Front row, left to right: Joseph DiPaolo, Giang Ton, Amy Cullinan. Second row, left to right: Charles Evans, Michael Chen, Jean Chung, Drazen Zimonjic. Third row, left to right: Luiz Alvarez-Salas, Scott Simpson, Maite Iglesias, Nicolae Popescu. Top row, left to right: Pat Baker, Louis Rezanka, Dayton Nance, Bruce Sabath.
The Laboratory of Biology consists of three Principal Investigators: Joseph A. DiPaolo, Charles H. Evans and Craig D. Woodworth. The Laboratory of Biology has two sections, the Somatic Cell Genetics Section and the Tumor Biology Section, and plans, develops, and conducts in vitro and in vivo investigations aimed at elucidating the role of chemical, physical, and biological agents in the modulation of carcinogenesis. Coordinated biochemical and biological studies utilizing human and animal cell models are used to characterize the cellular alterations associated with carcinogenesis. These include assessment of the effect of physiological host mediating factors; determination of cell surface changes; and evaluation of relationships between differentiation, chromosome alterations and carcinogenesis. The Somatic Cell Genetics Section plans and conducts research on: (1) molecular studies on keratinocytes and cervical epithelium immortalized with recombinant human papilloma DNA; (2) molecular cytogenetics of proto-oncogenes and cloning of genes at breakage sites; (3) interactions of chemical, physical or biological agents that initiate, promote, enhance, or inhibit in vitro transformation; (4) isolation and characterization of oncogenes from in vitro transformed cell lines (human, hamster, and guinea pig) responsible for the neoplastic phenotype; (5) the influence of chemical, biological, or physical agents on chromatid exchange, and chromosome alterations as they relate to carcinogenesis; (6) development of transformation models utilizing human fibroblast and epithelial cells with specific biological markers; (7) investigation of cellular determinants required for transformation of human cells. The Tumor Biology Section plans and conducts research on: (1) characterization of natural immunity and other physiological mechanisms capable of preventing, suppressing, or otherwise modifying carcinogenesis; (2) elucidation of cell surface and membrane alterations accompanying carcinogenesis and their relationship to tumor growth; (3) definition of mechanisms whereby cytokines interact during the various stages of carcinogenesis and alter the development of neoplasia.
The Laboratory of Biology periodically has openings for outstanding postdoctoral fellows. Please direct inquiries to the appropriate Principal Investigator via the indicated e-mail address or via regular mail at Bldg. 37 Room 2A19, NIH, Bethesda, MD 20892-4255.
Updated: May 10, 1996