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Cancer Prevention Fellowship Program U.S. National Institutes of Health National Cancer Institute
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2008 Application Catalog

Preceptorships — Division of Cancer Prevention

Foundations of Prevention Research Groups

The Basic Prevention Science Research Group develops and implements a program of molecular prevention of cancer by integrating laboratory-based basic/clinical research of NCI intramural and extramural research divisions with that of the Division of Cancer Prevention. Attention is given to molecular genetics and molecular pathogenesis of precancer and the application of these approaches to clinical trials in cancer prevention.

Acting Chief: Peter Greenwald, M.D., Dr.P.H.

Potential Preceptor:

Iqbal U. Ali, Ph. D.

Molecular studies of cancer prevention using state-of-the-art technologies that focus on tumor suppressor genes, oncogenes, various signaling pathways and repair mechanisms.

Studies are performed at the Frederick Cancer Research and Development Center, NCI, Frederick, Maryland. Fellows will have the opportunities of exposure, training, and publication in the latest in the area of molecular genetics and technology. An outline of the projects currently being studied include:

  • Functional significance of genetic polymorphisms using DCP-funded clinical trials
    • Analysis of single nucleotide polymorphisms (SNPs) in genes relevant for colorectal cancer (PLCO Trial and Arizona Clinical Trial).
    • SNPs analysis in genes relevant for susceptibility to breast cancer (Fenritinide Trial).
    • Role of SNPs in the arachidonic acid pathway in determining the molecular basis of response vs. nonresponse to Celecoxib (FAP/Celecoxib Trial).
  • Expression microarrays and proteomic analyses
    • Molecular fingerprinting of matching sets of normal tissues, precancerous and invasive lesions from multiple cancers.
    • Analysis of serum proteins from cancer patients to identify markers for early detection and chemopreventive/therapeutic efficacy monitoring.
  • Analysis of key genes in angiogenesis, apoptosis, and cellular senescence that can serve as molecular biomarkers and as molecular targets for chemoprevention.

 

A Service of the National Cancer Institute

Department of Health and Human Services National Institutes of Health USA.gov