B., Tang, Z. Z., Fan, J. H., Aldrich, M. C., Amos, C., Blot, W. J., Bock, C. H., Gillanders, E. M., Harris, C. C., et al., Chanock, S. J.: Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genetics, 44: 651-658, 2012.

474. Schetter, A. J. and Harris, C. C.: Tumor Suppressor p53 (TP53) at the crossroads of the exposome and the cancer genome, Proc Natl Acad Sci USA, 109: 7955-7956, 2012.

475. Shaked, H., Hofseth, L. J., Chumanevich, A., Chumanevich, A. A., Wang, J., Wang, Y., Taniguchi, K., Guma, M., Shenouda, S., Clevers, H., Harris, C. C. and Karin, M.: Chronic epithelial NF-ΚB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proc Natl Acad Sci USA, 109: 14007-14012, 2012.

476. Jang, J. S., Jeon, H. S., Sun, Z., Aubry, M. C., Tang, H., Park, C. H., Pakhshan, F., Shultz, D. A., Kolbert, C. P., Lupu, R., Park, J. Y., Harris, C. C., Yang, P. and Jin, J.: Increased miR-708 expression in NSCLC and its association with poor survival in lung adenocarcinoma from never smokers. Clin.Cancer Res., 18: 3658-3667, 2012.

477. Ryan, B. M., McClary, A. C., Valeri, N., Robinson, D., Paone, A., Bowman, E. D., Robles, A. I., Croce, C. and Harris, C. C.: rs4919510 in has-mir-608 is associated with outcome but not risk of colorectal cancer. PLos One, 7: e36306.

478. Ryan, B. M., Calhoun, K. M., Pine, S. R., Bowman, E. D., Robles, A. I., Ambs, S. and Harris, C. C.: MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer. Int J Cancer, 131: 2710-2716, 2012.

479. Okayama, H., Saito, M., Oue, N., Weiss, J. M., Stauffer, J., Takenoshita, S., Wiltrout, R. H., Hussain, S. P. and Harris, C. C.: NOS2 enhances KRAS-induced lung carcinogenesis, inflammation and microRNA-21 expression. Int J Cancer. 132: 9-18, 2012.

480. Ryan, B. M., Robles, A. I. and Harris, C. C.: KRAS-LCS6 genotype as a prognostic marker in early-stage CRC--letter. Clin Cancer Res., 18: 3487-3488, 2012.

481. Tang, Y., Horikawa, I., Ajiro, M., Robles, A. I., Fujita, K., Mondal, A. M., Stauffer, J. K., Zheng, Z. M. and Harris, C. C.: Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence. Oncogene. 2012 July 9 [Epub ahead of print].

482. Gaedcke, J., Grade, M., Camps, J., Sokide, R., Kaczkowski, B., Schetter, A. J., Difilippantoio, M. J., Harris, C. C., Ghadimi, B. M., Moller, S., Beissbarth, T., Ried, T. and Litman, T.: The rectal cancer microRNAome – microRNA expression in rectal cancer and matched normal mucosa. Clin Cancer Res., 18: 4919-4930, 2012.

483. Sohn, J. J., Schetter, A. J., Yfantis, H. G., Ridnour, L. A., Khan, M. A., Robles, A. I., Hussain, S. P., Goto, A., Bowman, E. D., Hofseth, L. J., Bartkova, J., Bartek, J., Wogan, G. N., Wink, D. A. and Harris, C. C.: Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease. PLoS One, 7: e44156, 2012.

484. Weng, M. T., Lee, J. H., Wei, S. C., Li, Q., Shahamatdar, S., Hsu, D., Schetter, A. J., Swatkoski, S., Mannan, P., Garfield, S., Gucek, M., Kim, M. K. H., Annunziata, C. M., Creighton, C. J., Emanuele, M. J., Harris, C. C., Sheu, J. C., Giaccone, G. and Luo, J.: The evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells. Proc. Natl. Acad. Science, 109: E3659-67, 2012.

485. Zhao, Y., Schetter, A. J., Yang, G. B., Nguyen, G., Mathe, E. A., Li, P., Cai, H., Yu, L., Liu, F., Hang, D., Yang, H., Wang, X. W., Ke, Y. and Harris, C. C.: Inflammatory and microRNA gene expression as prognostic marker for overall survival in esophageal squamous cell carcinoma. Int J Cancer, 2012 Nov 23 [Epub ahead in print].

486. Cui, X., Witalison, E. E., Chumanevich, A. P., Chumanevich, A. A., Poudyal, D., Subramanian, V., Schetter, A. J., Harris, C. C., Thompson, P. R. and Hofseth, L. J.: The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest. PLoS One, 8: e53791, 2013.

487. Nguyen, G. H., Dexheimer, T. S., Rosenthal, A. S., Chu, W. K., Singh, D. K., Mosedale, G., Bachrati, C. Z., Schultz, L., Sakurai, M., Savitsky, P., Abu, M., McHugh, P. J., Bohr, V. A., Harris, C. C., Jadhav, A., Gileadi, O., Maloney, D. J., Simeonov, A. and Hickson, I. D.: A Small Molecule Inhibitor of the BLM Helicase Modulates Chromosome Stability in Human Cells. Chem Biol., 20: 55-62, 2013.

488. Okayama, H., Saito, M., Oue, N., Weiss, J. M., Stauffer, J., Takenoshita, S., Wiltrout, R. H., Hussain, S. P. and Harris, C. C.: NOS2 enhances KRAS-iduced lung carcinogenesis, inflammation and microRNA-21 expression. Int J. Cancer, 132: 9-18, 2013.

Reviews and Invited Reports in Journals

1. Harris, C.: Immunosuppressive anticancer drugs in man: Their oncogenic potential. Radiology ll4: 163-167, 1975.

2. Harris, C.: Cause and prevention of lung cancer. Semin. Oncol. 1: 163-167, 1974.

3. Harris, C.: The carcinogenicity of anticancer drugs: A hazard in man. Cancer 37: 1014-1023, 1976.

4. Harris, C.: Chemical carcinogenesis and experimental models using human tissues. Beitrage zur Pathologie 158: 389-404, 1976.

5. Harris, C. C., Saffiotti, U. and Trump, B. F.: Carcinogenesis studies in human cells and tissues. Cancer Res. 38: 474-475, 1978.

6. Harris, C. C.: A delayed complication of cancer therapy--cancer. J. Natl. Cancer Inst. 63: 275-278, 1979.

7. Trump, B. F. and Harris, C.C.: Human tissues in biomedical research. Human Pathology 10: 245-248, 1979.

8. Harris, C. C.: Individual differences in cancer susceptibility. Harris, C. C. (moderator). Ann. Intern. Med. 92: 809-825, 1980.

9. Yolken, R. H., Stopa, P. J. and Harris, C. C.: Enzyme immunoassay for the detection of rotavirus antigen and antibody. In Rose, N. R. and Freedman, H. (Eds.): Manual of Clinical Immunology, 2nd ed. Amer. Soc. for Microbiology, Washington, D.C., 1980, pp 692-699.

10. Harris, C. C., Trump, B. F., Grafstrom, R. and Autrup, H.: Differences in metabolism of chemical carcinogens in cultures human epithelial tissues and cells. J. Cell. Biochem. 18: 285-294, 1982.

11. Harris, C. C.: Carcinogenesis studies using cultured human tissues and cells. Cancer Res 43: 1880-1883, 1983.

12. Harris, C. C. and Trump, B. F.: Human tissues and cells in biomedical research. Surv. Synth. Path. Res. 1: 165-171, 1983.

13. Harris, C. C. and Suemasu, K.: Multiple primary neoplasms. Cancer Res. 43: 5629-5630, 1983.

14. Harris, C. C. and Sun, T. T.: Multifactoral etiology of human liver cancer. Carcinogenesis 5: 697-701, 1984.

15. Gabrielson, E. W. and Harris, C. C.: Use of cultured human tissues and cells in carcinogenesis research. J. Cancer Res. Clin. Oncol. 110: 1-10, 1985.

16. Harris, C. C.: Future directions for use of carcinogen-DNA adducts as internal dosimeters to monitor human exposure to mutagens and carcinogens. Environ. Health Perspect. 62: 185-192, 1985.

17. Vahakangas, K., Trivers, G., Rowe, M. and Harris, C.C.: Benzo(a)pyrene diol epoxide-DNA adducts detected by synchronous fluorescence spectro-photometery. Environ. Health Perspect. 62: 101-104, 1985.

18. Autrup, H., Wakhisi, J., Vahakangas, K., Wasunna, O. A. and Harris, C. C.: Detection of 8, 9-dihydro-(71guanyl)-9-hydroxyaflatoxin B1 in human urine. Environ. Health Perspect. 62: 105-109, 1985.

19. Harris, C. C.: Tobacco smoke, lung disease: Who is susceptible?  Ann. Int. Med. 105: 607-609, 1986.

20. Autrup, H., Grafstrom, R., Vahakangas, K. and Harris, C. C.: Inter-individual variations in carcinogen metabolism. Arch. Toxicol., Suppl. 9: 147-153, 1986.

21. Harris, C. C. and Sun, T. T.: Interactive effects of chemical carcinogens and hepatitis B virus in the pathogenesis of human hepatocellular carcinoma. Cancer Survey 5: 765-780, 1986.

22. Harris, C. C.: Human tissues and cells in carcinogenesis research. Cancer Res. 47: 1-10, 1987.

23. Brash, D. E., Mark, G. E., Farrell, M. P. and Harris, C. C.: Overview of human cells in genetic research: Altered phenotypes in human cells caused by transferred genes. Somatic Cell Mol. Genet. 13: 429-440, 1987.

24. Harris, C. C., Weston, A., Willey, J. C., Trivers, G. E. and Mann, D. L.: Biochemical and molecular epidemiology of human cancer: Indicators of carcinogen exposure, DNA damage and genetic predisposition. Environ. Health Perspect. 75: 109-119, 1987.

25. Miyashita, M., Sasajima, K., Matsukura, N., Masui, T., Lechner, J. F. and Harris, C. C.: Cultured human bronchial epithelial cells and in vitro carcinogenesis study. Respir. Res. 7: 1152-1156, 1988.

26. Pfeifer, A. M. A., Lechner, J. F., Masui, T., Reddel, R. R., Mark, G. E. and Harris, C. C.: Control of growth and squamous differentiation in normal human bronchial epithelial cells by chemical and biological modifiers and transferred genes. Environ. Health Perspect. 80: 209-220, 1989.

27. Harris, C. C., Lechner, J., Grafstrom, R., Miyashita, M., Willey, J. and Trump, B. F.: In vitro models using human epithelial cells in toxicology. In Vitro Toxicol. 2: 183-196, 1988/89.

28. Harris, C. C.: Interindividual variation among humans in carcinogen metabolism, DNA adduct formation and DNA repair. Carcinogenesis 10: 1563-1566, 1989.

29. Weston, A., Manchester, D. K., Povey, A. and Harris, C. C.: Detection of carcinogen-macromolecular adducts in humans. J. Am. Coll. Toxicol. 8: 913-932, 1989.

30. Shields, P. G. and Harris, C. C.: Environmental causes of cancer. Med. Clin. North Am. 74: 263-277, 1990.

31. Suemasu, K., Fortner, J. G., Harris, C. C., Hasegawa, H., Hirohashi, S., Shimosato, Y. and Sugimura, T.: Symposium on fundamental and clinical research in liver cancer. Jpn. J. Clin. Oncol. 20: 110-112, 1990.

32. Willey, J. C. and Harris, C. C.: Cellular and molecular biological aspects of human bronchogenic carcinogenesis. CRC Crit. Rev. Hematol/Oncol. 10: 181-209, 1990.

33. Watanabe, S. and Harris, C. C.: Multiple primary cancer: the U.S.-Japan cooperative cancer research program. Jpn. J. Cancer Res. 81: 201-205, 1990.

34. Harris, C. C.: Hepatocellular carcinogenesis: recent advances and speculations. Cancer Cells 2: 146-148, 1990.

35. Benedict, W. F., Harris, C. C., Fujiki, H. and Toyoshima, K.: U.S.-Japan seminar on "Molecular mechanisms of initiation, promotion and progression." Cancer Res. 50: 7085-7088, 1990.

36. Suemasu, K., Harris, C. C., Melamed, M. R., Shimosato, Y., Watanabe, S., Mukai, K. and Sugimura, T.: Report of the meeting on fundamental and clinical research in multiple primary cancer. Jpn. J. Clin. Oncol. 20: 436-440, 1990.

37. Iman, D. S. and Harris, C. C.: Oncogenes and tumor suppressor genes in human lung carcinogenesis. CRC Crit. Rev. Oncogenesis 2: 161-171, 1991.

38. Harris, C. C.: Chemical and physical carcinogenesis: advances and perspectives for the 1990s. Cancer Res. 51: 5023s-5044s, 1991.

39. Shields, P. G. and Harris, C. C.: Molecular epidemiology and the genetics of environmental cancer. JAMA 266: 681-687, 1991.

40. Lehman, T. A., Reddel, R. R., Pfeifer, A. M. A., Spillare, E., Kaighn, M. E., Weston, A., Gerwin, B. I. and Harris, C. C.: Oncogenes and tumor suppressor genes. Environ. Health Perspect. 93: 133-144, 1991.

41. Bennett, W. P., Hollstein, M. C., Hsu, I. C., Sidransky, D., Lane, D. P., Vogelstein, B. and Harris, C. C.: Mutational spectra and immunohistochemical analyses of p53 in human cancers. Chest 101:19S-20S, 1992.

42. Harris, C. C., Hirohashi, S. Ito, N., Pitot, H.C., Sugimura, T., Terada, Masaaki, Yokota, Y.: Multistage Carcinogenesis: The 22nd international symposium of the Princess Takamatsu Cancer Research Fund. Cancer Res. 52: 4837-4840, 1992.

43. Harris, C. C. and Hollstein, M.: P.P.O. Updates: p53 tumor suppressor gene. Update: Cancer Principles and Practice of Oncology 6: 1-12, 1992.

44. Harris, C. C. and Hirohashi, S.: U.S.-Japan seminar on "genomic instability during carcinogenesis and tumor progression. Jpn. J. Cancer Res. 83: 1108-1111, 1992.

45. Weston, A., Caporaso, N. E., Perrin, L. S., Sugimura, H., Tamai, S., Krontiris, T. G., Trump, B. F., Hoover, R. N. and Harris, C. C.: Relationship of H-ras-1, L-myc and p53 polymorphisms with lung cancer risk and prognosis. Environ. Health. Perspect. 98: 61-67, 1992.

46. Shields, P. G., Sugimura, H., Caporaso, N. E., Petruzzelli, S. F., Bowman, E. D., Trump, B. F., Weston, A. and Harris, C. C.: Polycyclic aromatic hydrocarbon-DNA adducts and the CYP1A1 RFLP. Environ. Health Prospectives 98: 191-194, 1992.

47. Tennant, R. W., Harris, C. C., Kaufman, D. G., Nesnow, S., Slaga, T. J., Stevenson, D. E. and Trump, B. F.: Sixth Aspen Cancer Conference: molecular mechanisms of genetic deregulation in toxicity and carcinogenesis. Mol. Carcinog. 7: 67-72, 1993.

48. Harris, C. C., Suemasu, K., Skinner, D. B., Watanabe, H. and Kakizoe, T.: Report of the Sixth International Symposium of the Foundation for the Promotion of Cancer Research: Fundamental and Clinical Research in Esophageal Cancer. Jpn. J. Clin. Oncol. 23: 263-272, 1993.

49. Harris, C. C.: Multistep Carcinogenesis. Jpn. J. Cancer Res. 84: 1330-1331, 1993.

50. Lehman, T. A., Greenblatt, M. Bennett, W. P. and Harris, C. C.: Mutational spectrum of the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Drug Metabol Rev. 26: 221-235, 1994.

51. Harris, C. C.: Solving the viral-chemical puzzle of human liver carcinogenesis. Editorial: Cancer Epidemiol. Biomarkers Prev. 3: 1-2, 1994.

52. Burger, M. M. and Harris, C. C.: UICC study group on basic and clinical cancer research: apoptosis in normal and tumor cells. Int. J. Cancer 60: 590-592, 1995.

53. Harris, C. C.: The 1995 Walter Hubert Lecture - molecular epidemiology of human cancer: insights from the mutational analysis of the p53 tumour-suppressor gene. Brit. J. Cancer 73: 261-269, 1996.

54. Harris, C. C.: Editorial. Molecular epidemiology of basal cell carcinoma. J. Natl. Cancer Inst. 88: 315-317, 1996.

55. Harris, C. C.: p53 Tumor suppressor gene: from the basic research laboratory to the clinic--an abridged historical perspective. Carcinogenesis 17: 1187-1198, 1996.

56. De Benedetti, V., Bennett, W. P., Greenblatt, M. S. and Harris, C. C.: p53 tumor suppressor gene: implications for iatrogenic cancer and cancer therapy. Medical and Pediatric Oncol. Suppl. 1: 2-11, 1996.

57. Harris, C. C.: 1995 Deichmann Lecture: p53 Tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology and cancer risk assessment. Toxicol. Let. 82/83: 1-7, 1996.

58. Harris, C. C.: Tumor suppressor genes: at the crossroads of molecular carcinogenesis, molecular epidemiology and human risk assessment. Prev. Med. 25: 10-12, 1996.

59. Harris, C. C.: p53 Tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology and cancer risk assessment. Environ. Health Perspect. 104: 435-439, 1996.

60. Harris, C. C.: Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies. J.Natl.Cancer Inst. 88: 1442-1455, 1996.

61. Harris, C. C.: p53: At the crossroads of molecular carcinogenesis and molecular epidemiology. J. Invest. Dermatol Sympos. Proc. 1: 115-118, 1996.

62. Bunn, P., Carbone, D., Grim, J., Harris, C., Havemann, K., Mabry, M., Roth, J., Saijo, N., Poulen, H. S., Stahel, R., Takahashi, T. and Twentyman, P.: 5th I.A.S.L.C. Lung Tumor Biology Workshop, August 13-17, 1996, Ermatingen, Switzerland. Lung Cancer 16: 239-257, 1997.

63. Wang, X. W. and Harris, C. C.: p53 tumor-suppressor gene: clues to molecular carcinogenesis. J. Cellul. Physiol. 173: 247-255, 1997.

64. Hainaut, P., Hernandez, T., Robinson, A., Rodriguez-Tome, P., Flores, T., Hollstein, M., Harris, C. C. and Montesano, R.: IARC database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualization tools. Nucl. Acids Res. 26: 205-213, 1998.

65. Nesnow, S., Harris, C. C., Trump, B. F., Mendelsohn, M. L., Dellarco, V., Gilmer, T. M., Cavanee, W. and Tennant, R.: Twelfth Aspen cancer conference: mechanisms of toxicity and carcinogenesis. Mol. Carcinogen. 22: 1-8, 1998.

66. Harris, C. C.: The p53 tumor suppressor gene as a target for new anticancer therapies. Adv. in Oncol. 14: 3-10, 1998.

67. Hussain, S. P. and Harris, C. C.: Molecular epidemiology of human cancer. ICT Proceedings, Toxicology Let. 102-103: 219-225, 1998.

68. Haugen, A. and Harris, C. C.: Meeting Report: Clinical implications of molecular epidemiology of human lung cancer. Lung Cancer 22: 255-263, 1998.

69. Bennett, W. P., Hussain, S. P., Vahakangas, K. H., Khan, M. A., Shields, P. G. and Harris, C. C.: Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer. J. of Pathol. 187: 8-18, 1999.

70. Hussain, S. P. and Harris, C. C: p53 mutation spectrum and load: The generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer. Mutation Res. 428: 23-32, 1999.

71. Ambs, S., Hussain, S. P., Marrogi, A. J. and Harris, C. C.: Chapter VII, mutagenesis and carcinogenesis: Cancer-prone oxyradical overload disease. In Singer, B. and Hartsch, H. (Eds): Exocyclic DNA Adducts in Mutagenesis and Carcinogenesis. IARC Sci. Publ. 150: 295-302, 1999.

72. Nesnow, S., Cavenee, W., Gilmer, T. M., Kaufman, D. G., Slaga, T. J., Hohman, R., Bishop, J. M., Poirier, M. C., Harris, C. C., Trump, B. F., Yuspa, S. H., Pfeifer, A. M., Sherman, M. I. and Tennant, R.: Thirteenth Aspen Cancer Conference: workshop on mechanisms of toxicity and carcinogenesis. Mol. Carcinog. 25: 99-106, 1999.

73. Hussain, S. P. and Harris, C. C.: Molecular epidemiology and carcinogenesis: endogenous and exogenous carcinogens. Montesano Tribute. Mutation Res. 462: 311-322, 2000.

74. Balmain, A. and Harris, C. C.: Carcinogenesis in mouse and human cells: Parallels and paradoxes. Carcinogenesis 21: 371-377, 2000.

75. Barrett, J. C., Bishop, J. M., DeGeorge, J. J., DuBois, R. N., Harris, C. C., Varmus, H., Wood, A., Yuspa, S. H. and Tennant, R. W.: Meeting Report. Fourteenth Aspen Cancer Conference: Mechanisms of toxicity, carcinogenesis and cancer prevention. Molecular Carcinogenesis 27: 259-267, 2000.

76. Shields, P. G. and Harris, C. C.: Cancer risk and low-penetrance susceptibility genes in gene-environment interactions. J. Clin. Oncol. 18: 2309-2315, 2000.

77. Hussain, S. P., Hollstein, M. H. and Harris, C. C.: p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology and human cancer risk assessment. Ann. New York Acad. of Sci. 919: 79-85, 2000.

78. Sander, M., Trump, B. F., Harris, C. C. and Tennant, R. W.: Meeting Report. Fifteenth Aspen Cancer Conference: Mechanisms of toxicity, carcinogenesis and cancer prevention. Molecular Carcinogenesis 30: 14-25, 2001.

79. Lechner, J. F., Fugaro, J. M., Wong, Y., Pass, H. I., Harris, C. C. and Belinsky, S. A.: Perspective: cell differentiation theory may advance early detection of and therapy for lung cancer. Radiat. Res. 155: 235-238, 2001.

80. Harris, C. C.: Tobacco smoking and cancer risk in women. J. Women's Cancer 3: 1-4, 2001.

81. Robles, A. I. and Harris, C. C.: p53-mediated apoptosis and genomic instability diseases. Nobel Conference 2000 Proceedings. Suppl. Acta Oncologica 40: 696-701, 2001.

82. Hussain, S. P., Hofseth, L. J. and Harris, C. C.: Tumor suppressor genes: at the crossroads of molecular carcinogenesis, molecular epidemiology and human risk assessment. Lung Cancer 34: S7-S15, 2001.

83. Sander, M., Trump, B. F., Harris, C. C. and Tennant, R. W.: Sixteenth Aspen Cancer Conference: Mechanisms of Carcinogenesis, Cancer Prevention and Cancer Therapy. Mol. Carcinog. 33: 67-80, 2002.

84. Oliver, M., Eeles, R., Hollstein, M., Khan, M. A., Harris, C. C. and Hainaut, P.: The IARC TP53 Database: new online mutation analysis and recommendations to users. Mutation Res., 19: 607-614, 2002.

85. Zheng, Y. L., Seker, H., Butkiewicz, D., Rusin, M., Bowman, E. D., Hussain, S. P. and Harris, C. C.: Gene-environment interactions in lung carcinogenesis: A brief review. In Heinrich, U. and Mohr, U. (Eds-in-Chief): Crucial Issues in Inhalation Research - Mechanistic, Clinical and Epidemiologic. 8th International Inhalation Symposium. INIS Monographs, 23-38, 2002.

86. Robles, A. I., Linke, S. P. and Harris, C. C.: The p53 network in lung carcinogenesis. Oncogene, 21: 6898-6907, 2002.

87. Wang, X. W., Hussain, S. P., Huo, T. I., Wu, C. G., Forgues, M., Hofseth, L. J., Brechot, C. and Harris, C. C.: Molecular pathogenesis of human hepatocellular carcinoma. Toxicology, 181-182: 43-47, 2002.

88. Staib, F., Hussain, S. P., Hofseth, L. J., Wang, X. W. and Harris, C. C.: TP53 and liver carcinogenesis. Human Mutation, 21: 201-216, 2003.

89. Sander, M., Trump, B. F., Harris, C. C. and Tennant, R. W.: Seventeenth Aspen Cancer Conference: Mechanisms of toxicity, carcinogenesis, cancer prevention and cancer therapy. Meeting Report. Mol. Carcinog., 36: 101-114, 2003.

90. Hussain, S. P., Hofseth, L. J. and Harris, C. C.: Radical causes of cancer. Nature Reviews: Cancer, 3: 276-285, 2003.

91. Hofseth, L. J., Hussain, S. P., Wogan, G. N. and Harris, C. C.: Nitric oxide in cancer and chemoprevention. Free Radical Biol. and Med., 34: 955-968, 2003.

92. Harris, C. C.: Pathogenesis of respiratory diseases: new solutions to old problems? Exp. Lung Res., 29 Suppl 3-92, 2003.

93. Harris, C. C.: The end game. Toxicol. Pathol., 31: 144-145, 2003.

94. Hofseth, L. J., Hussain, S. P. and Harris, C. C.: p53: 25 years after its discovery. Trends in Pharmacol. Sci., 25: 177-181, 2004.

95. Hofseth, L. J., Robles, A. I., Yang, Q., Wang, X. W., Hussain, S. P. and Harris, C. C.: p53: At the crossroads of molecular carcinogenesis and molecular epidemiology. Chest, 125: 83S-85S, 2004.

96. Goodman, J. E., Hofseth, L. J., Hussain, S. P. and Harris, C. C.: Nitric oxide and p53 in cancer-prone chronic inflammation and oxyradical overload disease. Environ Mol Mutagen. 44: 3-9, 2004.

97. Veigl, M. L. and Harris, C. C.: Introduction to a special section: Impact of the environment on colon cancer. Environ Mol Mutagen. 44: 1-2, 2004.

98. Sengupta, S. and Harris C. C.: p53: Traffic Cop at the Crossroads of DNA Repair and Recombination. Nature Reviews: Mol. Cell Biol., 6: 44-55, 2005.

99. Harris, C. C.: Editorial. Carcinogenesis, 26: 261, 2005.

100. Harris, C. C.: Editorial. Carcinogenesis, 27: 177, 2006.

101. Harris, C. C.: Protein-protein interactions for cancer therapy. Proc. Natl. Acad. Sci. USA, 103: 1659-1660, 2006.

102. Hussain, S. P. and Harris, C. C.: p53 biological network: at the crossroads of the cellular-stress response pathway and molecular carcinogenesis. J Nippon Med Sch, 73: 54-64, 2006.

103. Nakachi, K., Harris, C. C. and Tahara, E.: Japan-U.S. cooperative cancer research seminar on molecular epidemiological characteristics of lung and colon cancer development among atomic bomb survivors. Cancer Sci., 97: 1279-1282, 2006.

104. Harris, C. C.: Editorial. Carcinogenesis, 28: 1, 2007.

105. Hussain, S. P., Schwank, J., Staib, F., Wang, X. W. and Harris, C. C.: TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene, 26: 2166-2176, 2007.

106. Sander, M., Trump, B. F. and Harris, C. C.: The twenty-first Aspen Cancer Conference: Mechanisms of toxicity, carcinogenesis, cancer prevention and cancer therapy, 2006. Mol. Carcinogenesis, 46: 415-435, 2007.

107. Hussain, S. P. and Harris, C. C.: Inflammation and cancer: An ancient link with novel potentials. Int. J. Cancer, 121: 2373-2380, 2007.

108. Harris, C. C.: Editorial. Carcinogenesis, 29: 1, 2008.

109. Sander, M., Trump, B. F., Harris, C. C. and Tennant, R. W.: The 20th Aspen cancer conference: mechanisms of toxicity, carcinogenesis, cancer prevention and cancer therapy, 2005. Mol. Carcinogenesis, 47: 707-732, 2008.

110. Sander, M., Slaga, T. J., Trump, B. F. and Harris, C. C.: The twenty-second Aspen cancer conference: mechanisms of toxicity, carcinogenesis, cancer prevention and cancer therapy, 2007. Mol. Carcinogenesis, 47: 554-571, 2008.

111. Wink, D. A., Ridnour, L. A., Hussain, S. P. and Harris, C. C.: The reemergence of nitric oxide and cancer. Nitric Oxide, 19: 65-67, 2008.

112. Loeb, L. A. and Harris, C. C.: Advances in chemical carcinogenesis: a historical review and prospective. Cancer Res., 68: 6863-6872, 2008.

113. Ellis, N. A., Sander, M., Harris, C. C. and Bohr, V. A.: Bloom's syndrome workshop focuses on the functional specificities of RecQ helicases. Mech. Ageing Dev., 129: 681-691, 2008.

114. Sander, M., Trump, B. F. and Harris, C. C.: The 23rd Aspen cancer conference: mechanisms of toxicity, carcinogenesis, cancer prevention and cancer therapy, 2008. Mol. Carcinogenesis, 48: 465-478, 2009.

115. Unoko, M., Kumamoto, K., Takenoshita, S., Harris, C. C.: Reviewing the current classification of inhibitor of growth family proteins. Cancer Science, 100: 1173-1179, 2009.

116. Unoki, M., Kumamoto, K. and Harris, C. C.: ING proteins as potential drug targets. Curr. Drug Targets, 10: 442-454, 2009.

117. Schetter, A. J., Heegaard, N. H. and Harris, C. C.: Inflammation and Cancer: Interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis 31: 37-49, 2009.

118. Sander, M., Slaga, T. J. and Harris, C. C.: The 24th Aspen Cancer Conference: Mechanisms of toxicity, carcinogenesis, cancer prevention and cancer therapy 2009. Mol. Carcinogenesis, 49:410-428, 2010.

119. Robles, A. I. and Harris, C. C.: Clinical outcomes and correlates of TP53 mutations and cancer. Cold Spring Harbor Perspect. Biol. 2: a001016, 2010.

120. Tahara, E., Yasui, W., Ito, H. and Harris, C. C.: Recent progress in carcinogenesis, progression and therapy of lung cancer: the 19th Hiroshima Cancer Seminar: the 3rd Three Universities' Consortium International Symposium, November 2009. Jap J Clin Oncol., 40: 702-708, 2010.

121. Ryan, B. M., Robles, A. I. and Harris, C. C.: Genetic variation in microRNA networks: the implications for cancer research. Nat Rev Cancer, 10: 389-402, 2010.

122. Horikawa, I., Fujita, K. and Harris, C. C.: p53 governs telomere regulation feedback too, via TRF2. Aging (Albany, NY), 3: 26-32, 2011.

123. Zhao, X., Elmore, L. W., Harris, C. C. and Wang, X. W.: Hepatocellular Carcinoma. Encyclopedia of Life Sciences, 1-7, 2011.

124. Schetter, A. J., Okayama, H. and Harris, C. C.: The role of microRNAs in colorectal cancer. The Cancer Journal: The Journal of Principles & Practice of Oncology, 18: 244-252, 2012.

Books

1. Harris, C. (Ed.): Pathogenesis and Therapy of Lung Cancer. New York, M. Dekker, Inc., l978.

2. Harris, C. C., Trump, B. F. and Stoner, G. D. (Eds.): Cultured Normal Human Tissues and Cells. vol. 21A, in the series "Methods in Cell Biology." New York, Academic Press, l980.

3. Harris, C. C., Trump, B. F. and Stoner, G. D. (Eds.): Cultured Normal Human Tissues and Cells. vol. 2lB, in the series "Methods in Cell Biology." New York, Academic Press, l980.

4. Harris, C. C. and Cerutti, P. A. (Eds.): Mechanisms of Chemical Carcinogenesis. New York, A. R. Liss, 1982.

5. Harris, C. C. and Autrup, H. (Eds.): Human Carcinogenesis. New York, Academic Press, 1983.

6. Harris, C. C. (Ed.): Biochemical and Molecular Epidemiology of Cancer. New York, A. R. Liss, 1986.

7. Harris, C. C. and Hoffmann, D. (Eds.): Mechanisms of Tobacco Carcinogenesis. Banbury Reports 23, Cold Spring Harbor, 1986.

8. Harris, C. C. and Liotta, L. (Eds.): Genetic Mechanisms in Carcinogenesis and Tumor Progression, New York, A. R. Liss, 1990.

9. Harris, C. C., Lechner, J. F. and Brinkley, B. R. (Eds.): Cellular and Molecular Aspects of Fiber Carcinogenesis. Current Communications in Cell and Molecular Biology 2, New York, Cold Spring Harbor Laboratory Press, 1991.

10. Harris, C. C., Hirohashi, S., Ito, N., Pitot, H. C., Sugimura, T., Terada, M. and Yokota, J. (Eds.): Multistage Carcinogenesis, Proceedings of the 22nd International Symposium of The Princess Takamatsu Cancer Research Fund. Tokyo, Japan, Scientific Societies Press, 1992.

11. Mohr, U., Dungworth, D. L., Adler, K. B., Harris, C. C. and Plopper, C. G.: Correlations Between In Vitro and In Vivo Investigations in Inhalation Toxicology. Washington, DC, ILSI Press, 1998.

12. Heinrich, U., Mohr, U., Bates, D. V., Brain, J. D., Driscoll, K. E., Dungworth, D. L., Grafstrom, R. C., Harris, C. C., Heyder, J., Koren, H. S., Mauderly, J. L., Pauluhn, J., Samet, J. M., Utell, M. J. (Eds.): Relationships Between Acute and Chronic Effects of Air Pollution. Washington, DC, ILSI Press, 2000.

13. Travis, W. D., Brambilla, E., Harris, C. C. and Muller-Hermelink, H. K. (Eds.): World Health Organization Classification of Tumours, Pathology and Genetics: Tumours of the Lung, Pleura, Thymus and Heart. Lyon, IARC Press, 2004.

Chapters in Books

1. Boren, H., Wright, E. and Harris, C.: Quantitative light microscopic autoradiography. In Prescott, D. (Ed.): Methods in Cell Biology, Vol. 8. New York, Academic Press, 1974, pp. 277-288.

2. Kaufman, D., Genta, V. and Harris, C.: Studies on carcinogen binding in vitro in isolated hamster tracheas. In Karbe, E. and Park, J. (Eds.): Experimental Lung Cancer: Carcinogenesis and Bioassays, Berlin, Springer-Verlag, 1974, pp. 564-574.

3. Port, C. D., Baxter, D. W. and Harris, C. C.: Surface morphology of tracheal epithelium in vitamin A deficiency and reversal. In Karbe, E. and Park, J. F. (Eds.): Experimental Lung Cancer: Carcinogenesis and Bioassays. Berlin, Springer-Verlag, 1974, pp. 257-264.

4. Trump, B., McDowell, E. M., Barrett, L. A., Frank, A. and Harris, C.: Studies of ultrastructure, cytochemistry and organ culture of human bronchial epithelium. In Karbe, E. and Park, J. (Eds.): Experimental Lung Cancer: Carcinogenesis and Bioassays, Berlin, Springer-Verlag, 1974, pp. 548-564.

5. Harris, C.: Respiratory carcinogenesis. In Straus, M. (Ed.): Lung Cancer: Clinical Diagnosis and Treatment, Grune and Stratton, 1977, pp. 1-17.

6. Harris, C., Autrup, H., Stoner, G., Trump, B.: Carcinogenesis studies in human respiratory epithelium: An experimental model system. In Harris, C. (Ed.): Pathogenesis and Therapy of Lung Cancer, New York, M. Dekker, Inc., 1978, pp. 559-608.

7. Harris, C., Autrup, H., Stoner, G., Valerio, M., Fineman, E., Schafer, P., Barrett, L., McDowell, E. and Trump, B.: Explant culture and xenotransplantation of human bronchi. In Saffiotti, U. and Autrup, H. (Eds.): In Vitro Carcinogenesis, NCI Carcinogenesis Technical Report No. 44, DHEW Publication No. (NIH) 78-844, Washington, D.C., U. S. Government Printing Office, 1978, pp. l44-l53.

8. Harris, C., Autrup, H., van Haaften, C., Connor, R., Frank, A., Barrett, L., McDowell, E. and Trump, B.: Inhibition of benzo[a]pyrene binding to DNA in cultured human bronchi. In Nieburgs, H. (Ed.): Proc. 3rd Int. Symposium Cancer Detection and Prevention, Amsterdam, Excerpta Medica, 1978, pp 1359-1366.

9. Harris, C., Autrup, H. and Stoner, G.: Metabolism of benzo[a]pyrene by cultured human tissues and cells. In Ts'o, P. O. P. and Gelboin, H. V. (Eds.): Polycylic Hydrocarbons and Cancer: Chemistry, Molecular Biology and Environment, vol. 2. New York, Academic Press, 1978, pp. 331-342.

10. Saffiotti, U. and Harris, C. C.: Carcinogenesis studies on organ cultures of animal and human respiratory tissues. In Griffin, A. C. and Shaw, C. R. (Eds.): Carcinogens: Identification and Mechanisms of Action, M. D. Anderson Hospital and Tumor Institute Monograph, New York, Raven Press, 1979, pp. 67-84.

11. Stoner, G. D., Katoh, Y., Foidart, J. M., Myers, G. A. and Harris, C. C.: Identification and culture of human bronchial epithelial cells. In Harris, C. C., Trump, B. F. and Stoner, G. D. (Eds.): Methods in Cell Biology, vol. 21A: Normal Human Tissue and Cell Culture, New York, Academic Press, 1980, pp. 15-35.

12. Harris, C. C.: Culture of cells and tissues from human lung--An overview. In Harris, C. C., Trump, B. F. and Stoner, G. D. (Eds.): Methods in Cell Biology, vol. 21A: Normal Human Tissue and Cell Culture, New York, Academic Press, 1980, pp. ll3-ll6.

13. Hillman, E. A., Vocci, M. J., Combs, J. W., Sanefuji, H., Robbins, T., Janss, D. H., Harris, C. C. and Trump, B. F.: Human breast organ culture studies. In Harris, C. C., Trump, B. F. and Stoner, G. D. (Eds.): Methods in Cell Biology, vol. 21B: Normal Human Tissue and Cell Culture, New York, Academic Press, 1980, pp. 79-106.

14. Hillman, E. A., Vocci, M. J., Schurch, W., Harris, C. C. and Trump, B. F.: Human esophageal organ culture studies. In Harris, C. C., Trump, B. F. and Stoner, G. D. (Eds.): Methods in Cell Biology, vol. 21B: Normal Human Tissues and Cell Culture, New York, Academic Press, 1980, pp. 331-348.

15. Autrup, H., Jeffreys, A. M. and Harris, C. C.: Metabolism of benzo[a]-pyrene in cultured human bronchus, trachea, colon and esophagus. In Bjorseth, A. and Dennis, A. J. (Eds.): Polycyclic Aromatic Hydrocarbons, vol. 4. New York, Raven Press, 1980, pp. 89-l05.

16. Harris, C. C. and Autrup, H.: Interspecies, interindividual and inter-tissue variations in benzo[a]pyrene metabolism. In: Luftverunreinigung durch Polycyclische Aromatische Kohlenwasserstoffe-Erfassung und Bewertung, Dusseldorff, VDI-Bericht Nr. 358, 1980, pp. 293-300.

17. Hsu, I. C., Yolken, R. and Harris, C. C.: Ultrasensitive enzymatic radioimmunoassay. In Langone, J. J. and Van Vunakis, H. (Eds.): Methods in Enzymology, vol. 73B. New York, Academic Press, 1981, pp. 383-394.

18. Yuspa, S. and Harris, C. C.: Molecular and cellular basis of chemical carcinogenesis. In Schottenfeld, D. and Fraumeni, Jr., J. (Eds.): Cancer Epidemiology and Prevention, Philadelphia, W. B. Saunders, 1982, pp. 23-43.

19. Haugen, A. and Harris, C. C.: Asbestos carcinogenesis: Asbestos inter-actions and epithelial lesions in cultured human tracheobronchial tissues and cells. Recent Advances in Cancer Research Vol. 82, 1982, pp. 32-42.

20. Trump, B. F., Wilson, T. and Harris, C. C.: Recent progress in the pathology of lung neoplasms. In Ishikawa, S., Hayata, Y. and Suemasu, K. (Eds.): Lung Cancer, 1982, Amsterdam, Excerpta Medica, 1982, pp. 101-124.

21. Harris, C. C., Yolken, R. H. and Hsu, I. C.: Enzyme immunoassays: Applications in cancer research. In Busch, H. and Yeoman, L. C. (Eds.): Methods in Cancer Research, New York, Academic Press, 1982, pp. 213-242.

22. Valerio, M. G., Fineman, E. L., Bowman, R. L., Harris, C. C., Trump, B. F., Hillman, E. A. and Heatfield, B. M.: Preliminary studies of normal untreated and/or carcinogen-treated adult human breast, prostate and esophagus as xenografts in nude mice. In Reed, N. (Ed.): Proc. Third International Workshop, Gustav Fischer Verlag, 1982, pp. 283-296.

23. Harris, C. C., Grafstrom, R. C., Lechner, J. F. and Autrup, H.: Metabolism of N-nitrosamines and repair of DNA damage in cultured human tissues and cells. In Magee, P. (Ed.): Banbury Report 12: Nitrosamines and Human Cancer, Cold Spring Harbor, Cold Spring Harbor Laboratory, 1982, pp. 121-139.

24. Harris, C. C.: Respiratory carcinogenesis and cancer epidemiology. In Straus, M. (Ed.): Lung Cancer: Clinical Diagnosis and Treatment, New York, Grune and Stratton, 1982, pp. 1-20.

25. Harris, C. C., Trump, B. F., Autrup, H., Hsu, I. C., Haugen, A. and Lechner, J.: Studies of host factors in carcinogenesis using cultured human tissues and cells. In Bartsch, H. and Armstrong, A. (Eds.): Host Factors in Human Carcinogenesis, International Agency for Research on Cancer (IARC Scientific Publications No. 39), Lyon, 1982, pp. 497-514.

26. Autrup, H., Grafstrom, R. and Harris, C. C.: Metabolism of chemical carcinogens by tracheobronchial tissues. In Rice, J., Langenbach, R. and Nesnow, S. (Eds.): Organ and Species Specificity in Chemical Carcinogenesis, New York, Plenum Press, 1982, pp. 473-495.

27. McDowell, E., Harris, C. C. and Trump, B. F.: Histogenesis and morpho-genesis of bronchial neoplasms. In Shimosato, Y., Melamed, M. and Nettesheim, P. (Eds.): Morphogenesis of Lung Cancer, CRC Press, Inc., 1982, pp. 1-36.

28. Autrup, H., Lechner, J. F. and Harris, C. C.: The use of human tissues and cells in carcinogen metabolism and toxicity studies. In Homburger, F. (Ed.): Safety Evaluation and Regulation of Chemicals, Basel, S. Karger, 1983, pp. 151-159.

29. Harris, C. C.: Role of carcinogens, cocarcinogens and host factors in human cancer risk. In Harris, C. C. and Autrup, H. (Eds.): Human Carcinogenesis, New York, Academic Press, 1983, pp. 941-970.

30. Lechner, J. F., Haugen, A., Tokiwa, T., Trump, B. F. and Harris, C. C.: Effects of asbestos and carcinogenic metals on cultured human bronchial epithelium. In Harris, C. C. and Autrup, H. (Eds.): Human Carcinogenesis, New York, Academic Press, 1983, pp. 561-585.

31. Autrup, H. and Harris, C. C.: Metabolism of chemical carcinogens by cultured human tissues. In Harris, C. C. and Autrup, H. (Eds.): Human Carcinogenesis, New York, Academic Press, 1983, pp. 169-194.

32. Grafstrom, R. C. and Harris, C. C.: Metabolism of N-nitrosamines and effects of formaldehyde on DNA repair in cultured human tissues and cells. In Rydstrom, J., Montelius, J. and Bengtsson, M. (Eds.): Extrahepatic Drug Metabolism and Chemical Carcinogenesis, Amsterdam, Elsevier Biomedical, 1983, pp. 527-540.

33. Trivers, G. E., Harris, C. C., Rougeot, C. and Dray, F.: Development and use of ultrasensitive enzyme immunoassays. In Conn, P. M. (Ed.): Methods in Enzymology, Vol. 103, New York, Academic Press, 1983, pp. 409-434.

34. Harris, C. C., Grafstrom, R. C., Shamsuddin, A., Sinopoli, N., Trump, B. F. and Autrup, H.: Activation and deactivation of chemical carcinogens in cultured human tissues and cells. In Greim, H., Jung, R., Kramer, M., Marguardt, H. and Oesch, F. (Eds.): Bio-chemical Basis of Chemical Carcinogenesis, New York, Raven Press, 1983, pp. 123-137.

35. Rougeot, C., Trivers, G. E., Harris, C. C. and Dray, F.: ACTH immuno-assays: development of ultrasensitive and specific procedures for the measurement in biological materials. In Avrameas, S. (Ed.): Enzyme Immuno assay Techniques, New York, Elsevier Science Publishers, 1984, pp. 179-191.

36. Harris, C. C., Autrup, H., Vahagangas, K. and Trump, B. F.: Inter-individual variation in carcinogen activation and DNA repair. In Omenn, G. (Ed.): Banbury Reports: Genetic Variability in Responses to Chemical Exposure, Vol. 16. Cold Spring Harbor, Cold Spring Harbor Laboratory, 1984, pp. 145-154.

37. Willey, J. C. and Harris, C. C.: Interaction between host and environ-mental factors. In Stoll, B. A. (Ed.): Risk Factors and Multiple Cancer, New York, J. Wiley and Sons, 1984, pp. 13-32.

38. Banks-Schlegel, S. P., Vocci, J., Combs, J. and Harris, C. C.: Normal human esophageal epithelium in cell culture. In Webber, M. and Sekely, L. (Eds.): In Vitro Models for Cancer Research, New York, CRC Press, 1985, pp. 9-38.

39. Harris, C. C., Willey, J. C., Saladino, A. J. and Grafstrom, R. C.: Effects of Tumor Promoters, Aldehydes, Peroxides and Tobacco Smoke Condensate on Growth and Differentiation of Cultured Normal and Transformed Human Bronchial Cells. In Mass, M., Kaufman, D. G., Siegfried, J. M., Steele, V. E. and Nesnow, S. (Eds.): Cancer of the Respiratory Tract, Predisposing Factors, New York, Raven Press, 1985, pp. 159-172.

40. Vahakangas, K., Autrup, H. and Harris, C. C.: Interindividual variation in carcinogen metabolism, DNA damage and DNA repair. In Berlin, A., Draper, M., Hemminki, K. and Vainio, H. (Eds.): Methods of Monitoring Human Exposure to Carcinogenic and Mutagenic Agents, New York, Plenum Press, 1984, pp. 85-98.

41. Grafstrom, R. C., Willey, J. C., Sundquist, K. and Harris, C. C.: Toxicity of tobacco-related aldehydes in cultured human bronchial epithelial cells. U.S. Airforce Technical Report 84-002, 1985, pp. 255-265.

42. Harris, C. C., Vahakangas, K., Autrup, H., Trivers, G. E., Shamsuddin, A. K. M., Trump, B. F., Boman, B. M. and Mann, D. L.: Biochemical and molecular epidemiology of human cancer risk. In Scarpelli, D., Craighead, J. and Kaufman, N. (Eds.): The Pathologist and the Environment, Baltimore, Williams and Wilkins, 1985, pp. 140-167.

43. Trump, B. F., McDowell, E. M., Shamsuddin, A. K. M., Phelps, P. C., Purnell, D. M., Wilson, T. S., Banks-Schlegel, Kurland, C. and Harris, C. C.: Preneoplasia and neoplasia in the bronchus, esophagus and colon: The use of markers in determining phenotypes and classification. In Scarpelli, D., Craighead, J. and Kaufman, N. (Eds.): The Pathologist and the Environment, Baltimore, Williams and Wilkins, 1985, pp. 101-139.

44. Harris, C. C., Lechner, J. F., Yoakum, G. H., Amstad, P., Korba, B. E., Gabrielson, E., Shamsuddin, A. and Trump, B. F.: In vitro studies of human lung carcinogenesis. In Barrett, J. C. and Tennant, R.W. (Eds.): Cell Transformation Assays. Carcinogenesis, Volume 9, New York, Raven Press, 1985, pp. 257-269.

45. Lechner, J. F., Tokiwa, T., Yeager, Jr., H. and Harris, C. C.: Asbestos-associated chromosomal changes in human mesothelial cells. In Beck, J. and Bignon, J. (Eds.): The In Vitro Effects of Mineral Dusts, Volume G3, Berlin, Springer-Verlag, 1985, pp. 197-202.

46. Grafstrom, R. C., Pegg, A. E., Harris, C. C., Sundquist, K. and Krokan, H.: O6-methylguanine-DNA methyltransferase activity and aldehyde-induced inhibition of O6-methylguanine repair in human lung cells. In Myrnes, B. and Krokan, H. (Eds.): Repair of DNA Lesions Introduced by N-Nitroso-compounds, England, Oxford University Press, 1986, pp. 154-175.

47. Krokan, H., Haugen, A., Giercksky, K. E., Nilsen, I. W., Yoakum, G. H., Harris, C. C. and Myrnes, B.: O6-methylguanine-DNA methyltransferase activity in human tissues and the possible suppressive effect of some activated ras-oncogenes in cultured cells. In Krokan, H. (Ed.): Repair of DNA Lesions Introduced by N-Nitrosocompounds, England, Oxford University Press, 1986, pp. 199-209.

48. Lechner, J. F., Stoner, G. D., Yoakum, G. H., Willey, J. C., Grafstrom, R. C., Masui, T., LaVeck, M. A. and Harris, C. C.: In vitro carcinogenesis studies with human tracheobronchial tissues and cells. In Schiff, L. J. (Ed.): In Vitro Models of Respiratory Epithelium, New York, CRC Press, 1986, pp. 143-160.

49. Harris, C. C., Yoakum, G. H., Lechner, J. F., Willey, J. C., Masui, T., Gerwin, B., Schlegel, S. and Mark, G.: Growth, differentiation and neoplastic transformation of human bronchial epithelial cells. In Harris, C. C. (Ed.): Biochemical and Molecular Epidemiology of Cancer, New York, A. L. Liss, 1986, pp. 213-226.

50. Yoakum, G. H., Korba, B. E., Boumpas, D. C., Mann, D. L. and Harris, C. C.: The molecular biology of human hepatitis B virus infection. In Harris, C.C. (Ed.): Biochemical and Molecular Epidemiology of Cancer, New York, A. L. Liss, 1986, pp. 271-282.

51. Grafstrom, R., Willey, J., Sundqvist, K. and Harris, C. C.: Pathobio-logical effects of tobacco-related aldehydes in cultured human bronchial epithelial cells. In Hoffmann, D. and Harris, C. C. (Eds.): Mechanisms of Tobacco Carcinogenesis, Banbury Reports 23, New York, Cold Spring Harbor Laboratory, 1986, pp. 273-285.

52. Grafstrom, R. C., Curren, R. D., Yang, L. L. and Harris, C. C.: Aldehyde-induced inhibition of DNA repair and N-nitrosocompound-induced mutagenesis in human cells. In Krokan, H. and Myrnes, B. (Eds.): Genetic Toxicology of Environmental Chemicals Part A: Basic Principles and Mechanisms of Action, New York, Alan R. Liss, 1986, pp. 255-264.

53. Masui, T., Yoakum, G. H., Lechner, J. F., Willey, J. C., Amstad, P., Trump, B. F. and Harris, C. C.: In vitro carcinogenesis studies of human bronchial epithelial cells. In Hoffmann, D. and Harris, C. C. (Eds.): Mechanisms of Tobacco Carcinogenesis, Banbury Reports 23, New York, Cold Spring Harbor Laboratory, 1986, pp. 299-314.

54. Harris, C. C. and Hoffmann, D.: Concluding Remarks. In: Hoffmann, D. and Harris, C. C. (Eds.): Mechanisms of Tobacco Carcinogenesis, Banbury Reports 23, New York, Cold Spring Harbor Laboratory, 1986, pp. 397-402.

55. Weston, A., Trivers, G., Vahakangas, K., Newman, M., Rowe, M., Mann, D. and Harris, C. C.: Detection of carcinogen-DNA adducts in human cells and antibodies to these adducts in human sera. In Homburger, F. (Ed.): Progress in Experimental Tumor Research, Basel, S. Karger, 1987, pp. 76-85.

56. Harris, C. C.,: Biochemical and molecular effects of N-nitroso compounds in cultured human cells: An overview. In Bartsch, H. (Ed.): 9th International Meeting on N-Nitroso Compounds, Lyon, IARC, 1987, pp. 20-25.

57. Weston, A., Newman, M., Trivers, G. E., Vahakangas, K., Rowe, M., Mann, D. L. and Harris, C. C.: Measurement of carcinogen-macromolecular adducts and serum antibodies recognizing DNA-adducts in biological specimens from people exposed to chemical carcinogens. In Sandhu, S. F., DeMarini, D. M., Mass, M. J., Moore, M. M. and Mumford, J. S. (Eds.): Short-term Bioassays in the Analysis of Complex Environmental Mixtures V, New York, Plenum Press, 1987, pp. 91-102.

58. Masui, T., Lechner, J. F., Mark, III, G. E., Pfeifer, A. M. A., Miyashita, M., Yoakum, G. H., Willey, J. C., Mann, D. L. and Harris, C. C.: Growth and differentiation programs of normal and transformed human bronchial epithelial cells. In Colburn, N. H., Moses, H. L. and Stanbridge, E. J. (Eds.): UCLA Symposium on Molecular and Cellular Biology, Vol. 32, New York, Alan R. Liss, Inc., 1988, pp. 191-202.

59. Harris, C. C. and Trump, B. F.: Laboratory and epidemiological studies of human carcinogenesis. In Rand, M. J. and Raper, C. (Eds.): Pharmacology, Amsterdam, Elsevier Biomedical, 1987, pp. 845-852.

60. Willey, J. C., Weston, A., Haugen, A., Krontiris, T., Resau, J., McDowell, E., Trump, B. and Harris, C. C.: DNA restriction fragment length polymorphism analysis of human broncogenic carcinoma. In Bartsch, H., Hemminki, K. and O'Neill, I. K. (Eds.): Methods for Detecting DNA Damaging Agents in Humans: Applications in Cancer Epidemiology and Prevention, IARC Scientific Publications No. 89, 1988, pp. 439-450.

61. Haugen, A., Becher, G., Benestad, C., Vahakangas, K., Trivers, G. E., Newman, M. J. and Harris, C. C.: Biomonitoring of individuals exposed to high levels of PAH in the work environment. In Cooke, W. M. and Dennis, A. G. (Eds.): Polynuclear Aromatic Hydrocarbons, Columbus, Ohio, Battelle Press, 1988, pp. 377-392.

62. Grafstrom, R. C., Sundqvist, K., Dypbukt, J. M. and Harris, C. C.: Pathobiological effects of aldehydes in cultured human bronchial cells. In Bartsch, H., O'Neill, I. and Schulte-Hermann, R. (Eds.): Relevance of N-Nitroso Compounds to Human Cancer, United Kingdom, Oxford University Press, 1987, pp. 443-445.

63. Weston, A., Willey, J. C., Newman, M., Trivers, G. E., Haugen, A., Manchester, D., Choi, J. S., Krontiris, T., Light, B., Mann, D. and Harris, C. C.: Application of biochemical and molecular techniques to the epidemiology of human lung cancer. In Miners, J. O., Birkett, D. J., Drew, R., May, B. and McManus, M. (Eds.): Microsomes and Drug Oxidations, London, Taylor & Frances, Ltd., 1987, pp. 380-391.

64. Harris, C. C., Grafstrom, R., Willey, J. C., Gabrielson, E., Lechner, J., Somers, A., Miyashita, M., Sundqvist, K., Dypbukt, J. M., Matsukura, N. and Trump, B. F.: Pathobiological effects of tobacco smoke, tumor promoters and asbestos in human lung cells in vitro. In Cerutti, P. A., Fridovich, I. and McCord, J. M. (Eds.): Oxy-Radicals in Molecular Biology and Pathology, New York, Alan R. Liss, 1988, pp. 405-423.

65. Weston, A., Willey, J. C., Manchester, D. K., Wilson, V. L., Brooks, B. R., Choi, J. S., Poirier, M. C., Trivers, G. E., Newman, M. J., Mann, D. L. and Harris, C. C.: Dosimeters of human exposure to carcinogens: polycyclic aromatic hydrocarbon-macromolecular adducts. In Bartsch, H., Hemminki, K. and O'Neill, I. K. (Eds.): Methods for Detecting DNA Damaging Agents in Humans: Applications in Cancer Epidemiology and Prevention, Lyon, IARC, 1988, pp. 181-189.

66. Vahakangas, K., Pelkonen, O. and Harris, C. C.: Sychronous fluorescence spectrophotometry of benzo[a]pyrene diol epoxide-DNA adducts: a tool for detection of in vitro and in vivo DNA damage by exposure to benzo[a]pyrene. In Bartsch, H., Hemminki, K. and O'Neill, I. K. (Eds.): Methods for Detecting DNA Damaging Agents in Humans: Applications in Cancer Epidemiology and Prevention, Lyon, IARC, 1988, pp. 208-212.

67. Reddel, R. R. and Harris, C. C.: Carcinogenesis. In Roth, J. A., Ruckdeschel, J. C. and Weisenburger, T. H. (Eds.): Thoracic Oncology, Philadelphia, W. B. Saunders Co., 1989, pp. 16-37.

68. Lechner, J. F., Masui, T., Miyashita, M., Willey, J. C., Reddel, R., LaVeck, M. A., Ke, Y., Yoakum, G. H., Amstad, P., Gerwin, B. I. and Harris, C. C.: Human lung cells: In vitro models for studying carcinogens. In Langenbach, R., Elmore, E. and Barrett, J. C. (Eds.): Tumor Promotors: Biological Approaches for Mechanistic Studies and Assay Systems, New York, Raven Press, 1988, pp. 275-288.

69. Harris, C. C., Brash, D. E., Lechner, J. F. and Mark, G.: Aberrations of growth and differentiation pathways during neoplastic transformation of human epithelial cells. In Kakunaga, T., Sugimura, T., Tomatis, L. and Yamasaki, H. (Eds.): Cell Differentiation, Genes and Cancer, Lyon, IARC, 1988, pp. 139-148.

70. Trivers, G. E., Harris, C. C., Rougeot, C. and Dray, F.: Development and use of ultrasensitive enzyme immunoassays. In Conn, M. P. (Ed.): Neuroendocrine Peptide Methodology: Selected Methods in Enzymology, New York, Academic Press, Inc., 1989, pp. 629-654.

71. Lechner, J. F., Stoner, G. D., Haugen, A., Autrup, H., Willey, J. C., LaVeck, M. A., Trump, B. F. and Harris, C. C.: In vitro human bronchial model systems for carcinogenesis studies. In Webber, M. M. and Sekely, L. (Eds.): In Vitro Models for Cancer Research. Vol. 4, New York, CRC Press, 1988, pp. 3-17.

72. Mark, G. E., Pfeifer, A., Mann, D. L., Harris, C. C., Berman, R. and Pert, C. B.: raf protooncogene expression in neural and immune tissues. In Bridge, T. P. (Ed.): Psychological, Neuropsychiatric and Substance Abuse Aspects of AIDS, New York, Raven Press, 1988, pp. 45-55.

73. Harris, C. C., Reddel, R. R., Ke, Y., Pfeifer, A., Mark, G., Masui, T., Yoakum, G., Gerwin, B. I., Amstad, P. and Lechner, J. F.: Cellular and molecular studies of growth, differentiation and neoplastic transformation of human bronchial epithelial cells in vitro. In Feo, F., Pani, P., Columbano, A. and Garcea, R. (Eds.): Chemical Carcinogenesis: Models and Mechanisms, New York, Plenum Press, 1988, pp. 179-183.

74. Harris, C. C., Gerwin, B., Ke, Y., Masui, T., Miyashita, M., Pfeifer, A., Reddel, R., Wilson, V. L. and Lechner, J. F.: Growth, differentiation and neoplastic transformation of human bronchial epithelial cells. In Moses, H. L., Lengyel, P. and Stiles, C. C. (Eds.): Growth Factors and Their Receptors: Genetic Control and Rational Application, New York, Alan R. Liss, 1989, pp. 269-282.

75. Harris, C. C., Reddel, R., Pfeifer, A., Amstad, P., Mark, G., Weston, A., Modali, R., Iman, D., McMenamin, M., Kaighn, E., Gabrielson, E., Jones, R. and Trump, B. F.: Oncogenes and tumor suppressor genes in human lung carcinogenesis. In Harris, C. C. and Liotta, L. (Eds.): Genetic Mechanisms in Carcinogenesis and Tumor Progression, New York, Wiley-Liss, 1990, pp. 127-152.

76. Lechner, J. F., Gerwin, B. I., Ke, Y., Reddel, R. R., Pfeifer, A. M. A., Masui, T., Miyashita, M., Wilson, V. L. and Harris, C. C.: Regulation of squamous differentiation in human bronchial epithelial cells. In Harris, C. C. and Liotta, L. (Eds.): Genetic Mechanisms in Carcinogenesis and Tumor Progression, New York, Wiley-Liss, 1990, pp. 31-51.

77. Haugen, A. and Harris, C. C.: Interactive effects between viruses and chemical carcinogens. In Grover, P. L. and Cooper, C. S. (Eds.): Carcinogenesis and Mutagenesis, Handbook of Experimental Pharmacology, London, Springer-Verlag, 1990, pp. 249-268.

78. Gerwin, B. I., Betsholtz, C., Linnainmaa, K., Pelin, K., Reddel, R., Gabrielson, E., Seddon, M., Greenwald, R., Harris, C. C. and Lechner, J.: In vitro studies of human mesothelioma. In Thomassen, D. G. and Nettesheim, P. (Eds.): Biology, Toxicology and Carcinogenesis of Respiratory Epithelium, New York, Hemisphere Publishing Corp., 1990, pp. 112-124.

79. Lechner, J. F., Ke, Y., Masui, T., Reddel, R. R., Pfeifer, A. M. A., Gerwin, B. I. and Harris, C. C.: Growth, differentiation and transformation studies of human bronchial epithelial cells. In Thomassen, D. G. and Nettesheim, P. (Eds.): Biology, Toxicology and Carcinogenesis of Respiratory Epithelium, New York, Hemisphere Publishing Corp., 1990, pp. 217-227.

80. Weston, A., Sugimura, H., Modali, R., Bowman, E. D., Caporaso, N. E., Manchester, D. K., Shields, P. G., Poirier, M. C. and Harris, C. C.: Molecular dosimetry, genetic susceptibility and cancer risk. In Volans, G. N., Sims, J., Sullivan, F. M. and Turner, P. (Eds.): Basic Science in Toxicology: Proceedings of the V International Congress of Toxicology, Philadelphia, Taylor and Francis, Ltd., 1990, pp. 263-279.

81. Trump, B. F., Jones, T. W., Berezesky, I. K., Elliget, K. A., Smith, M. W., Phelps, P. C., Miyashita, M., Harris, C. C. and Jones, R. T.: Cell toxicity and ion regulation in the bronchus and kidney: An hypothesis. In Volans, G. N., Sims, J., Sullivan, F. M. and Turner, P. (Eds.): Basic Science in Toxicology: Proceedings of the V International Congress of Toxicology, Philadelphia, Taylor and Francis, Ltd., 1990, pp. 636-650.

82. Harris, C. C.: Interindividual variation in human chemical carcinogenesis: Implications for risk assessment. In Moolgavkar, S. H. (Ed.): Scientific Issues in Quantitative Risk Assessment, 1990, pp. 235-251.

83. Povey, A. C., Plummer, S. M., Grafstrom, R. C. and Harris, C. C.: Genotoxic mechanisms of fecapentaene-12 in human cells. In Pariza, M. W., Aeschbacher, H. U., Felton, J. S. and Sato, S. (Eds.): Carcinogens and Mutagens in the Diet, New York, Wiley-Liss, 1990, pp. 155-166.

84. Weston, A., Bowman, E. D., Manchester, D. K. and Harris, C. C.: Fluorescence detection of lesions in DNA. In Sutherland, B. M. and Woodhead, A. D. (Eds.): DNA Damage and Repair in Human Tissues, New York, Plenum Press, 1990, pp. 63-82.

85. Harris, C. C., Reddel, R., Modali, R., Lehman, T. A., Iman, D., McMenamin, M., Sugimura, H., Weston, A. and Pfeifer, A.: Oncogenes and tumor suppressor genes involved in human lung carcinogenesis. In Sutherland, B. M. and Woodhead, A. D. (Eds.): DNA Damage and Repair in Human Tissues, New York, Plenum Press, 1990, pp. 363-380.

86. Harris, C. C., Weston, A., Sugimura, H., Iman, D., Shows, T., Stanbridge, E., Kaighn and McMenamin, M.: Tumor suppression studies of human lung cancer. In Mendelsohn, M. L. and Albertini, R. J. (Eds.): Mutation and the Environment, New York, Wiley-Liss, 1990, pp. 21-31.

87. Shields, P. G., Weston, A., Sugimura, H., Bowman, E. D., Caporaso, N. E., Manchester, D. K., Trivers, G. E., Tamai, S., Resau, J. H., Trump, B. F. and Harris, C. C.: Molecular epidemiology: dosimetry, susceptibility and cancer risk. In Vanderlaan, M., Stanker, L. H., Watkins, B. E. and Roberts, D. W. (Eds.): Immunoassays for Trace Chemical Analysis. Monitoring Toxic Chemicals in Humans, Food and the Environment, Washington, D.C., American Chemical Society, 1991, pp. 186-206.

88. Lechner, J. F., Gerwin, B. I., Reddel, R. R., Gabrielson, E. W., Van Der Meeren, A., Linnainmaa, K., Somers, A. N. A. and Harris, C. C.: Studies on human mesothelial cells: Effects of growth factors and asbesti-form fibers. In Harris, C. C., Lechner, J. F. and Brinkley, B. (Eds.): Cellular and Molecular Aspects of Fiber Carcinogenesis. Current Communications in Cell and Molecular Biology 2, New York, Cold Spring Harbor Laboratory Press, 1991, pp. 115-129.

89. Harris, C. C., Reddel, R., Pfeifer, A., Iman, D., McMenamin, M., Trump, B. F. and Weston, A.: Role of oncogenes and tumour suppressor genes in human lung carcinogenesis. In O'Neill, I. K., Chen, J. S. and Bartsch, H. (Eds.): Relevance to Human Cancer of N-Nitroso Compounds, Tobacco Smoke and Mycotoxins, Lyon, IARC, 1991, pp. 294-304.

90. Harris, C. C., Willey, J. C., Matsukura, N., Lechner, J., Miyashita, M., Grafstrom, R. C. and Trump, B. F.: Pathobiological effects of fibers and tobacco-related chemicals in human lung cells in vitro. In Bates, D. V., Dungworth, D. L., Lee, P. N., McClellan, R. O. and Roe, F. J .C. (Eds.): Assessment of Inhalation Hazards: Integration and Extrapolation Using Diverse Data, New York, Springer-Verlag, 1991, pp. 103-117.

91. Sugimura, H., Weston, A., Caporaso, N., Shields, P., Metcalf, R. A. and Harris, C. C.: Biochemical and molecular epidemiology of cancer. In Chang, L. W. and Hart, R. (Eds.): Recent Advances in Biomarker Research, New York, Academic Press, 1991, pp. 73-92.

92. Weston, A., Bowman, E. D., Povey, A. C., Manchester, D. K., Newman, M. J., Trivers, G. E., Beland, F. A., Farmer, P. B., Poirier, M. C. and Harris, C. C.: Indicators of aromatic-adducts in human DNA. In Garner, R. C. and Martin, C. N. (Eds.): International Workshop on Biomonitoring and Carcinogen Risk Assessment, England, IRL Press, 1991, pp. 429-438.

93. Harris, C. C.: Molecular epidemiology: overview of biochemical and molecular basis. In Groopman, J. and Skipper, P. (Eds.): Molecular Dosimetry and Human Cancer, Boca Raton, CRC Press, 1991, pp. 15-26.

94. Harris, C. C.: Molecular epidemiology of human cancer in the 1990's. In Gledhill, B. L. and Mauro, F. (Eds.): New Horizons in Biological Dosimetry, New York, Wiley-Liss, 1991, pp. 543-558.

95. Lechner, J. F., Smoot, D. T., Pfeifer, A. M. A., Cole, K. H., Weston, A., Groopman, J. D., Shields, P. G., Tokiwa, T. and Harris, C. C.: A non-tumorigenic human liver epithelial cell culture model for chemical and biological carcinogenesis investigations. In Rhim, J. S. and Dritschilo, A. (Eds.): Neoplastic Transformation in Human Cell Systems: Mechanisms of Carcinogenesis, New Jersey, The Humana Press Inc., 1991, pp.307-321.

96. Lehman, T. A. and Harris, C. C. Neoplastic transformation and suppression of transformation of human bronchial epithelial cells in vitro. In Rhim, J. S. and Dritschilo A. (Eds.): Neoplastic Transformation in Human Cell Culture, The Humana Press, Inc., New Jersey. 1991, pp.251-258.

97. Harris, C. C., Bennett, W. P., Gerwin, B. I., Iman, D. S., Lehman, T. A., Metcalf, R. A., Pfeifer, A. M. A., Reddel, R. R., Sugimura, H. and Weston, A.: Oncogenes and tumor suppressor genes involved in human lung carcinogenesis. In Brugge, J., Curran, T., Harlow, E. and McCormick, F. (Eds.): Origins of Human Cancer, New York, Cold Spring Harbor Laboratory Press, 1991, pp. 739-44.

98. Stoner, G. D., Light, B. A. and Harris, C. C.: Immortalizations and oncogene transformation of human esophageal epithelial cells. In Rhim, J. S. and Dritschilo, A. (Eds.): Neoplastic Transformation in Human Cell Systems: Mechanisms of Carcinogenesis, New Jersey, Humana press, 1991, pp. 297-306.

99. Lehman, T. A., Pfiefer, A. M. A., Metcalf, R. A., Bennett, W. P., Weston, A., Gerwin, B. I. and Harris, C. C.: Oncogenes and tumor suppressor genes in human lung carcinogenesis. In Waxman, S. (Ed.): Second Volume on Differentiation Therapy, New York, Raven Press, 1991, pp. 87-98.

100. Gabrielson, E. W., Lechner, J. F., Gerwin, B. I. and Harris, C. C.: Cultured human mesothelial cells are selectively sensitive to cell killing by asbestos and related fibers: a potential in vitro assay for carcinogenicity. In Brown, R. C., Hoskins, J. and Johnson, N. (Eds.): Proceedings of NATO Advanced Research Workshop on Mechanisms in Fiber Carcinogenesis, Plenum Press, New York, 1991, pp. 505-511.

101. Lehman, T. A. and Harris, C. C.: Oncogene and tumor suppressor gene involvement in human lung carcinogenesis. In Milo, G. E., Casto, B. and Schuler C. (Eds.): Transformation of Human Epithelial Cells: Molecular and Oncogenetic Mechanisms, Florida, CRC Press,1992, pp. 235-259.

102. Sinopoli, N., Ficorells, C., Trivers, G. E., D'Andrea, V., Cagnazzo, P., Tomao, S., Harris, C. C. and Frati, L.: Determination of PAH-DNA adducts in lung tissue of cancer patients. In Columbano, A. (Ed.): Chemical Carcinogenesis: 5th Sardinian Meeting on Modulating Factors in Multistage Carcinogenesis, New York, Plenum Press, 1992, pp. 631-634.

103. Harris, C. C.: Tumour suppressor genes, multistage carcinogenesis and molecular epidemiology. In Vainio, H., Magee, P. N., McGregor, D. B. and McMichael, A. J. (Eds.): Mechanisms of Carcinogenesis in Risk Identification, Lyon, I.A.R.C., 1992, pp. 67-85.

104. Harris, C. C.: Molecular basis of multistage carcinogenesis. In Harris, C. C., Hirohashi, S., Ito, N., Pitot, H. C., Sugimura, T., Terada, M., Yokota, J. (Eds.): Multistage Carcinogenesis, Tokyo, Japan Sci. Soc. Press, 1992, pp. 3-19.

105. Weston, A. and Harris, C. C.: Chemical carcinogenesis. In Holland, J. F., Frei, E., Bast, R. C., Kufe, D. W., Morton, D. L. and Weichselbaum, R. R. (Eds.): Cancer Medicine, 3rd Edition, Philadelphia, Lea & Febiger, 1993, pp. 211-222.

106. Shields, P. G. and Harris, C. C.: Genetic predisposition to lung cancer. In Roth, J. A., Cox, J. D. and Hong, W. K. (Eds.): Advances in the Diagnosis and Therapy of Lung Cancer, Cambridge, Blackwell Scientific Publications, Inc., 1993, pp. 3-19.

107. Shields, P. and Harris, C. C.: Principles of carcinogenesis: chemical. In DeVita, Jr., V. T., Hellman, S. and Rosenberg, S. A. (Eds.) Cancer Principles and Practice of Oncology, 4th Edition, Philadelphia, J. B. Lippincott, 1993, pp. 200-212.

108. Harris, C. C.: p53 mutational spectrum and molecular epidemiology of human cancer. In Fortner, J. G. and Rhoads, J. E. (Eds.): Accomplishments in Cancer Research 1992, Philadelphia, J. B. Lippincott Co., 1993, pp. 179-188.

109. Harris, C. C.: p53 tumor suppressor gene: mutational spectrum. In Marks, P. A., Turler, H. and Weil, R. (Eds.): Precancerous Lesions: A multidisciplinary approach, challenges of modern medicine. Vol. 1, Rome, Christengraf, 1993, pp. 209-220.

110. Lehman, T. A. and Harris, C. C.: Mutational spectra of protooncogenes and tumor suppressor genes: clues to predict cancer etiology. In Hemminki, K., Dipple, A., Shuker, D. E. G., Kaadlubar, F. F., Segerback, D. and Bartsch, H. (Eds.): DNA Adducts: Identification and Biological Significance, Lyon, I.A.R.C. Publications, No. 125, 1994, pp. 399-412.

111. Okamoto, A., Demetrick, D. J., Spillare, E. A., Hagiwara, K., Hussain, S. P., Bennett, W. P., Forrester, K., Gerwin, B. I., Greenblatt, M. S., Serrano, M., Shiseki, M., Yokota, J., Beach, D. H., Harris, C. C.: p16^INK4 mutations and altered expression in human tumors and cell lines. In Molecular Genetics of Cancer - Symposium 59. New York, Cold Spring Harbor Laboratory Press, 1994, pp. 49-57.

112. Harris, C. C.: p53: At the crossroads of molecular carcinogenesis and risk assessment. In Waxman, S. (Ed.): Challenges of Modern Medicine, Differentiation Therapy. Rome, Ares-Serona Symposia Publ., 1995, pp. 43-55.

113. Greenblatt, M. S., Reddel, R. R. and Harris, C. C.: Carcinogenesis and cellular and molecular biology of lung cancer. In Roth, J. A., Ruckdeschel, J. C. and Weisenburger, T. H. (Eds.): Thoracic Oncology. Philadelphia, W. B. Saunders Co., 1995, pp. 5-25.

114. Mace, K., Harris, C. C., Lipsky, M. M. and Pfeifer, A. M. A.: Human hepatocytes. In Freshney, R. I. and Freshney, M. G.(Eds.): Culture of Immortalized Cells. New York, Willey-Liss, 1996, pp. 161-181.

115. Weston, A. and Harris, C. C.: Chemical carcinogenesis. In Holland, J. F., Frei, E., Bast, R. C., Kufe, D. W., Morton, D. L. and Weichselbaum, R. R. (Eds.): Cancer Medicine, 4th Edition, Philadelphia, Lea & Febiger, 1997, 261-276.

116. Greenblatt, M. S., Bennett, W. P. and Harris, C. C.: p53 Tumor suppressor gene: Implications for respiratory carcinogenesis. In Mohr, U. (Ed.): Correlation between In Vitro and In Vivo Investigation in Inhalation Toxicology, Proceedings of the 5th International Symposium. Washington, DC, ILSI Press, 1997, pp. 40-48.

117. Klein-Szanto, A. J. P., Harris, C. C., Momiki, S., Iizasa, T. and Baba, M.: A combined in vitro-in vivo approach for the study of human respiratory tract carcinogenesis. In Mohr, U. (Ed.): Correlation between In Vitro and In Vivo Investigation in Inhalation Toxicology, Proceedings of the 5th International Symposium. Washington, DC, ILSI Press, 1997, pp. 271-297.

118. Jia, L., Wang, X. W., Sun, Z. T. and Harris, C. C.: Interactive effects of p53 tumor suppressor gene and hepatitis B virus in hepatocellular carcinogenesis. In Tahara, E. (Ed.): Molecular Pathology of Gastro-enterological Cancer: Application to Clinical Practice, Tokyo, Springer-Verlag, 1997, pp. 209-218.

119. Elmore, L. W. and Harris, C. C.: Hepatocellular carcinoma. In Vogelstein, B. and Kinzler, K. W. (Eds.): The Genetic Basis of Human Cancer, New York, McGraw-Hill Inc., 1998, pp. 681-689.

120. Wang, X. W., Greenblatt, M. S. and Harris, C. C.: Molecular genetics of lung cancer. In Martinet, Y., Hirsch, F. R., Martinet, N., Vignaud, J. M. and Mulshine, J. L. (Eds.): Clinical and Biological Basis of Lung Cancer Prevention, Basel, Switzerland, Birkhauser Verlag, 1998, pp. 117-127.

121. Reddel, R. R., Harris, C. C. and Brash, D. E.: Strontium phosphate transfection. In Ravid, K. and Freshney, R. I. (Eds.): DNA Transfer to Immortalized Cells, New York, Wiley-Liss, 1998, pp. 147-155.

122. Hussain, S. P. and Harris, C. C.: p53 Tumor suppressor gene: at the crossroads of molecular carcinogenesis and molecular epidemiology of human cancer. In Rom, W. R. (Ed.): Environmental and Occupational Medicine, 3rd ED., Philadelphia, Lippincott-Raven Publ., 1998, pp. 167-176.

123. Hussain, S. P. and Harris, C. C.: Molecular epidemiology of human cancer. In Schwab, M., Rabes, H., Munk, K., Hofschneider, P. H. (Eds.): Recent Results in Cancer Research: Genes and Environment in Cancer, Vol 154, Berlin, Springer-Verlag, 1998, pp. 22-36.

124. Hussain, S. P., Ambs, S. and Harris, C. C.: Cancer-prone oxyradical overload disease. In Beger, H. G. and Link, K. H. (Eds.): 2nd International Congress on Gastrenterological Carcinogenesis, Bologna, Monduzzi Editore, 1999, pp. 9-20.

125. Hussain, S. P., Wang, X. W., Shields, P. G. and Harris, C. C.: Gene-environment interactions in human cancer risk. In: Chemicals in the 21st Century, Chemicals for Sustainable Development, Proceedings of the Fourth Princess Chulabhorn International Science Congress. Bangkok, Trinity Publ. Co., 1999, pp. 39-49.

126. Weston, A. and Harris, C. C.: Chemical Carcinogenesis. In Holland, J. F., Frei, E., Bast, R., Kufe, D., Pollock, R. and Weichselbaum, R. (Eds.): Cancer Medicine, 5th Edition, B. C. Decker Inc., Canada, Ontario, 2000, pp. 185-194.

127. Hussain, S. P. and Harris, C. C.: p53 Mutation spectrum and load: The generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer. In Heinrich, U., Mohr, U., Bates, D. V., Brain, J. D., Driscoll, K. E., Dungworth, D. L., Grafstrom, R. C., Harris, C. C., Heyder, J., Koren, H. S., Mauderly, J. L., Pauluhn, J., Samet, J. M., Utell, M. J. (Eds.): Relationships Between Acute and Chronic Effects of Air Pollution, Washington, DC, ILSI Press, 2000, pp. 209-220.

128. Hussain, S. P. and Harris, C. C.: p53 Mutation Load: A molecular linkage to carcinogen exposure and cancer. In Butterworth, F. M., Gunatilaka, A. and Gonsebatt, M. E. (Eds.): Biomonitors and Biomarkers as Indicators of Environmental Change, Volume 2. New York, Plenum Publishing Corp., 2000, pp. 333-346.

129. Elmore, L. E. and Harris, C. C.: Hepatocellular carcinoma. In Scriver, C. R., Beaudet, A. L., Sly, W. S., Valle, D., Childs, B., Kinzler, K. W. and Vogelstein, B. (Eds.): The Metabolic and Molecular Bases of Inherited Disease, 8th Ed. New York, McGraw-Hill, Inc., 2001, pp. 1157-1166.

130. Hussain, S. P., Hofseth, L. J., Shields, P. G. and Harris, C. C.: Gene-Environment Interactions in Human Cancer Risk. In Lung, M. L. and Hsiao W. L. W. (Eds.): Molecular Genetic Basis of Cancer, Hong Kong, Hong Kong University of Science and Technology, 2001, pp. 294-308.

131. Elmore, L. E. and Harris, C. C.: Hepatocellular Carcinoma. In Vogelstein, B. and Kinzler, K. W. (Eds.): The Genetic Basis of Human Cancer, Volume 2. New York, McGraw-Hill, Inc., 2002, pp. 741-750.

132. Harris, C. C.: Tumor suppressor genes: At the crossroads of molecular carcinogenesis, molecular epidemiology and human risk assessment. In Wilson, S., Jones, L., Coussens, C. and Hanna, K. (Eds.): Cancer and the Environment: Gene-Environment Interaction, Washington, DC, National Academy Press, 2002, pp. 81-84.

133. Hofseth, L. J., Hussain, S. P., Wang, X. W. and Harris, C. C.: Hepatocellular Cancer: Molecular biology and genetics. In Kelsen, D. P., Daly, J. M., Kern, S. E., Levin, B. and Tepper, J. E. (Eds.): Gastrointestinal Oncology: Principles and Practice, Philadelphia, Lippincott Williams & Wilkins. 2002, pp. 539-558.

134. Elmore, L. W., Wang, X. W. and Harris, C. C.: Hepatocellular Carcinoma. In Cooper, D. N., (Ed.): Nature Encyclopedia of the Human Genome, Volume 3. London, Nature Publishing Group, 2003, pp. 216-220.

135. Weston, A. and Harris, C. C.: Chemical Carcinogenesis. In Holland, J. F., Frei, E., Bast, R., Kufe, D., Pollock, R. and Weichselbaum, R. (Eds.): Cancer Medicine, 6th Edition, Ontario, Canada, B. C. Decker Inc., 2003, pp. 267-278.

136. Oliver, M., Hussain, S. P., Caron de Fromentel, C., Hainaut, P. and Harris, C. C.: TP53 Mutation Spectra and Load: A Tool for Generating Hypotheses on the Etiology of Cancer. In Buffler, P., Rice, J., Baan, R., Bird, M. and Boffetta, P. (Eds): Mechanisms of Carcinogenesis: Contributions of Molecular Epidemiology, Publ. No. 157. Lyon, IARC, 2004, pp. 247-270.

137. Hofseth, L. J., Sawa, T., Hussain, S. P. and Harris, C. C.: Inducible nitric oxide synthase as a target for chemoprevention. In Kelloff, G. L., Hawk, E. T. and Sigman, C. C. (Eds.): Cancer Chemoprevention Vol. 1: Promising Cancer Chemopreventive Agents, Totowa, NJ, The Humana Press, 2004, pp. 133-151.