Recent Publications Wiltrout, R.H., Gregorio, T.A., Fenton, R.G., Longo, D.L., Ghosh, P., Murphy, W.J., and Komschlies, K.L.: Cellular and molecular studies in the treatment of murine renal cancer. Yarbro, J.W., Bornstein, R.S., and Mastrangelo, M.J. (Eds.) Seminars in Oncology, Vol. 22. W.B Sanders Company, Harcourt Brace Jovanovich, Inc., Philadelphia, PA, pp. 9-16, 1995. Grzegorzewski, K., Komschlies, K.L., Jacobsen, S.E.W., Ruscetti, F.W., Keller, J.R., and Wiltrout, R.H.: Mobilization of long-term reconstituting hematopoietic stem cells in mice by recombinant human interleukin 7. J. Exp. Med. 181:369-374, 1995.
Fogler, W.E., Pearson, J.W., Volker, K., Ariyoshi, K., Watabe, H., Riggs, C.W., Wiltrout, R.H., and Longo, D.L.: Enhancement by recombinant human interferon alpha of the reversal of multidrug resistance by MRK-16 monoclonal antibody. J. Natl. Cancer Inst. 87:94-104, 1995.
Boerman, O.C., Gregorio, T.A., Grzegorzewski, K., Faltynek, C.R., Kenny, J.J., Wiltrout, R.H., and Komschlies, K.L.: Recombinant human IL-7 administration in mice affects colony-forming units-spleen and lymphoid precursor cell localization and accelerates engraftment of bone marrow transplants. J. Leukoc. Biol. 58:151-158, 1995.
Franco, J.L., Ghosh, P., Wiltrout, R.H., Carter, C.R.D., Zea, A.H., Momozaki, N., Ochoa, A.C., Longo, D.L., Sayers, T.J., and Komschlies, K.L.: Partial degradation of T-cell signal transduction molecules by contaminating granulocytes during protein extraction of splenic T cells from tumor-bearing mice. Cancer Res. 55:3840-3846, 1995.
Komschlies, K.L., Grzegorzewski, K.J., and Wiltrout, R.H.: Diverse immunological and hematological effects of interleukin 7: implications for clinical application. J. Leukoc. Biol., in press.
Fogler, W.E., Volker, K., McCormick, K.L., Watanabe, M., Ortaldo, J.R., and Wiltrout, R.H.: NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J. Immunol. 156: 4707-4714, 1996.
Wigginton, J., Komschlies, K.L., Back, T.C., Franco, J.L., Brunda, M.J., and Wiltrout, R.H.: Administration of interleukin-12 with pulse interleukin-2 induces rapid and complete regression of established tumor. JNCI 88:38-43, 1996.
Wigginton, J.M., Kuhns, D.B., Back, T.C., Brunda, M.J., Wiltrout, R.H., and Cox, G.W.: Interleukin 12 primes macrophages for nitric oxide production in vivo and restores depressed nitric oxide production by macrophages from tumor-bearing mice: implications for the antitumor activity of interleukin 12 and/or interleukin-2. Cancer Res. 56:1131-1136, 1996.
Grzegorzewski, K.J., Komschlies, K.L., Franco, J.L., Ruscetti, F.W., Keller, J.R., and Wiltrout, R.H.: Quantitative and cell-cycle differences in progenitor cells mobilized by recombinant human interleukin-7 and recombinant human granulocyte colony-stimulating factor. Blood 88:4139-4148, 1996.
Watanabe, M., McCormick, K.L., Volker, K., Ortaldo, J.R., Wigginton, J.M., Brunda, M.J., Wiltrout, R.H., and Fogler, W.E.: Regulation of local host mediated anti-tumor mechanisms by cytokines: Direct and indirect effects on leukocyte recruitment and angiogenesis. Amer. J. Pathol., in press.
United States Patent Number 5,061,488 issued October 29, 1991. Flavone-8-acetic Acid and Interleukin-2 for Cancer Therapy.
United States Patent Number 5,096,707 issued March 17, 1992. Flavone-8-acetic Acid and Interleukin-2 in a Method of Treating Certain Cancers.
United States Patent Number 5,278,145 issued January 11, 1994. Method for Protecting Bone Marrow Against Chemotherapeutic Drugs and Radiation Therapy Using Transforming Growth Factor 1.United States patent application filed Nov. 16, 1994. Method of Mobilizing Pluripotent-hematopoietic Stem Cells with IL-7.
United States Patent Allowed (Serial #08/341,399), October 2, 1996. Method of Mobilizing Pluripotential Hematopoietic Stem Cells with IL-7.
Last updated January 1997
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