Cellular and Molecular Immunology Section
YOUNGH@NCIFCRF.GOV
Section Goals:
The Cellular and Molecular Immunology Section (CMIS) studies the control of gene
expression during the development and maturation of the cellular immune system in
mediating antitumor immune responses. In addition, the CMIS studies cell signaling events that lead to cellular growth and differentiation in both immune and non-immune cell systems.
The general goals of this section are to use
molecular approaches to: 1) investigate in detail the molecular mechanisms by which BRM
gene expression is regulated during natural and acquired antitumor immune responses; and
2) study the mechanism(s) by which tumor cell susceptibility to biological and immunological
defense systems can be enhanced through the control of specific gene expression; 3) investigate
signal transduction pathways involved in immune responses.
The specific aims of the CMIS are: 1) to study human and murine cell-mediated immunity,
with emphasis on T-cell and LGL specific regulation of gene expression, utilizing
IFN-gamma as a model system, 2) to study the control of lymphocyte activation at the
molecular level and 3) to study the role of the FK506 binding protein (FKBP65) in cell proliferation and transformation.
Cellular and Molecular Immunology Section
References
Laboratory of Experimental Immunology Home Page
National Cancer Institute Home Page
Updated: July 1, 1996