CURRICULUM VITAE

Date: December 8, 2009

Name: Curtis C. Harris, M.D.

Education:

1965 B.A., University of Kansas

1969 M.D., University of Kansas School of Medicine

1970 Intern Certificate, Internal Medicine, U.C.L.A. Hospital, Los Angeles, CA

1976 Resident Certificate, Internal Medicine, V. A. Hospital, Washington, DC

Brief Chronology of Employment and Training:

1964 - 1965 Undergraduate Teaching and Research Assistant, Department of Zoology, University of Kansas

1969 - 1970 Intern, Department of Medicine, U.C.L.A. Hospital, Los Angeles, CA

1970 - 1972 Research Associate, Lung Cancer Unit, OASDC, DCCP, NCI, NIH, Bethesda, MD

1972 - 1975 Head, Ultrastructure Unit, Pathogenesis Section, Lung Cancer Branch, DCCP, NCI, NIH, Bethesda, MD

1973 - 1976 Resident and Trainee in Clinical Oncology, NCI-VA Oncology Branch, Department of Medicine, VA Hospital, Washington, DC (4 months/year)

1975 - 1981 Head, Human Tissue Studies Section, Laboratory of Experimental Pathology, DCCP, NCI, NIH, Bethesda, MD

1979 - 1981 Associate Chief, Laboratory of Experimental Pathology, NCI, NIH, Bethesda, MD

1981 - Pres. Chief, Laboratory of Human Carcinogenesis, CCR, NCI, NIH and Head, Molecular Genetics and Carcinogenesis Section, Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, MD

Academic Appointments:

Clinical Professor of Medicine (Hematology-Oncology), Department of Medicine, Georgetown University School of Medicine, Washington, DC, 1989-1999, 2007-Pres.

Military Service: USPHS: July 1970-2000

Rank: Medical Director (Captain), 0-6

Medical Certification and License:

1970 Diplomate, National Board of Medical Examiners

1971 Medical License, District of Columbia

1975 Medical License, California

1976 Diplomate, American Board of Internal Medicine

Societies:

American Association for Cancer Research

American Association for the Advancement of Science

American Society for Clinical Investigation

International Society for Gastroenterological Carcinogenesis

International Association for the Study of Lung Cancer

International Liver Cancer Association

Editor-in-Chief:

Carcinogenesis, 1984 -

Associate Editor:

Cancer Research, 1981 - 2007

Experimental Pathology, 1982 - 1991

Cell Biology and Toxicology, 1983 - 1992

Cancer Epidemiology, Prevention and Biomarkers, 1991 - 2001

American Journal of Respiratory Cell and Molecular Biology, 1992 - 1998, 2000-2003

Clinical Cancer Research, 1996 - 2004

Cancer Science, 2004-2009

Cancer Prevention Research, 2008-

Editorial Boards:

Carcinogenesis, 1979 - 1984

ILSI Monographs on Pathology of Laboratory Animals, 1981 - 1991

Japanese Journal of Clinical Oncology, 1992 -

Journal of Cellular Biochemistry, 1982 -

Journal of Cell Biochemistry and Function, 1982 - 1991

Chemico-Biological Interactions, 1983 - 1992

Lung Cancer, 1985 - 1995

Cancer Science (Japanese Journal for Cancer), 1986 -

Molecular and Cellular Probes, 1986 - 1991

Toxicologic Pathology, 1988 - 1996

International Journal of Cancer 1991 - 2004

International Journal of Oncology 1992 - 2001

Tumori, 1992 - 2004

Predictive Oncology, 1995 - 2001

Environmental Health Perspectives, 1997 - 2004

Journal of the National Cancer Institute, 1998 - 2007

Women and Cancer, 1998 -

Gene Expression, 2000 - 2006

Hepatology, 2001 - 2004

Journal of the Nippon Medical School, 2002 -

Journal of Molecular Medicine, 2004 -

Cancer Prevention Research, 2008 -

Scientific and Organizational Responsibilities:

Advisory Activities

Member, Ad Hoc Scientific Advisory Group on In Vitro Carcinogenesis, DCCP, NCI, 1974-1975

Member, Clinical Advisory Group to Viral Oncology, DCE, NCI, 1976-1977

Reviewer and Advisor, Thesis Advisory Committee, Department of Pathology, University of Maryland School of Medicine, 1977-1999

Expert Witness, Hearings concerning OSHA Regulations entitled "Identification, Classification and Regulation of Toxic Substances Posing a Potential Occupational Carcinogenic Risk", June 1978

Reviewer, Biomedical Division, Lawrence Livermore Laboratory, University of California, 1980

Consultant, Committee on Human Risk Assessment, Office of the Commissioner, Food and Drug Administration, 1980

Member, International Advisory Committee for the Danish Cancer Society, 1984-1990

Member, Research Committee, Health Effects Institute, 1984-1991

Member, External Advisory Committee, Institute of Environmental Medicine, New York University, 1985-1992

Member, Technical Review Committee, USPHS Surgeon General Report on Harmful Effects of Smokeless Tobacco, 1985-86

Founder and Member, Board of Directors, Aspen Cancer Conference (not for profit), 1985-

Member, External Advisory Committee, School of Public Health, Johns Hopkins University, 1986-1990

Member, External Advisory Committee, Institute of Environmental Health, Oregon State University, 1986-1988

Member, Scientific Advisory Board, American Health Foundation, 1986-1998

Member, General Motors Mott Award Selection Committee, 1986

Overseer, Colby College, Waterville, Maine, 1988-1995

Member, Scientific Advisory Panel, Chemical Industry Institute of Technology, 1988

Member, Whitaker College Visiting Committee, M.I.T., 1988-1994

Chairman, Scientific Advisory Panel, Chemical Industry Institute of Technology, 1989-1994

Member, Scientific Council of the Radiation Effects Research Foundation, N.A.S. 1989-1997

Member, Scientific Advisory Council, International Agency for Research on Cancer, W.H.O., Lyon, 1989-1994

Chairman, Scientific Advisory Board, Dana Institute, American Health Foundation, 1989-1998

Chairman, Scientific Advisory Board and Secretary, Keystone Executive Committee, Keystone Symposia on Molecular and Cellular Biology (not for profit), 1990-2006

Member, Visiting Committee for the Brookhaven National Laboratory, N.A.S., Biology Department, 1990-1994

Member, Board of Directors, Intl. Society of Differentiation, 1990-1996

Chairman, Program Committee, AACR Annual Meeting, 1991

Committee Member, Risk Assessment of Hazardous Air Pollutants, National Research Council, Washington, DC, 1991-1993

Member, Advisory Committee for the Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, 1995-1997

Member, Board of Directors, American Association of Cancer Research, 1992-1995

Advisor, Howard Hughes Medical Institute Scholars Program, NIH, 1993-1995

Member, NIH Fogarty Scholars-in-Residence Advisory Panel, 1994-1996

Member, Division of Cancer Epidemiology and Genetics Promotions and Tenure Panel, 1995-1999

Member, Board of Directors, International Society of Gastroenterological Carcinogenesis, 1996-

Member, AACR Special Conference Committee, 1996-1999

Member, U.S.-Japan Promotion of Research Progress, NCI Steering Committee, 1997-1999

Member, AACR Public Relations Committee, 1997-2000

Member, AACR G. B. Elion Cancer Research Award Committee, 2000-2001

Member, AACR Education Committee, 2000-2002

Member, Tenure-Track Review Panel, Cancer Prevention Studies Branch, NCI, 2001

Co-Chair, Biology, Lung Cancer, NCI Program Review Group, 2001

Member, Tenure-Track Review Panel, Biostatistics Branch, NCI, 2001

Member, AACR Special Conference Committee, 2001-2006

Member, NCI Core Genotyping Oversight Committee, 2001-

Chair and Member, AACR Nomination Committee, 2003-2005

Consultant (non-paid), Radiation Effects Research Foundation, Hiroshima, Japan 2004-

Member, AACR Grants Committee, 2004-2005

Member, AACR Program Committee, Annual Meeting, 2005 and 2007

Contributing Author, The Health Consequences of Smoking: A Report of the Surgeon General, 2004

Member, Advisory Board, Center for Cancer Research, NCI, 2005-2007

Member, NCI 2015 Strategy Development Team, 2005

Member, AACR, Centennial Committee, 2006-

Member, Nominating Committee, AACR-Princess Takamatsu Lectureship, 2007

Chairman, Board of Directors, Aspen Cancer Conference (not for profit), 2007-

Chairman, Board of Directors, Keystone Symposia on Molecular and Cellular Biology (not for profit), 2007-2010

Member, Steering Committee, Center of Excellence in Integrative Cancer Biology and Genomics, 2008-

Member, International Liver Cancer Association Governing Board, 2009-2012

Member, INFLA-CARE Scientific Advisory Board, 2009-

Honors and Other Special Scientific Recognition:

NSF Research Participation Awardee and Gifted Student Program, University of Kansas, 1963-1965

George Bailey Award, University of Kansas, School of Medicine, 1967

Commendation Medal, USPHS Honor Award, 1979

Medical Alumni Scholar and Lecturer, first to be awarded, University of Kansas School of Medicine, 1982

NCI Equal Employment Opportunity Special Recognition Award, 1983

Fellow, American Society of Clinical Investigation, 1984

Meritorious Service Award, USPHS, 1986

G. Scott Award, Toxicology Forum, 1991

Keynote Address, Princess Takamatsu Symposium, 1991

George Peabody Award, Southwestern University School of Medicine, 1993

Alton Ochsner Award Relating Smoking and Health, Alton Ochsner Medical Foundation and American College of Chest Physicians, 1993

Keynote Address, Beatson International Cancer Conference, 1993

Keynote Address, Japanese Research Society for Gastrointestinal Cancers, 1993

William A. Gardner Award and Lecturer, Yale University, 1994

Keynote Address, Barton Creek Cancer Conference, University of Texas, 1994

Keynote Address, Annual Meeting, Chinese Oncology Society, 1994

Maud L. Menten Award and Lecturer, University of Pittsburg School of Medicine, 1995

Walter Hubert Award and Lecturer, British Association for Cancer Research, Nottingham, 1995

Don Coffey Award and Lecturer, Society for Basic Urological Research, Las Vegas, 1995

CIIT Founders Award, Durham, 1995

Deichmann Award and Keynote Lecture: VII International Congress of Toxicology, Seattle, 1995

Keynote Address, 5th International Inhalation Symposium, Hannover, 1995

Keynote Address, Japanese Lung Cancer Society, 1995

International Keynote Lecturer, Japanese Surgical Society Annual Meeting, Chiba, 1996

Lewis M. Schiffer Memorial Award and Lecturer, Cell Proliferation Society, Toledo, 1996

Bob Champion Award and Lecturer, British Oncological Association, 1996

Keynote Address, AACR-IARC Conference, Molecular Epidemiology, Budapest, 1996

William Stenberg Memorial Lecture, Tulane, 1997

Elizabeth and James Miller Distinguished Lecturer, Rutgers University, New Jersey, 1997

Keynote Address, Genes and Environment in Cancer, Dr. Mildred Stiftung FDN, Bonn, 1997

Robert Greenfield Memorial Lecturer, University of Nebraska, 1998

Federal Technology Transfer Award, 1998-2006

Distinguished Lectureship, Japanese Foundation for Cancer Research, Tokyo, 1998

Identified as one of the 50 most cited scientists in biomedical research in the 1990s (ISI Science Watch, March, 1998)

Keynote Address, Latin-American Meeting, Environmental Mutagenesis, Carcinogenesis and Teratogenesis, Curitiba, 1998

Distinguished Lecturer, Cancer Institute of New Jersey, Rutgers University, 1999

Robert F. E. Stier Memorial Lecturer, Washington State University, 1999

Keynote Address, 2nd International Congress on Gastroenterological Carcinogenesis, Ulm, 1999

Charles Heidelberger Award, International Society on Gastroenterological Carcinogenesis, Ulm, 1999

Distinguished Service Medal, highest award of the U.S.Public Health Service, 1999

Gerald N. Wogan Lecturer, Massachusettes Institute of Technology, 2000

Keynote Address, Molecular Epidemiology of Human Cancer Conference, International Agency for Research on Cancer, Lyon, 2000

Distinguished Alumni Lecturer, University of Kansas, Lawrence, 2001

Honorary Member, Japanese Cancer Association, Tokyo, 2001

Special Lecturer, Japanese Cancer Association, Annual Meeting, Tokyo, 2002

Award of Merit, Princess Takamatsu Cancer Research Fund, Japan, 2002

Keynote Address, Lovelace Symposium, Santa Fe, 2002

Fellow, AAAS, 2003

Senior Fellow and Lecturer, Japanese Cancer Research Foundation, 2003

Keynote Address, Environmental Health Conference, Lancaster, 2003

Keynote Address, p53 Satellite Meeting, Tenth International Toxicology Congress, Finland, 2004

Keynote Address, Tenth International Toxicology Congress, Finland, 2004

Undergraduate Scholarship Program Recognition Award, National Institutes of Health, Bethesda, MD, 2005

Keynote Address, Environmental Mutagen Society United Kingdom, Bradford, 2005

Keynote Address, International Symposium, Chronic Oxidative Stress and Cancer: Mechanisms, Biomarkers and Prevention, German Cancer Research Center, Heidelberg, 2005

Keynote Address and Visiting Professor: Frontiers in Biomedical Research, Hong Kong School of Medicine, Hong Kong, 2005

Presidential Lecture, International Liver Congress, Shanghai, 2006

Keynote Address, Microenvironment and Cancer Symposium, Japanese Foundation Cancer Research, Tokyo, 2006

State of the Art Address, International Liver Cancer Association, Barcelona, 2007

NCI Outstanding Mentor Award, 2007

Keynote Address, Nitric Oxide Gordon Conference Research Conference, Barga, Italy, 2009

AACR-Princess Takamatsu Award, AACR Annual Meeting, Denver, CO, 2009

Inflammation and Cancer: microRNA and p53 isoforms in cancer diagnosis, prognosis, and therapeutic therapy, 1st International Meeting on Molecular Based Treatment of GI-Cancer, Göttengen, Germany, 2009

Invited Talks (2005-present):

1. “Radical causes of human cancer”. Keystone Symposia, Breckenridge, CO, March 2005

2. “p53: At the Crossroads of DNA Repair, DNA Recombination and Carcinogenesis”. Keystone Symposia, Taos, New Mexico, March 2005

3. “p53: At the Crossroads of Inflammation, Aging and Cancer”. FAMRI Advisory Board Mtg/Weizman Institute, Rehovot, Israel, March 2005

4. “Chronic Inflammation and Cancer”. Oregon State University, Portland OR, April 2005;

5. “p53 Tumor Suppressor: At the Crossroads of Molecular, Pathogenesis, Therapy and Epidemiology of Hepatocellular Carcinoma”. Barcelona, Spain, June 2005

6. “p53 tumor suppressor and genomic instability diseases”. University of Oxford, London, England, June 2005

7. “p53 at the Crossroads of DNA repair and DNA Recombination”. 28^th Annual Conference of the UK Environmental Mutagenesis Society, Bradford, United Kingdom, August 2005

8. “Inflammation and Cancer”. Mechanisms, Biomarkers and Prevention Symposium, Heidelberg, Germany, October 2005

9. “p53 Senescence and Cancer”. Keystone Symposium, Singapore, October 2005

10. “Chronic Inflammation and Cancer: Radical Causes of Cancer”. Boston University, Boston, MA, October 2005

11. “Chronic Inflammation and Cancer”. China, Beijing, November 2005

12. “p53 Tumor Suppressor Colon: At the Crossroads of Inflammatory Stress and Cancer”. Second International Workshop, Ein Gedi, Israel, November 2005

13. “p53 Biological Network: Chronic inflammation and Cancer”. University of Hong/Frontiers in Biomedical Research Symposium, Hong Kong, December 2005

14. “p53 Biological network: Inflammation and cancer”. 11^th International Charles Heidelberger Symposium on Cancer Research, Naresuan University Hospital, Phitsanulok, Thialand, January 2006

15. “p53 Tumor Suppressor network: At the crossroads of the molecular carcinogenesis and molecular epidemiology of liver cancer”. Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, March 2006

16. “Cause and Prevention of Colon Cancer”. University of South Carolina, National Colorectal Awareness, Columbia, SC, March 2006

17. “p53 Biological network: chronic inflammation and cancer”. International Symposium on Carcinogenesis and Tissue Environment, Tokyo, Japan, April 2006

18. “p53 mediated senescence”. International p53 workshop, Columbia University, New York, NY, May 2006

19. “p53 biological network: chronic inflammation and cancer”. CNIO Cancer Conference on Inflammation and Cancer, Madrid, Spain, May 2006

20. “Chronic Inflammation and Cancer: Radical Causes of Human Cancer”. 4^th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide, Monterey, CA, June 2006

21. “Microenvironment and Cancer: Inflammation microRNA profiles and p53 Network”. Kansas University Cancer Center Symposium, Kansas City, KS, June 2006

22. “Inflammation and Cancer”. 46^th annual meeting of Japanese Respiratory Society, Japan, Tokyo, June 2006

23. “Molecular and Profiling of Lung Cancer”. National Cancer Center Research Institute, Tokyo, Japan, June 2006

24. “Unique microRNAs predict lung cancer diagnosis and prognosis”. Aspen Cancer Conference, Aspen, CO, July 2006

25. “Microenvironment and p53 Biological Network”. European Environmental Mutagen Society Meeting, Prague, Czech Republic, July 2006

26. “Chronic Inflammation and Cancer: Radical causes of cancer”. 4^th International Gastroenterological Carcinogenesis Conference 2006, Honolulu, HI, August 2006

27. “Microenvironment and Cancer: Inflammation, microRNA and cytokine profiles, and p53 network”. University of California, San Francisco, CA, August 2006

28. “Microenvironment and Cancer: Inflammation, microRNA and cytokine profiles, and p53 network”. University of Calgary, Alberta, Canada, August 2006

29. “p53 Biological Network”. Eurotox 2006 meeting, Cavtat/Dubrovnik, Croatia, September 2006

30. “Microenvironment and Cancer: inflammation, microRNA and cytokines”. Northwestern University School of Medicine Pathology Department, Chicago, IL, September 2006

31. “Microenvironment and Cancer: Inflammation, microRNAs and Cytokines”. 5^th Cytokines and Inflammation Conference, Breckenridge, CO, January 2007

32. “Inflammation and Cancer”. Keystone Symposium on Genome Instability & Repair, Breckenridge, CO, January 2007

33. “Microenvironment and Cancer: Inflammation, microRNA and p53”. Weizmann Institute of Science, Rehovot, Israel, February 2007

34. “Microenvironment and Cancer: Inflammation, microRNA and p53”. Mainz University, Mainz, Germany, February 2007

35. “microRNAs and Cytokines modulate lung cancer progression and prognosis: Mechanistic insights and clinical potential”. AEK Congress of the Experimental Branch of the German Cancer Society, Frankfurt, Germany, March 2007

36. “microRNAs predict cancer diagnosis and prognosis”. AACR annual meeting, Los Angeles, CA, April 2007

37. “microRNA and cytokine profiling predict cancer diagnosis and prognosis”. 12^th International Heidelberger Symposium on Cancer Research, Jerusalem, Israel, May 2007

38. “Microenvironment and Cancer: inflammation and microRNA”. San Antonio Cancer Institute, San Antonio, TX, May 2007

39. “Microenvironment and Cancer”. IN University, Center for Environmental Health, Indianapolis, IN, May 2007

40. “Microenvironment and Cancer: Inflammation, microRNA and p53”. The Falk Symposium, Portoroz, Slovenia, June 2007

41. “microRNAs in cancer diagnosis and prognosis”. Gordon Research Conference on Molecular Therapeutics of Cancer, New London, NH, July 2007

42. “Inflammation and Cancer: Interactions of microRNA cytokine and p53 pathways”. XIII Charles Heidelberger International Symposium, New York, NY, September 2007

43. “Chronic Inflammation and Cancer: Interaction of free radical, microRNA cytokine pathways”. University of Geneva Department of Molecular Biology, Geneva, Switzerland, October 2007

44. “Inflammation and Cancer: Interactions of microRNA cytokine and p53 pathways”. International Liver Cancer Association Meeting, Barcelona, Spain, October 2007

45. “Inflammation and Cancer”. 4^th Nestle International Nutrition Symposium, Lausanne, Switzerland, October 2007

46. “Inflammation and Cancer: Interactions of microRNA cytokine and p53 pathways”. Keystone Symposium on Frontiers in Gastrointestinal Cancer, Beijing, China, October 2007

47. “Inflammation and Cancer: Interactive MicroRNA, Cytokine and free radicals pathways”. Sixth Princess Chulabhorn International Science Congress, Bangkok, Thialand, November 2007

48. “MicroRNAs as biomarkers of colon cancer and prognosis”. AACR Special Conference on Advances in Colon Cancer Research, Cambridge, MA, November 2007

49. “Inflammation and Cancer: Interaction of the p53, microRNA and cytokine pathways”. 3^rd International Workshop on Mutant p53, Lyon, France, November 2007

50. “Inflammation and Cancer: Interactions of microRNA, cytokine and p53 pathways”. National Cancer Center Research Institute, Tokyo, Japan; December 2007

51. “Chronic Inflammation and Cancer: Interaction of microRNA, free radical and cytokine and p53 pathway”. Ludwig Institute for Cancer Research/University of Oxford Branch, Headington, Oxford, UK, April 2008

52. “Inflammation and cancer: Interpretation of microRNA, free radical cytokine and p53 pathway”. UCLA Schools of Medicine and Public Health, Los Angeles, CA, April 2008

53. “Chronic inflammation and cancer”. Offices of Life Sciences, National University of Singapore, Singapore, May 2008

54. “Chronic Inflammation: and Cancer: Interweaving microRNA, cytokine, free radical and p53 pathways”. Nippon Medical School, Tokyo, Japan, May 2008

55. “Inflammation and Cancer: Interaction of microRNA, free radical and cytokine and p53 pathway”. University of Dundee, Biomedical Research Centre Ninewells Hospital & Medical School, Dundee, Scotland, May 2008

56. “Inflammation and liver cancer: interweaving hepatitis virus, microRNA, aflatoxin B1 and p53 pathways”. Hong Kong-Shanghai International Liver Conference, Hong Kong, China, June 2008

57. “Inflammation at the intersect of chemical microbial carcinogenesis”. University of Vienna, Vienna Switzerland, September 2008

58. “p53 independent cellular senescence”. p53 Workshop, Shanghai, China, October 2008

59. “MicroRNAs and inflammatory cytokines as clinical biomarkers of cancer diagnosis, prognosis and therapeutic outcome”. Dublin Cancer Conference, Dublin, Ireland, December 2008

60. “Inflammation and cancer”. Brupbacker Symposium, Zurich, Germany, February 2009

61. “Inflammation and cancer: Interweaving microRNA, p53 and cytokine pathways”. Japan Foundation of Cancer Research, February 2009

62. “MicroRNAs in cellular senescence and carcinogenesis”. National Cancer Research Institute, February 2009

63. “MicroRNA and p53 pathways in cellular senescence and cancer”. p53 Workshop, Acore, Israel, March 2009

64. “MicroRNAs as cancer biomarkers”. AACR Symposium, AACR, Denver, CO, April 2009

65. “MicroRNA and inflammatory cytokines as cancer biomarkers”. MicroRNA and Cancer, Keystone Symposium, Keystone, CO, June 2009

Committees and Conferences:

Member, Lung Cancer Segment, DCCP, NCI, 1972-1974

Member, Working Party for Therapy of Lung Cancer, DCT, NCI, 1973-1975

Member, Organizing Committee, International Conference on Late Effects of Cancer Therapy, sponsored by Cancer Clinical Investigations Review Committee, NCI, January 1975

Chairman, Human Studies Collaborative Group, NCI, 1975-1985

Chairman, Organizing Committee, International Conference on Methods to Culture Human Cells and Tissues, sponsored by NHLBI and NCI, 1979

Member, Pathology Study Section B, Ad Hoc Committee on Chemical Pathology, National Cancer Institute, 1978-1979

Member, Carcinogenesis Committee, NCI Occupational Cancer Task Force, 1978

Member, Environmental Pathology Registry Advisory Committee, International Academy of Pathology, 1979-1984

Member, Scientific Program Committee, Second World Conference on Lung Cancer, Copenhagen, sponsored by the International Association for the Study of Lung Cancer, 1980

Co-organizer, Interspecies Correlations in Chemical Carcinogenesis, U.S.-Japan Cooperative Cancer Research Program Conference, Tokyo, Japan, 1981

Co-organizer, Mechanisms of Chemical Carcinogenesis, ICN-UCLA Symposia on Molecular and Cellular Biology, Keystone, 1981

Co-organizer, Cancer and Aging, Given Institute of Pathobiology, Aspen, 1981

Member, Program Committee, III World Congress on Lung Cancer, Tokyo, 1982

Program Chairman, Carcinogenesis Studies Using Cultured Human Tissues and Cells, sponsored by National Cancer Institute, Aspen, 1982

Co-organizer, Multiple Primary Cancers, U.S.-Japan Cooperative Cancer Research Program Conference, Tokyo, Japan, 1983

Member, Program Committee, International Conf. on Cell Biochemistry and Function, Guilford, 1983

Member, Program Committee, Chemical and Radiation Carcinogenesis Conference, Bethesda, MD 1983

Organizer, Tumor Promotion in Human Cancer, NIH Combined Clinical Staff Conference, Bethesda, MD 1983

Member, Promotion Review Committee, Division of Cancer Etiology, NCI, 1983-1986

Member, Program Committee, Conference on “Interspecies Correlations in Carcinogenesis,” Aspen, 1985

Member, Program Committee, IV World Congress on Lung Cancer, Toronto, August 1985

Co-organizer, Mechanisms of Tobacco Carcinogenesis, Banbury Conference, Cold Spring Harbor, NY, 1985

Organizer, Biochemical and Molecular Epidemiology of Cancer, UCLA Symposium on Cellular and Molecular Biology, Steamboat Spr., April, 1985

Chairman, Carcinogenesis Section, AACR Program Committee, 1986

Member, Program Committee, Biochemical and Cellular Indices of Human Toxicity in Occupational Medicine, Milan, 1986

Chairman, Program Committee, III International Workshop on Carcinogenesis Studies Using Human Tissues and Cells, Copenhagen, 1987

Co-chairman, Board of Directors, Aspen Cancer Conference, 1988 -

Co-organizer, Genetic Mechanisms of Carcinogenesis and Tumor Progression, UCLA Symposium on Cellular and Molecular Biology, Keystone, 1989

Co-chairman, Fundamental and Clinic Research on Liver Cancer, Japanese Promotion for Cancer Research, Tokyo, 1989

Chairman, Program Committee, International Workshop on Prevention of Liver Cancer, Hawaii, 1989

Co-chairman, U.S.-Japan Cooperative Cancer Program Workshop on Multiple Primary Cancer, Hawaii, 1989

Chairman, Program Committee, International Symposium on N-Nitroso Compounds, Mycotoxins and Tobacco Smoke, Lyon, 1989

Co-organizer, Molecular Mechanisms of Fiber Toxicity and Carcinogenesis, Banbury Conference, 1990

Co-organizer, U.S.-Japan Cancer Cooperative Workshop, Osaka, Japan, 1990

Co-organizer, International Conference on Multiple Primary Tumors, Tokyo, Japan, 1990

Co-organizer, Genetic Instability and Cancer, Keystone Symposia on Cellular and Molecular Biology, Tamarron, 1991

Chairman, Program Committee, AACR Annual Meeting, Houston, Texas, 1991

Co-organizer, Princess Takamatsu Symposium, Tokyo, 1991

Co-organizer, Genetic Instability in Carcinogenesis and Tumor Progression, U.S.-Japan, Cooperative Cancer Research Program, Hawaii, 1992

Co-organizer, AACR-IARC Conference, Lyon, 1992

Co-organizer, 6th International Symposium on Fundamental & Clinical Research in Esophageal Cancer, Tokyo, 1993

Co-organizer, p53 in Growth Control and Neoplasia, Brupbacher Foundation, Zurich, 1993

Co-organizer, Tumor Suppressor Genes, Keystone Symposium, Taos, NM, 1994

Co-organizer, Apoptosis, UICC Workshop, Woodshole, 1994

Co-organizer, Cancer Susceptibility and Molecular Carcinogenesis, AACR Special Conference, Keystone, CO, 1996

Co-organizer, Creating a Strategy for Science-Based National Policy, Addressing Conflicting Scientific Views on the Health Risks of Low- Level Ionizing Radiation, Wingspread, 1997

Co-organizer, Molecular Epidemiology of Lung Cancer: Clinical Implications, Oslo, 1998

Co-organizer, p53 Workshop, Crete, 1998

Co-organizer, Molecular Epidemiology of Cancer, Keystone Cellular and Molecular Biology Symposium, Taos, NM, 2000

Member, Organizing Committee, p53 Workshop, Monterey, CA, 2000

Co-chair, Biology, Lung Cancer, NCI Program Review Group, Bethesda, MD, 2001

Co-chair, Impact of the Environment on Colon Cancer, Miami, FL, 2003

Co-chair, 13th International Symposium of the Hiroshima Cancer Center, Hiroshima, 2003

Co-organizer, Lung Cancer Workshop, NCI, Bethesda, MD, 2003

Member, Organizing Committee, p53 Workshop, Dunedin, New Zealand, 2004

Chair, Organizing Committee, Bloom Syndrome: Molecular Basis of Genomic Instability, NIH, Bethesda, MD, 2005

Member, Organizing Committee, Keystone Sym., Stem Cells, Senescence and Cancer, Singapore, 2005

Co-organizer, Inflammation and Colon Cancer, NCI, Bethesda, MD 2006

Co-organizer, International Symposium on Human Carcinogenesis, NCI, Bethesda, MD, 2006

Member, Organizing Committee, p53 Workshop, New York, 2006

Co-organizer, Japan-US Cooperative Cancer Research Seminar on Molecular Epidemiological Characteristics of Lung and Colon Cancer Development Among Atomic-Bomb Survivors, Bethesda, MD, 2006

Member, Organizing Committee, Inflammation and Cancer, NCI, Bethesda, MD, 2007

Member, Steering Committee, Center of Excellence in Cancer Biology and Human Genomics, NCI, 2007

Member, Organizing Committee, p53 Workshop, Shanghai, China, 2008

Co-organizer, Bloom Syndrome Conference, Chicago, IL, 2008

Member, Governing Board, International Liver Cancer Association, 2009-1013

Co-organizer, MicroRNA and Non-coding RNAs in Cancer, Keystone Symposium, 2011

Research Interests:

1. Human carcinogenesis.

2. Molecular epidemiology of cancer.

Inventions and Patents Assigned to U.S. Government:

1. Ultrasensitive enzymatic radioimmunoassay method (USERIA), U.S. patent

4,289,748.

2. Protoplast Fusion Method for High Frequency DNA Transfection in Human Cells; U.S. patent 4,608,339.

3. Cascade Amplification Enzyme Immunoassay, U.S. patent 4,463,090.

4. A Method and Kit for Detecting Human Exposure to Genotoxic Agents; U.S. patent 4,794,074.

5. Immortalized Human Bronchial and Mesothelial Epithelial Cell Lines; U.S. patent 4,885,238.

6. Cell Culture Medium for Human Liver Epithelial Cell Line; U.S. patent 5,342,777.

7. Immortalized Human Cell Lines Containing Exogenous Cytochrome P450; U.S. patent 5,356,806.

8. An Immortalized Human Bronchial Epithelial Cell Line; U.S. patent 5,432,060.

9. Immortalized Nontumorigenic Human Bronchial Epithelial Cell Lines; U.S. patent 5,443,954.

10. Immortalized Human Cell Lines containing Exogenous Cytochrome p450 Genes; U.S. patent 5,660,986.

11. Eukaryotic Expression Vector System; U.S. patent 5,604,118.

12. Human Liver Epithelial Cell Line and Culture Media Therefore; U.S. patent 5,529,920.

13. Human Liver Epithelial Cell Lines; U.S. patent 5,759,765.

14. Screening Assays for Compounds that cause Apoptosis; U.S. patent 6,602,979.

15. Methods for Identifying Inhibitors of GADD45 Peptide Activity and Inhibitors of Such Activity; U.S. patent 60,126,069; 7,125,850.

16. Telomerase-Immortalized Human Cell Lines; U.S. patent 60,255,722.

17. Immortalization of Human Epithelial Cells; U.S. patent 60,260,625.

18. Anticancer, Apoptosis-Inducing Compounds; application pending.

19. Methods for Assaying for Modulations of GADD45 Activity; U.S. patent 7,005,419.

20. New Tumor Suppressor Gene p33 ING2; U.S. patent 6,790,948.

21. New Tumor Suppressor Gene p47ING3; Application number 11/962,906; pending.

22. p53 and VEGF Regulate Tumor Growth of NOS2 Expressing Cancer Cells; Application number 11/195,006, pending.

23. New Tumor Suppressor Gene p28ING5; U.S. patent 60,351,504.

24. Telomerase Immortalized Human Cell Lines; application pending.

25. Methods and Compositions for the Diagnosis of Neuroendocrine Lung Cancer; Application number 10/533,459, pending.

26. POT1 alternative splicing variants in Hereditary Nonpolyposis Colorectal Carcinoma (HNPCC), Application number 11/665,944, pending.

27. MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Lung Cancer, application pending.

28. MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Colon Cancer, application pending.

29. Methods of Determining the Prognosis of an Adenocarcinoma, Application number PCT/US2007/07 3637; application pending.

30. Molecular Characteristics of non-small cell lung cancer, Application number 10/486,844

31. Molecular Characteristics of non-small cell lung cancer, Application number 11/829,483

32. Mirna Biomarkers predict esophageal carcinoma diagnosis and Barrett’s esophagus status, Application number 60/979,300

33. Diagnostic and therapeutic applications of a p53 isoform in regenerative medicine, aging, and cancer, Application number 60/987,340

34. Method and analysis of tissue samples for diagnosis and prognosis, Application number 61/034,868

35. Unique MicroRNA molecular profiles in lung cancer diagnosis and prognosis, Application number PCT/US2007/00 0103

36. MicroRNA profiles predict colon cancer prognosis, Application number PCT/US2007/01 5892

37. Compositions and methods for diagnosis and treatment of tumors, Application number PCT/US2007/07 1712

38. Inflammatory genes and MicroRNA-21 as biomarkers for colon cancer prognosis, Application number 61/194,340, 2008

39. New Tumor Suppressor Gene, p28ING5, Application number 12/198,897

40. New Tumor Suppressor Gene, p28ING5, issued U.S. Patent number 7,432,349

41. Tumor Suppressor Gene p33ING2, 12/203,836, Sept. 3, 2008

42. Therapeutic applications of a p53 isoform in regenerative medicine, aging and cancer, PCT/US08/80648, filed Oct. 21, 2008

43. Methods of determining the prognosis of an adenocarcinoma, 12/373,191, Jan. 9, 2009

Laboratory Address: Laboratory of Human Carcinogenesis

NIH, NCI, CCR

Building 37, Room 3068A

Bethesda, MD 20892-4258

Tel: 301-496-2048

Fax: 301-496-0497

Email: curtis_harris@nih.gov

Homepage: http://www.nci.nih.gov/intra/lhc/lhcpage.htm

Home Address: P.O. Box 77

Garrett Park, MD 20896-0077

BIBLIOGRAPHY

Articles in Journals

1. Harris, C. and Leone, C. A.: Some effects of EDTA and tetraphenylboron on the ultrastructure of mitochondria in mouse liver cells. J. Cell Biology 28: 405-408, 1966.

2. Harris, C., Grady, H. and Svoboda, D.: Segregation of the nucleolus produced by Anthramycin. Cancer Res. 28: 81-90, 1968.

3. Reddy, J., Harris, C. and Svoboda, D.: Inhibition by lasiocarpine of RNA synthesis, RNA polymerase and induction of tryptophan pyrrolase activity. Nature 217: 659-661, 1968.

4. Harris, C., Grady, H. and Svoboda, D.: Alterations in pancreatic and hepatic ultrastructure following acute cycloheximide intoxication. J.Ultrastructure Res. 22: 240-251, 1968.

5. Harris, C., Reddy, J., Svoboda, D.: Isolation and ultrastructure of nucleoli altered in vivo. Exp. Cell Res. 51: 268-274, 1968.

6. Harris, C., Reddy, J. and Svoboda, D.: The effect of cycloheximide on ribonucleic acid and protein synthesis in rat liver. Biochem. Pharmacol. 18: 951-954, 1969.

7. Harris, C., Reddy, J., Chiga, M. and Svoboda, D.: Polyribosome disaggregation in rat liver by lasiocarpine. Biochem. Biophys. Acta 182: 587-589, 1969.

8. Reddy, J., Chiga, M., Harris, C. and Svoboda, D.: Polyribosome disaggregation in rat liver following administration of tannic acid. Cancer Res. 30: 58-65, 1970.

9. Svoboda, D., Reddy, J. and Harris, C.: Invasive tumors induced in rats with Actinomycin D. Cancer Res. 30: 2271-2279, 1970.

10. Harris, C.: Malignancy during methotrexate and steroid therapy for psoriasis. Arch. Derm. 103: 501-504, 1971.

11. Harris, C., Sporn, M., Kaufman, D., Smith, J., Baker, M. and Saffiotti, U.: Acute ultrastructural effects of benzo(a)pyrene and ferric oxide on the hamster tracheobronchial epithelium. Cancer Res. 31: 1977-1989, 1971.

12. Harris, C., Sporn, M., Kaufman, D., Smith, J., Jackson, F. and Saffiotti, U.: Histogenesis of squamous metaplasia in the hamster tracheal epithelium caused by vitamin A deficiency or by benzo-(a)pyrene-ferric oxide. J. Natl. Cancer Inst. 48: 743-761, 1972.

13. Kaufman, D., Baker, M., Harris, C., Smith, J., Boren, H., Sporn, M. and Saffiotti, U.: Coordinated biochemical and morphologic examination of hamster tracheal epithelium. J. Natl. Cancer Inst. 49: 783-792, 1972.

14. Kaufman, D., Baker, M., Smith, J., Henderson, W., Harris, C., Sporn, M. and Saffiotti, U.: RNA metabolism in tracheal epithelium: Alteration in hamsters deficient in vitamin A. Science 177: 1105-1108, 1972.

15. Harris, C., Kaufman, D., Sporn, M., Boren, H., Jackson, F., Smith, J., Pauley, J., Dedick, P. and Saffiotti, U.: Localization of benzo(a)- pyrene-3H and alterations in nuclear chromatin caused by benzo(a)pyrene-ferric oxide in the hamster respiratory epithelium. Cancer Res. 33: 2842-2848, 1973.

16. Harris, C., Kaufman, D., Sporn, M. and Saffiotti, U.: Histogenesis of squamous metaplasia and squamous cell carcinoma of the respiratory epithelium in an animal model. Cancer Chemotherapy Rep. 4: 43-54, 1973.

17. Harris, C.: The epidemiology of different histologic types of bronchogenic carcinoma. Cancer Chemotherapy Rep. 4: 59-61, 1973.

18. Port, C., Henry, M., Kaufman, D., Harris, C. and Ketels, K.: Acute changes in the surface morphology of hamster tracheobronchial epithelium following benzo(a)pyrene and ferric oxide administration. Cancer Res. 33: 2498-2506, 1973.

19. Harris, C., Kaufman, D., Sporn, M., Smith, J., Jackson, F. and Saffiotti, U.: Ultrastructural effects of N-methyl-N-nitrosourea on the tracheobronchial epithelium of the Syrian golden hamster. Int. J. Cancer 12: 259-269, 1973.

20. Kaufman, D., Genta, V., Harris, C., Smith, J., Sporn, M. and Saffiotti, U.: Binding of 3H-labeled benzo[a]pyrene to DNA in hamster tracheal epithelial cells. Cancer Res. 33: 2837-2841, 1973.

21. Harris, C., Silverman, T., Jackson, F., Smith, J. and Boren, H.: Proliferation of tracheal epithelial cells in normal and vitamin A deficient Syrian golden hamsters. J. Natl. Cancer Inst. 51: 1059-1064, 1973.

22. Kripke, M., Steinmuller, D., Harris, C., Lofgreen, P. and Eichwald, E.: Effects of chronic cyclophosphamide and methotrexate treatment on skin allograft survival in mice and rats. J. Natl. Cancer Inst. 51: 1355-1358, 1973.

23. Wenk, M., Reddy, J. and Harris, C.: Pancreatic regeneration caused by ethionine in the guinea pig. J. Natl. Cancer Inst. 52: 533-538, 1974.

24. Harris, C., Primack, A. and Cohen, M.: Elevated alpha1-antitrypsin serum levels in lung cancer patients. Cancer 34: 280-281, 1974.

25. Genta, V., Kaufman, D., Harris, C., Jackson, F., Smith, J., Sporn, M. and Saffiotti, U.: Vitamin A deficiency enhances binding of benzo(a)-pyrene to tracheal epithelial DNA. Nature 247: 48-49, 1974.

26. Harris, C., Kaufman, D., Jackson, F., Smith, J., Dedick, P. and Saffiotti, U.: Atypical cilia in the tracheobronchial epithelium of the hamster during respiratory carcinogenesis. J. Path. 114: 17-19, 1974.

27. Yuspa, S. and Harris, C.: Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro. Exp. Cell Res. 86: 95-105, 1974.

28. Meadows, A., D'Angio, G., Evans, A., Harris, C., Miller, R. and Mike, V.: Oncogenesis and other late effects of cancer treatment in children. Radiol. 114: 175-181, 1975.

29. Harris, C., Connor, R., Jackson, F. and Lieberman, M.: Intranuclear distribution of DNA repair synthesis induced by chemical carcinogens or ultraviolet light in human diploid fibroblasts. Cancer Res. 34: 3461-3469, 1974.

30. Boren, H., Pauley, J., Wright, E., Kaufman, D., Smith, J. and Harris, C.: Cell populations in the hamster tracheal epithelium in relation to vitamin A status. Int. J. Vit. Res. 44: 382-390, 1974.

31. Boren, H., Wright, E. and Harris, C.: Quantitative light microscopic autoradiography - Emulsion sensitivity and latent image fading. J. Cytochem. Histochem. 23: 901-909, 1975.

32. Harris, C., Genta, V., Frank, A., Kaufman, D., Barrett, L., McDowell, E. and Trump, B.: Carcinogenic polynuclear hydrocarbons bind to macromolecules in cultured human bronchi. Nature 252: 68-69, 1974.

33. Harris, C., Cohen, M., Connor, R., Primack, A., Saccomanno, G. and Talamo, R.: Serum alpha1-antitrypsin in patients with lung cancer or abnormal sputum cytology. Cancer 38: 1655-1657, 1976.

34. Harris, C., Frank, A., van Haaften, C., Kaufman, D., Connor, R., Jackson, F., Barrett, L., McDowell, E. and Trump, B.: Binding of [3H] benzo(a)pyrene to DNA in cultured human bronchus. Cancer Res. 36: 1011-1018, 1976.

35. Barrett, L., McDowell, E., Frank, A., Harris, C. and Trump, B.: Long-term organ culture of human bronchial epithelium. Cancer Res. 36: 1003-1010, 1976.

36. D'Angio, G., Meadows, A., Mike, V., Harris, C., Evans, A., Jaffe, N., Newton, W., Schweisguth, O., Sutow, W. and Morris-Jones, P.: Decreased risk of radiation-associated second malignant neoplasms in actinomycin- D-treated patients. Cancer 37: 1177-1185, 1976.

37. McDowell, E., Barrett, L., Harris, C. and Trump, B.: Abnormal cilia in human bronchial epithelium. Arch. Pathol. 100: 429-436, 1976.

38. Harris, C., Autrup, H., Connor, R., Barrett, L., McDowell, E. and Trump, B.: Interindividual variation in binding of benzo[a]pyrene to DNA in cultured human bronchi. Science 194: 1067-1069, 1976.

39. Weinstein, I. B., Jeffrey, A., Jennette, K., Blobstein, S., Harvey, R., Harris, C., Autrup, H., Kasai, H. and Nakanishi, K.: Benzo[a]pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo. Science 193: 592-595, 1976.

40. Trump, B., McDowell, E., Barrett, L., Jones, R., Valerio, M. and Harris, C.: Ultrastructural and cytochemical studies on the mechanism of chemical carcinogenesis in the human. Microscopical Society of Canada 3: 142-145, 1976.

41. Jones, R., Barrett, L., van Haaften, C., Harris, C. and Trump, B.: Carcinogenesis in the pancreas. I. Long-term explant culture of human and bovine pancreatic ducts. J. Natl. Cancer Inst. 58: 557-565, 1977.

42. Yang, S. F., Gelboin, H. V., Trump, B. F., Autrup, H. N. and Harris, C.: Metabolic activation of benzo[a]pyrene and DNA binding in cultured human bronchus. Cancer Res. 37: 1210-1215, 1977.

43. Autrup, H. N., Harris, C. C., Stoner, G. D., Jesudason, M. L. and Trump, B. F.: Binding of chemical carcinogens to macromolecules in cultured human colon. J. Natl. Cancer Inst. 59: 351-355, 1977.

44. Harris, C. C., Autrup, H. N., Stoner, G. D., McDowell, E. M., Trump, B. F. and Schafer, P.: Metabolism of dimethylnitrosamine and l,2-dimethyl- hydrazine in cultured human bronchi. Cancer Res. 37: 2309-2311, 1977.

45. Levitt, M., Harris, C., Squire, R., Wenk, M., Mollelo, C., Thomas, D., Kingsbury, E. and Newkirk, C.: Experimental pancreatic carcinogenesis. I. Morphogenesis of pancreatic adenocarcinoma in the Syrian golden hamster induced by N-nitroso-bis(2-hydroxypropyl)amine. Amer. J. Path. 88: 5-28, 1977.

46. Harris, C., Autrup, H., Stoner, G., Yang, S., Leutz, J., Gelboin, H., Selkirk, J., Connor, R., Barrett, L., Jones, R., McDowell, E. and Trump, B.: Metabolism of benzo[a]pyrene and 7,l2-dimethylbenz[a]-anthracene in cultured human bronchus and pancreatic duct. Cancer Res. 37: 3349-3355, 1977.

47. Barrett, L., McDowell, E., Harris, C. and Trump, B.: Studies on the pathogenesis of Ischemic cell injury. XV. Reversal of Ischemic cell injury in hamster trachea and human bronchus by explant culture. Beitrage zur Pathologie 161: 109-122, 1977.

48. Meadows, A. T., D'Angio, G. J. Mike, V., Banfi, A., Harris, C., Jenkin, R. D. T. and Schwartz, A.: Patterns of second malignant neoplasms in children. Cancer 40: 1903-1912, 1977.

49. Harris, C., Autrup, H., Stoner, G., McDowell, E., Trump, B. and Schafer, P.: Metabolism of acyclic and cyclic N-nitrosamines in cultured human bronchi. J. Natl. Cancer Inst. 59: 1401-1406, 1977.

50. Autrup, H., Harris, C. C., Fugaro, S. and Selkirk, J.: Effect of various chemicals on the metabolism of benzo(a)pyrene by cultured rat colon. Chem. Biol. Interact. 18: 337-347, 1977.

51. Jeffrey, A. M., Weinstein, I. B., Jennette, K. W., Grzeskowiak, K., Nakanishi, K., Harvey, R. G., Autrup, H. and Harris, C.: Structures of benzo[a]pyrene-nucleic acid adducts formed in human and bovine bronchial explants. Nature 269: 348-350, 1977.

52. Autrup, H., Harris, C., Stoner, G., Selkirk, J., Schafer, P. and Trump, B.: Metabolism of [3H]benzo[a]pyrene by cultured human bronchus and cultured human pulmonary alveolar macrophages. Lab. Invest. 38: 217-223, 1978.

53. Autrup, H., Barrett, L. A., Jackson, F. E., Jesudason, M. L., Stoner, G., Phelps, P., Trump, B. F. and Harris, C. C.: Explant culture of human colon. Gastroenterology 74: 1248-1257, 1978.

54. Levitt, M., Harris, C., Squire, R., Wenk, M., Mollelo, C. and Springer, S.: Experimental pancreatic carcinogenesis. II. Lifetime carcinogenesis studies in the outbred Syrian golden hamster with N-nitroso-bis(2-hydroxypropyl)amine. J. Natl. Cancer Inst. 60: 701-706, 1978.

55. Stoner, G. D., Harris, C. C., Bostwick, D. G., Jones, R. T., Trump, B. F., Kingsbury, E. W., Fineman, E. and Newkirk, C.: Isolation and characterization of epithelial cells from bovine pancreatic duct. In Vitro 14: 581-590, 1978.

56. Stoner, G. D., Harris, C. C., Autrup, H., Trump, B. F., Kingsbury, E. W. and Myers, G. A.: Explant culture of human peripheral lung. I. Metabolism of benzo[a]pyrene. Lab. Invest. 38: 685-692, 1978.

57. Harris, C. C., Hsu, I. C., Stoner, G. D., Trump, B. F. and Selkirk, J. K.: Human pulmonary alveolar macrophages metabolize benzo[a]pyrene to proximate and ultimate mutagens. Nature 272: 633-634, 1978.

58. Hsu, I. C., Autrup, H., Stoner, G. D., Trump, B. F., Selkirk, J. K. and Harris, C. C.: Human bronchus-mediated mutagenesis of mammalian cells by carcinogenic polynuclear aromatic hydrocarbons. Proc. Natl. Acad. Sci. 75: 2003-2007, 1978.

59. McDowell, E. M., Barrett, L. A., Glavin, F., Harris, C. C. and Trump, B. F.: The respiratory epithelium. I. Human bronchus. J. Natl. Cancer Inst. 61: 539-550, 1978.

60. Trump, B. F., McDowell, E. M., Becci, P. J., Barrett, L. A., Glavin, F., Kaiser, H. and Harris, C. C.: The respiratory epithelium. III. Histogenesis of epidermoid metaplasia and carcinoma in situ. J. Natl. Cancer Inst. 61: 563-576, 1978.

61. McDowell, E. M., McLaughlin, J. S., Merenyl, D. K., Kieffer, R. F., Harris, C. C. and Trump, B. F.: The respiratory epithelium. V. Histogenesis of lung carcinomas in the human. J. Natl. Cancer Inst. 61: 587-606, 1978.

62. Autrup, H., Stoner, G., Jackson, F., Harris, C. C., Shamsuddin, T., Trump, B. F. and Barrett, L. A.: Explant culture of rat colon: A model system for studying metabolism of chemical carcinogens. In Vitro 14: 868-877, 1978.

63. Autrup, H., Harris, C. C., Trump, B. F. and Jeffrey, A. M.: Metabolism of benzo[a]pyrene and identification of the major benzo[a]pyrene-DNA adducts in cultured human colon. Cancer Res. 38: 3689-3697, 1978.

64. Autrup, H., Harris, C. C. and Trump, B. F.: Metabolism of acyclic and cyclic N-nitrosamines by cultured human colon. Proc. Soc. Exp. Biol. Med. 159: 111-115, 1978.

65. Autrup, H., Essigman, J. M., Croy, R., Trump, B. F., Wogan, G. N. and Harris, C. C.: Metabolism of aflatoxin B1 and identification of the major aflatoxin B1-DNA adducts formed in cultured human bronchus and colon. Cancer Res. 39: 694-698, 1979

66. Katoh, Y., Stoner, G. D., McIntire, K. R., Hill, T., Anthony, R., McDowell, E. M., Trump, B. F. and Harris, C. C.: Immunologic markers of human bronchial epithelial cells in tissue sections and in culture. J. Natl. Cancer Inst. 62: 1177-1186, 1979.

67. Daynes, R. A., Harris, C.C., Connor, R. J. and Eichwald, E. J.: Skin cancer development in mice exposed chronically to immunosuppressive agents. J. Natl. Cancer Inst. 62: 1075-1082, 1979.

68. Shamsuddin, A. K. M., Barrett, L. A., Autrup, H., Harris, C. C. and Trump, B. F.: Long term organ culture of adult rat colon. Path. Res.Pract. 163: 362-372, 1978.

69. Autrup, H., Harris, C. C., Trump, B. F., Stoner, G. D. and Hsu, I. C.: Uptake of benzo[a]pyrene-ferric oxide particulates by human pulmonary macrophages and release of benzo[a]pyrene and its metabolites. Proc.Soc. Exp. Biol. Med. 161: 280-284, 1979.

70. Hsu, I. C., Harris, C. C., Trump, B. F., Schafer, P. W. and Yamaguchi, M.: Induction of ouabain-resistant mutation and sister chromatid exchanges in Chinese hamster cells with chemical carcinogens mediated by human pulmonary macrophages. J. Clin. Invest. 64: 1245-1252, 1979.

71. Bradley, M. O., Hsu, I. C. and Harris, C. C.: Relationships between sister chromatid exchange and mutagenicity, toxicity and DNA damage. Nature 282: 318-319, 1979.

72. Harris, C. C., Autrup, H., Stoner, G. D., Trump, B. F., Hillman, E., Schafer, P. and Jeffrey, A.: Metabolism of benzo[a]pyrene, N-nitrosodi-methylamine and N-nitrosopyrrolidine and identification of the major carcinogen-DNA adducts formed in cultured human esophagus. Cancer Res. 39: 4401-4407, 1979.

73. Hsu, I. C., Bowden, G. T. and Harris, C. C.: A comparison of cytotoxicity, ouabain-resistant mutation, sister-chromatid exchanges and nascent DNA synthesis in Chinese hamster cells treated with dihydrodiol epoxide derivatives of benzo[a]pyrene. Mutat. Res. 63: 351-359, 1979.

74. Bowden, G. T., Hsu, I. C. and Harris, C. C.: The effect of caffeine on cytotoxicity, mutagenesis and sister-chromatid exchanges in Chinese hamster cells treated with dihydrodiol epoxide derivatives of benzo[a]pyrene. Mutat. Res. 63: 361-370, 1979.

75. Harris, C. C., Yolken R., Krokan, H. and Hsu, I. C.: Ultrasensitive enzymatic radioimmunoassay: Application to detection of cholera toxin and rotavirus. Proc. Natl. Acad. Sci. 76: 5336-5339, 1979.

76. Stoner, G. D., Harris, C. C., Myers, G. A., Trump, B. F. and Connor, R. D.: Putrescine stimulates growth of human bronchial epithelial cells in primary culture. In Vitro 16: 399-406, 1980.

77. Autrup, H., Wefald, F., Jeffrey, A., Tate, H., Schwartz, R. D., Trump, B. F. and Harris, C. C.: Metabolism of benzo[a]pyrene by cultured tracheobronchial tissues from mice, rats, hamsters, bovines and humans. Int. J. Cancer 25: 293-300, 1980.

78. Autrup, H., Schwartz, R. D., Essigmann, J. M., Smith, L., Trump, B. F. and Harris, C. C.: Metabolism of aflatoxin B1, benzo[a]pyrene and 1,2- dimethylhydrazine by cultured rat and human colon. Teratogenesis, Mutagenesis and Carcinogenesis 1: 3-13, 1980.

79. Autrup, H., Harris, C. C., Schwartz, R. D., Trump, B. F. and Smith, L.: Metabolism of l,2-dimethylhydrazine by cultured human colon. Carcinogenesis 1: 375-380, 1980.

80. Barrett, L. A., McDowell, E. M., Hill, T. A., Pyeatte, J. C., Harris, C. C. and Trump, B. F.: Induction of atypical squamous metaplasia with benzo[a]pyrene in cultured hamster tracheas. Pathol. Res. Pract. 168: 134-145, 1980.

81. Hsu, I. C., Poirier, M., Yuspa, S., Yolken, R. and Harris, C. C.: Ultra-sensitive enzymatic radioimmunoassay (USERIA) detects femtomoles of acetylaminofluorene-DNA adducts. Carcinogenesis 1: 455-458, 1980.

82. Hsu, I. C., Poirier, M. C., Yuspa, S. H., Grunberger, D., Weinstein, I. B., Yolken, R. H. and Harris, C.: Measurement of benzo(a)pyrene-DNA adducts by enzyme immunoassays and radioimmunoassay. Cancer Res. 41: 1091-1096, 1981.

83. Stoner, G. D., Katoh, Y., Foidart, J-M., Trump, B. F., Steinert, P. M. and Harris, C. C.: Cultured human bronchial epithelial cells: Blood group antigens, keratin, collagens and fibronectin. In Vitro 17: 577-587, 1981.

84. Valerio, M. G., Fineman, E. L., Bowman, R. L., Harris, C. C., Stoner, G. D., Autrup, H., Trump, B. F., McDowell, E. M. and Jones, R.: Long-term survival of normal adult human tissues as xenografts in congenitally athymic nude mice. J. Natl. Cancer Inst. 66: 849-859, 1981.

85. Haugen, A., Groopman, J., Hsu, I. C., Goodrich, G., Wogan, G. and Harris, C. C.: Monoclonal antibody to aflatoxin B1-modified DNA detected by enzyme immunoassay. Proc. Natl. Acad. Sci. 78: 4124-4127, 1981.

86. Lechner, J. F., Haugen, A., Autrup, H., McClendon, I., Trump, B. F. and Harris, C. C.: Clonal growth of epithelial cells from normal adult human bronchus. Cancer Res. 41: 2294-2304, 1981.

87. Fornace, A. J. Jr., Seres, D. S., Lechner, J. F. and Harris, C. C.: DNA- protein crosslinking by chromium salts. Chem.-Biol. Interactions 36: 345-354, 1981.

88. Stoner, G. D., Pettis, W., Haugen, A., Jackson, F. and Harris, C. C.: Explant culture of rat esophagus in a chemically defined medium. In Vitro 17: 681-688, 1981.

89. Autrup, H., Grafstrom, R. C., Brugh, M., Lechner, J. F., Haugen, A., Trump, B. F. and Harris, C. C.: Comparison of benzo[a]pyrene metabolism in bronchus, esophagus, colon and duodenum from the same individual. Cancer Res. 42: 934-938, 1982.

90. Groopman, J. D., Haugen, A., Goodrich, G. R., Wogan, G. N. and Harris, C. C.: Quantitation of aflatoxin B1-modified DNA using monoclonal antibodies. Cancer Res. 42: 3120-3124, 1982.

91. Haugen, A., Schafer, P., Lechner, J. F., Stoner, G. D., Trump, B. F. and Harris, C. C.: Cellular ingestion, toxic effects and lesions observed in human bronchial epithelial tissue and cells cultured with asbestos and glass fibers. Int. J. Cancer 30: 265-272, 1982.

92. Fornace, A. J., Lechner, J. F., Grafstrom, R. C. and Harris, C. C.: DNA repair in human bronchial epithelial cells. Carcinogenesis 3: 1373-1378, 1982.

93. Cohen, G. M., Grafstrom, R., Gibby, E. M., Smith, L., Autrup, H. and Harris, C. C.: Metabolism of benzo[a]pyrene and 1-naphthol in cultured human tumorous and non-tumorous colon. Cancer Res. 43:1312-1315, 1983.

94. Grafstrom, R. C., Fornace Jr., A. J., Autrup, H., Lechner, J. L. and Harris, C. C.: Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells. Science 220: 216-218, 1983.

95. Hsia, C. C., Tzian, B. L. and Harris, C. C.: Proliferative and cytotoxic effects of fusarium T2 toxin on cultured human fetal esophagus. Carcinogenesis 4: 1101-1107, 1983.

96. Shamsuddin, A. K. M. and Harris, C. C.: Improved enzyme immunoassays using biotin-avidin-enzyme complex. Arch. Path. Lab. Med. 107: 514-517, 1983.

97. Banks-Schlegel, S. P. and Harris, C. C.: Tissue-specific expression of keratin proteins in human esophageal and epidermal epithelium and their cultured keratinocytes. Exp. Cell Res. 146: 271-280, 1983.

98. Yoakum, G. H., Korba, B. E., Lechner, J. F., Tokiwa, T., Gazdar, A. F., Seeley, T., Siegel, M., Leeman, L., Autrup, H. and Harris, C. C.: High frequency transfection and cytopathology of the hepatitis B virus core antigen gene in human cells. Science 222: 385-389, 1983.

99. Lechner, J. F., McClendon, I. A., LaVeck, M. A., Shamsuddin, A. K. M. and Harris, C. C.: Differential control by platelet factors of squamous differentiation in normal and malignant human bronchial cells. Cancer Res. 43: 5915-5921, 1983.

100. Banks-Schlegel, S. P., McDowell, E. M., Wilson, T.S., Trump, B.F. and Harris, C. C.: Keratin proteins in human lung carcinomas: Combined use of morphology, keratin immunocytochemistry and keratin immuno-precipitation. Am. J.Pathol. 114: 273-286, 1984.

101. Willey, J. C., Saladino, A. J., Lechner, J. F. and Harris, C. C.: Acute effects of 12-0-tetradecanoylphorbol-13-acetate, teleocidin B, or 2,3,7,8-tetrachlorodibenzo-p-dioxin in cultured normal human bronchial epithelial cells. Carcinogenesis 5: 209-215, 1984.

102. Willey, J. C., Lechner, J. F. and Harris, C. C.: Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells. Exp. Cell Res. 153: 245-248, 1984.

103. Grafstrom, R. C., Pegg, A. E., Trump, B. F. and Harris, C. C.: O6-Alkyl-guanine-DNA alkyltransferase activity in normal human tissues and cells. Cancer Res. 44: 2855-2857, 1984.

104. Banks-Schlegel, S. P. and Harris, C. C.: Aberrant expression of keratin proteins and cross-linked envelopes in human esophageal carcinoma. Cancer Res. 44: 1153-1157, 1984.

105. Autrup, H., Harris, C. C., Wu, S. M., Bao, L. Y., Pei, H. T., Lu, S., Sun, T. T. and Hsia, C. C.: Activation of chemical carcinogens by cultured human fetal liver, esophagus and stomach. Chem.-Biol. Inter. 50: 15-25, 1984.

106. Trump, B. F., McDowell, E. M. and Harris, C. C.: Chemical carcinogenesis in the tracheobronchial epithelium. Environ. Health Perspec. 55: 77-84, 1984.

107. Grafstrom, R. C., Fornace, Jr., A. J. and Harris, C. C.: Repair of DNA damage caused by formaldehyde in human cells. Cancer Res. 44: 4323-4327, 1984.

108. Willey, J. C., Moser, C. E., Lechner, J. F. and Harris, C. C.: Differential effects of 12-0-tetradecanoylphorbol-13-acetate on cultured normal and neoplastic bronchial epithelial cells. Cancer Res. 44: 5124-5126, 1984.

109. Willey, J. C., Moser, C. E. and Harris, C. C.: Effects of aplysiatoxin and debromoaplysiatoxin on growth and differentiation of normal human bronchial epithelial cells. Cell Biol. Toxicol. 1: 145-154, 1984.

110. Shamsuddin, A. K. M., Sinopoli, N. T., Hemminki, K., Boesch, R. R. and Harris, C. C.: Detection of benzo(a)pyrene-DNA adducts in human white blood cells. Cancer Res. 45: 66-68, 1985.

111. Banks-Schlegel, S. P., Gazdar, A. F. and Harris, C. C.: Intermediate filament and cross-linked envelope expression in human lung tumor cell lines. Cancer Res. 45: 1187-1197, 1985.

112. Yoakum, G. H., Lechner, J. F., Gabrielson, E., Korba, B. E., Malan-Shibley, L., Willey, J. C., Valerio, M. G., Shamsuddin, A. K. M., Trump, B. F. and Harris, C. C.: Transformation of human bronchial epithelial cells transfected by Harvey ras oncogene. Science 227: 1174-1179, 1985. Note: We have discovered that the TBE-1 cells are infected with the SV-40 virus (McMenamin, M G. and Harris, C.C., 1999, unpublished results).

113. Grafstrom, R. C., Curren, R. D., Yang, L. L. and Harris, C. C.: Genotoxicity of formaldehyde in cultured human bronchial cells. Science 228: 89-91, 1985.

114. Saladino, A. J., Willey, J. C., Lechner, J. F., Grafstrom, R. C., LaVeck, M. and Harris, C. C.: Effects of formaldehyde, acetaldehyde, benzoyl peroxide and hydrogen peroxide on cultured human bronchial epithelial cells in vitro. Cancer Res. 45: 2522-2526, 1985.

115. Lechner, J. F., Tokiwa, T., Benedict, W. F., Banks-Schlegel, S., Yeager, Jr., H., Banerjee, A. and Harris, C. C.: Asbestos-associated chromosomal changes in human mesothelial cells. Proc. Natl. Acad. Sci. USA 82: 3884-3888, 1985.

116. Vahakangas, K., Haugen, A. and Harris, C. C.: An applied synchronous fluorescence spectrophotometric assay to study benzo(a)pyrene-diol epoxide-DNA adducts. Carcinogenesis 6: 1109-1116, 1985.

117. Harris, C. C., Vahakangas, K., Newman, M., Trivers, G. E., Mann, D. L. and Wright, W.: Detection of benzo(a)pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in sera from coke oven workers. Proc. Natl. Acad. Sci. USA 82: 6672-6676, 1985.

118. Krokan, H., Lechner, J., Krokan, R. H. and Harris, C. C.: Normal human bronchial epithelial cells do not show an adaptive response after treatment with N-methyl-N'-nitrosoguanidine. Mutat. Res. 146: 205-209, 1985.

119. Garner, R. C., Stanton, C. A., Martin, C. N., Harris, C. C. and Grafstrom, R. C.: Rat and human explant metabolism binding studies and DNA adduct analysis on benzo(a)pyrene and its 6-nitro-derivative. Cancer Res. 45: 6225-6232, 1985.

120. Krokan, H., Grafstrom, R. C., Sundqvist, K., Esterbauer, H. and Harris, C. C.: Cytotoxicity, thiol depletion and inhibition of O6-methyl-guanine-DNA methyltransferase by various aldehydes in cultured human bronchial fibroblasts. Carcinogenesis 6: 1755-1759, 1985.

121. Wilson, V., Smith, R., Autrup, H., Krokan, H., Musci, D.E., Le, N.-N.-T., Longoria, J., Ziska, D. and Harris, C. C.: Genomic 5-methylcytosine determination by 32P-ostlabeling analysis. Anal. Biochem. 152: 275-284, 1986.

122. Burg-Kurland, C. L., Purnell, D. M., Combs, J. W., Hillman, E. A., Harris, C. C. and Trump, B. F.: Immunocytochemical evaluation of primary human esophageal neoplasms and preneoplastic lesions for beta-chorionic gonadotropin, human placental lactogen, α-fetoprotein, carcino-embryonic antigen and nonspecific cross-reacting antigen. Cancer Res. 46: 5730-5737, 1986.

123. Masui, T., Wakefield, L. M., Lechner, J. F., LaVeck, M. A., Sporn, M. B. and Harris, C. C.: Type β transforming growth factor: A differentiation-inducing serum factor for normal human bronchial epithelial cells. Proc. Natl. Acad. Sci. USA 83: 2438-2442, 1986.

124. Harris, C. C., LaVeck, G., Groopman, J. Wilson, V. and Mann, D. L.: Measurement of aflatoxin B1, its metabolites and DNA adducts by synchronous fluorescence spectrophotometry. Cancer Res. 46: 3249-3253, 1986.

125. Boumpas, D. T., Tsokos, G. C., Mann, D. L., Eleftheriades, E. G., Harris, C. C. and Mark, G. E.: Increased proto-oncogene expression in peripheral blood lymphocytes of patients with sytemic lupus erythematosus. Arth. Rheum. 29: 755-760, 1986.

126. Haugen, A., Bechner, G., Benestad, C., Vahakangas, K., Trivers, G. E., Newman, M. J. and Harris, C. C.: Determination of polycyclic aromatic hydrocarbons (PAH) in the urine, benzo(a)pyrene diol epoxide-DNA adducts in lymphocyte DNA and antibodies to the adducts in sera from coke oven workers exposed to measured amounts of PAH in the work atmosphere. Cancer Res. 46: 4178-4183, 1986.

127. Gabrielson, E. W., Rosen, G. M., Grafstrom, R. C., Strauss, K. E. and Harris, C. C.: Studies on the role of oxygen radicals in asbestos-induced cytopathology of cultured human mesothelial cells. Carcinogenesis 7: 1161-1164, 1986.

128. Plummer, S. M., Grafstrom, R. C., Yang, L. L., Curren, R. D., Linnainmaa, K. and Harris, C. C.: Fecapentaene-12 causes DNA damage and mutations in human cells. Carcinogenesis 7: 1607-1610, 1986.

129. Masui, T., Lechner, J. F., Yoakum, G. H., Willey, J. C. and Harris, C. C.: Growth and differentiation of normal and transformed human bronchial epithelial cells. J. Cell. Physiol. Suppl. 4: 73-81, 1986.

130. Burg-Kurland, C. L., Purnell, D. M., Combs, J. W., Valerio, M. G., Harris, C. C. and Trump, B. F.: Immunocytochemical evaluation of human esophageal neoplasms for β-chorionic gonadotropin, placental lactogen, α-feto-protein, carcinoembryonic antigen and nonspecific cross-reacting antigen. Cancer Res. 46: 2936-2943, 1986.

131. Weston, A., Plummer, S. M., Grafstrom, R. C., Trump, B. F. and Harris, C. C.: Genotoxicity of chemical and physical agents in cultured human tissues and cells in vitro. Food Chem. Toxicol. 24: 675-679, 1986.

132. Mitchell, S. C., Waring, R. H., Wilson, V. L., Idle, J. R., Autrup, H., Harris, C. C., Ritchie, J. C., Crothers, M. J. and Sieber, S. M.: Sulphoxidation of S-carboxymethyl-L-cysteine in rhesus monkey (Macaca mulatta), cynomologus monkey (Macaca fascicularis), African green monkey (Cercopithecus aethiops) and the marmoset (Callithrix jacchus). Comp. Biochem. Physiol. 84B: 143-144, 1986.

133. Wakefield, L. M., Robert, A. B., Assoian, R. K., Fanger, B. O., Masui, T., Lechner, J. F., Harris, C. C. and Sporn, M. B.: Structure and function of transforming growth factor beta. Proc. Western Pharmacol. Soc. 29: 475-477, 1986.

134. Burg-Kurland, C. L., Purnell, D. M., Combs, J. W., Harris, C. C. and Trump, B. F.: Monolayer culture of normal human esophageal epithelial cells. J. Tissue Cult. Meth. 10: 227-232, 1986.

135. Baba, M., Klein-Szanto, A. J. P., Trono, D., Obara, T., Yoakum, G. H. and Harris, C. C.: Preneoplastic and neoplastic growth of xenotransplanted lung-derived human cell lines using de-epithelialized rat tracheas. Cancer Res. 47: 573-578, 1987.

136. Shamsuddin, A. K. M., Harris, C. C. and Hinzman, M. J.: Localization of aflatoxin B₁ - nucleic acid adducts in mitochondria and nuclei. Carcinogenesis 8: 109-114, 1987.

137. Curren, R. D., Putman, D. L., Yang, L. L., Haworth, S. R., Lawlor, T. E., Plummer, S. M. and Harris, C. C.: Genotoxicity of Fecapentaene-12 in bacterial and mammalian cell assay systems. Carcinogenesis 8: 349-352, 1987.

138. Sasajima, K., Willey, J. C., Banks-Schlegel, S. P. and Harris, C. C.: Effects of tumor promoters and cocarcinogens on growth and differentiation of cultured human esophageal epithelial cells. J. Natl. Cancer Inst. 78: 419-423, 1987.

139. Willey, J. C., Grafstrom, R. C., Moser, Jr., C. E., Ozanne, C. Sundqvist, K. and Harris, C. C.: Biochemical and morphological effects of cigarette smoke condensate and its fractions on normal human bronchial epithelial cells in vitro. Cancer Res. 47: 2045-2049, 1987.

140. Brash, D. E., Reddel, R. R., Quanrud, M., Farrell, M. and Harris, C. C.: Strontium phosphate transfection of human cells in primary culture. Cell Mol. Biol. 7: 2031-2034, 1987.

141. Gabrielson, E. W., Lechner, J. F., Gerwin, B. I., LaVeck, M. A. and Harris, C. C.: Growth factors for mesothelial and mesothelioma cells. Chest Suppl. 91: 17-18, 1987.

142. Wilson, V. L., Smith, R. A., Longoria, J., Liotta, M. A., Harper, C. M. and Harris C. C.: Chemical carcinogen-induced decreases in genomic 5-methyl-deoxycytidine content of normal human bronchial epithelial cells. Proc. Natl. Acad. Sci USA 84: 3298-3301, 1987.

143. Wakefield, L. M., Smith, D. M., Masui, T., Harris, C. C. and Sporn, M. B.: Distribution and modulation of the cellular receptor for transforming growth factor-beta. J. Cell Biol. 105: 965-975, 1987.

144. Gerwin, B. I., Lechner, J. F., Reddel, R. R., Roberts, A. B., Robbins, K. C., Gabrielson, E. W. and Harris, C. C.: Comparison of production of transforming growth factor-β and platelet-derived growth factor by normal human mesothelial cells and mesothelioma cell lines. Cancer Res. 47: 6180-6184, 1987.

145. Gabrielson, E. W., Rosen, G. M., Grafstrom, R. C., Strauss, K. E., Miyashita, M. and Harris, C. C.: Role of oxygen radicals in 12-0-tetradecanoyl-phorhol-13-acetate-induced squamous differentiation of cultured normal human bronchial epithelial cells. Cancer Res. 48: 822-825, 1988.

146. Hsu, I. C., Harris, C. C., Lipsky, M. M., Snyder, S. and Trump, B. F.: Cell and species differences in metabolic activation of chemical carcinogens. Mutat. Res. 177: 1-7, 1987.

147. Reddel, R. R., Ke, Y., Gerwin, B. I., McMenamin, M. G., Lechner, J. F., Su, R. T., Brash, D. E., Park, J-B., Rhim, J. S. and Harris, C. C.: Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes. Cancer Res. 48: 1904-1909, 1988.

148. Grafstrom, R. C., Dypbukt, J. M., Willey, J. C., Sundqvist, K., Edman, C., Atzori, L. and Harris, C. C.: Pathobiological effects of acrolein in cultured human bronchial epithelial cells. Cancer Res. 48: 1717-1721, 1988.

149. Wilson, V. L., Basu, A. K., Essigmann, J. M., Smith, R. A. and Harris, C. C.: O6 Alkyldeoxyguanosine detection by 32P postlabeling and nucleotide chromatographic analysis. Cancer Res. 48: 2156-2161, 1988.

150. Weston, A., Rowe, M., Poirier, M., Trivers, G., Vahakangas, K., Newman, M., Haugen, A., Manchester, D., Mann, D. and Harris, C.: The application of immunoassays and fluorometry to the detection of polycyclic hydrocarbon-macromolecular adducts and anti-adduct antibodies in humans. Int. Arch. Occup. Environ. Health 60: 157-162, 1988.

151. Gabrielson, E. W., Gerwin, B. I., Harris, C. C., Roberts, A. B., Sporn, M. B. and Lechner, J. L.: Stimulation of DNA synthesis in cultured primary human mesothelial cells by specific growth factors. FASEB J. 2: 2717-2722, 1988.

152. Newman, M. J., Light, B. A., Weston, A., Tollerude, D., Clark, J., Mann, D. L. and Harris, C. C.: Detection and characterization of human serum antibodies to polycyclic aromatic hydrocarbon diol-epoxide DNA adducts. J. Clin. Invest. 82: 145-153, 1988.

153. Santella, R. M., Weston, A., Perera, F. P., Trivers, G. T., Harris, C. C., Young, T. L., Nguyen, D., Lee, B. M. and Poirier, M. C.: Interlaboratory comparison of antisera and immunoassays for benzo[a]pyrene-diol-epoxide-I-modified DNA. Carcinogenesis 9: 1265-1269, 1988.

154. Ke, Y., Reddel, R. R., Gerwin, B. I., Miyashita, M., McMenamin, M., Lechner, J. F. and Harris, C. C.: Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation. Differentiation 38: 60-66, 1988.

155. Curren, R. D., Yang, L. L., Conklin, P. M., Grafstrom, R. C. and Harris, C. C.: Mutagenesis of xeroderma pigmentosum fs ibroblastby acrolein. Mutat. Res. Lett. 209: 17-22, 1988.

156. Reddel, R. R., Ke, Y., Kaighn, M. E., Malan-Shibley, L., Lechner, J. F., Rhim, J. S. and Harris, C.C.: Human bronchial epithelial cells neoplastically transformed by v-Ki-ras: Altered response to inducers of terminal squamous differentiation. Oncogene Res. 3: 401-408, 1988.

157. Bonnard, C., Lechner, J. F., Gerwin, B. I., Fujiki, H. and Harris, C. C.: Effects of palytoxin or ouabain on growth and squamous differentiation of human bronchial epithelial cells in vitro. Carcinogenesis 9: 2245-2249, 1988.

158. Wilson, V. L., Masui, T., Smith, R. A. and Harris, C. C.: Genomic 5-methyldeoxycytidine decreases associated with the induction of squamous differentiation in cultured normal human bronchial epithelial cells. Carcinogenesis 9: 2155-2160, 1988.

159. Manchester, D. K., Weston, A., Choi, J. S., Trivers, G. E., Fennessey, P. V., Quintana, E., Farmer, P. B., Mann, D. L. and Harris, C. C.: Detection of benzo[a]pyrene diol-epoxide-DNA adducts in human placenta. Proc. Natl. Acad. Sci. USA 85: 9243-9247, 1988.

160. Miyashita, M., Smith, M. W., Willey, J. C., Lechner, J. F., Trump, B. F. and Harris, C. C.: Effects of serum, transforming growth factor type beta or 12-0-tetradecanoylphorbol-13-acetate on ionized cytosolic calcium concentration in normal and transformed human bronchial epithelial cells. Cancer Res. 49: 63-67, 1989.

161. Amstad, P., Reddel, R. R., Pfeifer, A., Malan-Shibley, L., Mark, G. E. and Harris, C. C.: Neoplastic transformation of a human bronchial epithelial cell line by a recombinant retrovirus encoding viral Harvey ras. Mol. Carcinogenesis 1: 151-160, 1988.

162. Weston, A., Rowe, M. L., Manchester, D. K., Farmer, P. B., Mann, D. L. and Harris, C. C.: Fluorescence and mass spectral evidence for the formation of benzo[a]pyrene anti-diol-epoxide-DNA and -hemoglobin adducts in humans. Carcinogenesis 10: 251-257, 1989.

163. Bonfil, R. D., Reddel, R. R., Ura, H., Reich, R., Fridman, R., Harris, C. C. and Klein-Szanto, A. J. P.: Invasive and metastatic potential of a Ha-ras transformed human bronchial epithelial cell line. J. Natl. Cancer Inst. 81: 587-594, 1989.

164. Weston, A., Manchester, D. K., Poirier, M. C., Choi, J. S., Trivers, G. E., Mann, D. L. and Harris, C. C.: Derivative fluorescence spectral analysis of polycyclic aromatic hydrocarbon-DNA adducts in human placenta. Chem. Res. Toxicol. 2: 104-108, 1989.

165. Ke, Y., Reddel, R. R., Gerwin, B. I., Reddel, H. K., Somers, A. N. A., McMenamin, M., LaVeck, M. A., Stahel, R. A., Lechner, J. F. and Harris, C. C.: Establishment of a human in vitro mesothelial cell model system for investigating mechanisms of asbestos-induced mesothelioma. Am. J. Pathol. 134: 979-991, 1989.

166. Kaighn, M. E., Reddel, R. R., Lechner, J. F., Peehl, D. M., Camalier, R. F., Brash, D. E., Saffiotti, U. and Harris, C. C.: Transformation of human neonatal prostate epithelial cells by strontium phosphate transfection with a plasmid containing SV40 early region genes. Cancer Res. 49: 3050-3056, 1989.

167. Weston, A., Willey, J. C., Modali, R., Sugimura, H., McDowell, E., Resau, J., Light, B., Haugen, A., Mann, D. L., Trump, B. F. and Harris, C. C.: Differential DNA sequence deletions from chromosomes 3, 11, 13 and 17 in squamous cell carcinoma, large cell carcinoma and adenocarcinoma of the human lung. Proc. Natl. Acad. Sci. USA 86: 5099-5103, 1989.

168. Reddel, R. R., Malan-Shibley, L., Gerwin, B. I., Metcalf, R. A. and Harris, C. C.: Tumorigenicity of a human mesothelial cell line transfected with the EJ-ras oncogene. J. Natl. Cancer Inst. 81: 945-948, 1989.

169. Ura, H., Bonfil, R. D., Reich, R., Reddel, R., Pfeifer, A. M., Harris, C. C. and Klein-Szanto, A. J. P.: Expression of type IV collagenase and pro-collagen genes in oncogene transformed human bronchial epithelial cells: Correlation with tumorigenic, invasive and metastatic abilities. Cancer Res. 49: 4615-4621, 1989.

170. Dypbukt, J. M., Edman, C. C., Sundqvist, K., Kakefuda, T., Plummer, S. M., Harris, C. C. and Grafstrom, R. C.: Reactivity of fecapentaene-12 towards thiols, DNA and these constituents in human fibroblasts. Cancer Res. 49: 6058-6063, 1989.

171. Bonfil, R. D., Momiki, S., Fridman, R., Reich, R., Reddel, R., Harris, C. C. and Klein-Szanto, A.: Enhancement of the invasive ability of a transformed human bronchial epithelial cell line by TPA and diacylglycerol. Carcinogenesis 10: 2335-2338, 1989.

172. Wilson, V. L., Weston, A., Manchester, D. K., Trivers, G. E., Roberts, D. W., Kadlubar, F. F., Wild, C. P., Montesano, R., Willey, J. C., Mann, D. L. and Harris, C. C.: Alkyl and aryl carcinogen adducts detected in human peripheral lung. Carcinogenesis 11: 2149-2153, 1989.

173. Nigro, J. M., Baker, S. J., Preisinger, A. C., Jessup, J. M., Hostetter, R., Cleary, K., Bigner, S. H., Davidson, N., Baylin, S., Devilee, P., Glover, T., Weston, A., Modali, R., Harris, C. C. and Vogelstein, B.: Mutations in the p53 gene occur in diverse human tumor types. Nature 342: 705-708, 1989.

174. Lechner, J. F., Cole, K. H., Reddel, R. R., Anderson, L. and Harris, C. C.: Replicative cultures of adult human and rhesus monkey liver epithelial cells. Cancer Detect. Prevent. 14: 239-244, 1989.

175. Pfeifer, A. M. A., Mark, G. E., Malan-Shibley, L., Graziano, S., Amstad, P. and Harris, C. C.: Cooperation of c-raf-1 and c-myc protooncogenes in the neoplastic transformation of SV-40 T antigen immortalized human bronchial epithelial cells. Proc. Natl. Acad. Sci. USA 86: 10075-10079, 1989.

176. Miyashita, M., Willey, J. C., Sasajima, K., Lechner, J. F., LaVoie, L. J., Hoffmann, D., Smith, M., Trump, B. F. and Harris, C. C.: Differential effects of cigarette smoke condensate and its fractions on cultured normal and malignant human bronchial epithelial cells. Exp. Pathol. 38: 19-29, 1990.

177. Sugimura, H., Caporaso, N. E., Hoover, R. N., Modali, R., Resau, J., Trump, B. F., Lonergan, J. A., Krontiris, T. G., Mann, D. L., Weston, A. and Harris, C. C.: Association of rare alleles of the Ha-ras-1 locus with lung cancer. Cancer Res. 50: 1857-1862, 1990.

178. Kaighn, M. E., Gabrielson, E. W., Iman, D. S., Pauls, E. A. and Harris, C. C.: Suppression of tumorigenicity of a human lung carcinoma line by nontumorigenic bronchial epithelial cells in somatic cell hybrids. Cancer Res. 50: 1890-1896, 1990.

179. Manchester, D. K., Wilson, V. L., Hsu, I. C., Choi, J. S., Parker, N. B., Mann, D. L., Weston, A. and Harris, C. C.: Synchronous fluorescence spectroscopic, immunoaffinity chromatographic and ³²P-postlabeling analyses of human placental DNA known to contain benzo(a)pyrene diol epoxide adducts. Carcinogenesis 11: 553-559, 1990.

180. Pelin-Enlund, K., Husgafvel-Pursiainen, K., Tammilehto, L., Klockars, M., Jantunen, K., Gerwin, B. I., Harris, C. C., Tuomi, T., Vanhala, E., Mattson, K. and Linnainmaa, K.: Asbestos-related malignant mesothelioma: growth, cytology, tumourigenicity and consistent chromosome findings in cell lines from five patients. Carcinogenesis 11: 673-681, 1990.

181. Caporaso, N. E., Tucker, M. A., Hoover, R., Hayes, R. B., Pickle, L. W., Issaq, H., Muschik, G., Green-Gallo, L., Buivys, D., Aisner, S., Resau, J., Trump, B., Tollerud, D., Weston, A. and Harris, C. C.: Lung cancer and the debrisoquine metabolic phenotype. J. Natl. Cancer Inst. 85: 1264-1272, 1990.

182. McDonald, J. W., Brash, D. E., Oseroff, A. R. and Harris, C. C.: Photosensitizing dyes for the selection of nontumorigenic revertants from human lung cancer cell lines. Cancer Res. 50: 5369-5373, 1990.

183. Shields, P. G., Povey, A. C., Wilson, V. W., Weston, A. and Harris, C. C.: Combined high performance liquid chromatography/³²P-postlabeling assay of N⁷methyldeoxyguanosine. Cancer Res. 50: 6580-6584, 1990.

184. Sugimura, H., Caporaso, N. E., Shaw, G. L., Modali, R. V., Gonzalez, F. J., Hoover, R. N., Resau, J. H., Trump, B. F., Weston, A. and Harris, C. C.: Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls. Carcinogenesis 11: 1527-1530, 1990.

185. Tamai, S., Sugimura, H., Caporaso, N. E., Resau, J. H., Trump, B. F., Weston, A. and Harris, C. C.: Restriction fragment length polymorphism analysis of the L-myc gene locus in a case-control study of lung cancer. Int. J. Cancer 46: 411-415, 1990.

186. Gerwin, B. I., Keski-Oja, J., Seddon, M., Lechner, J. F. and Harris, C. C.: TGF-β₁ modulation of urokinase and PAI-1 expression in human bronchial epithelial cells. Am. J. Physiol. 259 (Lung Cell. Mol. Physiol. 3): L262-L269, 1990.

187. Ke, Y., Gerwin, B. I., Ruskie, S. E., Pfeifer, A. M. A., Harris, C. C. and Lechner, J. F.: Cell density governs the ability of human bronchial epithelial cells to recognize serum and transforming growth factor β-1 as squamous differentiation inducing agents. Am. J. Pathol. 137: 833-843, 1990.

188. Newman, M. J., Weston, A., Carver, D. C., Mann, D. L. and Harris, C. C.: Serological characterization of polycyclic aromatic hydrocarbon diol epoxide-DNA adducts using monoclonal antibodies. Carcinogenesis 11: 1903-1907, 1990.

189. Trump, B. F., Berezesky, I. K., Smith, M. W., Jones, R. T., Phelps, P. C., Miyashita, M. and Harris, C. C.: Studies of human bronchial epithelium in vitro: changes of [Ca²⁺]_i in relation to injury, growth and differentiation. Toxicol. In Vitro 4: 646-653, 1990.

190. Hollstein, M., Metcalf, R. A., Welsh, J., Montesano, R. and Harris, C. C.: Frequent mutation of the p53 gene in human esophageal cancer. Proc. Natl. Acad. Sci. USA 87: 9958-9961, 1990.

191. Stoner, G. D., Kaighn, M. E., Reddel, R. R., Resau, J. H., Bowman, D., Naito, Z., Matsukura, N., You, M., Galati, A. J. and Harris, C. C.: Establishment and characterization of SV40 T-antigen immortalized human esophageal epithelial cells. Cancer Res. 51: 365-371, 1991.

192. Hsu, I. C., Metcalf, R. A, Welsh, J., Sun, T., Wang, N. J. and Harris, C. C.: p53 gene mutational hotspot in human hepatocellular carcinomas from Qidong, China. Nature 350: 427-428, 1991.

193. Matsukura, N., Willey, J., Miyashita, M., Taffe, B., Waldren, C., Puck, T. T. and Harris, C. C.: Detection of direct mutagenicity of cigarette smoke condensate in mammalian cells. Carcinogenesis 12: 685-689, 1991.

194. Povey, A. C., Schiffman, M., Taffe, B. G. and Harris, C. C.: Laboratory and epidemiologic studies of fecapentaenes. Mutat. Res. 259: 387-397, 1991.

195. Pfeifer, A. M. A., Jones, R. T., Bowden, P. E., Mann, D., Klein-Szanto, A. J. P., Trump, B. F. and Harris, C. C.: Human bronchial epithelial cells transformed by the c-raf-1 and c-myc protooncogenes induce multidifferentiated carcinomas in nude mice: A model for lung carcinogenesis. Cancer Res. 51: 3793-3801, 1991.

196. Lehman, T. A., Bennett, W. P., Metcalf, R. A., Reddel, R., Welsh, J. A., Ecker, J., Modali, R. V., Ullrich, S., Romano, J. W., Appella, E., Testa, J. R., Gerwin, B. I., Harris, C. C.: p53 mutations, ras mutations and p53-heat shock 70 protein complexes in human lung cell lines. Cancer Res. 51: 4090-4096, 1991.

197. Leone, A., McBride, O. W., Weston, A., Wang, M., Anglard, P., Cropp, C. S., Gorpel, J., Lidereau, R., Callahan, R., Linehan, W. M., Rees, R. C., Harris, C. C., Liotta, L. A. and Steeg, P. S.: Somatic allelic deletion of nm23 in human cancer. Cancer Res. 51: 2490-2493, 1991.

198. Vahakangas, K., Trivers, G. E., Plummer, S., Krokan, H., Rowe, M., Yeager, H., Swartz, R. P. and Harris, C. C.: O⁶-Methylguanine DNA methyltransferase and uracil DNA glycosylase in human broncho-alveolar lavage cells and peripheral blood mononuclear cells from tobacco smokers and non-smokers. Carcinogenesis 12: 1389-1394, 1991.

199. Reddel, R. R., Hsu, I. C., Mass, M. J., Hukku, B., Gerwin, B. I., Salghetti, S. E., Somers, A. N. A., Galati, A. J., Gunning, III, W. T., Harris, C. C. and Stoner, G. D.: A human bronchial epithelial cell strain with unusual in vitro growth potential which undergoes neoplastic transformation after SV40 T antigen gene transfection. Int. J. Cancer 48: 764-773, 1991.

200. Hollstein, M., Sidransky, D., Vogelstein, B. and Harris, C. C.: p53 mutations in human cancers. Science 253: 49-53, 1991.

201. Hollstein, M. C., Peri, R., Mandard, A., Welsh, J., Montesano, R., Metcalf, R., Bak, M. and Harris, C. C.: Genetic analysis of human esophageal tumors from two high incidence areas: frequent p53 base substitutions and absence of ras mutations. Cancer Res. 51: 4102-4106, 1991.

202. Wilson, V. L., Foiles, P. G., Chung, F. L., Povey, A. C., Frank, A. A. and Harris, C. C.: Detection of acrolein and crotonaldehyde DNA adducts in cultured human cells and canine peripheral blood lymphocytes by ³²P postlabeling and nucleotide chromatography. Carcinogenesis 12: 1483-1490, 1991.

203. LaForgia, S., Morse, B., Levy, J., Barnea, G., Cannizzaro, L. A., Li, F., Nowell, P. C., Boghosian-Sell, L., Glick, J., Weston, A., Harris, C. C., Drabkin, H., Patterson, D., Croce, C. M., Schlessinger, J. and Huebner, K.: Receptor protein-tyrosine-phosphatase, PTPγ, is a candidate tumor suppressor gene at human chromosome region 3p21. Proc. Natl. Acad. Sci. USA 88: 5036-5040, 1991.

204. Weston, A., Caporaso, N. E., Taghizadeh, K., Hoover, R. N., Tannenbaum, S. R., Skipper, P. L., Resau, J. H., Trump, B. F. and Harris, C. C.: Measurement of 4-aminobiphenyl-hemoglobin adducts in lung cancer cases and controls. Cancer Res. 51: 5219-23, 1991.

205. Willey, J. C., Broussoud, A., Sleemi, A., Bennett, W. P., Cerutti, P. and Harris, C. C.: Immortalization of normal human bronchial epithelial cells by human papillomaviruses 16 or 18. Cancer Res. 51: 5370-77, 1991.

206. Bennett, W. P., Hollstein, M. C., He, A., Zhu, S. M., Resau, J., Trump, B. F., Metcalf, R. A., Welsh, J. A., Gannon, J. V., Lane, D. P. and Harris, C. C.: Archival analysis of p53 genetic and protein alterations in Chinese esophageal cancer. Oncogene 6: 1779-84, 1991.

207. Maehle, L., Metcalf, R. A., Ryberg, D., Bennett, W. P., Harris, C. C. and Haugen, A.: Altered p53 gene structure and expression in human epithelial cells after exposure to nickel. Cancer Res. 52: 218-221, 1992.

208. Vahakangas, K. H., Samet, J. M., Metcalf, R. A., Welsh, J. A., Bennett, W. P., Lane, D. P. and Harris, C. C.: p53 and ras mutations in radon-associated lung cancer from uranium miners. Lancet 339: 576-580, 1992.

209. Povey, A. C., Wilson, V. L., Zweier, J. L., Kuppusamy, P., O'Neill, I. K. and Harris, C. C.: Detection by ³²P-postlabeling of DNA adducts induced by free radical and unsaturated aldehydes formed during the aerobic decomposition of fecapentaene-12. Carcinogenesis 13: 395-401, 1992.

210. Gerwin, B. I., Spillare, E., Lehman, T. A., Forrester, K., Kispert, J., Pfeifer, A. M. A., Baker, S. J., Vogelstein, B. and Harris, C. C.: Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor β₁. Proc. Natl. Acad. Sci. USA 89: 2759-2763, 1992.

211. Metcalf, R. A., Welsh, J. A., Bennett, W. P., Seddon, M. B., Lehman, T. A., Pelin, K., Linnainmaa, K., Tammilehto, L., Mattson, K., Gerwin, B. I. and Harris, C. C.: p53 and Kirsten-ras mutations in human mesothelioma cell lines. Cancer Res. 52: 2610-2615, 1992.

212. Gabrielson, E. W., Van der Meeren, A., Reddel, R. R., Reddel, H., Gerwin, B. I. and Harris, C. C.: Human mesothelioma cells and asbestos-exposed mesothelial cells are selectively resistant to amosite toxicity: a possible mechanism for tumor promotion by asbestos. Carcinogenesis 13: 1359-1363, 1992.

213. Klein-Szanto, A. J. P., Iizasa T., Momiki, S., Garcia-Palazzo, I., Caamano, J., Metcalf, R., Welsh, J. and Harris, C. C.: A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells. Proc. Natl. Acad. Sci. USA 89: 6693-6697, 1992.

214. Bennett, W. P., Hollstein, M. C., Metcalf, R. A., Welsh, J. A., He, A., Zhu, S., Kusters, I., Resau, J. H., Trump, B. F., Lane, D. P. and Harris, C. C.: p53 mutation and protein accumulation during multistage human esophageal carcinogenesis. Cancer Res. 52: 6092-6097, 1992.

215. Kato, S., Shields, P. G., Caporaso, N. E., Hoover, R. N., Trump, B. F., Sugimura, H., Weston, A. and Harris, C. C.: Cytochrome P450IIE1 (CYP2E1) genetic polymorphisms, racial variation and lung cancer risk. Cancer Res. 52: 6712-6715, 1992.

216. Caporaso, N. E., Shields, P. G., Landi, M. T., Shaw, G. L., Tucker, M. A., Hoover, R., Sugimura, H., Weston, A. and Harris, C. C.: The epidemiologic and laboratory implications of non-correspondence between the debrisoquine metabolic phenotype and DNA-based assays: implications of misclassification for the association of lung cancer and the debrisoquine metabolic phenotype. Environ. Health Perspect. 98: 101-105, 1992.

217. Weston, A., Perrin, L. S., Forrester, K., Hoover, R. N., Trump, B. F., Harris, C. C. and Caporaso, N. E.: Allelic frequency of a p53 polymorphism in human lung cancer. Cancer Epidemiology, Biomarkers & Prevention 1: 481-483, 1992.

218. Gabrielson, E. W., Kuppusamy, P., Povey, A. C., Zweier, J. L. and Harris, C. C.: Measurement of neutrophil activation and epidermal cell toxicity by palytoxin and 12-0-tetracanoylphorbol-13-acetate/ Carcinogenesis 13: 1671-1674, 1992.

219. Hollstein, M. C., Wild, C. P., Bleicher, F., Chutimataewin, S., Harris, C. C., Srivatanakul, P. and Montesano, R.: p53 mutations and aflatoxin B₁ exposure in hepatocellular carcinoma patients from Thailand. Int. J. Cancer 53: 51-55, 1993.

220. Reddel, R. R., Salghetti, S. E., Willey, J. C., Ohnuki, Y., Ke, Y., Gerwin, B. I., Lechner, J. F. and Harris, C. C.: Development of tumorigenicity in Simian virus 40-immortalized human bronchial epithelial cell lines. Cancer Res. 53: 985-991, 1993.

221. Grafstrom, R. C., Hsu, I. C. and Harris, C. C.: Mutagenicity of formaldehyde in Chinese hamster lung fibroblasts: synergy with ionizing radiation and N-Nitroso-N-Methylurea. Chem. Biol. Interactions 86: 41-49, 1993.

222. Lehman, T. A., Modali, R., Boukamp, P., Stanek, J., Bennett, W. P., Welsh, J. A., Metcalf, R. A., Stampfer, M. R., Fusenig, N., Rogan, E. M., Reddel, R. and Harris C. C.: p53 mutations in human immortalized epithelial cell lines. Carcinogenesis 14: 833-839, 1993.

223. Hsu, I. C., Tokiwa, T., Bennett, W., Metcalf, R. A., Welsh, J. A., Sun, T. and Harris, C. C.: p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines. Carcinogenesis 14: 987-992, 1993.

224. Vertino, P. M., Spillare, E., Harris, C. C. and Baylin, S. B.: Altered chromosomal methylation patterns accomplany oncogene-induced transformation of human bronchial epithelial cells. Cancer Res. 53: 1684-1689, 1993.

225. Noguchi, M., Murakami, M., Bennett, W., Lupu, R., Hui Jr., Harris, C. C. and Gerwin, B.I.: Biological consequences of overexpression of a transfected c-erbB-2 gene in "immortalized" human bronchial epithelial cells. Cancer Res. 53: 2035-2043, 1993.

226. Pfeifer, A. M. A., Cole, K. E., Smoot, D.T., Weston, A., Groopman, J. D., Shields, P. G., Vignaud, J.-M., Juillerat, M., Lipsky, M. M., Trump, B. F., Lechner, J. F. and Harris, C. C.: SV40 T-antigen immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens. Proc. Natl. Acad. Sci. USA 90: 5123-5127, 1993.

227. Wilson, V. L., Taffe, B. G., Shields, P. G., Povey, A. C. and Harris, C. C.: Detection and quantitation of 8-hydroxyguanosine adducts in peripheral blood of people exposed to ionizing radiation. Environ. Health Prospectives 99: 261-263, 1993.

228. Evans, M. K., Taffe, B. G., Harris, C. C. and Bohr, V. A.: DNA strand bias in the repair of the p53 gene in normal human and Xeroderma Pigmentosum Group C fibroblasts. Cancer Res. 53: 5377-5381, 1993.

229. Esteve, A., Lehman, T. A., Jiang, W., Weinstein, I. B., Harris, C. C., Ruol, A., Peracchia, A., Montesano, R. and Hollstein, M.: Correlation of p53 mutations with epidermal growth factor receptor overexpression and absence of mdm2 amplification in human esophageal carcinomas. Mol. Carcinogenesis 8: 306-311, 1993.

230. Shields, P. G., Harris, C. C., Petruzzelli, S., Bowman, E. D. and Weston, A.: Standardization of the 32P-postlabeling assay for polycyclic aromatic hydrocarbon-DNA adducts. Mutagenesis 8: 121-126, 1993.

231. Felley-Bosco, E. Weston, A., Cawley, H. M., Bennett, W. P. and Harris, C. C.: Functional studies of a germline polymorphism at codon 47 within the p53 gene. Am. J. Human Genetics 53: 752-759, 1993.

232. Bennett, W. P., Colby, T. V., Vahakangas, K. H., Soini, Y., Takeshima, Y., Metcalf, R. A., Welsh, J. A., Borkowski, A., Jones, R. T., Trump, B. F., Lane, D. P., Travis, W. D., Samet, J. M. and Harris, C. C.: p53 protein accumulates frequently in early bronchial neoplasia. Cancer Res. 53: 4817-4822, 1993.

233. Jiang, W., Zhang, Y. J., Kahn, S. M., Hollstein, M. C., Santella, R. M., Lu, S. H., Harris, C. C., Montesano, R. and Weinstein, I. B.: Altered expression of the cyclin D1 and retinoblastoma genes in human esophageal cancer. Proc. Natl. Acad. Sci. USA 90: 9026-9030, 1993.

234. Iizasa, T., Momiki, S., Bauer, B., Caamano, J., Metcalf, R., Harris, C. C. and Klein-Szanto, A. J. P.: Invasive tumors derived from xenotransplanted, immortilized human cells after in vivo exposure to chemical carcinogens. Carcinogenesis 14: 1789-1794, 1993.

235. Van der Meeren, A., Seddon, M. B., Kispert, J., Harris, C. C. and Gerwin, B. I.: Lack of expression of the retinoblastoma gene is not frequently involved in the genesis of human mesothelioma. Eur. Respir. Rev. 3: 177-179, 1993.

236. Shields, P. G., Caporaso, N. E., Falk, R. T., Sugimura, H., Trivers, G. E., Trump, B. F., Hoover, R. N., Weston, A. and Harris, C. C.: Lung cancer, race and a CYP1A1 genetic polymorphism. Cancer Epidemiol. Biomarkers Prev. 2: 481-485, 1993.

237. Harris, C. C.: p53: At the crossroads of molecular carcinogenesis and risk assessment. Science 262: 1980-1981, 1993.

238. Harris, C. C. and Hollstein, M. C.: Clinical implications of the p53 tumor suppressor gene. New Engl. J. Med. 329: 1318-1327, 1993.

239. Takeshima, Y., Seyama, T., Bennett, W. P., Akiyama, M., Tokuoka, S., Inai, K., Mabuchi, K., Land, C. E. and Harris, C. C.: p53 mutations in lung cancers from non-smoking atomic bomb survivors. Lancet 342: 1520-1521, 1993.

240. Mace, K., Gonzales, F., McConnell, I. R., Garner, R. C., Aventi, O., Harris, C. C. and Pfeifer, A. M. A.: Activation of promutagens in a human bronchial epithelial cell line stably expressing the human CYP1A2. Mol. Carcinogenesis 11: 65-73, 1994.

241. Hollstein, M. C., Marion, M. J., Lehman, T., Welsh, J., Harris, C. C., Martel-Planche, G., Kusters, I. and Montesano, R.: p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers. Carcinogenesis 15: 1-3, 1994.

242. Wang, X. W., Forrester, K., Yeh, H., Feitelson, M. A., Gu, J. and Harris, C. C.: Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity and association with transcription factor ERCC3. Proc. Natl. Acad. Sci. USA 91: 2230-2234, 1994.

243. Weston, A., Ling-Cawley, H. M., Caporaso, N. E., Bowman, E. D., Hoover, R. N., Trump, B. F. and Harris, C. C.: Determination of the allelic frequencies of an L-myc and a p53 polymorphism in human lung cancer. Carcinogenesis 15: 583-589, 1994.

244. Aguilar, F., Harris, C. C., Sun, T., Hollstein, M. and Cerutti, P.: Geographic variation of p53 mutational profile in nonmalignant human liver. Science 264: 1317-1319, 1994.

245. Grafstrom, R. C., Dypbukt, J. M., Sundqvist, K., Atzori, L., Nielsen, I., Curren, R. D. and Harris, C. C.: Pathobiological effects of acetaldehyde in cultured human epithelial cells and fibroblasts. Carcinogenesis 15: 985-990, 1994.

246. Kato, S., Shields, P. G., Caporaso, N. E., Sugimura, H., Trivers, G. E., Tucker, M. A., Trump, B. F., Weston, A. and Harris, C. C.: Analysis of cytochrome P450 2E1 genetic polymorphisms in relation to human lung cancer. Cancer Epidemiol. Biomarkers and Prev. 3: 515-518, 1994.

247. Forrester, K., Kispert, J., Sanchez, J. H., Gerwin, B. I., Tlsty, T. D. and Harris, C. C.: Clonal variation of tumorigenic potential in v-Ha-ras oncogene expression and CAD gene amplification. Molecular Carcinogenesis 11: 34-41, 1994.

248. Felley-Bosco, E., Ambs, S., Lowenstein, C. J., Keefer, L. K. and Harris, C. C.: Constitutive expression of inducible nitric oxide synthase in human bronchial epithelial cells induces c-fos and stimulates the cGMP pathway. Am. J. Respir. Cell Mol. Biol. 11: 159-164, 1994.

249. Hollstein, M., Rice, K., Greenblatt, M. S., Soussi, T., Fuchs, R., Sorlie, T., Hovig, E., Smith-Sorensen, B., Montesano, R. and Harris, C. C.: Database of p53 gene somatic mutations in human tumors and cell lines. Nucl. Acids Res. 22: 3551-3555, 1994.

250. Zabrenetzky, V., Harris, C. C., Steeg, P. S. and Roberts, D. D.: Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines. Internatl. J. Cancer 58: 191-195, 1994.

251. Takeshima, Y., Inai, K., Bennett, W. P., Metcalf, R. A., Welsh, J. A., Yonehara, S., Hayashi, Y., Fujihara, M., Yamakido, M., Akiyama, M., Tokuoka, S., Land, C. E. and Harris, C. C.: p53 mutations in lung cancers from Japanese mustard gas workers. Carcinogenesis 15: 2075-2079, 1994.

252. Okamoto, A., Demetrick, D. J., Spillare, E. A., Hagiwara, K., Hussain, S. P., Bennett, W. P., Forrester, K., Gerwin, B. I., Serrano, M., Beach, D. H. and Harris, C. C.: Mutations and altered expression of p16^INK4 in human cancer. Proc. Natl. Acad. Sci. USA 91: 11045-11049, 1994.

253. Okamoto, A., Jiang, W., Kim, S. J., Spillare, E. A., Stoner G. D., Weinstein, I. B. and Harris, C. C.: Overexpression of human cyclin D1 reduces the TGF-β type II receptor and growth inhibition of TGF-β1 in an immortalized human esophageal epithelial cell line. Proc. Natl. Acad. Sci. USA 91: 11576-11580, 1994.

254. De Silva, R., Englezou, A., Schevzov, G., Gerwin, B. I., Harris, C. C., Gunning, P. and Reddel, R. R.: Induction of anchorage independent growth and serum resistance in immortalized human bronchial epithelial cells by alteration of the cytoskeleton. Cellul. and Molec. Biol. Res. 40: 323-335, 1994.

255. Greenblatt, M. S., Bennett, W. P., Hollstein, M. and Harris, C. C.: Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54: 4855-4878, 1994.

256. Okamoto, A., Hussain, S. P., Hagiwara, K., Spillare, E. A., Rusin, M. R., Demetrick, D. J., Serrano, M., Hannon, G. J., Shiseki, M., Zariwala, M., Xiong, Y., Beach, D. H., Yokota, J. and Harris, C. C.: Mutations in the p16^INK4/MTS1/CDKN2, p15^INK4B/MTS2 and p18 genes in primary and metastatic lung cancer. Cancer Res. 55: 1448-1451, 1995.

257. Reddel, R. R., De Silva, R., Duncan, E. L., Rogan, E. M., Whitaker, N. J., Zahra, D. G., Ke, Y., McMenamin, M. G., Gerwin, B. I. and Harris, C. C.: SV-40-induced immortalization and ras-transformation of human bronchial epithelial cells. Int. J. Cancer 61: 199-205, 1995.

258. Guinee, Jr., D. G., Travis, W. D., Trivers, G. E., De Benedetti, V. M. G., Cawley, H., Welsh, J. A., Bennett, W. P., Jett, J., Colby, T. V., Tazelaar, H., Abbondanzo, S. L., Pairolero, P., Trastek, V., Caporaso, N. E., Liotta, L. A. and Harris, C. C.: Gender comparisons in human lung cancer: analysis of p53 mutations, anti-p53 serum antibodies and c-erbB-2 expression. Carcinogenesis 16: 993-1002, 1995.

259. Shields, P. G., Xu, G. X., Blot, J., Fraumeni, Jr., J. F., Trivers, G. E., Pellizzari, E. D., Qu, Y. H., Gao, Y. T. and Harris, C. C.: Mutagens and from heated Chinese and U. S. cooking oils. J. Natl. Cancer Inst. 87: 836-841, 1995.

260. Pellizzari, E. D., Michael, L. C., Thomas, K. W., Shields, P. G. and Harris, C.: Identification of 1,3-butadiene, benzene and other volatile organics from wok oil emissions. J. Expos. Anal. Environ. Epidemiol. 5: 77-87, 1995.

261. Borkowski, A., Bennett, W. P., Jones, R. T., Borkowski, P., Harris, C. C., Ferreira, L. R., Kao, G. and Trump, B. F.: Quantitative image analysis of p53 protein accumulation in keratoacanthomas. Am. J. Dermatol. Path. 17: 335-338, 1995.

262. Forrester, K., Lupold, S. E., Ott, V. L., Chay, C. H., Band, V., Wang, X. W. and Harris, C. C.: Effects of p53 mutants on wild-type p53 mediated transactivation are cell type dependent. Oncogene 10: 2103-2111, 1995.

263. Trivers, G. E., Cawley, H. L., De Benedetti, V. M. G., Hollstein, M., Marion, M. J., Bennett, W. P., Hoover, M. L., Prives, C., Tamburro, C. and Harris, C. C.: Anti-p53 antibodies in the serum of workers occupationally exposed to vinyl chloride. J. Natl. Cancer Inst. 87: 1400-1407, 1995.

264. Wang, X. W., Yeh, H., Schaeffer, L., Roy, R., Moncollin, V., Egly, J. M., Wang, Z., Friedberg, E. C., Evans, M. K., Taffe, B. G., Bohr, V. A., Weeda, G., Hoeijmakers, J. H. J., Forrester, K. and Harris, C. C.: p53 Modulation of TFIIH-associated nucleotide excision repair activity. Nature Genet. 10: 188-195, 1995.

265. Felley-Bosco, E., Mirkovitch, J., Ambs, S., Mace, K., Pfeifer, A., Keefer, L. K. and Harris, C. C.: Nitric oxide and ethylnitrosurea: relative mutagenicity in the p53 tumor suppressor and hypoxanathine-phosphoribosyltransferase genes. Carcinogenesis 16: 2069-2074, 1995.

266. Ueda, H., Ohkoshi, S., Harris, C. C. and Jay, G.: Synergism between the HBx gene and aflatoxin B₁ in the development of murine liver cancer. Int. J. Oncol. 7: 735-740, 1995.

267. Wang, X. W., Gibson, M. K., Vermeulen, W., Yeh, H., Forrester, K., Sturzbacher, H. W., Hoeijmakers, J. H. J. and Harris, C. C.: Abrogation of p53-induced apoptosis by the hepatitis B virus X gene. Cancer Res. 55: 6012-6016, 1995.

268. Greenblatt, M. S. and Harris, C. C.: Molecular genetics of lung cancer. Cancer Surveys 25: 293-313, 1995.

269. Hollstein, M., Shomer, B., Greenblatt, M., Soussi, T., Hovig, E., Montesano, R. and Harris, C. C.: Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation. Nucl. Acids Res. 24: 141-146, 1996.

270. Forrester, K., Ambs, S., Lupold, S. E., Kapust, R. B., Weinberg, W. C., Felley-Bosco, E., Wang, X. W., Geller, D. A., Billiar, T. R. and Harris, C. C.: Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase (NOS2) expression by wild-type p53. Proc. Natl. Acad. Sci. USA 93: 2442-2447, 1996.

271. Rusin, M. R., Okamoto, A., Chorazy, M., Czyzewski, K., Harasim, J., Spillare, E., Hagiwara, K., Hussain, S. P., Xiong, Y., Demetrick, D. J. and Harris, C. C.: Intragenic mutations of the p16^INK4, p15^INK4B and the p18 genes in primary non-small-cell lung cancers. Int. J. Cancer 65: 734-739, 1996.

272. Greenblatt, M. S., Grollman, A. P. and Harris, C. C.: Deletions and insertions in the p53 tumor suppressor gene in human cancers: confirmation of the DNA polymerase slippage/misalignment model. Cancer Res. 56: 2130-2136, 1996.

273. Spillare, E. A., Okamoto, A., Hagiwara, K., Demetrick, D. J., Serrano, M., Beach, D. and Harris, C. C.: Suppression of growth in vitro and tumorigenicity in vivo of human carcinoma cell lines by transfected p16^INK4. Mol. Carcinogen. 16: 53-60, 1996.

274. Wang, X. W., Vermeulen, W., Coursen, J. D., Gibson, M., Lupold, S. E., Forrester, K., K., Xu, G., Elmore, L., Yeh, H., Hoeijmakers, J. H. J. and Harris, C. C.: The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. Genes and Development 10: 1219-1232, 1996.

275. Soini, Y., Chia, S. C., Bennett, W. P., Groopman, J. D., Wang, J. S., DeBenedetti, V. M. G., Cawley, H., Welsh, J. A., Hansen, C., Bergasa, N. V., Jones, E. A., DiBisceglie, A. M., Trivers, G. E., Sandoval, C. A., Calderon, I. E., Munoz Espinosa, L. E. and Harris, C. C.: An aflatoxin-associated mutational hotspot at codon 249 in the p53 tumor suppressor gene occurs in hepatocellular carcinomas from Mexico. Carcinogenesis 17: 1007-1012, 1996.

276. Hagiwara, K. and Harris, C. C.: 'Long distance sequencer' method; a novel strategy for large DNA sequencing projects. Nucl. Acids Res. 24: 2460-2461, 1996.

277. Takenoshita, S., Hagiwara, K., Nagashima, M., Gemma, A., Bennett, W. P., Harris, C. C.: The genomic structure of the gene encoding the human transforming growth factor β type II receptor (TGF-β RII). Genomics 36: 341-344, 1996.

278. Trivers, G. E., De Benedetti, V. G. M., Cawley, H. L., Caron, G., Harrington, A. M., Bennett, W. P., Jett, J. R., Colby, T. V., Tazalaar, H., Pairolero, P., Miller, R. D. and Harris, C. C.: Anti-p53 in sera from patients with chronic obstructive pulmonary disease can predate a diagnosis of cancer. Clin. Cancer Res. 2: 1767-1775, 1996.

279. Xu, G. W., Sun, Z. T., Forrester, K., Wang, X. W., Coursen, J. and Harris, C. C.: Tissue-specific growth suppression and chemosensitivity promotion in human hepatocellular carcinoma cells by retroviral-mediated transfer of the wild-type p53 gene. Hepatology 24: 1264-1268, 1996.

280. Ohnuki, Y., Reddel, R. R., Bates, S. E., Lechner, J. F. and Harris, C. C.: Chromosomal changes and progressive tumorigenesis of human bronchial epithelial cell lines. Cancer Genetics and Cytogenetics 92: 99-110, 1996.

281. Gemma, A., Takenoshita, S., Hagiwara, K., Okamoto, A., Spillare, E. A., McMenamin, M. G., Hussain, S. P., Forrester, K., Zariwala, M., Xiong, Y. and Harris, C. C.: Molecular analysis of the cyclin dependent kinase inhibitor genes p15INK4b/MTS2, p16INK4/MTS1, p18 and p19 in human cancer cell lines. Int. J. Cancer 68: 605-611, 1996.

282. Wang, X. W. and Harris, C. C.: TP53 tumor suppressor gene: clues to molecular carcinogenesis and cancer therapy. Genetic Instability of Cancer. Cancer Surveys 28: 169-196, 1996.

283. Harty, L. C., Guinee, D. G., Travis, W. D., Bennett, W. P., Jett, J., Colby, T. V., Tazelaar, H., Trastek, V., Pairolero, P., Liotta, L. A., Harris, C. C. and Caporaso, N. E.: p53 mutations and occupational exposures in a surgical series of lung cancers." Cancer Epidemiology, Biomarkers and Prev. 5: 997-1003, 1996.

284. Hussain, S. P., Kennedy, C. H., Amstad, P., Lui, H., Lechner, J. F. and Harris, C. C.: Radon and lung carcinogenesis: mutability of p53 codons 249 and 250 to ²³⁸Pu α-particles in human bronchial epithelial cells. Carcinogenesis 18: 121-125, 1997.

285. Bowman, E. D., Shields, P. G., Caporaso, N. E., Tucker, M. A., Hoover, R. N., Trump, B. F. and Harris, C. C.: Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk. Oncology Reports 4: 269-272, 1997.

286. Hainaut, P., Soussi, T., Shomer, B., Hollstein, M., Greenblatt, M., Hovig, E., Harris, C. C. and Montesano, R.: Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects. Nucl. Acids Res. 25: 151-157, 1997.

287. Greenblatt, M. S., Feitelson, M. A., Zhu, M., Bennett, W. P., Welsh, J. A., Jones, R., Borkowski, A. and Harris, C. C.: Integrity of p53 in hepatitis B x antigen-positive and -negative hepatocellular carcinomas. Cancer Res. 57: 426-432, 1997.

288. Adler, V., Pincus, M. R., Minamoto, T., Fuchs, S. Y., Bluth, M. J., Brandt-Rauf, P. W., Friedman, F., Robinson, R. C., Chen, J. M., Wang, X. W., Harris, C. C. and Ronai, Z.: Conformation-dependent phosphorylation of p53. Proc. Natl. Acad. Sci. USA 94: 1686-1691, 1997.

289. Gemma, A., Hagiwara, K., Ke, Y., Burke, L. M., Khan, M. A., Nagashima, M., Bennett, W. P. and Harris, C. C.: FHIT mutations in human primary gastric cancer. Cancer Res. 57: 1435-1437, 1997.

290. Takenoshita, S., Tani, M., Nagashima, M., Hagiwara, K., Bennett, W. P., Yokota, J. and Harris, C. C.: Mutation analysis of coding sequences region of the transforming growth factor beta type II receptor gene in sporadic human colon cancer using genomic DNA and intron primers. Oncogene 14: 1255-1258, 1997.

291. Mace, K., Vautravers, P., Granato, D., Gonzalez, F. J., Harris, C. C. and Pfeifer, A. M. A.: Development of CYP450-expressing human bronchial epithelial cell lines for in vitro pharmatoxicologic applications. In Vitro Toxicol. 10: 85-92, 1997.

292. Tani, M., Takenoshita, S., Kohno, T., Hagiwara, K., Nagamachi, Y., Harris, C. C. and Yokota, J.: Infrequent mutations of the transforming growth factor beta type II receptor gene at chromosome 3p22 in human lung cancers with chromosome 3p deletions. Carcinogenesis 18: 1119-1121, 1997.

293. Ambs, S., Hussain, S. P. and Harris, C. C.: Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression. FASEB J. 11: 443-448, 1997.

294. Mace, K., Aguilar, F., Wang, J. S., Vautravers, P., Gomez-Lechon, M., Gonzalez, F. J., Groopman, J., Harris, C. C. and Pfeifer, A. M. A.: Aflatoxin B₁ induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines. Carcinogenesis 18: 1291-1297, 1997.

295. Takenoshita, S., Hagiwara, K., Gemma, A., Nagashima, M., Ryberg, D., Lindstedt, B. A., Bennett, W. P., Haugen, A. and Harris, C. C.: Absense of mutations in the transforming growth factor-β type II receptor in sporadic lung cancers with microsatellite instability and rare H-ras alleles. Carcinogenesis 18: 1427-1429, 1997.

296. Coursen, J. D., Bennett, W. P., Khan, M. A., Forrester, K., Pietenpol, J. A. and Harris, C. C.: Differential effects of p53 mutants on the growth of human bronchial epithelial cells. Mol. Carcinogenesis 19: 191-203, 1997.